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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH

Leptomeningeal Carcinomatosis with Brain and Spinal Metastasis from Triple-negative Breast Cancer: A Case Report

Prateek Chauhan, Amogh Biradar, Rahul Dev

Leptomeningeal Carcinomatosis (LMC) is an uncommon but devastating complication of metastatic breast cancer, particularly associated with Triple-Negative Breast Cancer (TNBC). The authors report a 46-year-old female with previously treated TNBC and a parenchymal brain metastasis who presented with subacute, progressive bilateral lower-limb weakness and gait impairment. Contrast-Enhanced Magnetic Resonance Imaging (CE-MRI) of the brain and spine demonstrated diffuse leptomeningeal enhancement over the cerebellar hem …

01.09.2026journal-article

Frontiers in Oncology

Beyond STMN1: stathmin-family control of microtubule dynamics and paclitaxel resistance in cancer

Haoyu Li, Lizhou Shi, Qinghua Wang, Wei Han

Paclitaxel is a cornerstone microtubule-stabilizing agent, but intrinsic and acquired resistance limit durable benefit. Resistance emerges from interacting changes in drug transport, tubulin composition, microtubule regulation, mitotic fate, apoptosis, autophagy, cellular plasticity and the tumor microenvironment. The stathmin family—STMN1, STMN2, STMN3 and STMN4—controls microtubule assembly through tubulin sequestration and catastrophe-promoting activity and therefore occupies a direct functional interface with p …

01.09.2026journal-article

Blood Cancer Discovery

Spatial profiling identifies a distinct and topographically-defined tumor microenvironment that emerges during multiple myeloma evolution

Marnix Koops, Luca Bertamini, Natalie Papazian, Charlotte Korst, Mátyás János. Budai, Remco M. Hoogenboezem, Mathijs A. Sanders, Bronno van der Holt, Mark van Duin, Annemiek Broijl, Péter Balogh, Sonja Zweegman, Marc HGP. Raaijmakers, Niels W.C.J. van de Donk, Zoltán Kellermayer, Pieter Sonneveld, Tom Cupedo

Abstract The pathobiology of multiple myeloma is influenced by cells of the bone marrow, but whether tumor support is organized in a spatially-defined tumor microenvironment (TME) remains unclear. Using spatial transcriptomics and imaging mass cytometry, we show that myeloma cells initially exist as scattered cells throughout the marrow, yet with disease evolution condense into a spatially-defined TME. Dense tumor nodules contain a cellular ecosystem distinct from the surrounding marrow, enriched for macrophages, c …

01.09.2026journal-article

BMJ Open

Lock solutions for the prevention and treatment of catheter-related bloodstream infections in newborns: a systematic review and meta-analysis protocol

Giulia Maiocco, Sonia Deantoni, Elena Maggiora, Alessandra Coscia, Francesco Cresi

Introduction Bloodstream infections remain a major cause of morbidity and mortality for infants admitted to neonatal intensive care units (NICUs), with central venous catheter use representing one of the principal risk factors. Among the strategies developed to prevent and manage catheter-related bloodstream infections (CRBSIs) and central line-associated bloodstream infections (CLABSIs), catheter-lock therapy (CLT) has emerged as a particularly promising approach. CLT is defined as the instillation of antimicrobia …

01.09.2026journal-article

Journal of Medical Imaging and Radiation Oncology

Stereotactic Ablative Body Radiation Therapy for Spinal Oligometastases: Experience at a Single New Zealand Institution

Kathryn Tucker, Komeela Naidoo, Nur Azri Bin Mohd Yasin, John Chin, Charles De Groot, Roger Huang

ABSTRACT Purpose Spinal metastases are a common complication of advanced malignancy and can result in significant pain, neurological dysfunction, and reduced quality of life. In patients with oligometastatic disease, stereotactic ablative body radiation therapy (SABR) offers the potential for durable local control. This study reports outcomes following spinal SABR at Waikato Hospital and compares these with published literature. Methods A retrospective single‐centre cohort study was conducted of patients with oligo …

