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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
29.08.2026journal-article

Mathematics

Can IL-10 Inhibitor Therapy Alongside MDT Enhance Leprosy Treatment? A Comprehensive Mathematical Study

Salil Ghosh, Huina Zhang, Satyajit Mukherjee, Xianbing Cao, Amit Kumar Roy, Priti Kumar Roy

Leprosy is characterized by complex biological and cellular interactions, driven primarily by the interplay between Th1 and Th2 cells. In this study, we develop a deterministic mathematical model to investigate the interactions among healthy and infected Schwann cells, M. leprae bacteria, and Th1–Th2 immune responses. The positivity and boundedness of the proposed five-dimensional system are established, and the disease persistence condition is characterized in terms of the basic reproduction number (R0). The exist …

29.08.2026journal-article

Archiv Euromedica

SOTATERCEPT AS A POTENTIAL DISEASE-MODIFYING THERAPY IN PULMONARY ARTERIAL HYPERTENSION: A NARRATIVE REVIEW

Aleksandra Kamińska, Maria Miller, Aleksandra Pakulska, Aleksandra Błoch, Natalia Rządzińska

Background Pulmonary arterial hypertension (PAH) is a progressive and potentially fatal disease characterized by increased pulmonary vascular resistance, pulmonary vascular remodeling, and right ventricular failure. To date, therapy has relied mainly on vasodilatory action and has not sufficiently improved patients' long-term prognosis. There is therefore a need for therapies targeting pathways involved in disease progression and pulmonary vascular remodeling. Aims To summarize current data on the mechanism of acti …

29.08.2026journal-article

REiLA : Journal of Research and Innovation in Language

Interactional Pragmatics of Directive Speech Acts in Hypnotherapy: A Qualitative Case Study of a Mental-Block Client

Suci Ayu Kurniah, Gusnawaty Gusnawaty, Lukman Lukman, Ikhwan M. Said

Language serves as a therapeutic instrument in hypnotherapy, yet how directive speech acts are strategically organized to facilitate emotional regulation and behavioral transformation in naturally occurring sessions remains underexplored. Existing research predominantly emphasizes clinical efficacy and psychological outcomes, while micro-pragmatic analyses of how therapists linguistically construct suggestion, authority, and client agency across session phases remain limited, particularly in non-English therapeutic …

29.08.2026journal-article

Denta: Jurnal Kedokteran Gigi

Effect of Low-Level Laser Therapy on The Number of Lymphocytes in Oral Ulcer Healing of Immunosuppressed Rats

Reiska Kumala Bakti, Desiana Radithia, Nurina Febriyanti Ayuningtyas, Fatma Yasmin Mahdani, Ghinaya Shaliha Nursaida Nisa

Background: Glucocorticoid-induced immunosuppression disrupts cellular immune responses, including lymphocyte function, and delays oral traumatic ulcer healing. Low-Level Laser Therapy (LLLT) offers an alternative for healing traumatic oral ulcers in immunosuppressed patients. Objective: To analyze the effect of 650 nm LLLT on the number of lymphocytes in traumatic ulcer tissue of immunosuppressed Wistar rats. Materials and Methods: Experimental laboratory study with a randomized post-test-only control group design …

29.08.2026journal-article

Journal of Neuropsychology

Enhancing social and linguistic skills in children with autism: A semi‐randomized controlled clinical trial of a virtual reality‐based communicative rehabilitation programme

Hassnaa O. Mohammed, Ehab M. Eid, Enas Rady Younes

Abstract Autism spectrum disorder (ASD) is characterized by persistent deficits in social communication, and conventional therapies often struggle to facilitate the generalization of these skills to real‐world settings. This study aimed to determine the effectiveness of a virtual reality (VR)‐based communication rehabilitation intervention as a supplement to conventional treatment for improving the linguistic and social communication skills of Arabic‐speaking Egyptian children with ASD. A clinical trial with a pret …

29.08.2026journal-article

Journal of Neuro-Oncology

Radiological response of primary central nervous system lymphoma after corticosteroid therapy and its predictive value on overall survival: a multicenter study

