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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

JNCI: Journal of the National Cancer Institute

Evaluating the incidence and predictors of chronic opioid use in early survivorship for patients with diffuse large B-cell lymphoma

Mithunan Ravindran, Jessie Peng, Jonathan Zipursky, Jin Luo, Ning Liu, Kelvin K W Chan, Matthew C Cheung, Lee Mozessohn

Abstract Background Opioid exposure during cancer treatment is common and leads to new persistent opioid use (NPOU) in a subset of patients. There are limited data on the incidence and predictors of NPOU among patients with diffuse large B-cell lymphoma (DLBCL). Methods We conducted a population-based cohort study including patients with DLBCL ≥18 years old from Ontario, Canada who received first-line rituximab-based chemoimmunotherapy from 2014-2021 and survived >365 days after treatment. We defined opioid exposur …

01.09.2026journal-article

Current Nanomedicine

Non-Ionic Surfactants (NIOs) in Niosome Drug Delivery: In-Depth Review of Clinical Trials, Patents in Tuberculosis (TB) and Oncology

Manju Koli, Tapaskumar Mukeshkumar Shah, Prottay Dutta, Neetu Patel, Abhay Kumar Patel, Binita Ghosh, Akashdeep Singh, Rahul Pal

Niosomes (NIOs), as non-ionic surfactant based vesicles, have emerged as versatile nanocarriers in the targeted delivery of drugs due to their biocompatibility, chemical stability, and ability to encapsulate both hydrophilic and lipophilic drugs. Their utility has gained significant traction in addressing challenges associated with conventional therapies, for chronic and resistant diseases, Tuberculosis (TB), and cancer. This review critically evaluates the role of non-ionic surfactant in the formulation of NIOs, e …

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03.09.2026journal-article

Journal of Clinical Neuromuscular Disease

Clinical Feature and Treatment Outcomes of Necrotizing Autoimmune Myopathy in a Referral Neurological Center in Thailand

Sirilux Angsuwattanakul, Thanes Termglinjan, Arada Rojana-udomsart

Background: Necrotizing autoimmune myopathy (NAM) is classified into 3 subtypes according to antibodies. Data from Southeast Asian populations remain limited. Objective: To describe and compare clinical characteristics and treatment responses among the NAM subtypes. Methods: Retrospective cohort included three subtypes of 29 patients with NAM. Demographics, clinical data, treatment approach, and responses were assessed and compared. Results: There were 20 (68.97%) anti–signal recognition particle (SRP), 8 anti–hydr …

01.09.2026journal-article

Journal of Extracellular Vesicles

Small Extracellular Vesicle and Total Lipid Profiles Provide a Diagnostic Advantage Over CA‐125 Across Ovarian Cancer Subtypes

Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Lewis Perrin, Rohan Lourie, Vaibhavi Joshi, Amy E. McCart Reed, Kaltin Ferguson, Aase Handberg, Andreas Möller, Carlos Salomon

ABSTRACT Ovarian cancer remains the most lethal gynaecological malignancy, largely due to late‐stage diagnosis and the limited sensitivity of CA‐125 for borderline and low‐grade tumours. Dysregulated lipid metabolism may provide complementary diagnostic information. This study aimed to develop lipid‐based biomarkers to improve the differential diagnosis of adnexal masses. We profiled total plasma and small extracellular vesicle (sEV) lipids in women with benign, borderline and malignant ovarian tumours, using healt …

01.09.2026journal-article

Neurosurgical Focus

Diffusion MRI radiomics in meningiomas: imaging correlates of tumor grade and intraoperative consistency

Sabino Luzzi, Gianluca Lorenzo Fabozzi, Salvatore Cutillo, Tevfik Serhan Bora, Adriana Pintus, Sebastiano Cuccuru, Ivana Roskova, Abramo Agosti, Lorenzo Magrassi, Giuseppe Palmieri, Antonio Cossu, Mariano Scaglione, Salvatore Masala, Renato Galzio

