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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

International Journal of Science, Strategic Management and Technology

White Spot Lesions Following Orthodontic Treatment: Contemporary Management

Y.Muni Akash

White spot lesions (WSLs) often develop after fixed orthodontic treatment. They appear as milky white spots on teeth due to enamel demineralization. These lesions are a common aesthetic concern, affecting 45.8% to 97% of orthodontic patients [1]. Today, dentistry focuses on non-invasive remineralization therapies to treat WSLs and prevent their progression.

03.09.2026journal-article

Frontiers in Oncology

Deep learning model using contrast-enhanced CT imaging features and clinical variables to predict surgical risk after hepatic resection for hepatocellular carcinoma

Kimika Kato, Yasuhito Mitsuyama, Hiroji Shinkawa, Takuma Okada, Atsushi Sugimoto, Ryota Tanaka, Sadaaki Nishimura, Jun Tauchi, Masahiko Kinoshita, Genki Watanabe, Kohei Nishio, Takeaki Ishizawa

Background Accurate preoperative risk assessment is crucial for patients undergoing hepatic resection for hepatocellular carcinoma (HCC). Conventional prediction methods are limited by the inability to capture complex relationships among multiple factors, and existing deep learning (DL) approaches focus on individual surgical outcomes. In this study, we developed and evaluated a DL model that integrates preoperative contrast-enhanced computed tomography (CT) imaging features and clinical variables to predict intrao …

03.09.2026journal-article

Current Opinion in Otolaryngology & Head & Neck Surgery

Tympanomastoidectomy canal wall reconstruction with mastoid obliteration

Adam S. Vesole, Ravi N. Samy

Purpose of review To describe the various techniques in performing a tympanomastoidectomy canal wall reconstruction with mastoid obliteration for surgical management of chronic otitis media and cholesteatoma, and to assess the outcomes and complications compared to the more traditional canal wall up and canal wall down surgical techniques. Additionally, the purpose of this review is to highlight the versatility and novelty of this approach in addressing other middle ear pathologies such as glomus tympanicum. Recent …

03.09.2026journal-article

Global Spine Journal

Characteristics of Patients Achieving Clinically Meaningful Improvement in Neuropathic Pain After Surgery for Degenerative Cervical Myelopathy

Narihito Nagoshi, Junichi Yamane, Toshiki Okubo, Hitoshi Kono, Kentaro Fukuda, Takeshi Fujii, Yosuke Horiuchi, Yasuhiro Kamata, Norihiro Isogai, Takahito Iga, Kazuki Takeda, Masahiro Ozaki, Satoshi Suzuki, Morio Matsumoto, Masaya Nakamura, Kota Watanabe

Study Design Retrospective analysis of a prospectively maintained multicenter cohort. Objectives To identify clinical characteristics associated with clinically meaningful improvement in neuropathic pain and to evaluate its relationship with postoperative functional outcomes in patients with degenerative cervical myelopathy (DCM). Methods Among 816 patients with complete Neuropathic Pain Symptom Inventory (NPSI) data, 597 with baseline total NPSI scores ≥7 were included in the primary analysis because they were eli …

03.09.2026journal-article

European Journal of Trauma and Emergency Surgery

Repeated scoring with the adult appendicitis score improves the sensitivity and the specificity of appendicitis diagnosis in patients with early equivocal signs of appendicitis: a secondary analysis

Kirsi S. Lastunen, Ari K. Leppäniemi, Panu J. Mentula

Abstract Purpose The utilization of computed tomography in the early stage of acute appendicitis may result in overdiagnosis and unnecessarily expose patients to ionising radiation. The Adult Appendicitis Score (AAS) can be used to select patients for imaging. Observation and re-scoring in the DIAMOND trial reduced the need for imaging. Now, we wanted to determine if the change in AAS (∆AAS) can serve as a diagnostic tool to select patients for imaging even more precisely. Methods Eighty-eight patients with early e …

03.09.2026journal-article

Journal of Clinical Medicine

Long-Term Effects of Right Ventricular Pressure and Volume Overload: A Comparative Analysis in an Ovine Model

Hamida Al Hussein, Hussam Al Hussein, Simina-Elena Ghiragosian-Rusu, Simona Gurzu, Rita Szodorai, Carmen Sircuta, Marius Stefan Marusteri, Bogdan Cordos, David Emanuel Anitei, Andrei Atudorei, Sergiu Crisan, Dan Simionescu, Klara Brinzaniuc

