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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

Scientific Reports

Microbiome alterations in mismatch-repair deficient metastatic colorectal cancer patients

Gianmarco Piccinno, Paolo Manghi, Luca Lazzari, Chiara Pozzi, Salvatore Siena, Andrea Sartore-Bianchi, Michela Lizier, Carmen Correale, Federica Armanini, Katarina Mladenovic, Michele Palazzo, Alessandra Raimondi, Filippo Pietrantonio, Francesco Asnicar, Federica Marmorino, Chiara Cremolini, Lisa Derosa, Laurence Zitvogel, Alberto Bardelli, Silvia Marsoni, Maria Rescigno, Nicola Segata

Abstract Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide. Many efforts have been made to stratify CRC cases, from investigating the genomic characteristics of the tumor to – more recently – considering the gut microbiome. Differences in the composition of the gut microbiome occur along CRC stages and according to primary tumor location. The microbiome links with other tumor characteristics remain underinvestigated, including those related to microsatellite instability, that hav …

01.09.2026journal-article

Advanced Healthcare Materials

MYC‐Sensitized Cuproptosis Combined With PTT to Remodel the Immune Microenvironment of Prostate Cancer

Yan Gao, Ji Liu, Jiahui Hu, Chuansheng Xu, Shiyu Mao, Chen Li, Xudong Yao, Shuo Shi

ABSTRACT Prostate cancer (PCa) is the most prevalent malignancy in men, often progressing to a more refractory form castration‐resistant prostate cancer (CRPC) after primary androgen deprivation therapy. Immunotherapy has brought new hope to PCa patients, but the immunosuppressive characteristics of PCa cells limit its efficacy. Cuproptosis, which can affect tumorigenesis, therapeutic resistance, and immune modulation has received significant attention recently. However, it is limited by insufficient copper ion (Cu …

01.09.2026journal-article

Frontiers in Oncology

Leveraging machine learning algorithms to assess the impact of cervical cancer early detection on patients’ survival

Piero Mazimpaka Irakiza, Absolomon Gashaija, Semakula Muhammed, Felix K. Rubuga, Jean Damascene Hagenimana, Emmanuel Christian Nyabyenda, Belson Rugwizangoga

Background Cervical cancer morbidity and mortality remain a significant global health challenge worldwide, with an age-standardized incidence rate (ASR) of 7.3/100,000 in 2022. Low and Middle-Income Countries (LMICs), especially sub-Saharan Africa, have the highest incidence and mortality of cervical cancer, with 70% to 90% of cervical cancer cases and deaths, respectively. Despite Rwanda’s considerable efforts, cervical cancer remained the second most prevalent cancer among Rwandan women in 2023. Although numerous …

01.09.2026journal-article

Frontiers in Oncology

A LASSO-based nomogram for predicting sarcopenia-related nutritional risk in esophageal cancer patients: model development, validation, and an interactive clinical decision tool

Jiwei Zhang, Yayun Cui, Zhen Zong, Wei Zhang

Objective This study aims to construct an interpretable predictive model for esophageal cancer sarcopenia-related nutritional risk based on multidimensional clinical indicators and develop an interactive clinical decision support system. Methods The study cohort comprised 202 patients with a confirmed diagnosis of esophageal cancer who were retrospectively recruited from Taikang Xianlin Drum Tower Hospital. The study period spanned from January 2023 to December 2025. The sample was split into training and validatio …

01.09.2026journal-article

Frontiers in Medicine

Case Report: Blastic plasmacytoid dendritic cell neoplasm mimicking systemic lymphoma: a multidisciplinary diagnostic challenge

Baixue Lv, Qin Rong, Yan Li, Dongdong Zhang

Background Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive hematologic malignancy originating from plasmacytoid dendritic cell precursors. While classic cases present with prominent cutaneous nodules and lymphadenopathy, predominant generalized lymphadenopathy can obscure the diagnosis, frequently resulting in a misdiagnosis of systemic lymphoma. Case presentation A 56-year-old male presented with a one-month history of generalized pruritic erythema and multi-regional lymphadenopathy. Initial …

