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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Frontiers in Endocrinology

Association of preoperative fasting blood glucose with 1-year Harris Hip Score after hip fracture in older adults: a multicenter retrospective cohort study

Huazhong Liu, Jiajun Liao, Ji Li, Guixin Zhang, He Tian, Huai Wu, Haoze Yang, Shiwei Yang, Yun Lu

Background The impact of preoperative fasting blood glucose (FBG) on functional recovery after hip fracture remains uncertain. Methods We conducted a multicenter retrospective cohort study of older adults undergoing hip fracture surgery at three hospitals in Shenzhen, China, between January 2021 and May 2023. De-identified electronic health record data were pooled across centers. The primary outcome was 1-year functional recovery, assessed using the Harris Hip Score (HHS) and categorized as satisfactory (HHS ≥70) o …

27.08.2026journal-article

Journal of Family Medicine and Health Care

Prevalence and Predictors of Multimorbidity Among Older Adults Attending the General Outpatient Clinic of Federal Teaching Hospital Birnin-Kebbi

Hope Abitare

Multimorbidity is an emerging public health challenge associated with poor health outcomes, increased healthcare utilization, and rising healthcare costs, particularly among older adults. Despite its growing burden, evidence on multimorbidity among older adults in Northwestern Nigeria remains limited. This study determined the prevalence and predictors of multimorbidity among older adults attending the General Outpatient Clinic of the Federal Teaching Hospital, Birnin-Kebbi, Nigeria. A hospital-based cross-sectiona …

27.08.2026journal-article

Frontiers in Medicine

Single-dose dexamethasone increases perioperative glycemic variability in older patients with diabetes undergoing lung surgery: a continuous glucose monitoring-based randomized controlled trial

Xiaoyi Zhang, Cheng Huang, Xiang Wang, Jun Zhang, Xiaomei Ling, Jiahao Xu, Jue Ma, Fei Zhong, Haihua Shu

Objectives To investigate whether a single intraoperative dose of dexamethasone alters perioperative glycemic dynamics in older patients with type 2 diabetes undergoing thoracoscopic lung resection. Glycemic dynamics were captured using continuous glucose monitoring (CGM). Methods 72 patients aged ≥ 60 years with type 2 diabetes who underwent elective thoracoscopic lung resection were randomly assigned to receive either 8 mg of dexamethasone or placebo (0.9% saline) intravenously during anesthesia induction. The pr …

27.08.2026journal-article

The Anatolian Journal of Cardiology

Association Between Different Vericiguat Dose Exposures, Concomitant Quadruple Heart Failure Therapy, and Myocardial Fibrosis Burden in Older Adults with Worsening Heart Failure with Reduced Ejection Fraction

Liyong Ge, Guoqiu Wang, Anning Zeng, Wei Li

Background: Older adults with worsening heart failure with reduced ejection fraction (HFrEF) remain high risk despite quadruple guideline-directed medical therapy (GDMT-4). Whether vericiguat exposure relates to change in myocardial fibrosis is unknown. Methods: A single-center, prospective cohort of patients ≥65 years with HFrEF [left ventricular ejection fraction (LVEF) ≤40%] after a recent worsening event (enrollment from January 2022 to December 2023 with 12-month follow-up) was conducted. Vericiguat exposure w …

27.08.2026journal-article

Haemophilia

Healthcare Professional Identified Priorities for a New Musculoskeletal Examination Scoring System for People With Hemophilia—an International Consensus

Lizabeth Teshler, Audrey Abad, Magnus Aspdahl, Laura Avila, Melanie Bladen, Sharon Funk, Pamela Hilliard, Judy Ann John, Marilyn Manco‐Johnson, Janjaap van der Net, David Stephensen, Jean St‐Louis, Merel Timmer, Beth Boulden Warren, F. Virginia Wright, Nichan Zourikian, Brian M. Feldman

