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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Medicine

Safety profiles of cyclosporine and tacrolimus in pregnancy: a pharmacovigilance analysis using the FDA Adverse Event Reporting System

Yanhong Deng, Senling Feng, Shengying Shi, Zhongwen Yuan, Zhengrong Mei, Jinjin Yin, Dongdong Jing, Shaozhi Liu

Background The increasing use of calcineurin inhibitors (CNIs) among pregnant women highlights the importance of continuous safety surveillance. This study aimed to characterize the real-world safety signals of cyclosporine (CsA) and tacrolimus (TAC) during pregnancy using data from the FDA Adverse Event Reporting System (FAERS) database. Methods We applied four disproportionality data-mining algorithms (reporting odds ratio, proportional reporting ratio, Bayesian confidence propagation neural network, and empirica …

03.09.2026journal-article

Clinical Research in Cardiology

Routine versus selective use of a femoral protection wire in transfemoral TAVI: a single-centre analysis of vascular complications

Marc Adrian Rogmann, Victor Klingemann, Max Meertens, Majid Ahoopai, Karl-Philipp Rommel, Philipp Lurz, Ralph S. von Bardeleben, Martin Geyer

Abstract Background Transfemoral transcatheter aortic valve implantation (TAVI) is the treatment of choice for severe aortic stenosis in patients with elevated surgical risk. However, vascular complications remain a major source of morbidity and mortality. The protection wire technique was introduced to prevent major access-related complications, but its role in contemporary TAVI practice is uncertain. Aims To evaluate whether routine protection wire use reduces vascular complications in contemporary transfemoral T …

03.09.2026journal-article

BMC Public Health

Socio-economic factors associated with online health information seeking in the European Union: a panel data analysis (2016–2024)

Hasan Fehmi Demirci

Abstract Objective This study aims to investigate socio-economic factors associated with online health information seeking in the digital health environment across 27 European Union countries between 2016 and 2024. Method The analysis used a balanced panel dataset comprising 27 European Union countries for the period 2016 through 2024. The independent variables used include tertiary education attainment, income inequality (Gini coefficient), GDP per capita, internet access, age dependency ratio, and government and …

03.09.2026journal-article

The Economic and Labour Relations Review

When work hurts: The health consequences of job stress and part-time work among a longitudinal sample of older European workers

Sabela Siaba, Berta Rivera, Luis Currais

Abstract In the context of population ageing and extended working lives, understanding how employment quality affects older workers’ health is of growing policy relevance. Although previous research has linked working conditions to health, significant gaps remain in panel designs, unobserved heterogeneity, measurement validity, and sample representativeness. Using longitudinal microdata from the Survey of Health, Ageing, and Retirement in Europe (SHARE), we estimate individual fixed-effects models over a 12-year pe …

03.09.2026journal-article

Italian Journal of Pediatrics

The Digital Pact of Imola: development and implementation of a community-based public health initiative to promote healthy digital habits in childhood and adolescence

Irene Bonomelli, Laura Serra, Elisabetta Zucchini, Alessandra Ronchi, Laura Cavallazzi, Valentina Totti, Paolo Bottau

Abstract Background Digital media exposure in childhood and adolescence is an increasing public-health concern. Pediatric recommendations emphasize not only the duration of screen exposure, but also content, context, timing, parental co-use, developmental stage, and the activities displaced by screen use. Community-based approaches may help families receive coherent and developmentally appropriate guidance across healthcare, educational, family, and social settings. Methods This manuscript describes the development …

03.09.2026journal-article

Academia Biology

Honey as a functional food: composition, bioactive compounds, health benefits and applications

Houssam Lakhmili, Zineb Lakouam, Khawla Benbnidak, Karima Warda, Abdelilah El Abbassi

Honey is a natural bee-derived product that has been valued for centuries as both a food and a traditional remedy. While its composition is dominated by carbohydrates, accumulating evidence suggests that many of its health-promoting properties may be substantially influenced by its minor non-glucidic constituents, including phenolic acids, flavonoids, amino acids, proteins, organic acids, enzymes, vitamins, and minerals. This review provides a comprehensive overview of the physicochemical composition of honey and c …

03.09.2026journal-article

Frontiers in Public Health

Explainable ensemble transfer learning for skin lesion classification with multi-method explainability validation

Nemili Sravani, Srinivas Koppu

Introduction Skin cancer is among the most prevalent and life-threatening malignancies worldwide. Early and accurate detection significantly improves therapeutic outcomes. Automated classification of dermoscopic skin lesions remains challenging due to class imbalance, inter-class visual similarity, and lack of interpretable predictions. This study proposes an accurate and interpretable weighted soft voting ensemble for multi-class skin lesion classification. Methods A weighted soft voting ensemble of three heteroge …