Background/Objectives: Pressure overload (PO) and volume overload (VO) represent important mechanisms underlying right ventricular (RV) failure; however, long-term comparative data regarding their distinct pathophysiological consequences remain limited. This study aimed to compare the long-term effects of PO versus VO in a large animal model. Methods: Juvenile sheep were randomly assigned to either a PO group (n = 7) or a VO group (n = 8). PO was induced by pulmonary artery banding, whereas VO was induced by pulmon …

03.09.2026journal-article

Annals of Human Resource Management Research

Healthcare Human Resource Development: Organizational Support and Work Engagement among Clinical Clerkship Students

Gunawan Eko Nurtjahjono, Hefry Johan Ferdhianzah

Purpose: This study examined work engagement among clinical clerkship students from a healthcare human resource development perspective. Specifically, it analyzes how perceived organizational support and the clinical learning environment influence work engagement during pediatric clinical education and evaluates whether the clinical learning environment functions as a moderating condition in this relationship. Methodology: A quantitative cross-sectional survey involving 251 clinical clerkship students at Rumah Saki …

03.09.2026journal-article

Journal of Dance Medicine & Science

Dance as Rehabilitation in Parkinson’s Disease: A Scoping Review of Motor, Non-Motor, and Cognitive Outcomes

Simran Rooprai, Nicholas Ramcharran, Caitlin van den Hoorn, Jenna Smith-Turchyn, Nicole D. Anderson, Joseph FX DeSouza

Introduction: Dance is a multimodal experience, integrating movement and music, with cognitive and psychosocial effects, potentially providing a non-pharmacological care approach for persons with Parkinson’s disease (PwPD). While numerous studies have investigated motor outcomes following dance interventions, less is known about the degree to which cognitive and non-motor outcomes are explored. The objective of this scoping review was to explore the scope and characteristics of dance-based interventions for PD, foc …

03.09.2026journal-article

Journal of Clinical Investigation

Enhancing Gemcitabine Uptake by Promoting Dimerization of the ENT1 Transporter Improves Sarcoma Patient Response Rate

Aditya Ganju, Shyam Rao, Mark A. Dickson, Robert A. Lefkowitz, Chris Thompson, Jin Cheng, Katia Manova, Adriana Haimovitz-Friedman, Gary Schwartz, Zhigang Zhang, Zvi Fuks, William D. Tap, Richard Kolesnick

Transport of nucleoside chemotherapeutic drugs into tumor cells is primarily accomplished through Equilibrative Nucleoside Transporter 1 (ENT1), considered to be constitutively-active, redistributing drugs across lipid bilayers via facilitated diffusion. Here we discover that ENT1 is not constitutively-active but rather requires activation of acid sphingomyelinase (ASMase) by gemcitabine, generating ceramide-rich platforms (CRPs) on external plasma membranes of endothelial and tumor cells into which ENT1 inserts, d …

03.09.2026journal-article

Clinical Spine Surgery

Assessing Global Upper Extremity Function Before and After Decompressive Surgery in Patients With Degenerative Cervical Myelopathy (DCM)

Angie Zhang Lung, John Hong, Vicky Chan, Maya N. Hatch, Jay J. Han, Yu-Po Lee, Nitin N. Bhatia, Michael Oh

Study Design: A total of 20 patients with degenerative cervical myelopathy (DCM) and a plan for surgical decompression were recruited in this pilot study to assess a new outcome measure. Patients were evaluated preoperatively and 3 months, 6 months, and 1 year postoperatively using a 3-dimensional motion-tracking application (reachable workspace) to calculate an upper extremity (UE) relative surface area (RSA) and standard measurements [modified Japanese Orthopedic Association (mJOA), 12-Item Short Form Health Surv …

03.09.2026journal-article

Journal of Clinical Pathology

Anaplastic lymphoma kinase immunohistochemical positivity in high-grade pulmonary neuroendocrine carcinoma: an actionable signal or merely a shadow?

Ullas Batra, Sabeena Choudhary, Ritwika Choudhury, Alka Yadav, Mansi Sharma, Abhinav Dewan, Sunil Pasricha, Anurag Mehta, Priyanka Venkataraman

Aims Anaplastic lymphoma kinase (ALK) rearrangements are actionable drivers in non-small cell lung carcinoma (NSCLC), but the biological significance of ALK-immunohistochemistry (IHC) positivity in high-grade pulmonary neuroendocrine carcinoma (NEC) remains unclear. This study evaluated the diagnostic and therapeutic implications of discordant ALK IHC and genomic findings and the role of multimodal molecular testing in resolving them. Methods We retrospectively analysed eight South Asian patients (Indian and Nepali …

03.09.2026journal-article

Military Medicine

Military Medical Training for Role 1 and Role 2 Combat Casualty Care Skills: A Narrative Review

