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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

Cancer Research Communications

Targeting PRMT5 Inhibitor–Induced Adaptation in Pancreatic Cancer with the RBM39 Degrader Indisulam

Valentina Spielmann, Jonas Buchloh, Selen Selcen, Carolin Schneider, Shaishavi Jansari, Xin Fang, Ningjun Duan, Engin Demirdizen, Lukas Krauß, Jessica Eggert, Geraldine Siegfried, Sandrine Fedou, Christof Lenz, Lena Wieland, Lena-Christin Conradi, Maximilian Reichert, Volker Ellenrieder, Michael Ghadimi, Marian Grade, Elisabeth Hessmann, Abdel-Majid Khatib, Christian J. Braun, Florian Wegwitz, Dieter Saur, Matthias Wirth, Günter Schneider

Abstract Pancreatic ductal adenocarcinoma (PDAC) remains a formidable clinical challenge. Next-generation protein arginine methyltransferase 5 (PRMT5) inhibitors show promising clinical results in a subset of PDACs with codeletion of the tumor-suppressor CDKN2A and the methylthioadenosine phosphorylase (MTAP) gene, but resistance limits their efficacy. Our study suggests that compensatory spliceosomal reprogramming contributes to adaptation to PRMT5 inhibition. Through comprehensive molecular profiling, we demonstr …

01.09.2026journal-article

Frontiers in Immunology

Spatial immune biomarkers in triple-negative breast cancer: emerging evidence, technology trade-offs, and barriers to clinical translation

Liuhai Zeng, Wei Lin, Shihang Xue, Minzhi Chen, Haiyan Wu

Triple-negative breast cancer (TNBC) is an immunogenic but clinically heterogeneous breast cancer subtype. Stromal tumor-infiltrating lymphocytes (TILs), PD-L1 expression, and tumor mutational burden provide useful but incomplete summaries of the tumor immune microenvironment. Spatial immune biomarkers retain tissue architecture and ask where immune cells are located, which cells they contact, and whether local neighborhoods are inflamed, excluded, suppressive, or organized into tertiary lymphoid structures (TLS). …

01.09.2026journal-article

JAMA

Nicotine E-Cigarettes for Cigarette Smoking Cessation

Eleanor L. S. Leavens, Kinsey Pebley, Tracy T. Smith, Jasjit S. Ahluwalia, Mariel S. Bello, Krysten W. Bold, Jennifer Cantrell, Matthew J. Carpenter, Patricia A. Cioe, Nicholas J. Felicione, Alys Havard, Larry W. Hawk, Jesse T. Kaye, Elias M. Klemperer, Bethea A. Kleykamp, Nicola Lindson, Erin A. McClure, Hayden McRobbie, Cara M. Murphy, Nancy A. Rigotti, Natalie K. Walker, Min-Jeong Yang, Alana M. Rojewski, Adrienne L. Johnson, Members of the Society for Research on Nicotine and Tobacco, Treatment Research Network, Harm Reduction Workgroup

Importance Cigarette smoking, maintained predominantly by nicotine dependence, is a long-term and relapsing behavior that continues to be a leading cause of preventable death and disease worldwide. E-cigarettes with nicotine are less harmful than cigarettes and have been shown to be more effective for smoking cessation than US Food and Drug Administration–approved nicotine replacement therapies. However, misperceptions of the harms of e-cigarettes are common, even among clinicians. This Special Communication is a p …

1 Zitationen
01.09.2026journal-article

GBP Proceedings Series

A Study on the Mechanism of Canna Root in Treating Breast Cancer Based on Network Pharmacology

Wanyi Li

Objective: The present study was designed to investigate the prospective genetic targets of Boehmeria nivea root constituents for oncological applications via network pharmacology and laboratory validation, thereby clarifying the medicinal pathways of this plant. Methods: Major bioactive molecules from Boehmeria nivea root were sourced from the TCMSP platform, utilizing filters for oral bioavailability (OB) ≥30% and drug-likeness (DL) ≥0.18. Following the acquisition of molecular structures from PubChem, Swiss Targ …

01.09.2026journal-article

Radiation Oncology

Clinical evaluation using first-day assessment of patient suitability for successful performance of deep inspiration breath-hold for breast cancer radiotherapy

