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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

Journal for ImmunoTherapy of Cancer

Overall survival of immunotherapy versus standard of care in chemorefractory microsatellite stable metastatic colorectal cancer: a propensity score matched analysis of 708 patients

Guglielmo Vetere, Emerik Osterlund, Mahmoud M G Yousef, Songwit Payapwattanawong, Giulia Maddalena, Jumanah Alshenaifi, Kristin D Alfaro, Mark Knafl, Van K Morris, Christine M Parseghian, Kanwal P S Raghav, Robert A Wolff, Arvind Dasari, Michael J Overman, Scott Kopetz, John Paul Shen

Background Immune checkpoint inhibitors (ICIs) have limited efficacy in proficient mismatch repair/microsatellite stable (pMMR/MSS) metastatic colorectal cancer (mCRC). However, selected patients with specific metastatic patterns may derive benefit. Methods Patients with chemorefractory pMMR/MSS mCRC treated with ICI-based regimens were retrospectively identified. A comparison cohort treated with trifluridine/tipiracil±bevacizumab, regorafenib, or fruquintinib as standard of care (SOC) was generated through 1:1 pro …

01.09.2026journal-article

South Australian Journal of Medicine

Prostate cancer: to treat or not to treat, a cautionary tale from a doctor-patient

Leslie Jackowski

Background: A definitive diagnosis of prostate cancer can be established with a special type of MRI (multiparametric MRI) followed by core biopsy. An assessment of stage (extent of spread) and grade (aggressiveness of disease) from these investigations assists with clinical decision-making regarding early management. Objective: This article describes the evidence supporting active surveillance for low-risk prostate cancer and the limitations of diagnostic tools in choosing between active surveillance and surgery (r …

01.09.2026journal-article

Journal of Tissue Engineering

Hydrogel microspheres for osteoarthritis treatment: Fabrication strategies, smart responsiveness, and multimodal therapies

Zhuoxuan Song, Xinyue Song, Rui Zhao, Zhicong Zhou, Wei Huang, Meng Zhang, Fang He, Qiming Pang

Osteoarthritis (OA) is a chronic, progressive degenerative joint disease defined by the degradation of articular cartilage, with pathological involvement of periarticular tissues including the synovium and subchondral bone. Existing conservative interventions for OA are limited to symptomatic relief and cannot reverse established cartilage degeneration, underscoring the critical unmet need to address prevailing clinical treatment bottlenecks. Hydrogel microspheres, as an emerging delivery platform integrating drug …

04.09.2026journal-article

Cell Biochemistry and Function

Reactive Oxygen Species in Breast Cancer: From Redox Dysregulation to ROS‐Responsive Therapeutics

Marija Nikolovska, Radoslav Stojchevski, Aleksandar Eftimov, Mitko Mladenov, Dimiter Avtanski, Nikola Hadzi‐Petrushev

ABSTRACT Breast cancer is the most frequently diagnosed malignancy among women worldwide, with 2.3 million new cases and approximately 670,000 deaths reported in 2022 alone. Despite advances in therapy, metastasis and acquired drug resistance remain major clinical challenges. Reactive oxygen species (ROS) play a dual role in breast cancer biology: physiological levels sustain normal cellular signaling, moderately elevated levels promote tumorigenesis through DNA damage, proto‐oncogene activation, and tumor suppress …

01.09.2026journal-article

Medical Science of Armenia

Cancer Stem Cells: Between Biological Concept and Clinical Reality

S. S. Gasparyan

Рак остаётся одним из наиболее агрессивных и сложных заболеваний в мире. Несмотря на достижения в области биологии рака и клинической онкологии, метастазирование и рецидив опухоли по-прежнему представляют серьёзные терапевтические проблемы. Все больше данных свидетельствуют о том, что раковые стволовые клетки (РСК) играют ключевую роль в этих процессах. РСК считаются функциональной субпопуляцией опухолевых клеток, ключевыми характеристиками которых являются их способность к самообновлению, дифференцировке и повышен …

