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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

Frontiers in Oncology

Exploratory comparative profiling of 22 macro- and trace elements reveals disrupted elemental homeostasis in colorectal cancer tissues

Juanxian Cheng, Lishan Liang, Linyu Wang, Yan Lu, Cheng Xu, Huabin Gao

Colorectal cancer (CRC) is associated with systemic and local alterations in element homeostasis, yet tissue-level data remain limited and inconsistent. This study quantitatively profiled 22 macro- and trace elements in paired tumorous and histopathologically confirmed adjacent non-tumorous colonic tissues from 15 CRC patients using inductively coupled plasma mass spectrometry (ICP-MS). We observed significant accumulation of phosphorus (P), calcium (Ca), magnesium (Mg), iron (Fe), molybdenum (Mo), Rubidium (Rb), s …

01.09.2026journal-article

British Journal of Cancer

Why early pathology input matters in biologically rich cancer trials

Manas Dave, Maggie Chon U. Cheang, Guy Betts, Tomoko Iwata, Michelle Frost, Chiara Braconi, Menna Shamma, Timothy J. Kendall

Abstract Pathology is central to many biologically driven cancer clinical trials. Biomarker-led and translational studies depend on robust tissue pathways, cellular and molecular assays, pathology-derived endpoints, and clinically meaningful interpretation of discovery science. Where trials depend on tumour material, biomarker-defined eligibility or mechanism-focused endpoints, pathology expertise should be embedded early, before protocols, budgets, and assays are fixed. Early pathology input strengthens feasibilit …

01.09.2026journal-article

Frontiers in Oncology

CAR-HEMATOTOX score as a predictor of hematotoxicity, infection, and survival after CAR T-cell therapy in hematologic malignancies: a systematic review and meta-analysis

Juncheng Wei, Ziyu Chen, Mengfei Li, Miao Jiang

Background Immune effector cell-associated hematotoxicity (ICAHT) is a common and clinically important toxicity after chimeric antigen receptor (CAR) T-cell therapy. The CAR-HEMATOTOX score, also reported as CAR-HT, is a baseline risk score proposed to identify patients at higher risk of hematotoxicity and related adverse outcomes. Methods We conducted a systematic search of PubMed, the Web of Science, and the Cochrane Library on June 19, 2026. Included studies compared high- and low-risk groups defined by the CAR- …

01.09.2026journal-article

Frontiers in Immunology

The neuro-immune axis in cancer: mechanisms of neural regulation of immunity within the tumor microenvironment to promote cancer progression

Zhifan Ran, Chenghong Zeng, Jinli Han, Xinfeng Yu

The tumor microenvironment (TME) is a complex and dynamic ecosystem composed of cancer cells, stromal cells, immune cells, and the extracellular matrix, which significantly influences the initiation, progression, and therapeutic response of cancer. Emerging evidence indicates a crucial interaction between the nervous and immune systems within the TME, forming a “neuro-immune axis” that profoundly impacts tumor biology. This review not only synthesizes current knowledge on this critical bidirectional crosstalk but a …

01.09.2026journal-article

AppliedChem

Comparative Evaluation of the Antiproliferative and Pro-Apoptotic Activities of Origanum majorana, Salvia officinalis and Ribes nigrum Extracts in Human Colorectal Cancer and Normal Intestinal Cells

Oana-Roxana Haralambie, Emoke Pall, Mihai Cenariu, Katalin Szabo, Daria-Antonia Dumitraș, Sanda Andrei

Colorectal cancer remains a significant global health challenge, highlighting the need for targeted therapeutic strategies. Plant-derived bioactive compounds are of interest due to their antiproliferative and pro-apoptotic properties. This study investigated the total phenolic and flavonoid contents, antioxidant activity and anticancer potential of Origanum majorana, Salvia officinalis, and Ribes nigrum extracts using normal human intestinal epithelial cells (HIEC-6) and human colorectal carcinoma cells (HCT-116). …

01.09.2026journal-article

C

Eco-Friendly Chitosan/Graphene Oxide Hybrid Nanoparticles as a Dual-Action Platform for Methylene Blue Removal and Antimicrobial Water Treatment

Marco Fiore, Michele Pellegrino, Giuseppe Cirillo, Ludovica Scorzafave, Manuela Curcio, Roberta Pino, Michele De Luca, Stefania Marsico, Francesca Iemma, Fiore Pasquale Nicoletta

This work reports the synthesis and characterization of sustainable, multifunctional chitosan/graphene oxide hybrid nanoparticles (GOCSNPs) prepared via a low-temperature ionotropic gelation method utilizing sodium tripolyphosphate as a green crosslinker. Combined DLS and TEM analyses confirmed the successful formation of submicron spherical nanoparticles with a mean diameter of 295 ± 15 nm (PDI 0.26), and GOCSNPs were evaluated as a dual-action platform for the adsorption of a model cationic dye, Methylene Blue (M …