Florian Scheichel, D. Pinggera, T. Rossmann, B. Popadic, S. Aspalter, V. Schön, A. Woehrer, M. M. Dorostkar, C. Dorfer, C. F. Freyschlag, F. Marhold

Abstract Background Primary Large-B-Cell Lymphoma of the CNS (PCNS-LBCL) is a rare, aggressive tumor often sensitive to corticosteroid therapy (CST). This multicenter study investigated the spectrum of radiological responses to routine CST and evaluated its impact on patient prognosis. Methods The researchers utilized a prospective cohort of 18 patients for volumetric MRI analysis and a combined prospective-retrospective cohort of 31 patients for 2D tumor analysis. Patients received CST post-biopsy, with follow-up …

29.08.2026journal-article

Experimental Physiology

Cardiometabolic effects of contrast therapy: A systematic review

Veerle de Haan, Guy Plasqui, Hannah Pallubinsky

Abstract The rising prevalence of overweight and obesity, together with associated cardiometabolic disorders, underscores the need for additional strategies alongside established interventions. The growing popularity of contrast therapy – alternating exposure to heat and cold, a practice common in traditional Finnish sauna bathing – has prompted interest in its potential cardiovascular and metabolic health benefits. This systematic review outlines the acute and chronic effects of contrast therapy on cardiometabolic …

29.08.2026journal-article

Nutrients

Phase-Specific Nutritional Therapy in Critical Illness: When Protein May Help and When It May Harm, from Acute Metabolic Adaptation to Post-ICU Recovery

Mircea Stoian, Adina Stoian, Claudia Bănescu, Sergio Rares Bandilă Bandilă, Alina Danilesco, Hajnal Finta, Leonard Azamfirei

Background: Nutritional support in critically ill patients remains one of the most debated aspects of intensive care medicine. Although international guidelines have long recommended early nutritional support with progressive protein delivery, recent clinical evidence has questioned the benefit of aggressive early calorie and protein provision during the acute phase of critical illness, highlighting the need for phase-adapted nutritional strategies. Methods: This narrative review summarizes current evidence on indi …

29.08.2026journal-article

Journal of Clinical Medicine

Effects of Metformin Monotherapy Versus Metformin Plus SGLT-2 Inhibitor Therapy on Molecular and Cellular Inflammatory Markers in Patients with Newly Diagnosed Type 2 Diabetes Mellitus

Bennur Esen, Damla Yildiz, Ahmet Engin Atay

Background/Objectives: Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by insulin resistance and chronic low-grade inflammation. Tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), the systemic immune-inflammation index (SII), and the systemic inflammation response index (SIRI) are important markers used to evaluate inflammatory status in T2DM. This study aimed to compare inflammatory and metabolic parameters between patients receiving metformin monotherapy and those receiving metformin …

29.08.2026journal-article

Indonesian Journal of Electronics, Electromedical Engineering, and Medical Informatics

An Explainable XGBoost Framework for Mortality Prediction in People Living with HIV Receiving Antiretroviral Therapy

Ni Putu Likayuni Viona, Ngakan Nyoman Kutha Krisnawijaya, Desak Nyoman Widyanthini

Mortality remains an important concern among people living with HIV (PLHIV) receiving antiretroviral therapy (ART), particularly when high-risk patients are not identified early. This study presents an explainable mortality prediction approach based on an optimized Extreme Gradient Boosting (XGBoost) classifier. A retrospective dataset containing 393 clinical records was analyzed. Before model training, duplicate entries were removed, missing values were imputed, categorical variables were encoded, and class imbala …

29.08.2026journal-article

BMC Health Services Research

National trends in inpatient rehabilitation utilization among patients with sepsis in Japan: a nationwide cohort study from 2010 to 2020 by the Japan Sepsis Alliance (JaSA) study group

Taro Imaeda, Yusuke Kawamura, Takehiko Oami, Tatsuro Yokoyama, Satoshi Nakagawa, Hiroshi Ogura, Nobuaki Shime, Yutaka Umemura, Asako Matsushima, Kiyohide Fushimi, Taka-aki Nakada