01.09.2026journal-article

HRB Open Research

Cancer Survivorship Clinics in Tertiary Care: A Scoping Review Protocol

Linda Lisanti, Chris Crockford, Siobhán Cregan, Neil Kearney, Niamh Lucey, Oonagh Griffin, Linda O'Neill

Background As the number of people living with and beyond cancer grow, quality of life has become an increasing priority. Specialised tertiary care centres, as they follow patients throughout their cancer treatment and beyond, represent an opportunity to engage with and provide comprehensive support to patients. However, the support offered is often limited or fragmented, and patients consistently report unmet needs in survivorship, including addressing the short- and longer-term side effects of medical treatment, …

01.09.2026journal-article

Cancer Research Communications

Targeting PRMT5 Inhibitor–Induced Adaptation in Pancreatic Cancer with the RBM39 Degrader Indisulam

Valentina Spielmann, Jonas Buchloh, Selen Selcen, Carolin Schneider, Shaishavi Jansari, Xin Fang, Ningjun Duan, Engin Demirdizen, Lukas Krauß, Jessica Eggert, Geraldine Siegfried, Sandrine Fedou, Christof Lenz, Lena Wieland, Lena-Christin Conradi, Maximilian Reichert, Volker Ellenrieder, Michael Ghadimi, Marian Grade, Elisabeth Hessmann, Abdel-Majid Khatib, Christian J. Braun, Florian Wegwitz, Dieter Saur, Matthias Wirth, Günter Schneider

Abstract Pancreatic ductal adenocarcinoma (PDAC) remains a formidable clinical challenge. Next-generation protein arginine methyltransferase 5 (PRMT5) inhibitors show promising clinical results in a subset of PDACs with codeletion of the tumor-suppressor CDKN2A and the methylthioadenosine phosphorylase (MTAP) gene, but resistance limits their efficacy. Our study suggests that compensatory spliceosomal reprogramming contributes to adaptation to PRMT5 inhibition. Through comprehensive molecular profiling, we demonstr …

01.09.2026journal-article

Frontiers in Immunology

Spatial immune biomarkers in triple-negative breast cancer: emerging evidence, technology trade-offs, and barriers to clinical translation

Liuhai Zeng, Wei Lin, Shihang Xue, Minzhi Chen, Haiyan Wu

Triple-negative breast cancer (TNBC) is an immunogenic but clinically heterogeneous breast cancer subtype. Stromal tumor-infiltrating lymphocytes (TILs), PD-L1 expression, and tumor mutational burden provide useful but incomplete summaries of the tumor immune microenvironment. Spatial immune biomarkers retain tissue architecture and ask where immune cells are located, which cells they contact, and whether local neighborhoods are inflamed, excluded, suppressive, or organized into tertiary lymphoid structures (TLS). …

01.09.2026journal-article

JAMA

Nicotine E-Cigarettes for Cigarette Smoking Cessation

Eleanor L. S. Leavens, Kinsey Pebley, Tracy T. Smith, Jasjit S. Ahluwalia, Mariel S. Bello, Krysten W. Bold, Jennifer Cantrell, Matthew J. Carpenter, Patricia A. Cioe, Nicholas J. Felicione, Alys Havard, Larry W. Hawk, Jesse T. Kaye, Elias M. Klemperer, Bethea A. Kleykamp, Nicola Lindson, Erin A. McClure, Hayden McRobbie, Cara M. Murphy, Nancy A. Rigotti, Natalie K. Walker, Min-Jeong Yang, Alana M. Rojewski, Adrienne L. Johnson, Members of the Society for Research on Nicotine and Tobacco, Treatment Research Network, Harm Reduction Workgroup

Importance Cigarette smoking, maintained predominantly by nicotine dependence, is a long-term and relapsing behavior that continues to be a leading cause of preventable death and disease worldwide. E-cigarettes with nicotine are less harmful than cigarettes and have been shown to be more effective for smoking cessation than US Food and Drug Administration–approved nicotine replacement therapies. However, misperceptions of the harms of e-cigarettes are common, even among clinicians. This Special Communication is a p …