ABSTRACT Introduction The accurate physical examination of musculoskeletal (MSK) health is an essential part of proactive best practice care of people with hemophilia and must be consistently monitored in clinic. In response to current MSK tool limitations, the Musculoskeletal Health Expert Working Group (MSKH EWG) of the International Prophylaxis Study Group (IPSG) has identified developing an improved MSK scoring system a priority. Aim To identify the priority needs for healthcare professionals examining the MSK …

27.08.2026journal-article

Journal of Eye Movement Research

Saccadic Oscillations After Donepezil Administration in Patients with Dementia: Time Course and Clinical Correlates

Ileok Jung, Ji-Soo Kim, Moon-Ho Park

Donepezil, a cholinesterase inhibitor widely used in dementia, can be associated with saccadic oscillations (SO), but their time course and clinical relevance are unclear. In this prospective observational study, 18 patients with dementia underwent video-oculography at baseline (V0), one month (V1), and three months (V2) after initiation or dose escalation of donepezil. SO were counted over a single 30 s recording during visual fixation and in darkness, expressed as events/30 s. Dizziness was assessed with the Dizz …

27.08.2026journal-article

Alzheimer Disease & Associated Disorders

Co-Design and Development of Digital Health Solution for Informal Alzheimer’s Caregivers

Maria Maia Almeida, Carla Sílvia Fernandes, Marta Campos Ferreira

Introduction: Alzheimer disease (AD) imposes significant cognitive, emotional, and practical challenges on individuals and their caregivers. Informal caregivers, often family members, assume a central role in managing complex care routines, frequently with limited support. Digital tools offer promising avenues for addressing these challenges, yet existing solutions often lack integration, personalization, or user-centered design. Methods: This study presents the design, development, and validation of AlzCare, a dig …

27.08.2026journal-article

JAIDS Journal of Acquired Immune Deficiency Syndromes

Cellular immune response of COVID-19 vaccines in people living with HIV: a systematic review and meta-analysis

Shi Zou, Yajun Yan, Jiuhong Ye, Jie Liu, Yuting Tan, Shihui Song, Qian Du, Jing Chen, Jinding Zheng, Songjie Wu, Ke Liang

Background: Available data indicate that people living with HIV (PLWH) have weaker humoral immune responses to COVID-19 vaccines compared to the general population. However, data on cellular immune responses in this group has yet to be established. Methods: We searched the PubMed, Embase, and Cochrane Central Register of Controlled Trials databases and included studies reporting cellular immune response rates in PLWH after receiving COVID-19 vaccines. The random-effects models of proportions were performed. Results …

27.08.2026journal-article

Journal of the American Geriatrics Society

Artificial Intelligence and Health Care for Older Adults, a Future for All of Us

Peter M. Abadir, Phillip H. Phan, Márlon Juliano Romero Aliberti, Thiago Junqueira Avelino‐Silva, Caglar Cosarderelioglu, April Ehrlich, Thomas Horton, Thomas Laskow, Sohemi Pagan Leon, Sarah Lenz Lock, Mark A. Supiano, Daniel Thomas, Debra Saliba, Esther S. Oh

ABSTRACT We are racing towards a time wherein the largest demographic of the population will be comprised of older adults and where it is now also possible to measure, monitor, and diagnose long term risk factors and provide effective and valuable preventative interventions. Thanks to the achievements of modern health care, we have reached a tipping point in the need for a robust geriatric workforce. Through the implementation of thoughtful, deliberate, and collaborative processes, Artificial Intelligence can play …

27.08.2026journal-article

European Journal of Pain

Short‐Term Effect of Negative Verbal Language Versus Positive Verbal Language on Physical and Functional Capacity and Pain in People With Chronic Primary Low Back Pain

Yves Schwendenmann, Pierre‐Antoine Palacios, Martin Descarreaux, Andrée‐Anne Marchand

ABSTRACT Background Low back pain (LBP) is the leading cause of years lived with disability. While education is recommended by most guidelines, the type of language used can lead to a placebo or nocebo effect. This study aims to compare the short‐term effect of negative language versus positive language on physical and functional capacity in individuals with chronic primary LBP. Methods Forty‐six adults with chronic primary LBP were recruited and received standardized negative ( n = 23) or positive ( n = 23) messag …

