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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
04.09.2026journal-article

Frontiers in Immunology

In vivo CAR T-cell generation: delivery platforms, clinical progress, and translational barriers

Tianqun Huo, Hongping Yao, Ziyan Kong

Chimeric antigen receptor (CAR) T-cell therapy has transformed the treatment of several hematological malignancies, but its broader application remains constrained by the complexity, cost, and time required for conventional ex vivo manufacturing. In vivo CAR T-cell therapy has emerged as a promising next-generation strategy that aims to generate CAR T cells directly within the patient through targeted delivery of CAR-encoding genetic information to endogenous T cells. This approach has the potential to simplify tre …

04.09.2026journal-article

Frontiers in Oral Health

Snacking behaviors and early childhood caries severity among Myanmar preschool children: a cross-sectional study

Phue Wai Han, Kaung Myat Thwin, Wa Than Lin, Natcha Tassanapong, Sachiko Takehara, Hiroshi Ogawa

Background Early childhood caries (ECC) is highly prevalent among preschool children, particularly in Southeast Asian countries. Although dietary intake is a well-established risk factor, evidence on how specific snacking behaviors contribute to caries severity remains limited. This study examined the associations of food pocketing habit, main snack type, snack frequency, snack timing, and combined snacking patterns with ECC severity among Myanmar preschool children. Methods A cross-sectional analysis was performed …

04.09.2026journal-article

Jurnal Ilmiah Manajemen dan Kewirausahaan

Analisis Literasi Keuangan Sebelum dan Sesudah Adopsi Digital Payment Pada Pelaku UMKM di Kecamatan Kota Baru

Riski Novita Sari, Mulia Inda Purwati, Evrina Evrina

The evolution of digital financial technology encourages MSME actors to utilize digital payments to facilitate transactions and financial management. This study aims to analyze differences in the financial literacy of MSME actors before and after the implementation of digital payments in Kota Baru District. This study employed a quantitative method involving a sample of 60 MSME actors who had utilized digital payments. Data were collected through questionnaires and analyzed using validity, reliability, normality, a …

04.09.2026journal-article

The International Journal of Psychiatry in Medicine

Clinical Use of Aripiprazole Monohydrate Long-Acting Injectable in Adolescents: A Case Series and Review of the Literature

Fethiye Kılıçaslan, Harun Yardımcı, Berna Polat Tüysüz

Objective Long-acting injectable (LAI) antipsychotics may improve treatment adherence by maintaining stable plasma drug concentrations and reducing relapse risk associated with inconsistent oral medication use. Although LAIs are widely used in adults with severe psychiatric disorders, their use in pediatric populations remains off-label, and evidence is limited. Aripiprazole, a partial dopamine D 2 receptor agonist, has a favorable tolerability profile in adolescents, particularly regarding metabolic adverse effect …

04.09.2026journal-article

AkMen JURNAL ILMIAH

Accelerating Digital Transformation in MSMEs: The Role of Digital Transformational Leadership, Agility, and Digital Literacy in DIY

Jati Isa Imanika, Budi Sutiono Pratama Nugraha

The study explores how Digital Transformational Leadership (DTL) influences the Digital Transformation (DT) of micro, small, and medium-sized enterprises (MSMEs), using dynamic capabilities theory and examining how Digital Literacy (DL) and Organizational Agility (OA) mediate these relationships. The research uses data from 241 MSMEs in the DIY region and applies a quantitative SEM-PLS methodology. Results show that DTL significantly and consistently influences DT both directly and indirectly through DL-OA. A media …

04.09.2026journal-article

Artificial Life

Evolutionary Brain-Body Co-Optimization Consistently Fails to Select for Morphological Potential

Alican Mertan, Nick Cheney

Abstract Brain-body co-optimization remains a challenging problem. To understand and overcome its challenges, we exhaustively map a morphology-fitness landscape: we train controllers for each morphology in a design space of 1,305,840 voxel-based soft robots. We show that this design space constitutes a good model for studying brain-body co-optimization and that our mapping roughly captures its landscape. Complete knowledge of the landscape lets us analyze how evolutionary co-optimization algorithms unfold. We find …