01.09.2026journal-article

Genes, Chromosomes and Cancer

Pleomorphic Liposarcoma: Comprehensive Genomic Analysis of 39 Cases With Comparison to Other Genomically Complex Sarcomas

Mohamed A. Yakoub, Carla Saoud, David Kim, Mark A. Dickson, Aimee M. Crago, Meera Hameed, Narasimhan P. Agaram

ABSTRACT Pleomorphic liposarcoma (PLPS) is an aggressive high‐grade sarcoma that often shows diverse morphological features and can mimic high‐grade undifferentiated pleomorphic sarcoma (UPS)/spindle cell sarcoma or myxofibrosarcoma (MFS), especially when pleomorphic lipoblasts are sparse. The molecular profile of PLPS is distinct from well differentiated/dedifferentiated liposarcoma and myxoid liposarcoma. In this study, we investigate 39 cases of PLPS by comprehensive genomic profiling, occurring in 32 patients w …

01.09.2026journal-article

International Journal of Cancer

Developing Personalized Postoperative Follow‐Up Strategies for Patients With Locally Advanced Gastric Cancer Receiving Neoadjuvant Therapy Based on Dynamic Programming: A Multicenter Retrospective Cohort Study in China

Tianhao Li, Zheng Yang, Chenyu Liu, Lei Lian, Jianxian Lin, Peng Zhang, Hua Xiao, Xinxin Wang, Zhaoqing Tang, Wei Li, Kai Tao, Weiwei Sheng, Yi Cao, Linjun Wang, Jing Sun, Zizhen Zhang, Zheng Shi, Jie Yin, Zhen Wang, Shougen Cao, Shuqiang Yuan, Xinlu Liu, Liang Shang, Yuzhou Zhao, Kaixiong Tao

ABSTRACT The optimal follow‐up strategy for patients with locally advanced gastric cancer (LAGC) receiving neoadjuvant therapy (NAT) remains unknown. Traditional follow‐up strategies based on relatively fixed intervals fail to fully account for dynamic changes in recurrence risk. This study aimed to develop a personalized postoperative follow‐up strategy using dynamic programming (DP) to optimize follow‐up arrangements based on individual patient characteristics and dynamic recurrence risks. This study included 339 …

01.09.2026journal-article

Magazine of Concrete Research

Enhancing the performance of recycled rigid pavement coarse aggregate by mechanical–chemical synergistic treatment for lower-layer airport pavement concrete

Jie Wu, Changshan Jiang, Zizhuang Yang, Li Man, Peng Zhang, Mintao Bao, Feipeng Xiao

To promote high-value reuse of decommissioned rigid pavements, a synergistic treatment for recycled rigid pavement coarse aggregate was developed and its suitability for airport pavement lower-layer concrete was evaluated. The treatment combined mechanical grinding with sodium silicate impregnation. A two-way factorial experiment was used to determine the optimum treatment parameters. Concrete containing untreated or treated recycled aggregate (RA) was then assessed for workability, mechanical performance and salt– …

03.09.2026journal-article

Journal of Investigative Medicine High Impact Case Reports

Pulmonary Adenocarcinoma Arising From Somatic-type Malignant Transformation of a Nonseminomatous Germ Cell Tumor: A Case Report

Abdel Martinez, Brandon Cantazaro, Fatimah Bello, Christine Vega, Natacha Vargas, Payal Bhakta, Renzo Arauco

Somatic-type malignant transformation (STM) is a rare but aggressive complication of nonseminomatous germ cell tumors (NSGCTs), most commonly arising from the teratomatous component and frequently occurring in metastatic sites. We report the case of a man in his 20s with a history of mixed NSGCT (50% yolk sac tumor, 40% teratoma, and 10% embryonal carcinoma) treated with left orchiectomy and chemotherapy in 2023, who initially responded to treatment but was subsequently lost to follow-up. He presented with one week …

03.09.2026journal-article

Cancer Medicine

Association of Ferritin Levels With Cytokine Release Syndrome in CAR T‐Cell Therapy: A Systematic Review and Meta‐Analysis