02.09.2026journal-article

Bipolar Disorders

Hope as a Therapeutic Imperative for Treatment Resistant Depression

Qin Xiang Ng

ABSTRACT Objectives Treatment‐resistant depression poses substantial clinical challenges, particularly following multiple unsuccessful pharmacologic treatments. This brief report considers the role of hope as a therapeutic imperative in the management of treatment‐resistant depression. Methods The case presented by Malhi and colleagues is considered in relation to established approaches to staging treatment resistance and the broader humanistic dimensions of caring for patients with chronic and refractory illness. …

02.09.2026journal-article

JCC Plus

Efficacy of Interleukin‐12/23 and Interleukin‐23 Inhibitors for Moderately to Severely Active Crohn's Disease in Advanced Treatment Failure Populations: Systematic Review and Network Meta‐Analysis

Christopher Ma, Marla Dubinsky, Gil Y. Melmed, Namita Joshi, Jenny Griffith, Fernando Aponte, Brooke Kim, Eric B. Collins, Kristen Westerhoff, Remo Panaccione

ABSTRACT Background and Aims Earlier trials of advanced treatments indicated for moderately to severely active Crohn's disease used predominantly re‐randomized induction responder designs, whereas newer treatments were evaluated using treat‐through designs. Combining heterogeneous trial designs in network meta‐analysis violates core statistical assumptions and may bias estimates of efficacy in maintenance. This study compared the efficacy of interleukin‐12/23 and −23 inhibitors using only treat‐through trials among …

01.09.2026journal-article

Cancers

Proteoglycans as Regulators of Receptor Trafficking and Spatial Signaling in Cancer

Aikaterini Berdiaki, Maria Konstantaraki, Zuha Ajlan, Maria Marmara, Aristidis Tsatsakis, George Tzanakakis, Dragana Nikitovic

Cellular responses depend on the coordinated regulation of receptor activation, trafficking, and signaling across distinct membrane and intracellular compartments. Proteoglycans (PGs), traditionally regarded as structural components of the extracellular matrix and co-receptors, are now emerging as active organizers of receptor dynamics. This review examines the mechanisms through which PGs regulate receptor trafficking and spatial signaling in cancer. Recent studies addressing the roles of proteoglycans in receptor …

01.09.2026journal-article

Journal of Pediatric Gastroenterology and Nutrition

Dual biologic therapy in inflammatory bowel disease, a retrospective cohort study of vedolizumab and anti‐tumor necrosis factor alpha therapy in children

Jonathan E. M. O'Donnell, Carlie Bolles, Claire R. Reilly, Manal Morgan, Christopher Burgess, Fariha Balouch, Peter J. Lewindon

Abstract Objectives Despite advances in pediatric inflammatory bowel disease (PIBD) with biologics, remission rates remain at 47%–60% with loss‐of‐response rates at 60%–68%. Evidence for efficacy of dual biologic therapy (DBT) with anti‐tumor necrosis factor alpha therapy (anti‐TNF‐α)‐ vedolizumab (VDZ) for children refractory to anti‐TNF‐α therapy is limited. This study aimed to describe rates of steroid‐free clinical remission (CR), endoscopic and histological remission, trends in biochemistry, predictors of resp …

02.09.2026journal-article

The Oncologist

35 Targeting HIF2-Driven Endogenous Retroviral Antigens for Immunotherapy in Kidney Cancer

Qinqin Jiang, Gurcan Gunaydin, Vijyendra Ramesh, Justin Becker, Isabelle Lippincott, Karl Clauser, Sudarsana Addepalli, Jenn Abelin, Steven Carr, Bradley Bernstein, William Freed-Pastor, William Kaelin

Abstract Background Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer and remains a major clinical challenge. Although treatment options have expanded to include VEGF pathway inhibitors, immune checkpoint inhibitors (ICIs), and more recently a HIF2 inhibitor, many patients with metastatic disease eventually relapse, and overall survival rates remain below 50%. While ccRCC is considered an immunogenic tumor, the antigenic targets driving effective immune responses remain poorly unde …

02.09.2026journal-article

The Oncologist

47 Hemoglobin Drop is an Early Predictor of Erythropoietin Supplementation in VHL Syndrome Patients Under Belzutifan Treatment - First Report From The Real-Life BELIEVE-VHL Trial

Jose Claudio Casali-da-Rocha, Caroline Macedo da Silva, Sumin Koh

Abstract Background Von Hippel–Lindau syndrome (VHL) results from pathogenic germline variants in the VHL gene, predisposing individuals to retinal angiomas (RA), CNS hemangioblastomas (HB), renal cell carcinoma (RCC), pancreatic neuroendocrine tumors (PanNET), pheochromocytoma (PHEO), among others. The HIF-2A inhibitor belzutifan has shown robust activity in VHL-associated tumors. To evaluate its real-world effectiveness and toxicity profile, the BELIEVE-VHL prospective trial was approved by our institutional ethi …

