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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Public Health

Explainable ensemble transfer learning for skin lesion classification with multi-method explainability validation

Nemili Sravani, Srinivas Koppu

Introduction Skin cancer is among the most prevalent and life-threatening malignancies worldwide. Early and accurate detection significantly improves therapeutic outcomes. Automated classification of dermoscopic skin lesions remains challenging due to class imbalance, inter-class visual similarity, and lack of interpretable predictions. This study proposes an accurate and interpretable weighted soft voting ensemble for multi-class skin lesion classification. Methods A weighted soft voting ensemble of three heteroge …

03.09.2026journal-article

Frontiers in Immunology

Clinical remission trajectories and histopathological associations in patients with IgA nephropathy treated with targeted-release budesonide: a real-world cohort study

Dafeng He, Jun Xu, Bo Gao, Mingzhu Jiang, Wenjin Liu, Chuanyan Zhao, Xinrui Li, Chunlei Lu, Mengyue Zhu, Hongbin Mou, Guangyu Bi

Background Targeted-release (TR) budesonide provides upstream mucosal immunomodulation in IgA nephropathy (IgAN) by targeting the gut-associated lymphoid tissue. However, the extent to which distinct downstream immune-inflammatory phenotypes and established structural chronicity shape real-world remission trajectories remains insufficiently characterized. Methods We retrospectively analyzed 57 adults with biopsy-proven primary IgAN treated with TR-budesonide. Prespecified milestones were Very Early Response (VER) a …

03.09.2026journal-article

Journal of Advances in Medicine and Medical Research

Age-related BAX and Ki-67 Expression in Regional Lymph Nodes of Infants who Died from Measles: A Retrospective Immunohistochemical Study

Doniyor Saidovich Turdimatov

Background: Measles can produce substantial lymphoid tissue injury and immunosuppression, but age-related patterns of apoptotic and proliferative activity in regional lymph nodes during fatal measles in infancy remain insufficiently characterised. Aims: To evaluate age-related changes in BAX and Ki-67 immunohistochemical expression in regional lymph nodes of infants who died from measles. Study Design: A retrospective morphological and immunohistochemical study of archived autopsy specimens. Methodology: Regional l …

03.09.2026journal-article

Agriculture and Human Values

The diverse human/bird relationships in backyard bird keeping: implications for health and welfare

Niamh Mahon, Orla Shortall, Carol Kyle

Abstract In 2024 registration of all captive bird flocks became mandatory in Great Britain to improve disease surveillance at a time of increasing avian influenza outbreaks. However, little is known about how health and welfare practices are shaped by the diversity of relationships that characterise UK backyard birdkeeping. We use this moment of change to (1) examine the relationships between backyard keepers, their birds, and the poultry industry, and, (2) explore how registration legislation is responded to by ba …

03.09.2026journal-article

INTERNATIONAL JOURNAL OF HEALTH AND PHARMACEUTICAL RESEARCH

Body Image Perception, Lifestyle Behaviours and Awareness of Obesity Among Adults

Adesimisola Hephzibah Alowolodu

In the world at large, it is estimated that in 2022, 890 million adults live with obesity, which is 16% of the adult population. Moreover, 43% of the world’s adults are either overweight or obese. Obesity prevalence in Nigeria is about 15% among the adult population. Obesity is also more prevalent among women, urban dwellers, and people living in the south compared to the north. Obesity is caused by various factors, including lifestyle factors, biological factors, sociocultural factors, and environmental factors. L …

03.09.2026journal-article

INTERNATIONAL JOURNAL OF HEALTH AND PHARMACEUTICAL RESEARCH

Personality Traits, Social Support and Perinatal Depression Among Women Attending Tertiary Health Institutions in Makurdi, Nigeria