1 Zitationen
01.09.2026journal-article

GBP Proceedings Series

A Study on the Mechanism of Canna Root in Treating Breast Cancer Based on Network Pharmacology

Wanyi Li

Objective: The present study was designed to investigate the prospective genetic targets of Boehmeria nivea root constituents for oncological applications via network pharmacology and laboratory validation, thereby clarifying the medicinal pathways of this plant. Methods: Major bioactive molecules from Boehmeria nivea root were sourced from the TCMSP platform, utilizing filters for oral bioavailability (OB) ≥30% and drug-likeness (DL) ≥0.18. Following the acquisition of molecular structures from PubChem, Swiss Targ …

01.09.2026journal-article

Radiation Oncology

Clinical evaluation using first-day assessment of patient suitability for successful performance of deep inspiration breath-hold for breast cancer radiotherapy

Bahar Cepni, Vania Batista, Line Hoeltgen, Hanna Waldsperger, Lars Wessel, Jakob Liermann, Semi Harrabi, Fabian Weykamp, Nathalie Arians, Juliane Hörner-Rieber, Jürgen Debus, Eva Meixner

Abstract Background Deep inspiration breath-hold (DIBH) is a radiotherapy standard technique for cardiac-sparing in breast cancer, particularly for left-sided tumors. However, not all patients can successfully complete DIBH RT in clinical routine, necessitating conversion to free breathing (FB) techniques and replanning. This study aimed to identify clinical factors predictive of DIBH feasibility to optimize patient selection and resource utilization. Methods This retrospective study analyzed all patients ( n = 192 …

01.09.2026journal-article

Pharmaceutics

Natural Product-Based Nanomedicine in the Treatment of Breast Cancer

Kaiyan Su, Yan Li, Dongmei Zhang, Yuxuan Zhou, Jianping Zhang, Hongyan Zhu, Yun Zhao, Cheng Guo, Quanjun Yang

Background: Breast cancer remains the most common malignant tumor among women worldwide. Although conventional treatments including surgery, chemotherapy, and radiotherapy are effective, they are confronted with challenges such as tumor heterogeneity, systemic toxicity, and recurrence driven by drug resistance. To overcome these limitations, natural products have emerged as promising therapeutic alternatives owing to their multi-target efficacy and favorable biocompatibility. However, their clinical translation is …

01.09.2026journal-article

Oral

Network Pharmacology and Molecular Dynamics Identify CCL5 and CCR2 Small-Molecule Candidates for Intracanal Treatment of Chronic Apical Periodontitis

Juan Manuel Guzmán-Flores, Raúl Antonio Briseño-Neri, Fernando Martínez-Esquivias, María del Carmen Leal-Moya

Background/Objectives: Chronic apical periodontitis (CAP) is a persistent periapical inflammatory lesion whose treatment still fails in a substantial fraction of cases, and no molecularly targeted adjunct exists. We aimed to identify druggable hub genes and small-molecule candidates suitable for local intracanal delivery using an integrative computational pipeline. Methods: CAP-associated genes were retrieved from GeneCards and the Open Targets Platform. A protein–protein interaction network, MCODE modules, and thr …

01.09.2026journal-article

Journal of Korean Medicine

Weight Change After Korean Medicine Weight Management Treatment Combined with a Low-Carbohydrate Diet in Patients with Post-COVID-19 Condition: A Retrospective Multicenter Observational Study

Minwoo Bang, Suyong Shin, Jungsang Kim, Minwhee Kang, Donghun Lee, Junho Kim, Chunghee Kim, Jiyoung Son, Seonghyeon Jeon, Byungsoo Kang

Objectives: To retrospectively describe weight change after Korean medicine weight management treatment combined with a low-carbohydrate diet (LCD) in patients with post-COVID-19 condition.Methods: This multicenter retrospective observational study used electronic medical records from eight Korean medicine clinics. Patients with post-COVID-19 condition who received Korean medicine weight management treatment for weight management and had paired baseline and follow-up body weight or body composition data were includ …