Bahar Cepni, Vania Batista, Line Hoeltgen, Hanna Waldsperger, Lars Wessel, Jakob Liermann, Semi Harrabi, Fabian Weykamp, Nathalie Arians, Juliane Hörner-Rieber, Jürgen Debus, Eva Meixner

Abstract Background Deep inspiration breath-hold (DIBH) is a radiotherapy standard technique for cardiac-sparing in breast cancer, particularly for left-sided tumors. However, not all patients can successfully complete DIBH RT in clinical routine, necessitating conversion to free breathing (FB) techniques and replanning. This study aimed to identify clinical factors predictive of DIBH feasibility to optimize patient selection and resource utilization. Methods This retrospective study analyzed all patients ( n = 192 …

01.09.2026journal-article

Pharmaceutics

Natural Product-Based Nanomedicine in the Treatment of Breast Cancer

Kaiyan Su, Yan Li, Dongmei Zhang, Yuxuan Zhou, Jianping Zhang, Hongyan Zhu, Yun Zhao, Cheng Guo, Quanjun Yang

Background: Breast cancer remains the most common malignant tumor among women worldwide. Although conventional treatments including surgery, chemotherapy, and radiotherapy are effective, they are confronted with challenges such as tumor heterogeneity, systemic toxicity, and recurrence driven by drug resistance. To overcome these limitations, natural products have emerged as promising therapeutic alternatives owing to their multi-target efficacy and favorable biocompatibility. However, their clinical translation is …

01.09.2026journal-article

Oral

Network Pharmacology and Molecular Dynamics Identify CCL5 and CCR2 Small-Molecule Candidates for Intracanal Treatment of Chronic Apical Periodontitis

Juan Manuel Guzmán-Flores, Raúl Antonio Briseño-Neri, Fernando Martínez-Esquivias, María del Carmen Leal-Moya

Background/Objectives: Chronic apical periodontitis (CAP) is a persistent periapical inflammatory lesion whose treatment still fails in a substantial fraction of cases, and no molecularly targeted adjunct exists. We aimed to identify druggable hub genes and small-molecule candidates suitable for local intracanal delivery using an integrative computational pipeline. Methods: CAP-associated genes were retrieved from GeneCards and the Open Targets Platform. A protein–protein interaction network, MCODE modules, and thr …

01.09.2026journal-article

Journal of Korean Medicine

Weight Change After Korean Medicine Weight Management Treatment Combined with a Low-Carbohydrate Diet in Patients with Post-COVID-19 Condition: A Retrospective Multicenter Observational Study

Minwoo Bang, Suyong Shin, Jungsang Kim, Minwhee Kang, Donghun Lee, Junho Kim, Chunghee Kim, Jiyoung Son, Seonghyeon Jeon, Byungsoo Kang

Objectives: To retrospectively describe weight change after Korean medicine weight management treatment combined with a low-carbohydrate diet (LCD) in patients with post-COVID-19 condition.Methods: This multicenter retrospective observational study used electronic medical records from eight Korean medicine clinics. Patients with post-COVID-19 condition who received Korean medicine weight management treatment for weight management and had paired baseline and follow-up body weight or body composition data were includ …

01.09.2026journal-article

Journal of Engineering

Crown-Shaped Patch Antenna with CSRR and Nd:YAG Laser Surface Treatment for C-Band Communication

Russull Kha. Rustum, Ali H. Khidhir

In this paper a compact four-port crown-shaped MIMO antenna is proposed for sub-6 GHz wireless applications and fabricated on FR4 substrate. The peak gain is 4.57 dBi, and the radiation efficiency is above 75% at wide impedance bandwidth of 4.0–4.8 GHz, with operation against about 4.5 GHz as expected. The crown geometry allows for improved impedance matching, better structural symmetry and lower mutual coupling when compared to conventional patch antennas. In order to increase practical performance, Nd:YAG laser s …

01.09.2026journal-article

Journal of Complementary and Integrative Medicine

Prevalence of chemotherapy-induced anemia and its impact on quality of life in breast cancer patients

Ramsha Batool, Tehreem Hayat, Hira Rizwan Butt, Fatima Um Ul Baneen, Hooria Fayyaz, Tayyaba Rafiq, Mehrulnisa Akhtar, Uswa Fayyaz, Maria Ahmed, Ayesha Azeem, Mah Gul Khan, Mahnoor Ikram Khan, Ali Farooq, Amina Shahid