01.09.2026journal-article

Journal of Clinical Oncology

Dexamethasone-Free Antiemetic Prophylaxis for Children and Adolescents Receiving Highly Emetogenic Chemotherapy: A Multicenter, Phase III, Noninferiority Trial (CIVIC POD)

Venkatraman Radhakrishnan, Prasanth Srinivasan, Gargi Das, Sameer Bakhshi, Amita Mahajan, Prasanth Ganesan, Balaji Thiruvengadam Kothandan, Ramandeep Singh Arora, Swathi Parmpalli Manjunath, Shuvadeep Ganguly, Deepam Pushpam, Minakshi Bansal, Swaminathan Keerthivasagam, Aparajita Sharma, Aastha Goel, Mubina Begum, Aleeza Khan, Swaminathan Rajaraman

PURPOSE Dexamethasone combined with a 5-hydroxytryptamine-3 receptor antagonist and a neurokinin-1 receptor antagonist is the guideline-recommended prophylaxis for chemotherapy-induced nausea and vomiting (CINV) in children receiving highly emetogenic chemotherapy (HEC), but it is associated with clinically relevant toxicities. The role of olanzapine as a dexamethasone-sparing agent for pediatric CINV prophylaxis remains uncertain. METHODS The Chemotherapy Induced Vomiting in Children-Prophylaxis Omitting Dexametha …

1 Zitationen
01.09.2026journal-article

Journal of Korean Medicine

Changes in Facial Asymmetry following Chuna Manual Therapy-Centered Korean Medicine Treatment: A Retrospective Case Series of Four Patients

Eunho Jeong, Hoyeong Seong, Hyun-Jong Jung

Objectives: This study aimed to describe the treatment course and observed changes in patients with facial asymmetry who received Chuna Manual Therapy (CMT)-centered Korean Medicine (KM) treatment.Methods: This retrospective case series analyzed clinical records of four patients treated between January 2024 and April 2026. Eligible patients had no history of acute facial trauma or surgery, received no concurrent treatment for facial asymmetry, completed treatment, had complete pre- and post-treatment data, and prov …

01.09.2026journal-article

Journal of Neurosurgery

Understanding the role of neuroendoscopy for treatment of hydrocephalus in adults with intracranial mass lesions: a case series

Ryan M. Hess, D. Ryan Ormond

OBJECTIVE Hydrocephalus can result from mass lesions for several reasons. Due to limited numbers of adult patients with mass lesions in studies that examine outcomes of endoscopic third ventriculostomy, success in this population is unclear. Additionally, the role of other ventriculoscopic procedures in the management of associated hydrocephalus is unclear. In this retrospective case series, the authors investigated optimal management strategies for patients with mass lesions and hydrocephalus. METHODS A list of pa …

01.09.2026journal-article

Current Nanomedicine

Non-Ionic Surfactants (NIOs) in Niosome Drug Delivery: In-Depth Review of Clinical Trials, Patents in Tuberculosis (TB) and Oncology

Manju Koli, Tapaskumar Mukeshkumar Shah, Prottay Dutta, Neetu Patel, Abhay Kumar Patel, Binita Ghosh, Akashdeep Singh, Rahul Pal

Niosomes (NIOs), as non-ionic surfactant based vesicles, have emerged as versatile nanocarriers in the targeted delivery of drugs due to their biocompatibility, chemical stability, and ability to encapsulate both hydrophilic and lipophilic drugs. Their utility has gained significant traction in addressing challenges associated with conventional therapies, for chronic and resistant diseases, Tuberculosis (TB), and cancer. This review critically evaluates the role of non-ionic surfactant in the formulation of NIOs, e …

2 Zitationen
01.09.2026journal-article

Frontiers in Oncology

Preoperative serum HE4 combined with CA125 testing for predicting the risk of suboptimal cytoreduction in advanced epithelial ovarian cancer

Chun Zhou, Yanli Wu, Juan Wang, Fu Zheng

Objective To investigate the predictive value of preoperative serum markers centered on human epididymis protein 4 (HE4) combined with carbohydrate antigen 125 (CA125) for the risk of suboptimal cytoreduction in advanced epithelial ovarian cancer. Methods We retrospectively analyzed the clinical data of 102 patients with International Federation of Gynecology and Obstetrics (FIGO) stage IIIA–IV epithelial ovarian cancer who underwent primary cytoreductive surgery at the First People’s Hospital of Jiangxia District …