04.09.2026journal-article

Family Medicine

Trends in Rural and Urban Family Physician Teaching of Health Professions Students and Residents

C. Holly A. Andrilla, Lars E. Peterson, Davis G. Patterson, David V. Evans, Janessa M. Graves

Background and Objectives: Place-based clinical education is vital for promoting the growth of the rural clinician workforce; where learners receive their education strongly influences where they practice. Yet students may struggle to find rural placements. In this study, we sought to understand trends in teaching by family physicians for varied health professions and the associated physician, practice, and community factors. Methods: We analyzed data from 14,789 early career family physicians surveyed from 2016 to …

04.09.2026journal-article

Future Journal of Pharmaceuticals and Health Sciences

Artificial Intelligence - Driven Approaches in Drug Discovery and Development

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Artificial intelligence (AI) has transformed drug discovery and development by streamlining research processes, reducing development time and costs, and improving the efficiency and success of identifying promising therapeutic candidates. Drug targets can be quickly identified, compound efficacy may be predicted, and drug design can be optimized thanks toartificial intelligence (AI), which assesses massive datasets usingNatural language processing (NLP), machine learning (ML), and deep learning (DL).Through better …

04.09.2026journal-article

Journal of Clinical Medicine

Radiological and Clinical Evaluation of the Ipsilateral Ankle of Patients Who Underwent Total Knee Arthroplasty: A Prospective Study

Emre Tosun, Özal Özcan, Aylin Yücel, Serkan Savaş, Sakhi Ahmad Fazli

Background/Objectives: Total knee arthroplasty (TKA) corrects coronal malalignment at the knee, but its effect on the structural status of the ipsilateral ankle is poorly characterised. This prospective study evaluated clinical, radiographic, and MRI-detected changes in the ipsilateral ankle after TKA, and tested whether such changes are related to the magnitude of mechanical axis correction. Methods: Seventy-one consecutive patients (80 operated limbs; mean age 63.9 ± 7.2 years; 83.1% female) undergoing primary TK …

04.09.2026journal-article

Informatics

Perceptions of Wearable Health Data Governance Among Wearable Users and Health Professionals in South Africa

Lydia Osarugue Izu, Brenda Scholtz, Ifeoluwapo Fashoro

Personal health management and clinical health systems are increasingly being transformed by data-driven smart technologies that enable remote monitoring, predictive analytics, and digitally mediated care. Wearable technologies contribute to this transformation by continuously generating wearable health data (WHD), but integrating such data into routine and clinical health management raises governance requirements beyond those for traditional health data. This study examines perceptions of WHD governance among wear …

04.09.2026journal-article

Frontiers in Psychiatry

Follow-up attendance and documented reasons for non-attendance in child and adolescent mental health care: a retrospective analysis

Serkan Suren, Deniz Yavuz Baskiran

Background Failure to continue scheduled follow-up is a common challenge in child and adolescent mental health services and may reduce treatment effectiveness. Objective The present retrospective study aimed to examine demographic, clinical, and treatment-related characteristics associated with attendance at the last scheduled follow-up appointment among children and adolescents receiving outpatient psychiatric care and to identify characteristics associated with the documented reasons for non-attendance among pati …

04.09.2026journal-article

Frontiers in Medicine

Effect of ultrasound-guided small needle knife on patients with knee osteoarthritis: a randomized clinical trial

Xuefei Li, Lei Duan, Zhijun Hu, Bing Xu, Gengqi Wang

Background Although ultrasound-guided small needle knife (UG–SNK) treatment combined with resistance exercise has shown benefits for knee osteoarthritis (OA) patients, evidence supporting this combination remains limited. Objective To evaluate the efficacy and safety of combining ultrasound–guided small needle knife treatment with resistance exercise for patients with knee osteoarthritis. Methods (1) Design, Setting, and Participants This was an 8-week open-label, analyst-blinded, randomized clinical trial conducte …

04.09.2026journal-article

Frontiers in Cell Death

At the nucleus of neuronal health: Drosophila insights into LaminB-dependent homeostasis in aging and cell death