Abstract Background Rehabilitation is increasingly recognized as an essential component of recovery for patients with sepsis. However, the real-world delivery of rehabilitation services for sepsis has not been characterized at a national level. This study aimed to evaluate temporal trends and patterns in the utilization and delivery of inpatient rehabilitation among patients hospitalized with sepsis in Japan. Methods This nationwide retrospective cohort study used the Japanese Diagnosis Procedure Combination databa …

29.08.2026journal-article

Archives of Current Research International

Herbal Therapy in the Management of Polycystic Ovary Syndrome: A Critical Narrative Review of Mechanistic Claims, Clinical Evidence and Translational Barriers

Ayushi Masih, V. Paul

Polycystic ovary syndrome, still widely described as polycystic ovarian disease in parts of South Asia, is the most common endocrine and metabolic disorder affecting women of reproductive age. Its management remains symptom directed, and dissatisfaction with conventional pharmacotherapy has helped make herbal preparations one of the most frequently self-administered adjuncts in this population. The purpose of this critical narrative review is to evaluate what the accessible literature can and cannot establish about …

29.08.2026journal-article

Antibiotics

Specialty-Related Differences in Adherence to Antibiotic Therapy Guidelines for Infective Endocarditis in Older Patients

Lidvine Godaert, Claire Roubaud-Baudron, Emmanuel Forestier, Moustapha Dramé, the ENDOLA Study Group

Background/Objectives: Infective endocarditis (IE) is a condition with complex management, and several guidelines exist to guide clinicians. Adherence to these recommendations varies and could even be described as poor. The aim of this study was to determine whether the medical specialty of the unit that initiated first-line treatment for IE was associated with risk factors of non-adherence to the 2015 ESC treatment guidelines in a population of patients aged 75 years and over. Method: We analysed data from patient …

29.08.2026journal-article

Mini-Reviews in Medicinal Chemistry

Mitochondrial Dynamics and Bioenergetic Reprogramming: Drivers of Cancer Therapy Resistance

Varsha Johariya, Vaibhav Singh, Rakesh Kore, Santosh Kumar, Ravichandran Veerasamy, Amit K. Tiwari, Harish Rajak

Abstract: Mitochondria, often referred to as the powerhouses of the cell, play a pivotal role in maintaining cellular homeostasis through the regulation of energy production, redox balance, and apoptosis. Recent evidence highlights the significance of mitochondrial dynamics, fusion, fission, biogenesis, and mitophagy, enabling cells to adapt to changing physiological and environmental conditions. Dysregulation of these dynamic processes alters mitochondrial function, promoting metabolic reprogramming, evasion of ap …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Determinants for antibiotic therapy less or more than 7 days in pediatric oncology patients with bacteremia: a global multicenter retrospective study

Griselda Escobedo-Melendez, Joseph Wardell, Parthasarathi Bhattacharyya, Joanna Acebo, Riyadi Adrizain, Bambang Ardianto, Martha Avilés, Maribel Baquera Arteaga, Shymaa Elsayed, Dolores Freire Jijon, Samanmalee Gunasekara, Asher Hancock, Hilda Hernandez, Kim Hoa, Reham Khedr, Yanina Lagala, Jacqueline Levy, Sergio Licona, Medalit Luna, Alejandra Nava, Genara Santana, Eneida Sánchez Medina, Meenakshi Devidas, César Villegas, Sheena Mukkada

Abstract Background Randomized trials support the non-inferiority of short-course (≤7 days) antibiotic therapy for bacteremia; however, these studies commonly exclude immunocompromised patients. Shorter regimens may reduce drug toxicity while optimizing resource utilization and patient quality of life. Evidence to guide treatment duration in immunocompromised children remains limited. Methods We conducted a global, multicenter retrospective study of bacteremia in children with cancer ≤18 years old treated between A …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Impact of Fidaxomicin De-Restriction on Clostridioides difficile Episodes in Hospitalized Pediatric Cellular Therapy Patients