Ranjit Sah, Abhinav Bhattarai, Sangam Shah, Rachana Mehta, Sanjit Sah, Zeeshan Solangi, George P. Sorescu

ABSTRACT Background Ferritin elevation is frequently observed during cytokine release syndrome (CRS) following CAR T‐cell therapy; however, its independent clinical utility as a predictive or prognostic biomarker remains uncertain. We performed a systematic review critically evaluating the timing‐specific and context‐dependent role of ferritin in CRS risk stratification and outcomes. Methods We systematically searched PubMed, Web of Science, and Scopus for studies evaluating ferritin in CAR T‐cell recipients. We pe …

03.09.2026journal-article

Health Science Reports

Stigma‐Related Experiences and Their Associations With Sociodemographic and Clinical Characteristics Among Breast Cancer Survivors in a Tertiary Care Hospital, Muzaffarabad: A Cross‐Sectional Study

Nimra Gillani, Saman Waqar, Mudassir Kamal, Muhammad Iltaf, Amanullah Khan, Muhammad Hassaan Javaid, Hasibullah Aminpoor

ABSTRACT Background Breast cancer is the most commonly diagnosed cancer among women worldwide and remains a major cause of cancer‐related morbidity and mortality. Cancer‐related stigma may adversely affect social relationships, psychological well‐being, and financial security. Stigma affects the quality of life, treatment adherence, and mental health. The present study examined the associations between participant characteristics and stigma among breast cancer survivors in Muzaffarabad. Methods A total of 124 women …

01.09.2026journal-article

EXERCER

La décision partagée dans le dépistage du cancer colorectal. Points de vue des patients, médecins généralistes et pharmaciens

V BORGNE, A MOTTAIS

D’après une communication de Héloïse Garnier, Marlène Soares et Anne-Lise Vouillot (Université Paris Cité) Le cancer colorectal (CCR) est un cancer fréquent avec un pronostic grave en cas de diagnostic tardif. Un dépistage organisé (DO) national existe, mais la participation de 29,6 % en 2023 était insuffisante1. Cette étude était ancillaire de l’étude FACELE, un essai pragmatique contrôlé randomisé portant sur la supériorité d’une formation de médecins généralistes (MG) à l’approche centrée sur le patient sur la m …

01.09.2026journal-article

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH

Leptomeningeal Carcinomatosis with Brain and Spinal Metastasis from Triple-negative Breast Cancer: A Case Report

Prateek Chauhan, Amogh Biradar, Rahul Dev

Leptomeningeal Carcinomatosis (LMC) is an uncommon but devastating complication of metastatic breast cancer, particularly associated with Triple-Negative Breast Cancer (TNBC). The authors report a 46-year-old female with previously treated TNBC and a parenchymal brain metastasis who presented with subacute, progressive bilateral lower-limb weakness and gait impairment. Contrast-Enhanced Magnetic Resonance Imaging (CE-MRI) of the brain and spine demonstrated diffuse leptomeningeal enhancement over the cerebellar hem …

01.09.2026journal-article

Frontiers in Oncology

Beyond STMN1: stathmin-family control of microtubule dynamics and paclitaxel resistance in cancer

Haoyu Li, Lizhou Shi, Qinghua Wang, Wei Han

Paclitaxel is a cornerstone microtubule-stabilizing agent, but intrinsic and acquired resistance limit durable benefit. Resistance emerges from interacting changes in drug transport, tubulin composition, microtubule regulation, mitotic fate, apoptosis, autophagy, cellular plasticity and the tumor microenvironment. The stathmin family—STMN1, STMN2, STMN3 and STMN4—controls microtubule assembly through tubulin sequestration and catastrophe-promoting activity and therefore occupies a direct functional interface with p …

01.09.2026journal-article

Blood Cancer Discovery

Spatial profiling identifies a distinct and topographically-defined tumor microenvironment that emerges during multiple myeloma evolution