Abstract Background Chemotherapy-induced anemia (CIA) is a frequent condition among breast cancer patients who are treated with systemic chemotherapy, and is linked to fatigue, decreased functional capacity, and poor quality of life. Objectives To determine the prevalence of chemotherapy-induced anaemia and evaluate its impact on the quality of life of breast cancer patients receiving chemotherapy. Methods This cross-sectional study was performed at the Ghurki Trust Teaching Hospital in Lahore, Pakistan, from Janua …

01.09.2026journal-article

Journal of Korean Neurosurgical Society

Comparison of ERAS-Based Same-Day and Non-Same-Day Protocols in IDEM Spinal Cord Tumor Surgeries : A Propensity Score-Matched Analysis

Sang Hoon Hwang, Subum Lee, Seung Jun Ryu, Min Han Kim, Sun Woo Jang, Danbi Park, Chong Man Kim, Jin Hoon Park

Objective : We developed enhanced recovery after surgery (ERAS)-based same-day surgery (SDS) and non-SDS protocols for intradural extramedullary (IDEM) spinal cord tumor surgeries, which were implemented in 2022. This study compared healthcare costs, and clinical and surgical outcomes between SDS and non-SDS protocols and describes how they are applied in practice.Methods : This retrospective study included 173 patients who underwent surgery for IDEM spinal cord tumors performed by a single neurosurgeon at single i …

04.09.2026journal-article

Bioscience Reports

Proteomic profiling reveals that DPP4 overexpression increases cell adhesion, inhibits cell migration, and restores androgen sensitivity in prostate cancer

José María Mora-Rodríguez, Belén G. Sánchez, Alicia Bort, Alba Díaz-Yuste, Alicia Milla, Julie Courraud, Jerome Zoidakis, Inés Díaz-Laviada

Abstract Dipeptidyl peptidase-4 (DPP4), a serine protease with both enzymatic and non-enzymatic roles, has emerged as a context-dependent modulator of tumor progression. In the present study, we investigated the expression and function of DPP4 in androgen-sensitive and castration-resistant prostate cancer (CRPC) models. Proteomic analysis of androgen-resistant prostate cells overexpressing DPP4 identified the involvement of the cellular adhesion molecules pathway. In prostate cells, lentiviral-mediated DPP4 overexp …

04.09.2026journal-article

The Clinical Respiratory Journal

Pulmonary Sarcoidosis in Qatar: Clinical Features, Diagnostic Profile and Treatment Patterns in a Multi‐Ethnic Population

Aasir M. Suliman, Mousa Hussein, Hassan Magboul, Ahmed A. Alsayed, Wisam Alwassiti, Amjad Salman, Saif Alateeg, Amin S. Saied, Mona Allangawi, Hisham A. Sattar

ABSTRACT Introduction Sarcoidosis data from the Middle East are limited, and regional studies have been predominantly single‐ethnicity, leaving phenotyping in the region's diverse expatriate populations unexplored. We characterised pulmonary sarcoidosis across ethnic groups in Qatar and examined temporal trends over 9 years. Methods Retrospective cohort study of adults with pulmonary sarcoidosis managed at Hamad Medical Corporation, the principal public‐sector provider in Qatar, between 2015 and 2023. The primary e …

01.09.2026journal-article

Al-Khwarizmi Engineering Journal

Artificial Intelligence in Breast Tumor Classification: A Comparative Study of Logistic Regression, SVM, and KNN Algorithms Using the WBCD Dataset

Nada A. Muneam, Asma S. Atteah, Ekhlas Ali Hussein, Suha A. Muneam, Reem Ali Haddad, Nawar Sahib Khalil, Mahmood S. Jameel

Breast cancer as such, is one of the two fallaciously debilitating diseases known to woman (the other being cardiac disease) so in that context and with some qualifications it really shouldn't come as that much of a surprise. The concern, however, is: Yes, you could do it right — early detection is our nearest weapon to the Silent Killer (cancer). However, standard diagnostics are far from 100% accurate, can be mislead by virtually any kind of fake and often miss occasions that cry for assistance but which have not …

01.09.2026journal-article

International Journal of Cancer

Pretreatment EBV ‐ DNA / TLG ‐Based Risk Stratification Is Associated With Survival Outcomes in Nonmetastatic Nasopharyngeal Carcinoma: An Exploratory Study