02.09.2026journal-article

Journal for ImmunoTherapy of Cancer

Overall survival of immunotherapy versus standard of care in chemorefractory microsatellite stable metastatic colorectal cancer: a propensity score matched analysis of 708 patients

Guglielmo Vetere, Emerik Osterlund, Mahmoud M G Yousef, Songwit Payapwattanawong, Giulia Maddalena, Jumanah Alshenaifi, Kristin D Alfaro, Mark Knafl, Van K Morris, Christine M Parseghian, Kanwal P S Raghav, Robert A Wolff, Arvind Dasari, Michael J Overman, Scott Kopetz, John Paul Shen

Background Immune checkpoint inhibitors (ICIs) have limited efficacy in proficient mismatch repair/microsatellite stable (pMMR/MSS) metastatic colorectal cancer (mCRC). However, selected patients with specific metastatic patterns may derive benefit. Methods Patients with chemorefractory pMMR/MSS mCRC treated with ICI-based regimens were retrospectively identified. A comparison cohort treated with trifluridine/tipiracil±bevacizumab, regorafenib, or fruquintinib as standard of care (SOC) was generated through 1:1 pro …

01.09.2026journal-article

South Australian Journal of Medicine

Prostate cancer: to treat or not to treat, a cautionary tale from a doctor-patient

Leslie Jackowski

Background: A definitive diagnosis of prostate cancer can be established with a special type of MRI (multiparametric MRI) followed by core biopsy. An assessment of stage (extent of spread) and grade (aggressiveness of disease) from these investigations assists with clinical decision-making regarding early management. Objective: This article describes the evidence supporting active surveillance for low-risk prostate cancer and the limitations of diagnostic tools in choosing between active surveillance and surgery (r …

01.09.2026journal-article

Journal of Tissue Engineering

Hydrogel microspheres for osteoarthritis treatment: Fabrication strategies, smart responsiveness, and multimodal therapies

Zhuoxuan Song, Xinyue Song, Rui Zhao, Zhicong Zhou, Wei Huang, Meng Zhang, Fang He, Qiming Pang

Osteoarthritis (OA) is a chronic, progressive degenerative joint disease defined by the degradation of articular cartilage, with pathological involvement of periarticular tissues including the synovium and subchondral bone. Existing conservative interventions for OA are limited to symptomatic relief and cannot reverse established cartilage degeneration, underscoring the critical unmet need to address prevailing clinical treatment bottlenecks. Hydrogel microspheres, as an emerging delivery platform integrating drug …

04.09.2026journal-article

Cell Biochemistry and Function

Reactive Oxygen Species in Breast Cancer: From Redox Dysregulation to ROS‐Responsive Therapeutics

Marija Nikolovska, Radoslav Stojchevski, Aleksandar Eftimov, Mitko Mladenov, Dimiter Avtanski, Nikola Hadzi‐Petrushev

ABSTRACT Breast cancer is the most frequently diagnosed malignancy among women worldwide, with 2.3 million new cases and approximately 670,000 deaths reported in 2022 alone. Despite advances in therapy, metastasis and acquired drug resistance remain major clinical challenges. Reactive oxygen species (ROS) play a dual role in breast cancer biology: physiological levels sustain normal cellular signaling, moderately elevated levels promote tumorigenesis through DNA damage, proto‐oncogene activation, and tumor suppress …

01.09.2026journal-article

JAMA

Nicotine E-Cigarettes for Cigarette Smoking Cessation

Eleanor L. S. Leavens, Kinsey Pebley, Tracy T. Smith, Jasjit S. Ahluwalia, Mariel S. Bello, Krysten W. Bold, Jennifer Cantrell, Matthew J. Carpenter, Patricia A. Cioe, Nicholas J. Felicione, Alys Havard, Larry W. Hawk, Jesse T. Kaye, Elias M. Klemperer, Bethea A. Kleykamp, Nicola Lindson, Erin A. McClure, Hayden McRobbie, Cara M. Murphy, Nancy A. Rigotti, Natalie K. Walker, Min-Jeong Yang, Alana M. Rojewski, Adrienne L. Johnson, Members of the Society for Research on Nicotine and Tobacco, Treatment Research Network, Harm Reduction Workgroup

Importance Cigarette smoking, maintained predominantly by nicotine dependence, is a long-term and relapsing behavior that continues to be a leading cause of preventable death and disease worldwide. E-cigarettes with nicotine are less harmful than cigarettes and have been shown to be more effective for smoking cessation than US Food and Drug Administration–approved nicotine replacement therapies. However, misperceptions of the harms of e-cigarettes are common, even among clinicians. This Special Communication is a p …