Marnix Koops, Luca Bertamini, Natalie Papazian, Charlotte Korst, Mátyás János. Budai, Remco M. Hoogenboezem, Mathijs A. Sanders, Bronno van der Holt, Mark van Duin, Annemiek Broijl, Péter Balogh, Sonja Zweegman, Marc HGP. Raaijmakers, Niels W.C.J. van de Donk, Zoltán Kellermayer, Pieter Sonneveld, Tom Cupedo

Abstract The pathobiology of multiple myeloma is influenced by cells of the bone marrow, but whether tumor support is organized in a spatially-defined tumor microenvironment (TME) remains unclear. Using spatial transcriptomics and imaging mass cytometry, we show that myeloma cells initially exist as scattered cells throughout the marrow, yet with disease evolution condense into a spatially-defined TME. Dense tumor nodules contain a cellular ecosystem distinct from the surrounding marrow, enriched for macrophages, c …

01.09.2026journal-article

BMJ Open

Lock solutions for the prevention and treatment of catheter-related bloodstream infections in newborns: a systematic review and meta-analysis protocol

Giulia Maiocco, Sonia Deantoni, Elena Maggiora, Alessandra Coscia, Francesco Cresi

Introduction Bloodstream infections remain a major cause of morbidity and mortality for infants admitted to neonatal intensive care units (NICUs), with central venous catheter use representing one of the principal risk factors. Among the strategies developed to prevent and manage catheter-related bloodstream infections (CRBSIs) and central line-associated bloodstream infections (CLABSIs), catheter-lock therapy (CLT) has emerged as a particularly promising approach. CLT is defined as the instillation of antimicrobia …

01.09.2026journal-article

Journal of Medical Imaging and Radiation Oncology

Stereotactic Ablative Body Radiation Therapy for Spinal Oligometastases: Experience at a Single New Zealand Institution

Kathryn Tucker, Komeela Naidoo, Nur Azri Bin Mohd Yasin, John Chin, Charles De Groot, Roger Huang

ABSTRACT Purpose Spinal metastases are a common complication of advanced malignancy and can result in significant pain, neurological dysfunction, and reduced quality of life. In patients with oligometastatic disease, stereotactic ablative body radiation therapy (SABR) offers the potential for durable local control. This study reports outcomes following spinal SABR at Waikato Hospital and compares these with published literature. Methods A retrospective single‐centre cohort study was conducted of patients with oligo …

01.09.2026journal-article

Journal of Clinical Oncology

Dexamethasone-Free Antiemetic Prophylaxis for Children and Adolescents Receiving Highly Emetogenic Chemotherapy: A Multicenter, Phase III, Noninferiority Trial (CIVIC POD)

Venkatraman Radhakrishnan, Prasanth Srinivasan, Gargi Das, Sameer Bakhshi, Amita Mahajan, Prasanth Ganesan, Balaji Thiruvengadam Kothandan, Ramandeep Singh Arora, Swathi Parmpalli Manjunath, Shuvadeep Ganguly, Deepam Pushpam, Minakshi Bansal, Swaminathan Keerthivasagam, Aparajita Sharma, Aastha Goel, Mubina Begum, Aleeza Khan, Swaminathan Rajaraman

PURPOSE Dexamethasone combined with a 5-hydroxytryptamine-3 receptor antagonist and a neurokinin-1 receptor antagonist is the guideline-recommended prophylaxis for chemotherapy-induced nausea and vomiting (CINV) in children receiving highly emetogenic chemotherapy (HEC), but it is associated with clinically relevant toxicities. The role of olanzapine as a dexamethasone-sparing agent for pediatric CINV prophylaxis remains uncertain. METHODS The Chemotherapy Induced Vomiting in Children-Prophylaxis Omitting Dexametha …

1 Zitationen
01.09.2026journal-article

Journal of Korean Medicine

Changes in Facial Asymmetry following Chuna Manual Therapy-Centered Korean Medicine Treatment: A Retrospective Case Series of Four Patients