03.09.2026journal-article

Frontiers in Immunology

Clinical remission trajectories and histopathological associations in patients with IgA nephropathy treated with targeted-release budesonide: a real-world cohort study

Dafeng He, Jun Xu, Bo Gao, Mingzhu Jiang, Wenjin Liu, Chuanyan Zhao, Xinrui Li, Chunlei Lu, Mengyue Zhu, Hongbin Mou, Guangyu Bi

Background Targeted-release (TR) budesonide provides upstream mucosal immunomodulation in IgA nephropathy (IgAN) by targeting the gut-associated lymphoid tissue. However, the extent to which distinct downstream immune-inflammatory phenotypes and established structural chronicity shape real-world remission trajectories remains insufficiently characterized. Methods We retrospectively analyzed 57 adults with biopsy-proven primary IgAN treated with TR-budesonide. Prespecified milestones were Very Early Response (VER) a …

03.09.2026journal-article

Journal of Advances in Medicine and Medical Research

Age-related BAX and Ki-67 Expression in Regional Lymph Nodes of Infants who Died from Measles: A Retrospective Immunohistochemical Study

Doniyor Saidovich Turdimatov

Background: Measles can produce substantial lymphoid tissue injury and immunosuppression, but age-related patterns of apoptotic and proliferative activity in regional lymph nodes during fatal measles in infancy remain insufficiently characterised. Aims: To evaluate age-related changes in BAX and Ki-67 immunohistochemical expression in regional lymph nodes of infants who died from measles. Study Design: A retrospective morphological and immunohistochemical study of archived autopsy specimens. Methodology: Regional l …

03.09.2026journal-article

Agriculture and Human Values

The diverse human/bird relationships in backyard bird keeping: implications for health and welfare

Niamh Mahon, Orla Shortall, Carol Kyle

Abstract In 2024 registration of all captive bird flocks became mandatory in Great Britain to improve disease surveillance at a time of increasing avian influenza outbreaks. However, little is known about how health and welfare practices are shaped by the diversity of relationships that characterise UK backyard birdkeeping. We use this moment of change to (1) examine the relationships between backyard keepers, their birds, and the poultry industry, and, (2) explore how registration legislation is responded to by ba …

03.09.2026journal-article

INTERNATIONAL JOURNAL OF HEALTH AND PHARMACEUTICAL RESEARCH

Body Image Perception, Lifestyle Behaviours and Awareness of Obesity Among Adults

Adesimisola Hephzibah Alowolodu

In the world at large, it is estimated that in 2022, 890 million adults live with obesity, which is 16% of the adult population. Moreover, 43% of the world’s adults are either overweight or obese. Obesity prevalence in Nigeria is about 15% among the adult population. Obesity is also more prevalent among women, urban dwellers, and people living in the south compared to the north. Obesity is caused by various factors, including lifestyle factors, biological factors, sociocultural factors, and environmental factors. L …

03.09.2026journal-article

INTERNATIONAL JOURNAL OF HEALTH AND PHARMACEUTICAL RESEARCH

Personality Traits, Social Support and Perinatal Depression Among Women Attending Tertiary Health Institutions in Makurdi, Nigeria

Agada Onmonya Abo

Perinatal depression is a significant public health concern affecting women during pregnancy and the postpartum period. This study examined personality traits, social support, and perinatal depression among women attending tertiary health institutions in Makurdi Local Government Area, Benue State, Nigeria. A cross-sectional survey design was adopted involving 396 perinatal women, 254 prenatal and 142 postpartum attending antenatal clinics and immunization units in selected health institutions (Federal Medical Cente …

03.09.2026journal-article

Journal of Clinical Medicine

Preoperative Alanine Aminotransferase and Postoperative ALT Elevation: A Retrospective Cohort Study

Jisun Choi, Hyun Young Lim, Jeayoun Kim, Seungwon Lee, MiHye Park

Background: Modestly elevated serum alanine aminotransferase (ALT) levels are associated with increased morbidity and mortality in the general population; however, the perioperative significance of mildly elevated preoperative ALT levels in surgical patients remains unclear. Methods: This retrospective cohort study included adults undergoing non-hepatic, non-cardiac surgery at Samsung Medical Center. Patients with preoperative ALT measured within 3 months and 5 times the institutional ULN within 21 days after surge …

03.09.2026journal-article

International Journal of Health Management Review

THERAPEUTIC EXERCISE-INDUCED NEUROPLASTICITY IN MOTOR RECOVERY AFTER STROKE

Ayara Almeida Souza Cabral, Roberta Dich Siqueira, Liz Oliveira dos Santos, Karla Priscila de Souza Lobato, Raynara Donata dos Santos, Nataline de Oliveira Rocha, Josivane Quaresma Trindade, Maria do Socorro de Souza Gomes Pinheiro, Joana Darc Santos dos Santos, Iolene Melo da Silva, Diego Rodrigues da Silva