Mehmet Çağrı Duymaz, Ece Özkaya Duymaz, Nazlı Ünsal, Recep Bekiş, Büşra Tozduman, Özgür Appak, Ayşe Demiral, Oğuz Çetinayak

ABSTRACT Whether combining pretreatment plasma Epstein–Barr virus DNA (EBV‐DNA) with 18F‐FDG PET/CT‐derived total lesion glycolysis (TLG) improves prognostic stratification in nonmetastatic nasopharyngeal carcinoma (NPC) is unclear, particularly in nonendemic populations. We retrospectively analyzed 86 eligible nonmetastatic NPC patients treated with definitive radiotherapy (2010–2024) at a single nonendemic‐region institution. EBV‐DNA (prespecified cutoff 3500 copies/mL) and TLG (cutoff 200, ROC‐derived within thi …

01.09.2026journal-article

JOURNAL OF BIOTECHNOLOGY AND STRATEGIC HEALTH RESEARCH

Temporal Trends in Online Search Interest in Dental Implant Treatment in Türkiye: A Google Trends–Based Infodemiology Study

Saim Yanık, Mehmet Emrah Polat, Şeğmus Özdemir

ABSTRACT Objective: This study evaluated long-term trends in online search interest in dental implant treatment in Türkiye, level and slope changes around March 2020, and associations with year-on-year Consumer Price Index (CPI) change rates. Methods: Monthly relative search volume (RSV) data for five implant-related terms were obtained from Google Trends. Data from 2004–2025 were used for visual assessment and 2014–2025 for inference. Trends were evaluated using linear regression with Newey–West heteroskedasticity …

01.09.2026journal-article

Australasian Journal of Plastic Surgery

Paediatric mucormycosis: a retrospective review of manifestations, diagnosis and treatment at a major tertiary paediatric hospital

Amin Esmailian, Jevan Cevik, Daniel J Wilks, Daniel Keating, Sadhishaan Sreedharan

Background: Cutaneous mucormycosis is a rare yet severe fungal infection that affects immunocompromised paediatric patients. Although prompt diagnosis is essential, excisional tissue biopsy often necessitates general anaesthesia in the paediatric population, which presents risks in the unwell and immunocompromised patient. This study assessed the diagnostic value of the biopsy and associated outcomes in paediatric cutaneous mucormycosis. Methods: We retrospectively analysed 38 paediatric patients (aged 0–18 years) …

01.09.2026journal-article

Cancer Discovery

Malignant Transition in Three Dimensions

Zehua Jing, Mingyao Li

Summary: Breast and prostate cancers share notable similarities in their progression to invasive disease, providing a unique opportunity to uncover common mechanisms of malignant transition. By integrating volumetric reconstruction with multimodal spatial profiling, Storrs and colleagues revealed the precancer-to-cancer transition as a continuous three-dimensional process and identified shared molecular programs associated with invasion. See related article by Storrs et al., p. 1819

01.09.2026journal-article

Clinics in Shoulder and Elbow

The use of radiofrequency ablation for the treatment of lateral epicondylitis: a systematic review of the literature

Mohammed Ali, M K Chandrashekhar, Kapil Kumar, Richard Jeavons

Background: Lateral epicondylitis (LE) is a degenerative overuse angio-fibroblastic dysplasia caused by eccentric overload at the origin of the extensor carpi radialis brevis tendon. This systematic review aimed to evaluate the effectiveness of radiofrequency ablation for managing LE.Methods: This systematic review was registered with PROSPERO under the ID CRD420251165456. A comprehensive literature search was conducted in the NHS Knowledge and Library Hub and PubMed. Eleven studies met the inclusion criteria, incl …

01.09.2026journal-article

Water and Environment Journal

Role of Earthworms in Mitigating Antimicrobial Resistance During Wastewater Treatment by Vermifiltration Technology

Rishita Parihar, Sarita Vatwani, Sakshi Upadhyay, Amanpreet Kaur, Saniya Chawla, Harshita Jonwal, Tamanna Pamnani, Komal Sharma, Aakanksha Kalra, Sandeep K. Shrivastava, Sonia Sethi, Niha Mohan Kulshreshtha, Nimisha Singh, Sudipti Arora