27.08.2026journal-article

Dementia

“You Don’t Belong in Hospital”: How Hospital-Based Dementia Stigma Shapes Health-Related Quality of Life

Alixe Ménard, Mackda Donkor, Sarah Fraser

Health-related quality of life reflects individuals’ perceptions of how a health condition affects their physical, psychological, and social functioning. Amid increasing pressures on primary care systems, people living with dementia are presenting more frequently to hospital settings. However, limited research has explored how hospital-based care, and the dementia stigma that may operate within it, shapes health-related quality of life for people living with dementia and their caregivers. This exploratory qualitati …

27.08.2026journal-article

Assessment

Development of an AI-Enabled Remote Loneliness Assessment System for Older Adults Using Behavioral and Speech Data From IoT Sensors and Smart Speakers

Mohamed Kamel, Tamer Nadeem, Juyoung Park, Jane Chung

Loneliness is a critical risk factor for adverse health outcomes in older adults, yet remains under-detected due to social stigma, time constraints, and reliance on episodic self-report. We describe HomePal, a passive system designed to support future assessment of loneliness-relevant behavioral patterns in older adults living alone. HomePal integrates in-home sensors, smart speakers, and phone communication logs to capture mobility, environmental engagement, sedentary behavior, sleep, TV use, voice characteristics …

27.08.2026journal-article

PLANTS, PEOPLE, PLANET

Genomic architecture and breeding trade‐offs of coconut drought tolerance

Theodore S. Brook, Tom Versluys, Bi Tra Serges Doubi, Sam Acors, Jahcub Trew, Kyle Macleod, Louis Bell‐Roberts, Katarina Piponi, Jean Louis Konan, Konan Engueran Djaha, Hala N'klo, Benjamin J. Roberts, Catherine M. Collins, Matteo Fumagalli, Julien Godwin, Vincent Savolainen

Societal Impact Statement The coconut palm is an extremely popular and economically important crop, with around 65 million tonnes produced in 2023. Although Africa's coconut sector is growing rapidly, it—and the livelihoods that depend on it—is threatened by climate change, particularly increased drought. Although developing stress‐resilient crops remains challenging, here we aimed to first understand the variation in drought response and then to dissect the genomic basis of this complex trait, leveraging an experi …

27.08.2026journal-article

Inquiry@Queen's Undergraduate Research Conference Proceedings

Continuous Glucose Monitoring Trends Among Ethnically Diverse People with Type 2 Diabetes

Katherine Zhu

Background: Ethnic background and social determinants of health influence glycemic management and type 2 diabetes (T2D) outcomes, with inequities in risk and complications across diverse populations, even at similar body mass index. Hemoglobin A1c, the standard glycemic biomarker, may perform differently across ethnic groups and does not fully capture glucose variability, highlighting the need for alternative metrics. Intermittently scanned continuous glucose monitoring (CGM) offers a more granular assessment, but …

27.08.2026journal-article

Diabetes Care

The Joint Effects of Life’s Essential 8 and Genetics on Mild Cognitive Impairment and Dementia Risk in People With Diabetes: Findings From the UK Biobank and All of Us

Xiu Wu, Yuanhao Zu, You Lu, Yue Zhao, David Crosslin, Vivian Fonseca, Demetrius Maraganore, Yilin Yoshida

OBJECTIVE We examined how cardiovascular health (CVH), measured by Life’s Essential 8 (LE8), and genetic risk are jointly associated with risks of mild cognitive impairment (MCI), dementia, and related cognitive outcomes in people with diabetes. RESEARCH DESIGN AND METHODS We analyzed 41,374 participants without dementia from the UK Biobank (UKB) and 9,766 from All of Us (AoU). LE8, comprising diet, physical activity, nicotine exposure, sleep, body mass index, lipids, blood glucose, and blood pressure, was scored f …