Stroke is a major cause of disability and is frequently associated with motor impairments that limit mobility, functional independence, and the performance of activities of daily living. In this context, neuroplasticity represents an essential mechanism for recovery, enabling structural and functional adaptations of the nervous system in response to injury and therapeutic stimuli. This study aimed to analyze the influence of therapeutic exercise on the neuroplasticity mechanisms involved in motor recovery in indivi …

03.09.2026journal-article

Journal of Hospital Medicine

2026 AHA/ACC guideline for the evaluation and management of acute pulmonary embolism in adults

Nilesh Patel

Guideline Title: 2026 AHA/ACC/ACCP/ACEP/CHEST/SCAI/SHM/SIR/SVM/SVN Guideline for the Evaluation and Management of Acute Pulmonary Embolism in Adults. Release Date: February 19, 2026. Prior Version(s): None; de novo guideline. Developer: American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines, in collaboration with multiple partner societies including the Society of Hospital Medicine. Target Population: Adults aged 18 years or older with acute pulmonary embolism.

03.09.2026journal-article

Borneo Nursing Journal (BNJ)

Pengaruh Inovasi Media Edukasi Berbasis Mobile Learning Terhadap Kesiapsiagaan Bencana Gempa Bumi Pada Tenaga Pengajar Di TK ABA Kecamatan Piyungan

Dinna Azzahra, Endah Tri Wulandari, Heri Puspito

Latar Belakang: Kecamatan Piyungan merupakan wilayah rawan gempa bumi di Kabupaten Bantul, Daerah Istimewa Yogyakarta. Fenomena rendahnya kesiapsiagaan guru TK terhadap bencana telah dibuktikan oleh beberapa penelitian, di antaranya Solfiah et al. (2019) yang menemukan bahwa tingkat kesiapsiagaan guru TK hanya mencapai 30,26% dengan kategori kurang. Hal ini diperkuat oleh Lee et al. (2023) yang melaporkan skor kesiapsiagaan guru PAUD berada pada kategori sedang dengan rata-rata 61,0 dari 100, serta Kawasaki et al. …

03.09.2026journal-article

Pituitary

Importance of clinical profiling to determine excess mortality in prolactinomas: insights from a large, registry-based cohort

Tarik Ziyad Tarik Shwaish, Davide Gori, Claudio Sartori, Federica Guaraldi

Abstract Purpose Population-based studies overall report no excess mortality among patients with prolactinoma compared with the general population. However, since prolactinomas are clinically heterogeneous, mortality may not be uniform across data-driven patient profiles. Methods We analyzed 3,378 adult prolactinoma cases (26,118 person-years) from the Surveillance, Epidemiology, and End Results database (2004–2022). Standardized mortality ratios (SMRs) were calculated using US life tables matched by age, sex, cale …

03.09.2026journal-article

Bulletin of Pirogov National Medical & Surgical Center

AORTIC DISSECTION FOLLOWING CARDIAC SURGERY: ANALYSIS OF TWO CLINICAL CASES

M. A. Soborov, I. M. Parfenov, A. S. Serdiukov, S. S. Ismailov, E. A. Chernikova, V. A. Mironenko

Background . Aortic dissection following cardiac surgery represents a significant clinical challenge, necessitating individualized indications for ascending aorta replacement. Traditional diameter thresholds (≥5.5 cm) are insufficient for predicting dissection risk. Objective . To demonstrate the importance of comprehensive risk assessment for aortic dissection in post-cardiac surgery patients through analysis of two clinical cases. Material and Methods. Two cases of type A aortic dissection developing in the late …

03.09.2026journal-article

Neurocritical Care

Time-Stamped Annotations in High-Frequency Physiological Data: Evaluating an Approach for Assessing Annotation Plausibility in the CENTER-TBI Dataset

Sara Turella, Erta Beqiri, Stefan Yu Bögli, Bogdan Ianosi, Ihsane Olakorede, Tommaso Zoerle, Jeanette Tas, Raimund Helbok, Peter Smielewski, the Smart Neuromonitoring to Support Precision Medicine in Acute Central Nervous Injury (SOPRANI) collaborators and the CENTER-TBI High-Resolution Sub-Study Participants and Investigators, Audny Anke, Ronny Beer, Bo-Michael Bellander, David Nelson, Andras Buki, Giorgio Chevallard, Arturo Chieregato, Giuseppe Citerio, Endre Czeiter, Bart Depreitere, George Eapen, Shirin Frisvold, Stefan Jankowski, Daniel Kondziella, Lars-Owe Koskinen, Geert Meyfroidt, Kirsten Moeller, Anna Piippo-Karjalainen, Rahul Raj, Andreea Radoi, Juan Sahuquillo, Arminas Ragauskas, Saulius Rocka, Jonathan Rhodes, Rolf Rossaint, Ana Stevanovic, Oliver Sakowitz, Nina Sundström, Riikka Takala, Tomas Tamosuitis