01.09.2026journal-article

Medical Forum Monthly

Treatment of Delirium in Septic Shock Patients: A Focused Evidence Review

Muhammad Asim Rana, Moayad Nasser Alkhlewi, Kaouthar Sifaoui, Meshal Alharbi, Hector Emanuel Arias, Andres Saravia-Moya

Objective: To review pharmacological and non-pharmacological strategies for established delirium in adults with septic shock. Place and Duration of Study: This review was conducted Intensive Care Medicine, Department of Adult Intensive Care Medicine, King Abdullah Specialized Hospital, Ministry of National Guards Health Affairs, Qassim, KSA.from January to March 2026. Methods: PubMed/MEDLINE was searched for studies published between 2021 and 2026 on septic shock, delirium, sepsis-associated encephalopathy, dexmede …

03.09.2026journal-article

Journal of Clinical Neuromuscular Disease

Clinical Feature and Treatment Outcomes of Necrotizing Autoimmune Myopathy in a Referral Neurological Center in Thailand

Sirilux Angsuwattanakul, Thanes Termglinjan, Arada Rojana-udomsart

Background: Necrotizing autoimmune myopathy (NAM) is classified into 3 subtypes according to antibodies. Data from Southeast Asian populations remain limited. Objective: To describe and compare clinical characteristics and treatment responses among the NAM subtypes. Methods: Retrospective cohort included three subtypes of 29 patients with NAM. Demographics, clinical data, treatment approach, and responses were assessed and compared. Results: There were 20 (68.97%) anti–signal recognition particle (SRP), 8 anti–hydr …

01.09.2026journal-article

Serican Journal of Medicine

Dual DNMT–EZH2 Inhibition as a Stroma-Directed Strategy in Castration-Resistant Prostate Cancer: A Commentary

Rongxin Chang, Guodong Liu

Background: Castration-resistant prostate cancer (CRPC) remains a lethal progression state despite androgen-deprivation therapy, driven by epigenetic plasticity and a fibrotic tumour microenvironment. Single-agent epigenetic inhibitors have limited activity in solid tumours, partly because compensatory H3K27me3-mediated silencing may preserve gene repression after DNMT inhibition. Objective: To comment on a recent PNAS study and evaluate the mechanistic and translational rationale for dual DNMT–EZH2 inhibition as a …

01.09.2026journal-article

Journal of Extracellular Vesicles

Small Extracellular Vesicle and Total Lipid Profiles Provide a Diagnostic Advantage Over CA‐125 Across Ovarian Cancer Subtypes

Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Lewis Perrin, Rohan Lourie, Vaibhavi Joshi, Amy E. McCart Reed, Kaltin Ferguson, Aase Handberg, Andreas Möller, Carlos Salomon

ABSTRACT Ovarian cancer remains the most lethal gynaecological malignancy, largely due to late‐stage diagnosis and the limited sensitivity of CA‐125 for borderline and low‐grade tumours. Dysregulated lipid metabolism may provide complementary diagnostic information. This study aimed to develop lipid‐based biomarkers to improve the differential diagnosis of adnexal masses. We profiled total plasma and small extracellular vesicle (sEV) lipids in women with benign, borderline and malignant ovarian tumours, using healt …

01.09.2026journal-article

Biomedicines

Size-Transformable Nanoparticles for Tumor Drug Delivery: Distinct Roles of Shrinkage, Enlargement, and Reassembly

Kibeom Kim

Although fixed-size nanoparticles have achieved substantial therapeutic success, a single fixed size may not be optimal for the competing requirements of stability in circulation, tumor accumulation, deep tumor penetration, cellular uptake, and intra-tumoral retention. This review frames this fixed-property limitation as the need to switch structural states in response to successive biological barriers and analyzes original research articles published from 2021 to 2025 on large-to-small transformation, small-to-lar …