01.09.2026journal-article

Journal of Engineering

Crown-Shaped Patch Antenna with CSRR and Nd:YAG Laser Surface Treatment for C-Band Communication

Russull Kha. Rustum, Ali H. Khidhir

In this paper a compact four-port crown-shaped MIMO antenna is proposed for sub-6 GHz wireless applications and fabricated on FR4 substrate. The peak gain is 4.57 dBi, and the radiation efficiency is above 75% at wide impedance bandwidth of 4.0–4.8 GHz, with operation against about 4.5 GHz as expected. The crown geometry allows for improved impedance matching, better structural symmetry and lower mutual coupling when compared to conventional patch antennas. In order to increase practical performance, Nd:YAG laser s …

01.09.2026journal-article

Journal of Complementary and Integrative Medicine

Prevalence of chemotherapy-induced anemia and its impact on quality of life in breast cancer patients

Ramsha Batool, Tehreem Hayat, Hira Rizwan Butt, Fatima Um Ul Baneen, Hooria Fayyaz, Tayyaba Rafiq, Mehrulnisa Akhtar, Uswa Fayyaz, Maria Ahmed, Ayesha Azeem, Mah Gul Khan, Mahnoor Ikram Khan, Ali Farooq, Amina Shahid

Abstract Background Chemotherapy-induced anemia (CIA) is a frequent condition among breast cancer patients who are treated with systemic chemotherapy, and is linked to fatigue, decreased functional capacity, and poor quality of life. Objectives To determine the prevalence of chemotherapy-induced anaemia and evaluate its impact on the quality of life of breast cancer patients receiving chemotherapy. Methods This cross-sectional study was performed at the Ghurki Trust Teaching Hospital in Lahore, Pakistan, from Janua …

01.09.2026journal-article

Journal of Korean Neurosurgical Society

Comparison of ERAS-Based Same-Day and Non-Same-Day Protocols in IDEM Spinal Cord Tumor Surgeries : A Propensity Score-Matched Analysis

Sang Hoon Hwang, Subum Lee, Seung Jun Ryu, Min Han Kim, Sun Woo Jang, Danbi Park, Chong Man Kim, Jin Hoon Park

Objective : We developed enhanced recovery after surgery (ERAS)-based same-day surgery (SDS) and non-SDS protocols for intradural extramedullary (IDEM) spinal cord tumor surgeries, which were implemented in 2022. This study compared healthcare costs, and clinical and surgical outcomes between SDS and non-SDS protocols and describes how they are applied in practice.Methods : This retrospective study included 173 patients who underwent surgery for IDEM spinal cord tumors performed by a single neurosurgeon at single i …

04.09.2026journal-article

Bioscience Reports

Proteomic profiling reveals that DPP4 overexpression increases cell adhesion, inhibits cell migration, and restores androgen sensitivity in prostate cancer

José María Mora-Rodríguez, Belén G. Sánchez, Alicia Bort, Alba Díaz-Yuste, Alicia Milla, Julie Courraud, Jerome Zoidakis, Inés Díaz-Laviada

Abstract Dipeptidyl peptidase-4 (DPP4), a serine protease with both enzymatic and non-enzymatic roles, has emerged as a context-dependent modulator of tumor progression. In the present study, we investigated the expression and function of DPP4 in androgen-sensitive and castration-resistant prostate cancer (CRPC) models. Proteomic analysis of androgen-resistant prostate cells overexpressing DPP4 identified the involvement of the cellular adhesion molecules pathway. In prostate cells, lentiviral-mediated DPP4 overexp …

04.09.2026journal-article

The Clinical Respiratory Journal

Pulmonary Sarcoidosis in Qatar: Clinical Features, Diagnostic Profile and Treatment Patterns in a Multi‐Ethnic Population

Aasir M. Suliman, Mousa Hussein, Hassan Magboul, Ahmed A. Alsayed, Wisam Alwassiti, Amjad Salman, Saif Alateeg, Amin S. Saied, Mona Allangawi, Hisham A. Sattar