OBJECTIVE Despite advancements in imaging studies, the preoperative prediction of the biological behavior and intraoperative consistency of intracranial meningiomas remains limited. This study evaluated the association of volumetric diffusion-based and texture-derived radiomic features extracted from routine MRI with histopathological aggressiveness and intraoperative tumor consistency. METHODS Ninety-seven intracranial meningiomas resected at two tertiary centers were retrospectively analyzed. Volumetric segmentat …

01.09.2026journal-article

Serican Journal of Medicine

Dual DNMT–EZH2 Inhibition as a Stroma-Directed Strategy in Castration-Resistant Prostate Cancer: A Commentary

Rongxin Chang, Guodong Liu

Background: Castration-resistant prostate cancer (CRPC) remains a lethal progression state despite androgen-deprivation therapy, driven by epigenetic plasticity and a fibrotic tumour microenvironment. Single-agent epigenetic inhibitors have limited activity in solid tumours, partly because compensatory H3K27me3-mediated silencing may preserve gene repression after DNMT inhibition. Objective: To comment on a recent PNAS study and evaluate the mechanistic and translational rationale for dual DNMT–EZH2 inhibition as a …

01.09.2026journal-article

Cell Communication and Signaling

CircERBB2 and beyond: a new regulatory layer in HER2-driven cancer

Zhumeng Gu, Hui Liu, Sixiang Zheng, Pinghan Wang, Gang Wang, Xudong Zhang, Fangyi Long, Ting Wang

Abstract Human epidermal growth factor receptor 2 ( HER2 , also known as ERBB2 ) is aberrantly expressed in multiple malignancies and serves as both a key molecular tumor classification marker and an important therapeutic target. Although monoclonal antibodies, tyrosine kinase inhibitors, and antibody–drug conjugates targeting HER2 have significantly improved patient outcomes, challenges such as treatment resistance and disease relapse remain. To address these unmet clinical needs, circular RNAs (circRNAs) have eme …

01.09.2026journal-article

Acta Veterinaria Scandinavica

Equine neuroborreliosis in Scandinavia: cerebrospinal fluid PCR confirmation and successful treatment in a mare

Sofia Ruiz, Marianne Øverlie, Amanda Bergren, Ingunn Risnes Hellings

Abstract Background Lyme borreliosis (LB), caused by Borrelia burgdorferi sensu lato, is an emerging concern in human medicine, and is a controversial topic in equine medicine. Neuroborreliosis (NB), a neurologic manifestation of LB, remains challenging to diagnose due to nonspecific clinical signs and the lack of definitive diagnostic methods. This report describes the first documented case of equine NB in Scandinavia. Case presentation An 11-year-old mare presented with progressive weight loss, ataxia, muscle atr …

01.09.2026journal-article

International Journal of Population Studies

A Testable Model of Temporal Genomic Memory in Cancer Initiation Driven by Metabolic-Epigenetic Coupling

Bruno Lankoandé, Souleymane Sanogo, Soumaila Ouedraogo, Souleymane Rabo, Géraldine Duthé, Lamine Sawadogo

Population aging is accelerating in sub-Saharan Africa, yet evidence on mortality after retirement remains scarce due to limited data availability, even as the share of formal-sector retirees grows across the region. This study examines post-retirement mortality trajectories and occupational and socioeconomic inequalities in survival among male civil-service retirees in Burkina Faso using individual administrative data from the national civil-service pension register to follow 5,715 male retirees from the 2005–2015 …

01.09.2026journal-article

European Journal of Oral Sciences

Microbial dysbiosis and tumor biomarker expression in oral leukoplakia and oral squamous cell carcinoma: A quantitative polymerase chain reaction‐based immunohistochemical study

Ajay Kumar Verma, Anjali Narwal, Mala Kamboj, Anju Devi, Shikha Tewari, Gopikrishnan Vijayakumar