ABSTRACT Antibiotic‐resistant microorganisms in wastewater pose significant threats to public health and the environment due to the limited effectiveness of conventional treatment systems. This study investigates the potential of vermifiltration technology, utilising Eisenia fetida earthworms, to reduce antibiotic‐resistant bacteria (ARB) and pollutant load in institutional wastewater by comparing a vermifilter (VF) against a biofilter (BF) lacking earthworms at pilot scale. Treatment performance was evaluated base …

01.09.2026journal-article

Die Ophthalmologie

Das oregis-IVOM-Register – Einführung eines Registers für die systematische Erhebung repräsentativer IVOM-Versorgungsdaten aus dem Behandlungsalltag bei Makulaerkrankungen in Deutschland

Ildikó Piszár, Anais Buhl, Argyrios Chronopoulos, Lukas Schloesser, Christopher Dicke, Nicole Eter, Julian Alexander Zimmermann, oregis, Robert P. Finger

Zusammenfassung Hintergrund Intravitreale operative Medikamenteneingaben (IVOMs) im Versorgungsalltag erreichen häufig nicht die in klinischen Studien gezeigten Behandlungsergebnisse. In Deutschland fehlen bislang flächendeckende, repräsentative Real-World-Daten zur IVOM-Versorgung bei Makulaerkrankungen. Ziel der Arbeit Vor diesem Hintergrund wurde das oregis-IVOM-Register als Subregister des nationalen oregis-Registers etabliert. Ziel ist die standardisierte Erhebung und Analyse von IVOM-Therapieverläufen im klin …

01.09.2026journal-article

Gels

In Situ Gelling of TPZ-Loaded Nanogel for Sustained Intratumoral Delivery and Enhanced Cancer Immunotherapy

Ling Li, Kexin Wang, Zhe Song, Hongan Tian, Cai Wang, Ling Zhang, Houqiang Yu

TPZ is a hypoxia-activated anticancer agent that exerts selective cytotoxicity within hypoxic tumor microenvironments. Although intratumoral injection of TPZ can achieve localized antitumor activity, the drug is prone to rapid diffusion and clearance from the injection site, limiting its long-term retention and thereby reducing therapeutic durability and overall efficacy. To achieve sustained release and prolonged retention of TPZ in subcutaneous tumors, a thermosensitive nanogel loaded with TPZ (TPZ@PNA-TNG) was d …

01.09.2026journal-article

Nature Communications

Efficacy of everolimus and letrozole with or without ribociclib in recurrent endometrial cancer: a phase 2 randomized clinical trial

Jeffrey A. How, Shannon N. Westin, Melissa Pham, Barrett Lawson, Minxing Chen, Nidhi Tandon, Ying Yuan, Rugang Zhang, Amir A. Jazaeri, Anil K. Sood, Michaela Onstad Grinsfelder, Kathleen M. Schmeler, David J. Vining, Samantha M. Fix, Yibo Dai, Mikayla B. Bowen, Karen H. Lu, Melinda S. Yates, Russell Broaddus, Pamela T. Soliman

Abstract In this phase II trial, patients with endometrial cancer (EC) were randomized to everolimus/letrozole with (experimental arm) or without ribociclib (control arm) (ClinicalTrials.gov Identifier: NCT03008408). The primary endpoint was progression-free survival (PFS). Secondary endpoints included toxicity, overall survival (OS), objective response rate (ORR), and clinical benefit rate (CBR). For all-comers, there was no difference in PFS (HR 0.78, 95% CI 0.4-1.4, p = 0.38), OS (HR 0.8, 95% CI 0.4-1.5, p = 0.4 …

01.09.2026journal-article

BMC Gastroenterology

Development and internal evaluation of a nomogram for identifying current sleep disturbance in patients with colorectal cancer undergoing chemotherapy: a cross-sectional study

Ao Tang, Tian Xiao, Zhenrong Yin, Qing Li, Ruihan Xiao, Fangyi Li, Linyu Zhou, Biao He, Xiaoju Chen

Abstract Objectives This study aimed to identify factors associated with current sleep disturbance (SD) in patients with colorectal cancer (CRC) undergoing chemotherapy and to develop and internally evaluate a nomogram for estimating the probability of current SD. Methods A total of 630 patients with CRC undergoing chemotherapy were recruited from five hospitals in China. Participants were assessed using the Demographic Information Questionnaire, Pittsburgh Sleep Quality Index (PSQI), and Hospital Anxiety and Depre …