27.08.2026journal-article

Diabetology

Reply to Klonoff et al. Limitations of a Recent Study on Insulin Pen Needle Preferences in People with Diabetes. Comment on “Gentile et al. Enhancing Insulin Therapy Adherence Through Technology: Which Needles Do People with Diabetes Prefer? Diabetology 2026, 7, 56”

Sandro Gentile, Raffaella Fiorentino, Maddalena Lettieri, Giuseppina Guarino, Giampiero Marino, Elisabetta Tommasi, Vera Frison, Ersilia Satta, Maria Chiarello, Giuseppe Caccavale, Emilia Masuccio, Felice Strollo

This response letter addresses criticisms from a recent commentary regarding a real-world survey on insulin pen needle preferences. The authors clarify that their study was purposefully designed as an observational survey to capture genuine patient perceptions under routine clinical conditions, rather than functioning as a randomized controlled trial. Consequently, methodological constraints such as blinding were fundamentally inapplicable. Furthermore, the authors emphasize the limited relevance of the Hawthorne e …

27.08.2026journal-article

The Egyptian Journal of Internal Medicine

Molecular interaction mechanisms of muscle fiber type transition in aging sarcopenia and the role of exercise intervention

ShaoHui Zhang, Jialin Zhang, Tao Fu, Linliang Zhao, Kexin Li, Sifan Yan

Abstract Muscle fiber type transition is a core pathophysiological process in aging sarcopenia; however, existing research has often analyzed its underlying mechanisms in isolation. This review systematically characterizes the features of muscle fiber type transition in sarcopenia at the neural, cellular, and microenvironmental levels, and dissects the multidimensional molecular interaction mechanisms, including disrupted neural input, aberrant intracellular protein metabolism, and inflammaging. Based on this mecha …

27.08.2026journal-article

Scientific Reports

Clinical evaluation of a sit-to-stand dual-posture mobility device for people with spinal cord injuries

Yukiyo Shimizu, Hideki Kadone, Yosuke Eguchi, Kai Sasaki, Shunsuke Kido, Diego Paez-Granados, Modar Hassan, Yang Chen, Shigeki Kubota, Masashi Yamazaki, Yasushi Hada, Kenji Suzuki

Abstract Wheelchair users face health risks from prolonged sitting and social barriers owing to the vertical gap between their seated position and standing able-bodied individuals. We present Qolo, a novel standing mobility device equipped with passive exoskeletons for intuitive sit-to-stand transitions. Three prototypes were iteratively evaluated with 13 unique participants with spinal cord injury (SCI) from cervical to lumbar levels (C5-L3): Qolo-1 (n = 4), Qolo-2 (n = 12), and Qolo-3 (n = 5), with 3 participants …

27.08.2026journal-article

INTER DISCIPLINA

Prácticas alimentarias de personas adultas mayores durante la pandemia por COVID-19 y creencias asociadas

Vianney Daianee Fernández Iglesias, Rosario Román Pérez, Heliodoro Alemán Mateo, Sandra Elvia Domínguez Ibáñez, Víctor Alexander Quintana López

COVID-19 lockdown measures restricted mobility, particularly among older adults, limiting their access to food and modifying their dietary practices. These practices are closely linked to health beliefs, which have been widely studied through the Health Belief Model (HBM). However, the HBM does not fully incorporate the sociocultural context or the motivations that influence adherence to preventive measures. The aim of this study was to analyze how older adults associated the possibility of contracting COVID-19 wit …

27.08.2026journal-article

Cancer

Cancer statistics for Asian American, Native Hawaiian, and Pacific Islander people, 2026

Nikita Sandeep Wagle, Angela N. Giaquinto, Mandi Yu, Hyuna Sung, Tyler B. Kratzer, Kekoa Taparra, Jessica Star, Ahmedin Jemal, Rebecca L. Siegel