Jennifer L Patton, Kiffin R Smallegan, Emily R Latimer, Anna R Prendergast, Gary J Jimenez Pena, Angela K Phillips

Abstract Introduction Military medics are often tasked to train other medics. While there is ample content of what to train, there exists a lack of trainer education or emphasis on how to train others effectively. Current military medical training is highly variable, often relying on anecdotal methods, with limited evaluation of training effectiveness. Although the importance of readiness training is well recognized, little attention has been devoted to identifying evidence-based approaches for training military me …

03.09.2026journal-article

Clinical Anatomy

Integrating Professional‐Values‐Oriented Education Into PBL Teaching: Practice Based on Case Discussions in Anatomy Curriculum

Liu He, Yunwen Hu, Chengjun Hu

ABSTRACT This study, conducted among first‐year undergraduates, investigates the feasibility of integrating professional‐values‐oriented education into the discussion‐based human anatomy teaching module via the problem‐based learning (PBL) model. Over a three‐year reform period, PBL cases combining clinical scenarios with professional‐values‐oriented elements were designed and implemented specifically for this human anatomy module; the effectiveness of this approach was subsequently evaluated through a systematic a …

03.09.2026journal-article

Clinical and Translational Discovery

Gene therapy for hereditary deafness: Progress, challenges and translational implications from OTOF to GJB2

Jiahui Zhao, Mengzhao Xun, Yu Sun

Abstract Background Hereditary deafness is a common sensory disorder in infants and children. Gene therapy has achieved major clinical breakthroughs in OTOF ‐related deafness, establishing proof of concept for treating monogenic hearing loss. In contrast, GJB2 ‐related hearing loss remains more challenging because of its broad cochlear expression, complex supporting‐cell targets, developmental involvement, and narrow therapeutic window. Methods We reviewed recent advances in hereditary deafness gene therapy, focusi …

03.09.2026journal-article

Ege Tıp Dergisi

Can preoperative thrombocytopenia be a risk indicator for emergency surgery due to liver transplant complications?

Emrah Şahin, Ender Anılır, Abuzer Dirican, Bülent Ünal

Aim: This study aimed to investigate the effect of preoperative thrombocytopenia and other risk factors on the need for emergency surgery due to complications following living donor liver transplantation (LDLT), and to evaluate the impact of emergency surgery on patient survival.Materials and Methods: The data of 270 patients who underwent LDLT for end-stage liver disease between July 2021 and October 2023 were analyzed retrospectively. Patients were divided into two groups: those requiring postoperative emergency …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

A refined phenomenological model of viscoelastic clot formation and lysis in trauma-induced coagulopathy

Guanyun Liu, Amanda E. Shick, Maya Shamash, Caroline M. Cook, Mario L. Molina, Mitchell J. Cohen, Amor A. Menezes

Background Hyperfibrinolysis is strongly associated with early post-injury mortality, but the condition is preventable with timely detection and targeted interventions. Unfortunately, current hyperfibrinolysis diagnostic assays such as thromboelastography (TEG) are time-consuming, making them infeasible for use in real-time treatment strategies to guide adjustable, precise, and personalized interventions. Computational models offer a fast alternative to current practice for ascertaining patient hemostatic state fro …

03.09.2026journal-article

Clinical Chemistry and Laboratory Medicine (CCLM)

Validation of synthetic M-protein materials for external quality assessment: homogeneity, commutability, and stability

Moniek M. Bioch, Theo Rispens, Corrie M. de Kat Angelino, Anke J. ten Haaken-Meijer, Miranda van Berkel, Marc H.M. Thelen, Joannes F.M. Jacobs

Abstract Objectives Accurate quantification of M-proteins is important for clinical management of monoclonal gammopathies. Reliable assessment of trueness on M-protein quantification in External Quality Assessment (EQA) schemes is difficult due to the lack of reference methods and materials for target value assignment. We propose a strategy to produce targeted synthetic M-protein EQA materials by spiking known amounts of human(ised) therapeutic monoclonal antibodies (t-mAb) into null serum. This paper validates hom …

03.09.2026journal-article

Supportive Care in Cancer

Goal-directed nutritional support in preserving muscle mass and optimising recovery in treatment of oesophageal cancer: results of a prospective non-randomised cluster trial

Iris Barth, Iris Stelwagen, Linda B. M. Weerink, Dorienke Gort-van Dijk, Hanna Meinders, Milos Milovanovic, Jan Willem Haveman, Marc J. van Det, Gerard Dijkstra, Marjo J. E. Campmans-Kuijpers