Abstract Porphyromonas gingivalis is a major periodontal pathogen increasingly associated with oral leukoplakia (OL) and oral squamous cell carcinoma (OSCC) due to its role in microbial dysbiosis and carcinogenesis. This study aimed to evaluate the relative abundance of P. gingivalis in healthy controls, OL, and OSCC patients and to correlate the bacterial load with immunohistochemical (IHC) markers. A total of 48 oral swab samples were collected from three study groups: (1) healthy, (2) OL, and (3) OSCC. Quantitat …

01.09.2026journal-article

Pharmaceuticals

Two-Dimensional MXene-Loaded Butylphthalide Enhances the Treatment of Alzheimer’s Disease by Inhibiting Ferroptosis and Oxidative Stress

Yajun Zhou, Bangjian Liu, Hui Wang, Li Cao

Introduction: Alzheimer’s disease (AD) is a chronic progressive neurodegenerative disorder involving ROS and ferroptosis. MXene, a 2D material, functions as both a drug carrier and ROS scavenger. Butylphthalide (NBP), a neuroprotective agent, suffers from poor aqueous solubility and bioavailability. This study synthesized Ti2C@BSA-NBP, a novel MXene nanocomposite, to enhance NBP delivery and therapeutic efficacy for AD. Materials and Methods: Ti2C@BSA-NBP was synthesized via self-assembly and amidation reaction, an …

01.09.2026journal-article

Breast Cancer Research

Multilevel determinants of physical activity in rural breast cancer survivors: a mixed-methods study

Brittany Murley, Kathryn H. Schmitz, Scherezade K. Mama

Abstract Background Rural breast cancer survivors are less likely to meet physical activity (PA) recommendations than those residing in urban areas. Ecologic frameworks account for multilevel factors related to PA and may be used to contextually adapt interventions to meet the needs of underserved cancer survivors. This study explored ecologic determinants of PA in rural breast cancer survivors to inform future intervention adaptations and implementation in rural communities. Methods An explanatory sequential mixed …

01.09.2026journal-article

Frontiers in Oncology

Exploratory comparative profiling of 22 macro- and trace elements reveals disrupted elemental homeostasis in colorectal cancer tissues

Juanxian Cheng, Lishan Liang, Linyu Wang, Yan Lu, Cheng Xu, Huabin Gao

Colorectal cancer (CRC) is associated with systemic and local alterations in element homeostasis, yet tissue-level data remain limited and inconsistent. This study quantitatively profiled 22 macro- and trace elements in paired tumorous and histopathologically confirmed adjacent non-tumorous colonic tissues from 15 CRC patients using inductively coupled plasma mass spectrometry (ICP-MS). We observed significant accumulation of phosphorus (P), calcium (Ca), magnesium (Mg), iron (Fe), molybdenum (Mo), Rubidium (Rb), s …

01.09.2026journal-article

British Journal of Cancer

Why early pathology input matters in biologically rich cancer trials

Manas Dave, Maggie Chon U. Cheang, Guy Betts, Tomoko Iwata, Michelle Frost, Chiara Braconi, Menna Shamma, Timothy J. Kendall

Abstract Pathology is central to many biologically driven cancer clinical trials. Biomarker-led and translational studies depend on robust tissue pathways, cellular and molecular assays, pathology-derived endpoints, and clinically meaningful interpretation of discovery science. Where trials depend on tumour material, biomarker-defined eligibility or mechanism-focused endpoints, pathology expertise should be embedded early, before protocols, budgets, and assays are fixed. Early pathology input strengthens feasibilit …

01.09.2026journal-article

Frontiers in Oncology

CAR-HEMATOTOX score as a predictor of hematotoxicity, infection, and survival after CAR T-cell therapy in hematologic malignancies: a systematic review and meta-analysis