Andrew Karnaze, Darra Drucker, Regina Orbach, Leila C Posch

Abstract Background Pediatric patients undergoing cellular therapy (CT) with hematopoietic cell transplantation (HCT) or chimeric antigen receptor T-cell (CAR-T) therapy are vulnerable to Clostridioides difficile infection (CDI). Recent guidelines recommend fidaxomicin treatment for first and recurrent uncomplicated CDI episodes in this population, though pediatric real-world data is limited. Fidaxomicin is narrower spectrum, dosed less frequently, and can be used for shorter durations versus enteral vancomycin. In …

29.08.2026journal-article

Medical Oncology

Risk-adapted first-line therapy selection in advanced EGFR-mutant NSCLC: a practical clinical algorithm integrating tumor biology and patient factors

Ashish Sharma, Joecelyn Kirani Tan, Harendra Kumar, Hareesha Rishab Bharadwaj

Abstract Advanced EGFR -mutant non-small cell lung cancer (NSCLC), specifically tumors harboring classical activating mutations (exon 19 deletions and L858R substitutions, which are the exclusive focus of this review), is no longer a single-treatment landscape. The MARIPOSA and FLAURA2 phase 3 trials have established that combination regimens of amivantamab plus lazertinib and osimertinib plus platinum-pemetrexed, respectively, extend both progression-free and overall survival compared with osimertinib monotherapy. …

29.08.2026journal-article

Antimicrobial Resistance & Infection Control

Antimicrobial therapy among hospitalized older adults with suspected infection and negative blood cultures

Galadriel Pellejero-Sagastizabal, Elena Morte-Romea, José Antonio Girón Ortega, José Ramón Paño-Pardo, Raquel Fernández Guerrero, Francisca Guerrero, Montserrat Montes de Oca, Silvia Jiménez-Jorge, Zaira R. Palacios-Baena, Jesús Rodríguez-Baño, Pilar Retamar-Gentil, NO-BACT Team, Montserrat Montes de Oca Arjona, Fátima Galán Sánchez, María Eugenia Rodríguez Mateos, José Antonio Girón-González, Andrés Martín Aspas, Claudio Sánchez Tembleque, Francisca María Guerrero Sánchez, Pilar Luque Gómez, José Luis Sierra, Santiago Letona Gimenez, Pilar Palacián, Nora Mariela Rodriguez, Mercedes Arenere Mendoza, Maria Ángeles Allende Bandrés, Raquel Fresquet Molina, Irene Navarro Pardo, Raquel Fernández Guerero, Zaira Palacios-Baena, Marina de Cueto, Margarita Beltrán García, María Luisa Cantón Bulnes, Lorenzo Roberto Suarti

Abstract Background Managing infections in older adults is challenging due to their unique characteristics, which often drives empirical antimicrobial use, increasing risks of adverse outcomes and antimicrobial resistance (AMR). Data on antimicrobial adequacy in older patients with suspected infection but negative blood cultures (BC) remain scarce, despite this being a common clinical scenario. Methods In this multicenter prospective cohort study (NO-BACT project) across three Spanish hospitals (2018–2019), we comp …

29.08.2026journal-article

International Journal of Research in Medical Sciences

Bridging therapy during delayed definitive radiotherapy in locally advanced head and neck squamous cell carcinoma: a prospective randomized study comparing induction TPF chemotherapy with oral metronomic chemotherapy

Ipsita Palui, Abhishek Basu, Sayani Poddar, Koushik Chatterjee

Background: Prolonged waiting periods before definitive radiotherapy remain a major challenge in the management of locally advanced head and neck squamous cell carcinoma (LA-HNSCC), particularly in resource-constrained healthcare settings. Bridging systemic therapy during this interval may help maintain disease control until definitive radiotherapy can be initiated. The aim of the study was to compare the efficacy and safety of induction docetaxel, cisplatin, and 5-fluorouracil (TPF) chemotherapy with oral metronom …

29.08.2026journal-article

International Journal of Molecular Sciences

Enhancer of Zeste Homolog 2 (EZH2): From Glioblastoma Biology to Potential Epigenetic Therapy

Jan Grzegorzewski, Maria Lindner, Dagmara Lisińska, Aleksandra Majchrzak-Celińska