Eunho Jeong, Hoyeong Seong, Hyun-Jong Jung

Objectives: This study aimed to describe the treatment course and observed changes in patients with facial asymmetry who received Chuna Manual Therapy (CMT)-centered Korean Medicine (KM) treatment.Methods: This retrospective case series analyzed clinical records of four patients treated between January 2024 and April 2026. Eligible patients had no history of acute facial trauma or surgery, received no concurrent treatment for facial asymmetry, completed treatment, had complete pre- and post-treatment data, and prov …

01.09.2026journal-article

Journal of Neurosurgery

Understanding the role of neuroendoscopy for treatment of hydrocephalus in adults with intracranial mass lesions: a case series

Ryan M. Hess, D. Ryan Ormond

OBJECTIVE Hydrocephalus can result from mass lesions for several reasons. Due to limited numbers of adult patients with mass lesions in studies that examine outcomes of endoscopic third ventriculostomy, success in this population is unclear. Additionally, the role of other ventriculoscopic procedures in the management of associated hydrocephalus is unclear. In this retrospective case series, the authors investigated optimal management strategies for patients with mass lesions and hydrocephalus. METHODS A list of pa …

01.09.2026journal-article

Medical Forum Monthly

Treatment of Delirium in Septic Shock Patients: A Focused Evidence Review

Muhammad Asim Rana, Moayad Nasser Alkhlewi, Kaouthar Sifaoui, Meshal Alharbi, Hector Emanuel Arias, Andres Saravia-Moya

Objective: To review pharmacological and non-pharmacological strategies for established delirium in adults with septic shock. Place and Duration of Study: This review was conducted Intensive Care Medicine, Department of Adult Intensive Care Medicine, King Abdullah Specialized Hospital, Ministry of National Guards Health Affairs, Qassim, KSA.from January to March 2026. Methods: PubMed/MEDLINE was searched for studies published between 2021 and 2026 on septic shock, delirium, sepsis-associated encephalopathy, dexmede …

01.09.2026journal-article

Frontiers in Oncology

Preoperative serum HE4 combined with CA125 testing for predicting the risk of suboptimal cytoreduction in advanced epithelial ovarian cancer

Chun Zhou, Yanli Wu, Juan Wang, Fu Zheng

Objective To investigate the predictive value of preoperative serum markers centered on human epididymis protein 4 (HE4) combined with carbohydrate antigen 125 (CA125) for the risk of suboptimal cytoreduction in advanced epithelial ovarian cancer. Methods We retrospectively analyzed the clinical data of 102 patients with International Federation of Gynecology and Obstetrics (FIGO) stage IIIA–IV epithelial ovarian cancer who underwent primary cytoreductive surgery at the First People’s Hospital of Jiangxia District …

01.09.2026journal-article

Biomedicines

Size-Transformable Nanoparticles for Tumor Drug Delivery: Distinct Roles of Shrinkage, Enlargement, and Reassembly

Kibeom Kim

Although fixed-size nanoparticles have achieved substantial therapeutic success, a single fixed size may not be optimal for the competing requirements of stability in circulation, tumor accumulation, deep tumor penetration, cellular uptake, and intra-tumoral retention. This review frames this fixed-property limitation as the need to switch structural states in response to successive biological barriers and analyzes original research articles published from 2021 to 2025 on large-to-small transformation, small-to-lar …

01.09.2026journal-article

JNCI: Journal of the National Cancer Institute

Evaluating the incidence and predictors of chronic opioid use in early survivorship for patients with diffuse large B-cell lymphoma

Mithunan Ravindran, Jessie Peng, Jonathan Zipursky, Jin Luo, Ning Liu, Kelvin K W Chan, Matthew C Cheung, Lee Mozessohn

Abstract Background Opioid exposure during cancer treatment is common and leads to new persistent opioid use (NPOU) in a subset of patients. There are limited data on the incidence and predictors of NPOU among patients with diffuse large B-cell lymphoma (DLBCL). Methods We conducted a population-based cohort study including patients with DLBCL ≥18 years old from Ontario, Canada who received first-line rituximab-based chemoimmunotherapy from 2014-2021 and survived >365 days after treatment. We defined opioid exposur …