Abstract Purpose Oesophageal cancer (OEC) treated with neoadjuvant chemoradiotherapy (CRT) followed by oesophagectomy is associated with muscle loss and impaired recovery. We aim to evaluate whether a goal-directed nutritional support protocol (GDNS) is associated with muscle loss and improved survival after CRT and oesophagectomy compared with usual care. Methods Adults with OEC undergoing CRT and oesophagectomy were included. In this trial, a tertiary centre provided GDNS, and a secondary hospital offered usual c …

03.09.2026journal-article

Journal of the Endocrine Society

Intermediate risk thyroid cancer management: physician survey

Annu R Suresh, Amanda Kung, Jiling Chou, Jacqueline Jonklaas

Abstract Context Variability exists in use of radioactive iodine (RAI) treatment in intermediate risk (IR) thyroid cancer. Objective The study surveyed clinicians about their use of RAI in theoretical cases of patients with IR thyroid cancer. Design A survey presented patient cases with pathology results and two variations consisting of baseline thyroglobulin levels of ≤5 ng/mL and >5 ng/mL. Respondents were queried as to their use of RAI therapy in each case. Univariate Bayesian cumulative ordinal regression model …

03.09.2026journal-article

Frontiers in Medicine

Spirituality, religious affiliation, and health in Germany: a cross-sectional study including Bayesian network modeling

Christian S. Kessler, Michael Jeitler, Miriam Ortiz, Benno Brinkhaus, Maren M. Michaelsen, Julia K. Schiele, Florian Jeserich, Tido von Schoen-Angerer, Michael Teut, Manfred Wischnewsky

Background Spirituality has been proposed as a relevant dimension of health, yet its distribution in the general population and its associations with health-related factors remain insufficiently characterized. This study examined how self-reported spirituality and religious affiliation are distributed in Germany and how they are associated with chronic disease burden, health-related quality of life, nutrition-related attitudes, and attitudes toward traditional, complementary, and integrative medicine (TCIM). Method …

03.09.2026journal-article

Frontiers in Medicine

Artificial intelligence in personalized computed tomography dose optimization: a systematic review of techniques and clinical outcomes

Nora Almuqbil

Introduction Artificial intelligence (AI) for personalized computed tomography (CT) dose optimization has gained increasing attention due to its potential to reduce radiation exposure while maintaining image quality. CT dose optimization tailors according to individual patient characteristics, including age, weight, body composition, and clinical condition. The study aims to evaluate AI techniques in CT dose optimization, focusing on reducing radiation exposure while maintaining image quality. Methods The relevant …

03.09.2026journal-article

Clinical Microbiology Reviews

Emerging tick-borne viral diseases in East Asia: pathology-driven insights into pathogenesis and disease causality

Yuichiro Hirata, Yusuke Sakai, Tadaki Suzuki

SUMMARY Tick-borne viral infections have emerged as a significant and growing public health concern. In East Asia, severe fever with thrombocytopenia syndrome (SFTS) has served as a prototypical disease in which pathological analyses have substantially advanced the understanding of disease pathogenesis. SFTS is characterized by profound immune dysregulation driven by viral tropism for plasmablast-lineage B cells, leading to cytokine storm and hemophagocytic syndrome. Complementary analyses of human clinical specime …

03.09.2026journal-article

Clinical Journal of the American Society of Nephrology

A Randomized Pilot Trial of a Nephrologist Communication Tool for Discussing Conservative Management

Susan P. Y. Wong, Olivia Gaughran, David K. Prince, Jane Schell, Daniel Y. Lam, Dawn Bates, Grady Paden, Erin K. Kross

Background: It is difficult for patients to make informed decisions about kidney failure unless they know all their treatment options. Conservative management is an important option infrequently presented alongside other kidney failure treatments by nephrologists. Methods: We conducted a randomized pilot trial testing the feasibility and acceptability of a communication tool, called Conservative Kidney Management Jumpstart Tool, in assisting nephrologists with discussing conservative management with their patients. …

03.09.2026journal-article

PLOS One

IFC-HFlowVAE: A self-enhancing generative framework with structural anchoring for imbalanced clinical data augmentation

Lu Yuwen, Shuyu Chen

Class imbalance and limited minority-class samples remain major challenges for developing reliable clinical diagnostic models, as insufficient observations often fail to capture complex minority-class distributions. Existing augmentation methods either rely on heuristic interpolation or suffer from instability when learning sparse and heterogeneous medical tabular data. This study proposes IFC-HFlowVAE, an iterative feedback and consensus framework built upon a flow-enhanced heterogeneous variational autoencoder fo …