01.09.2026journal-article

Acta Veterinaria Scandinavica

Equine neuroborreliosis in Scandinavia: cerebrospinal fluid PCR confirmation and successful treatment in a mare

Sofia Ruiz, Marianne Øverlie, Amanda Bergren, Ingunn Risnes Hellings

Abstract Background Lyme borreliosis (LB), caused by Borrelia burgdorferi sensu lato, is an emerging concern in human medicine, and is a controversial topic in equine medicine. Neuroborreliosis (NB), a neurologic manifestation of LB, remains challenging to diagnose due to nonspecific clinical signs and the lack of definitive diagnostic methods. This report describes the first documented case of equine NB in Scandinavia. Case presentation An 11-year-old mare presented with progressive weight loss, ataxia, muscle atr …

01.09.2026journal-article

JNCI: Journal of the National Cancer Institute

Evaluating the incidence and predictors of chronic opioid use in early survivorship for patients with diffuse large B-cell lymphoma

Mithunan Ravindran, Jessie Peng, Jonathan Zipursky, Jin Luo, Ning Liu, Kelvin K W Chan, Matthew C Cheung, Lee Mozessohn

Abstract Background Opioid exposure during cancer treatment is common and leads to new persistent opioid use (NPOU) in a subset of patients. There are limited data on the incidence and predictors of NPOU among patients with diffuse large B-cell lymphoma (DLBCL). Methods We conducted a population-based cohort study including patients with DLBCL ≥18 years old from Ontario, Canada who received first-line rituximab-based chemoimmunotherapy from 2014-2021 and survived >365 days after treatment. We defined opioid exposur …

01.09.2026journal-article

Neurosurgical Focus

Diffusion MRI radiomics in meningiomas: imaging correlates of tumor grade and intraoperative consistency

Sabino Luzzi, Gianluca Lorenzo Fabozzi, Salvatore Cutillo, Tevfik Serhan Bora, Adriana Pintus, Sebastiano Cuccuru, Ivana Roskova, Abramo Agosti, Lorenzo Magrassi, Giuseppe Palmieri, Antonio Cossu, Mariano Scaglione, Salvatore Masala, Renato Galzio

OBJECTIVE Despite advancements in imaging studies, the preoperative prediction of the biological behavior and intraoperative consistency of intracranial meningiomas remains limited. This study evaluated the association of volumetric diffusion-based and texture-derived radiomic features extracted from routine MRI with histopathological aggressiveness and intraoperative tumor consistency. METHODS Ninety-seven intracranial meningiomas resected at two tertiary centers were retrospectively analyzed. Volumetric segmentat …

01.09.2026journal-article

Cell Communication and Signaling

CircERBB2 and beyond: a new regulatory layer in HER2-driven cancer

Zhumeng Gu, Hui Liu, Sixiang Zheng, Pinghan Wang, Gang Wang, Xudong Zhang, Fangyi Long, Ting Wang

Abstract Human epidermal growth factor receptor 2 ( HER2 , also known as ERBB2 ) is aberrantly expressed in multiple malignancies and serves as both a key molecular tumor classification marker and an important therapeutic target. Although monoclonal antibodies, tyrosine kinase inhibitors, and antibody–drug conjugates targeting HER2 have significantly improved patient outcomes, challenges such as treatment resistance and disease relapse remain. To address these unmet clinical needs, circular RNAs (circRNAs) have eme …

01.09.2026journal-article

European Journal of Oral Sciences

Microbial dysbiosis and tumor biomarker expression in oral leukoplakia and oral squamous cell carcinoma: A quantitative polymerase chain reaction‐based immunohistochemical study

Ajay Kumar Verma, Anjali Narwal, Mala Kamboj, Anju Devi, Shikha Tewari, Gopikrishnan Vijayakumar

Abstract Porphyromonas gingivalis is a major periodontal pathogen increasingly associated with oral leukoplakia (OL) and oral squamous cell carcinoma (OSCC) due to its role in microbial dysbiosis and carcinogenesis. This study aimed to evaluate the relative abundance of P. gingivalis in healthy controls, OL, and OSCC patients and to correlate the bacterial load with immunohistochemical (IHC) markers. A total of 48 oral swab samples were collected from three study groups: (1) healthy, (2) OL, and (3) OSCC. Quantitat …