Juncheng Wei, Ziyu Chen, Mengfei Li, Miao Jiang

Background Immune effector cell-associated hematotoxicity (ICAHT) is a common and clinically important toxicity after chimeric antigen receptor (CAR) T-cell therapy. The CAR-HEMATOTOX score, also reported as CAR-HT, is a baseline risk score proposed to identify patients at higher risk of hematotoxicity and related adverse outcomes. Methods We conducted a systematic search of PubMed, the Web of Science, and the Cochrane Library on June 19, 2026. Included studies compared high- and low-risk groups defined by the CAR- …

01.09.2026journal-article

Frontiers in Immunology

The neuro-immune axis in cancer: mechanisms of neural regulation of immunity within the tumor microenvironment to promote cancer progression

Zhifan Ran, Chenghong Zeng, Jinli Han, Xinfeng Yu

The tumor microenvironment (TME) is a complex and dynamic ecosystem composed of cancer cells, stromal cells, immune cells, and the extracellular matrix, which significantly influences the initiation, progression, and therapeutic response of cancer. Emerging evidence indicates a crucial interaction between the nervous and immune systems within the TME, forming a “neuro-immune axis” that profoundly impacts tumor biology. This review not only synthesizes current knowledge on this critical bidirectional crosstalk but a …

01.09.2026journal-article

AppliedChem

Comparative Evaluation of the Antiproliferative and Pro-Apoptotic Activities of Origanum majorana, Salvia officinalis and Ribes nigrum Extracts in Human Colorectal Cancer and Normal Intestinal Cells

Oana-Roxana Haralambie, Emoke Pall, Mihai Cenariu, Katalin Szabo, Daria-Antonia Dumitraș, Sanda Andrei

Colorectal cancer remains a significant global health challenge, highlighting the need for targeted therapeutic strategies. Plant-derived bioactive compounds are of interest due to their antiproliferative and pro-apoptotic properties. This study investigated the total phenolic and flavonoid contents, antioxidant activity and anticancer potential of Origanum majorana, Salvia officinalis, and Ribes nigrum extracts using normal human intestinal epithelial cells (HIEC-6) and human colorectal carcinoma cells (HCT-116). …

01.09.2026journal-article

C

Eco-Friendly Chitosan/Graphene Oxide Hybrid Nanoparticles as a Dual-Action Platform for Methylene Blue Removal and Antimicrobial Water Treatment

Marco Fiore, Michele Pellegrino, Giuseppe Cirillo, Ludovica Scorzafave, Manuela Curcio, Roberta Pino, Michele De Luca, Stefania Marsico, Francesca Iemma, Fiore Pasquale Nicoletta

This work reports the synthesis and characterization of sustainable, multifunctional chitosan/graphene oxide hybrid nanoparticles (GOCSNPs) prepared via a low-temperature ionotropic gelation method utilizing sodium tripolyphosphate as a green crosslinker. Combined DLS and TEM analyses confirmed the successful formation of submicron spherical nanoparticles with a mean diameter of 295 ± 15 nm (PDI 0.26), and GOCSNPs were evaluated as a dual-action platform for the adsorption of a model cationic dye, Methylene Blue (M …

02.09.2026journal-article

Bipolar Disorders

Hope as a Therapeutic Imperative for Treatment Resistant Depression

Qin Xiang Ng

ABSTRACT Objectives Treatment‐resistant depression poses substantial clinical challenges, particularly following multiple unsuccessful pharmacologic treatments. This brief report considers the role of hope as a therapeutic imperative in the management of treatment‐resistant depression. Methods The case presented by Malhi and colleagues is considered in relation to established approaches to staging treatment resistance and the broader humanistic dimensions of caring for patients with chronic and refractory illness. …

02.09.2026journal-article

JCC Plus

Efficacy of Interleukin‐12/23 and Interleukin‐23 Inhibitors for Moderately to Severely Active Crohn's Disease in Advanced Treatment Failure Populations: Systematic Review and Network Meta‐Analysis

Christopher Ma, Marla Dubinsky, Gil Y. Melmed, Namita Joshi, Jenny Griffith, Fernando Aponte, Brooke Kim, Eric B. Collins, Kristen Westerhoff, Remo Panaccione