Abstract Background/Objective High-resolution neuromonitoring data with time-stamped clinical annotations offer valuable insights into treatment responses, though reliability is limited by manual documentation. This study aims to develop and demonstrate a three-step methodological framework to evaluate the plausibility of time-stamped clinical annotations using a high-frequency dataset. The framework integrates visual inspection of reference annotations and automated classification based on predefined physiological …

03.09.2026journal-article

Eastern Mediterranean Health Journal

Assessing the predictors of treatment-seeking and health care access barriers among transgender individuals in Pakistan

Athar Memon, Sameena Ourangzaib, Benjamin R. Bates, Shiraz Shaikh

Background: Transgender individuals in Pakistan face barriers to health care access, increasing the risk of serious disease transmission. Aim: To identify the predictors of treatment-seeking intention and health care access delays among transgender individuals in Karachi, Pakistan. Methods: Between December 2024 and April 2025 we interviewed 360 individuals, aged ≥18 years, who identified as transgender and had accessed health care within the past 12 months. We analysed the data using SPSS version 20 and conducted …

03.09.2026journal-article

European Journal of Endocrinology

Adverse health outcomes across the life course in individuals with six rare bone diseases: a 10-year population-based cohort study

Pascal Gaechter, Christian Meier, Emanuel Christ, Fahim Ebrahimi, Alexander Kutz, Gabor Szinnai

Abstract Background Rare bone diseases comprise a heterogeneous group of complex and disabling conditions. Evidence on age-specific hospitalization patterns and in-hospital outcomes across multiple rare bone diseases is limited. Methods Population-based cohort study using national hospitalization data (01/2012–12/2021). Among 11,092,151 hospitalizations, 2,875 admissions of children and adults with rare bone diseases were identified via ICD-10 codes (X-linked hypophosphatemia, osteogenesis imperfecta, fibrous dyspl …

03.09.2026journal-article

British Journal of Nursing

Changing a Future Nurse undergraduate nursing programme to include more mental health content: initial evaluation

Laurence Baldwin, Judith McLeod, Rachel Bage, Frances Nicol, Maya Dixon, Lyndsay Khan, Helen Alcock-Towse, Donna-Marie Gordon, Catherine Shiels

The 2018 Nursing and Midwifery Council's ‘Future Nurse’ standards introduced increased genericism to UK nursing education, prompting criticism from specialist fields concerned about diluted field-specific knowledge. This article reports on a curriculum innovation at one UK university that addressed local implementation challenges through targeted module development to include an increased number of field-specific modules alongside core content. Among others, two new modules were introduced, one on mental health for …

03.09.2026journal-article

Sustainability

Protecting Blue Skies and Health: Can “Key Controlled Areas for Air Pollution Prevention and Control” Contribute to the Sustainable Development of Residents’ Health?

Xi Gu, Sijia Qiao, Xinran Yuan

This paper examines whether the establishment of “Key Controlled Areas for Air Pollution Prevention and Control” and its associated policy package in China improved residents’ health. Based on data from the China Health and Retirement Longitudinal Study (CHARLS) 2011–2018, Our study finds that this command-and-control environmental regulation is associated with notable declines in residents’ morbidity from asthma, lung disease, and heart disease, while also producing preventive effects. Potential channel analysis i …

03.09.2026journal-article

World Journal of Traditional Chinese Medicine

Simultaneous Harvesting of PINK1, Parkin, and FUNDC1 Ligands from Herbal Medicines Using “Net Fishing” Strategy

Zhong-Yu Fu, Min Zhang, Fan Zhang, Cheng-Zhu Song, Yang-Yang Fu, Tao Wang, Xu-Dong He, Mei Zhang, Jie Yu, Xing-Xin Yang

Abstract Objective: Targeting mitophagy represents a promising therapeutic strategy for human diseases. This study aimed to develop an efficient approach to simultaneously identify natural ligands for PTEN-induced kinase 1 (PINK1), Parkin, and FUN14 domain containing 1 (FUNDC1) – core regulators of mitophagy – from complex herbal medicine (HM) extracts. Materials and Methods: We established a novel capture strategy where PINK1, Parkin, and FUNDC1 proteins were individually and physically adsorbed on the surface of …