02.09.2026journal-article

Journal for ImmunoTherapy of Cancer

Overall survival of immunotherapy versus standard of care in chemorefractory microsatellite stable metastatic colorectal cancer: a propensity score matched analysis of 708 patients

Guglielmo Vetere, Emerik Osterlund, Mahmoud M G Yousef, Songwit Payapwattanawong, Giulia Maddalena, Jumanah Alshenaifi, Kristin D Alfaro, Mark Knafl, Van K Morris, Christine M Parseghian, Kanwal P S Raghav, Robert A Wolff, Arvind Dasari, Michael J Overman, Scott Kopetz, John Paul Shen

Background Immune checkpoint inhibitors (ICIs) have limited efficacy in proficient mismatch repair/microsatellite stable (pMMR/MSS) metastatic colorectal cancer (mCRC). However, selected patients with specific metastatic patterns may derive benefit. Methods Patients with chemorefractory pMMR/MSS mCRC treated with ICI-based regimens were retrospectively identified. A comparison cohort treated with trifluridine/tipiracil±bevacizumab, regorafenib, or fruquintinib as standard of care (SOC) was generated through 1:1 pro …

02.09.2026journal-article

The Oncologist

47 Hemoglobin Drop is an Early Predictor of Erythropoietin Supplementation in VHL Syndrome Patients Under Belzutifan Treatment - First Report From The Real-Life BELIEVE-VHL Trial

Jose Claudio Casali-da-Rocha, Caroline Macedo da Silva, Sumin Koh

Abstract Background Von Hippel–Lindau syndrome (VHL) results from pathogenic germline variants in the VHL gene, predisposing individuals to retinal angiomas (RA), CNS hemangioblastomas (HB), renal cell carcinoma (RCC), pancreatic neuroendocrine tumors (PanNET), pheochromocytoma (PHEO), among others. The HIF-2A inhibitor belzutifan has shown robust activity in VHL-associated tumors. To evaluate its real-world effectiveness and toxicity profile, the BELIEVE-VHL prospective trial was approved by our institutional ethi …

02.09.2026journal-article

The Oncologist

35 Targeting HIF2-Driven Endogenous Retroviral Antigens for Immunotherapy in Kidney Cancer

Qinqin Jiang, Gurcan Gunaydin, Vijyendra Ramesh, Justin Becker, Isabelle Lippincott, Karl Clauser, Sudarsana Addepalli, Jenn Abelin, Steven Carr, Bradley Bernstein, William Freed-Pastor, William Kaelin

Abstract Background Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer and remains a major clinical challenge. Although treatment options have expanded to include VEGF pathway inhibitors, immune checkpoint inhibitors (ICIs), and more recently a HIF2 inhibitor, many patients with metastatic disease eventually relapse, and overall survival rates remain below 50%. While ccRCC is considered an immunogenic tumor, the antigenic targets driving effective immune responses remain poorly unde …

01.09.2026journal-article

Journal of Pediatric Gastroenterology and Nutrition

Dual biologic therapy in inflammatory bowel disease, a retrospective cohort study of vedolizumab and anti‐tumor necrosis factor alpha therapy in children

Jonathan E. M. O'Donnell, Carlie Bolles, Claire R. Reilly, Manal Morgan, Christopher Burgess, Fariha Balouch, Peter J. Lewindon

Abstract Objectives Despite advances in pediatric inflammatory bowel disease (PIBD) with biologics, remission rates remain at 47%–60% with loss‐of‐response rates at 60%–68%. Evidence for efficacy of dual biologic therapy (DBT) with anti‐tumor necrosis factor alpha therapy (anti‐TNF‐α)‐ vedolizumab (VDZ) for children refractory to anti‐TNF‐α therapy is limited. This study aimed to describe rates of steroid‐free clinical remission (CR), endoscopic and histological remission, trends in biochemistry, predictors of resp …