ABSTRACT Background and Aims Earlier trials of advanced treatments indicated for moderately to severely active Crohn's disease used predominantly re‐randomized induction responder designs, whereas newer treatments were evaluated using treat‐through designs. Combining heterogeneous trial designs in network meta‐analysis violates core statistical assumptions and may bias estimates of efficacy in maintenance. This study compared the efficacy of interleukin‐12/23 and −23 inhibitors using only treat‐through trials among …

01.09.2026journal-article

Cancers

Proteoglycans as Regulators of Receptor Trafficking and Spatial Signaling in Cancer

Aikaterini Berdiaki, Maria Konstantaraki, Zuha Ajlan, Maria Marmara, Aristidis Tsatsakis, George Tzanakakis, Dragana Nikitovic

Cellular responses depend on the coordinated regulation of receptor activation, trafficking, and signaling across distinct membrane and intracellular compartments. Proteoglycans (PGs), traditionally regarded as structural components of the extracellular matrix and co-receptors, are now emerging as active organizers of receptor dynamics. This review examines the mechanisms through which PGs regulate receptor trafficking and spatial signaling in cancer. Recent studies addressing the roles of proteoglycans in receptor …

01.09.2026journal-article

Journal of Pediatric Gastroenterology and Nutrition

Dual biologic therapy in inflammatory bowel disease, a retrospective cohort study of vedolizumab and anti‐tumor necrosis factor alpha therapy in children

Jonathan E. M. O'Donnell, Carlie Bolles, Claire R. Reilly, Manal Morgan, Christopher Burgess, Fariha Balouch, Peter J. Lewindon

Abstract Objectives Despite advances in pediatric inflammatory bowel disease (PIBD) with biologics, remission rates remain at 47%–60% with loss‐of‐response rates at 60%–68%. Evidence for efficacy of dual biologic therapy (DBT) with anti‐tumor necrosis factor alpha therapy (anti‐TNF‐α)‐ vedolizumab (VDZ) for children refractory to anti‐TNF‐α therapy is limited. This study aimed to describe rates of steroid‐free clinical remission (CR), endoscopic and histological remission, trends in biochemistry, predictors of resp …

02.09.2026journal-article

The Oncologist

35 Targeting HIF2-Driven Endogenous Retroviral Antigens for Immunotherapy in Kidney Cancer

Qinqin Jiang, Gurcan Gunaydin, Vijyendra Ramesh, Justin Becker, Isabelle Lippincott, Karl Clauser, Sudarsana Addepalli, Jenn Abelin, Steven Carr, Bradley Bernstein, William Freed-Pastor, William Kaelin

Abstract Background Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer and remains a major clinical challenge. Although treatment options have expanded to include VEGF pathway inhibitors, immune checkpoint inhibitors (ICIs), and more recently a HIF2 inhibitor, many patients with metastatic disease eventually relapse, and overall survival rates remain below 50%. While ccRCC is considered an immunogenic tumor, the antigenic targets driving effective immune responses remain poorly unde …

02.09.2026journal-article

The Oncologist

47 Hemoglobin Drop is an Early Predictor of Erythropoietin Supplementation in VHL Syndrome Patients Under Belzutifan Treatment - First Report From The Real-Life BELIEVE-VHL Trial

Jose Claudio Casali-da-Rocha, Caroline Macedo da Silva, Sumin Koh

Abstract Background Von Hippel–Lindau syndrome (VHL) results from pathogenic germline variants in the VHL gene, predisposing individuals to retinal angiomas (RA), CNS hemangioblastomas (HB), renal cell carcinoma (RCC), pancreatic neuroendocrine tumors (PanNET), pheochromocytoma (PHEO), among others. The HIF-2A inhibitor belzutifan has shown robust activity in VHL-associated tumors. To evaluate its real-world effectiveness and toxicity profile, the BELIEVE-VHL prospective trial was approved by our institutional ethi …