Francesco Napoletano

Brain neurons play a crucial role to maintain organism health in response to macro/micro-environmental biophysical and biochemical cues, and their dysfunction and death drive aging and diseases. However, cellular mechanisms controlling neuronal health are incompletely understood. Drosophila has proven a paramount model to understand fundamental pathways of tissue development, homeostasis, and cell death in health and disease. Among these pathways, the regulation of nuclear structure and function, including genome o …

04.09.2026journal-article

International Journal For Multidisciplinary Research

Menstrual Irregularities and Their Public Health Implications among Bangladeshi Women

Mohammad Hannan, Shahjada Selim, Abu Shaim Uddin, Md. Masud Rana

Background: Women in reproductive age groups face menstrual irregularities that affect regularity, bleeding patterns, and symptomatology. Medical problems and endocrine disorders are the main causes of amenorrhea, oligomenorrhea, and menorrhagia. Objectives: The purpose of the study was to assess menstrual health in a representative sample of women in Bangladesh and evaluate the correlation between irregular menstruation and associated systemic diseases in Bangladesh. Methods: The study was cross-sectional in natur …

04.09.2026journal-article

Kent Akademisi

A Current Curriculum Analysis of Digital Design Methods in Interior Architecture Education: An Evaluation within the Framework of Traditional Design Education

Beytullah Beşkaya, Pelin Yıldız

The design process is a multilayered structure shaped by cognition, creativity, and representational tools. This study examines the curricular position, instructional structure, and conceptual orientation of digital design courses in interior architecture education, using traditional design and representation methods as a theoretical and pedagogical framework. The research is limited to undergraduate Interior Architecture and Environmental Design programs listed in YÖK Atlas under the Equal Weight (EA) score type i …

04.09.2026journal-article

Journal of Clinical Medicine

An Update on Osmotherapy in Acute Brain Injury: Current and Emerging Strategies

Sarah A. Howson, Benjamin Reddi, Rebecca J. Hood, Renée J. Turner, Mark P. Plummer

Intracranial hypertension is a major modifiable pathway of secondary brain injury after acute neurological insults. Osmotherapy is an early cornerstone of tiered intracranial pressure management. Hypertonic saline and mannitol reliably reduce intracranial pressure through osmotic reduction in brain water, with additional haemodynamic and rheological effects. However, neither agent has shown consistent improvement in survival or long-term neurological recovery. Current practice is therefore guided by physiological r …

04.09.2026journal-article

Journal of Clinical Medicine

Anterior Segment Complications After Radiotherapy for Sinonasal and Nasopharyngeal Cancer: High Frequency in Maxillary Sinus Cancer Treated with RADPLAT

Mutsumi Koyama, Seika Den, Akinori Baba, Hirokazu Ashida, Masao Kobayashi, Tadashi Nakano

Objectives: To characterize the frequency and temporal patterns of anterior segment findings after radiotherapy for sinonasal and nasopharyngeal cancer, with particular focus on anterior segment neovascularization and its association with superselective intra-arterial cisplatin infusion with concurrent radiotherapy (RADPLAT). Methods: We retrospectively reviewed 113 patients treated with intensity-modulated radiotherapy between 2019 and 2022. Anterior segment findings were evaluated using the whole cohort as the de …

04.09.2026journal-article

Frontiers in Cardiovascular Medicine

Pharmacological strategies for myocardial protection in cardiac surgery: current science and the emerging role of multi-omics and artificial intelligence

Hanad Ahmed, Jason Ali

Perioperative myocardial ischaemia-reperfusion injury continues to represent a significant source of morbidity and mortality in patients undergoing cardiac surgery, despite considerable advances in cardiopulmonary bypass technology and operative technique. Contemporary cardioprotective approaches, including cardioplegia, offer only partial attenuation of this injury. Intraoperative protection strategies have evolved little over recent decades, and clinical trials investigating pharmacological agents directed at isc …

04.09.2026journal-article

Observatorio (OBS*)

Coverage of mental health on X: an analysis of Spanish newspapers (2015-2022)