ABSTRACT Introduction Sarcoidosis data from the Middle East are limited, and regional studies have been predominantly single‐ethnicity, leaving phenotyping in the region's diverse expatriate populations unexplored. We characterised pulmonary sarcoidosis across ethnic groups in Qatar and examined temporal trends over 9 years. Methods Retrospective cohort study of adults with pulmonary sarcoidosis managed at Hamad Medical Corporation, the principal public‐sector provider in Qatar, between 2015 and 2023. The primary e …

01.09.2026journal-article

Al-Khwarizmi Engineering Journal

Artificial Intelligence in Breast Tumor Classification: A Comparative Study of Logistic Regression, SVM, and KNN Algorithms Using the WBCD Dataset

Nada A. Muneam, Asma S. Atteah, Ekhlas Ali Hussein, Suha A. Muneam, Reem Ali Haddad, Nawar Sahib Khalil, Mahmood S. Jameel

Breast cancer as such, is one of the two fallaciously debilitating diseases known to woman (the other being cardiac disease) so in that context and with some qualifications it really shouldn't come as that much of a surprise. The concern, however, is: Yes, you could do it right — early detection is our nearest weapon to the Silent Killer (cancer). However, standard diagnostics are far from 100% accurate, can be mislead by virtually any kind of fake and often miss occasions that cry for assistance but which have not …

01.09.2026journal-article

International Journal of Cancer

Pretreatment EBV ‐ DNA / TLG ‐Based Risk Stratification Is Associated With Survival Outcomes in Nonmetastatic Nasopharyngeal Carcinoma: An Exploratory Study

Mehmet Çağrı Duymaz, Ece Özkaya Duymaz, Nazlı Ünsal, Recep Bekiş, Büşra Tozduman, Özgür Appak, Ayşe Demiral, Oğuz Çetinayak

ABSTRACT Whether combining pretreatment plasma Epstein–Barr virus DNA (EBV‐DNA) with 18F‐FDG PET/CT‐derived total lesion glycolysis (TLG) improves prognostic stratification in nonmetastatic nasopharyngeal carcinoma (NPC) is unclear, particularly in nonendemic populations. We retrospectively analyzed 86 eligible nonmetastatic NPC patients treated with definitive radiotherapy (2010–2024) at a single nonendemic‐region institution. EBV‐DNA (prespecified cutoff 3500 copies/mL) and TLG (cutoff 200, ROC‐derived within thi …

01.09.2026journal-article

JOURNAL OF BIOTECHNOLOGY AND STRATEGIC HEALTH RESEARCH

Temporal Trends in Online Search Interest in Dental Implant Treatment in Türkiye: A Google Trends–Based Infodemiology Study

Saim Yanık, Mehmet Emrah Polat, Şeğmus Özdemir

ABSTRACT Objective: This study evaluated long-term trends in online search interest in dental implant treatment in Türkiye, level and slope changes around March 2020, and associations with year-on-year Consumer Price Index (CPI) change rates. Methods: Monthly relative search volume (RSV) data for five implant-related terms were obtained from Google Trends. Data from 2004–2025 were used for visual assessment and 2014–2025 for inference. Trends were evaluated using linear regression with Newey–West heteroskedasticity …

01.09.2026journal-article

Australasian Journal of Plastic Surgery

Paediatric mucormycosis: a retrospective review of manifestations, diagnosis and treatment at a major tertiary paediatric hospital

Amin Esmailian, Jevan Cevik, Daniel J Wilks, Daniel Keating, Sadhishaan Sreedharan

Background: Cutaneous mucormycosis is a rare yet severe fungal infection that affects immunocompromised paediatric patients. Although prompt diagnosis is essential, excisional tissue biopsy often necessitates general anaesthesia in the paediatric population, which presents risks in the unwell and immunocompromised patient. This study assessed the diagnostic value of the biopsy and associated outcomes in paediatric cutaneous mucormycosis. Methods: We retrospectively analysed 38 paediatric patients (aged 0–18 years) …