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01.09.2026journal-article

Radiation Oncology

Clinical evaluation using first-day assessment of patient suitability for successful performance of deep inspiration breath-hold for breast cancer radiotherapy

Bahar Cepni, Vania Batista, Line Hoeltgen, Hanna Waldsperger, Lars Wessel, Jakob Liermann, Semi Harrabi, Fabian Weykamp, Nathalie Arians, Juliane Hörner-Rieber, Jürgen Debus, Eva Meixner

Abstract Background Deep inspiration breath-hold (DIBH) is a radiotherapy standard technique for cardiac-sparing in breast cancer, particularly for left-sided tumors. However, not all patients can successfully complete DIBH RT in clinical routine, necessitating conversion to free breathing (FB) techniques and replanning. This study aimed to identify clinical factors predictive of DIBH feasibility to optimize patient selection and resource utilization. Methods This retrospective study analyzed all patients ( n = 192 …

01.09.2026journal-article

HRB Open Research

Cancer Survivorship Clinics in Tertiary Care: A Scoping Review Protocol

Linda Lisanti, Chris Crockford, Siobhán Cregan, Neil Kearney, Niamh Lucey, Oonagh Griffin, Linda O'Neill

Background As the number of people living with and beyond cancer grow, quality of life has become an increasing priority. Specialised tertiary care centres, as they follow patients throughout their cancer treatment and beyond, represent an opportunity to engage with and provide comprehensive support to patients. However, the support offered is often limited or fragmented, and patients consistently report unmet needs in survivorship, including addressing the short- and longer-term side effects of medical treatment, …

01.09.2026journal-article

Medical Science of Armenia

Cancer Stem Cells: Between Biological Concept and Clinical Reality

S. S. Gasparyan

Рак остаётся одним из наиболее агрессивных и сложных заболеваний в мире. Несмотря на достижения в области биологии рака и клинической онкологии, метастазирование и рецидив опухоли по-прежнему представляют серьёзные терапевтические проблемы. Все больше данных свидетельствуют о том, что раковые стволовые клетки (РСК) играют ключевую роль в этих процессах. РСК считаются функциональной субпопуляцией опухолевых клеток, ключевыми характеристиками которых являются их способность к самообновлению, дифференцировке и повышен …

01.09.2026journal-article

Frontiers in Immunology

Spatial immune biomarkers in triple-negative breast cancer: emerging evidence, technology trade-offs, and barriers to clinical translation

Liuhai Zeng, Wei Lin, Shihang Xue, Minzhi Chen, Haiyan Wu

Triple-negative breast cancer (TNBC) is an immunogenic but clinically heterogeneous breast cancer subtype. Stromal tumor-infiltrating lymphocytes (TILs), PD-L1 expression, and tumor mutational burden provide useful but incomplete summaries of the tumor immune microenvironment. Spatial immune biomarkers retain tissue architecture and ask where immune cells are located, which cells they contact, and whether local neighborhoods are inflamed, excluded, suppressive, or organized into tertiary lymphoid structures (TLS). …

01.09.2026journal-article

GBP Proceedings Series

A Study on the Mechanism of Canna Root in Treating Breast Cancer Based on Network Pharmacology

Wanyi Li

Objective: The present study was designed to investigate the prospective genetic targets of Boehmeria nivea root constituents for oncological applications via network pharmacology and laboratory validation, thereby clarifying the medicinal pathways of this plant. Methods: Major bioactive molecules from Boehmeria nivea root were sourced from the TCMSP platform, utilizing filters for oral bioavailability (OB) ≥30% and drug-likeness (DL) ≥0.18. Following the acquisition of molecular structures from PubChem, Swiss Targ …

01.09.2026journal-article

Journal of Complementary and Integrative Medicine

Prevalence of chemotherapy-induced anemia and its impact on quality of life in breast cancer patients

Ramsha Batool, Tehreem Hayat, Hira Rizwan Butt, Fatima Um Ul Baneen, Hooria Fayyaz, Tayyaba Rafiq, Mehrulnisa Akhtar, Uswa Fayyaz, Maria Ahmed, Ayesha Azeem, Mah Gul Khan, Mahnoor Ikram Khan, Ali Farooq, Amina Shahid

Abstract Background Chemotherapy-induced anemia (CIA) is a frequent condition among breast cancer patients who are treated with systemic chemotherapy, and is linked to fatigue, decreased functional capacity, and poor quality of life. Objectives To determine the prevalence of chemotherapy-induced anaemia and evaluate its impact on the quality of life of breast cancer patients receiving chemotherapy. Methods This cross-sectional study was performed at the Ghurki Trust Teaching Hospital in Lahore, Pakistan, from Janua …