Sergio Arce Garcia, Jesús Díaz-Campo

Mental health is a key social issue, and the media plays a vital role in shaping public awareness and attitudes. Social media platforms, such as X (formerly Twitter), have become important channels for disseminating information and influencing perceptions. This study explores how leading eleven Spanish online newspapers addressed mental health on X between 2015 and 2022, with a focus on language use, gender stereotypes, emotional tone, and the impact of the Covid-19 pandemic. A mixed-methods approach was used, comb …

04.09.2026journal-article

Advances in Research

Artificial Intelligence and Large Language Models in Agricultural Extension: Critical Synthesis of Adoption, Efficacy, and Equity in Smallholder Advisory Systems

Swati Sucharita, Pratima Sachan, T. Sravan Kumar

Agricultural extension and advisory services are undergoing a rapid digital transformation driven by artificial intelligence (AI), machine learning, natural language processing, and, more recently, generative artificial intelligence and large language models (LLMs). These technologies have the potential to address persistent constraints in conventional agricultural extension, including limited adviser-to-farmer ratios, geographical isolation, inadequate localisation of information, and delays in the dissemination o …

04.09.2026journal-article

Veterinary Record Case Reports

Laryngeal squamous cell carcinoma in a captive Eurasian lynx ( Lynx lynx ): Clinical, pathological and comparative oncologic findings

Jonas Spruyt, Laurens Van Mulders, Francis Vercammen, Koen Chiers

Abstract Laryngeal squamous cell carcinoma (SCC) is an invasive epithelial tumour without prior documentation in nondomestic felids. We describe a case of laryngeal SCC in a 19‐year‐old male Eurasian lynx housed in a wildlife sanctuary. The animal presented with progressive inspiratory to expiratory stridor and dyspnoea. Laryngoscopy under general anaesthesia revealed a multilobulated mass partially obstructing the glottis. Over the next weeks, respiratory signs worsened and euthanasia was elected. Necropsy identif …

04.09.2026journal-article

INTERNATIONAL JOURNAL OF HEALTH AND PHARMACEUTICAL RESEARCH

Type 2 Diabetes Mellitus in Young Adults: A Growing Public Health Concern

Abosede Opeyemi Oladosu

Type 2 Diabetes Mellitus (T2DM) in young adults has emerged as a pressing global public health concern. Once considered a disease of older populations, T2DM is increasingly diagnosed among individuals aged 15–39 years, a demographic undergoing critical life transitions. The rising prevalence is driven by lifestyle changes, urbanization, obesity, and genetic predisposition, with Africa and other low- and middle-income regions experiencing the fastest growth. Evidence shows that youth-onset T2DM progresses more aggre …

04.09.2026journal-article

Graefe's Archive for Clinical and Experimental Ophthalmology

Repeatability and reproducibility of corneal endothelial measurements using the topcon SP-1P specular microscope

Rubén D. Berrospi, Carolina M. Estrella, Virgilio Galvis, Sylvia J. Villamizar, Juan F. Urrea, Alejandro Tello

Abstract Purpose To evaluate the repeatability and reproducibility of corneal endothelial parameters measured with the Topcon SP-1P specular microscope in healthy eyes, comparing single and panoramic acquisition modes. Methods This reproducibility study included 137 eyes from 79 healthy adults. Endothelial cell density (ECD), average cell area, coefficient of variation (CV), hexagonality, and pachymetry were measured twice by two independent examiners using both single and panoramic modes. Statistical agreement was …

04.09.2026journal-article

Graefe's Archive for Clinical and Experimental Ophthalmology

Laser speckle flowgraphy (LSFG) in retinal vein occlusion and central serous chorioretinopathy: a systematic review of the recent literature

Carlo Bellucci, Medea Virgili, Alessandra Romano, Arturo Carta, Paolo Mora

Abstract Purpose Laser Speckle Flowgraphy (LSFG) is a non-invasive imaging technology that quantitatively evaluates retinal and choroidal blood flow by analyzing speckle patterns generated by laser light scattering. Compared with OCT-A, which provides detailed visualization of retinal and choroidal microvascular architecture, LSFG offers dynamic quantitative information on ocular blood flow. This systematic review summarizes the application of LSFG in two major vascular diseases: retinal vein occlusion (RVO), and c …