Epigenetic dysregulation is a hallmark of glioblastoma (GBM) pathogenesis, with histone methylation playing a central role in chromatin remodeling and gene expression regulation. Enhancer of zeste homolog 2 (EZH2) is a key epigenetic regulator responsible for histone methylation. It primarily functions as a transcriptional repressor and regulates signaling pathways associated with tumor progression. Importantly, EZH2 is frequently recruited to long non-coding RNA (lncRNA) scaffolds, including HOTAIR and AGAP2-AS1, …

29.08.2026journal-article

BMC Cancer

Continued high mortality following diagnosis of HIV-associated Kaposi sarcoma in East Africa in the “Treat All” antiretroviral therapy era ― 2021-2024

Helen Byakwaga, Aggrey Semeere, Megan Wenger, Esther Freeman, Miriam Laker-Oketta, Elyne Rotich, Beatrice P. Mushi, Matthew Ssemakadde, Hilda Muwando, Bronia Mwine, Racheal Ayanga, Celestine Lagat, Sigrid Collier, Zainab Illonga, Robert Lukande, Philippa Kadama-Makanga, Pendo Ibrahim, Linda Chemutai, Toby Maurer, Charles Kasozi, Winnie Muyindike, Elia Mmbaga, David V. Glidden, Samson Kiprono, Kara Wools-Kaloustian, Andrew Kambugu, Jeffrey Martin

Abstract Background Stage at time of diagnosis and survival after diagnosis are critical parameters regarding control of any cancer in any geographical setting. In earlier research focusing on the initial years of the “Treat All” era (2016–2019), we found that HIV-associated Kaposi sarcoma (KS) in East Africa continued to be diagnosed at advanced stage of disease and conferred high mortality. Given the potential for broader implementation of “Treat All” as well as the announcement of National Comprehensive Cancer N …

29.08.2026journal-article

International Forum of Allergy & Rhinology

Impact of Highly Effective Modulator Therapy on Olfactory‐Specific Gene Expression in People With Cystic Fibrosis

Michael R. Xiang, Ankit Chauhan, Gina Hong, Denis Hadjiliadis, Daniel Dorgan, Michael M. Rey, Samantha Kane, James N. Palmer, Nithin D. Adappa, Noam A. Cohen, Michael A. Kohanski, Jennifer E. Douglas

ABSTRACT Background Chronic rhinosinusitis is common in people with cystic fibrosis (PwCF). Highly effective modulator therapy (HEMT) has been shown to improve sinonasal outcomes. However, prior studies failed to show improvement in objective olfaction with HEMT, and the impact of HEMT on olfactory‐specific quality of life has yet to be studied. Furthermore, the underlying changes in gene expression within the olfactory epithelium (OE) of PwCF remains poorly understood. Methods Single‐center cross‐sectional cohort …

29.08.2026journal-article

Dentistry Journal

Clinical and Esthetic Outcomes of Vestibular Socket Therapy: A Systematic Review and Meta-Analysis

Yasser Sherif Soliman, Nadine Gräfin von Krockow, Fatma E. A. Hassanein, Mihad Ibrahim, Abdelsalam ElAskary, Hossam Ismail

Background/Objectives: Vestibular socket therapy (VST) is a minimally invasive technique for immediate implant placement (IIP) in compromised extraction sockets that reconstructs the deficient buccal plate while preserving the crestal soft tissue. Despite growing clinical adoption, the randomized evidence on its predictability and biological performance remains limited. Methods: Following PRISMA 2020 and prospectively registered in PROSPERO (CRD420261288724), PubMed/MEDLINE and EMBASE were searched to January 2026 …

29.08.2026journal-article

Translational Medicine

Early discontinuation of dual antiplatelet therapy after PCI in patients at high bleeding risk: an OCT-guided clinical case

A. A. Prokhorikhin, Yu. V. Kukushkina, D. D. Zubarev, A. V. Gorbatykh, K. A. Rzaeva

Background. Optimizing the duration of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) remains challenging, especially in patients with high bleeding risk and diabetes mellitus, where stent thrombosis risk is significantly increased due to delayed endothelialization. Objective. To demonstrate the safety of early DAPT discontinuation based on individual assessment of stent endothelialization using optical coherence tomography (OCT). Materials and Methods. We present a clinical case of …