ABSTRACT Background Cancer statistics for Asian American and Native Hawaiian and Pacific Islander (NHPI) people are usually aggregated, masking substantial variation within this heterogeneous population. Herein, the American Cancer Society reports cancer incidence and survival for 8 Asian American and 3 NHPI ethnic groups. Methods The authors used population‐based cancer registry data from the National Cancer Institute’s Surveillance, Epidemiology, and End Results program, for Asian American and NHPI ethnic groups …

27.08.2026journal-article

Frontiers in Nutrition

Joint trajectories of adiposity and systemic inflammation and incident diabetes among older adults: a bi-cohort prospective study with mediation analysis

Fubin Teng, Shichao Li, Di Liu

Background Obesity and chronic low-grade inflammation are established risk factors for type 2 diabetes, yet their joint longitudinal evolution and combined contribution to diabetes incidence remain poorly characterized in aging populations. Objective To identify joint trajectories of adiposity and systemic inflammation, evaluate their associations with incident diabetes, and quantify the mediating role of glycated hemoglobin (HbA1c) across two independent cohorts. Methods This prospective study included 3,733 diabe …

27.08.2026journal-article

JMIR Aging

Developing Digital Platforms to Help Older Adults Stay Physically and Socially Active: Co-Design Study to Develop a Toolkit and Evaluate Its Impact

Leonie Cooper, Hannah Bradwell, Colin B Shore, Simone A Tomaz, Rory Baxter, Gemma C Ryde, Swen E Gaudl, Richard Haynes, Catherine Hennessy, Ray B Jones, Anna C Whittaker, The GOALD Project

Abstract Background Digital technologies have the potential to support physical, cognitive, and social activity among older adults, but many small- and medium-sized enterprises (SMEs) lack the resources to conduct meaningful co-design with older adults. Toolkits derived from rigorous co-design processes may offer a scalable mechanism for translating end-user priorities into real-world product development. Objective The Generating Older Active Lives Digitally study aimed primarily to engage older adults in a co-desi …

27.08.2026journal-article

BMC Public Health

Engaging tuberculosis-affected people in investment decisions: applying a people-centered design approach in Viet Nam

Rachel Forse, Phuong-Tra Vu, Trang Nghiem, Luan Nguyen Quang Vo, Andrew James Codlin, Ngoc B. Pham, Ngan Huynh, Thanh Thi Nguyen, Luu Quang Vinh, Nguyen Thi Kim Ngan, Nguyen Thi Thuy, Pham Viet Phuong Khanh, Nguyen Duc Bang, Andrew Cross, Michael Wilson, Karolin Lüneburg, Montana Cherney, Tobias Silberzahn, Luong Van Dinh, Hoa Binh Nguyen, Lan Huu Nguyen, Ha Dang Thi Minh, Khai T. M. Nguyen, Tiep T. Hua, Jacqueline Huh, Kristi Sidney Annerstedt

Abstract Background Tuberculosis (TB) remains the leading cause of death from an infectious disease globally, yet financing for the TB response continues to fall far short of identified needs. Decisions about how resources are allocated are often made with limited engagement of people directly affected by TB, potentially overlooking lived experiences and community-defined priorities. This study was implemented in Viet Nam to align future TB investments with community-defined priorities and programmatic feasibility. …

27.08.2026journal-article

Frontiers in Dementia

Polygenic score for sleep duration in relation to the risk of Alzheimer’s disease: results from the UK biobank

Angel T. Y. Wong, Sarah Floud, Gillian K. Reeves, Michael V. Holmes, Ruth C. Travis, Cornelia M. van Duijn, Aiden Doherty, Karl Smith-Byrne

Studies have suggested that sleep duration may be associated with Alzheimer’s disease risk; however, findings based on self-reported sleep duration are likely to be influenced by reverse causation and residual confounding bias. We derived weights for genetic variants associated with wearable-derived sleep duration using the LDpred2-auto method in 77,770 white British participants from the UK Biobank, following the generation of new genome-wide association summary statistics. We then used these weights to generate p …