Agada Onmonya Abo

Perinatal depression is a significant public health concern affecting women during pregnancy and the postpartum period. This study examined personality traits, social support, and perinatal depression among women attending tertiary health institutions in Makurdi Local Government Area, Benue State, Nigeria. A cross-sectional survey design was adopted involving 396 perinatal women, 254 prenatal and 142 postpartum attending antenatal clinics and immunization units in selected health institutions (Federal Medical Cente …

03.09.2026journal-article

Journal of Clinical Medicine

Preoperative Alanine Aminotransferase and Postoperative ALT Elevation: A Retrospective Cohort Study

Jisun Choi, Hyun Young Lim, Jeayoun Kim, Seungwon Lee, MiHye Park

Background: Modestly elevated serum alanine aminotransferase (ALT) levels are associated with increased morbidity and mortality in the general population; however, the perioperative significance of mildly elevated preoperative ALT levels in surgical patients remains unclear. Methods: This retrospective cohort study included adults undergoing non-hepatic, non-cardiac surgery at Samsung Medical Center. Patients with preoperative ALT measured within 3 months and 5 times the institutional ULN within 21 days after surge …

03.09.2026journal-article

International Journal of Health Management Review

THERAPEUTIC EXERCISE-INDUCED NEUROPLASTICITY IN MOTOR RECOVERY AFTER STROKE

Ayara Almeida Souza Cabral, Roberta Dich Siqueira, Liz Oliveira dos Santos, Karla Priscila de Souza Lobato, Raynara Donata dos Santos, Nataline de Oliveira Rocha, Josivane Quaresma Trindade, Maria do Socorro de Souza Gomes Pinheiro, Joana Darc Santos dos Santos, Iolene Melo da Silva, Diego Rodrigues da Silva

Stroke is a major cause of disability and is frequently associated with motor impairments that limit mobility, functional independence, and the performance of activities of daily living. In this context, neuroplasticity represents an essential mechanism for recovery, enabling structural and functional adaptations of the nervous system in response to injury and therapeutic stimuli. This study aimed to analyze the influence of therapeutic exercise on the neuroplasticity mechanisms involved in motor recovery in indivi …

03.09.2026journal-article

Journal of Hospital Medicine

2026 AHA/ACC guideline for the evaluation and management of acute pulmonary embolism in adults

Nilesh Patel

Guideline Title: 2026 AHA/ACC/ACCP/ACEP/CHEST/SCAI/SHM/SIR/SVM/SVN Guideline for the Evaluation and Management of Acute Pulmonary Embolism in Adults. Release Date: February 19, 2026. Prior Version(s): None; de novo guideline. Developer: American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines, in collaboration with multiple partner societies including the Society of Hospital Medicine. Target Population: Adults aged 18 years or older with acute pulmonary embolism.

03.09.2026journal-article

Borneo Nursing Journal (BNJ)

Pengaruh Inovasi Media Edukasi Berbasis Mobile Learning Terhadap Kesiapsiagaan Bencana Gempa Bumi Pada Tenaga Pengajar Di TK ABA Kecamatan Piyungan

Dinna Azzahra, Endah Tri Wulandari, Heri Puspito

Latar Belakang: Kecamatan Piyungan merupakan wilayah rawan gempa bumi di Kabupaten Bantul, Daerah Istimewa Yogyakarta. Fenomena rendahnya kesiapsiagaan guru TK terhadap bencana telah dibuktikan oleh beberapa penelitian, di antaranya Solfiah et al. (2019) yang menemukan bahwa tingkat kesiapsiagaan guru TK hanya mencapai 30,26% dengan kategori kurang. Hal ini diperkuat oleh Lee et al. (2023) yang melaporkan skor kesiapsiagaan guru PAUD berada pada kategori sedang dengan rata-rata 61,0 dari 100, serta Kawasaki et al. …

03.09.2026journal-article

Pituitary

Importance of clinical profiling to determine excess mortality in prolactinomas: insights from a large, registry-based cohort

Tarik Ziyad Tarik Shwaish, Davide Gori, Claudio Sartori, Federica Guaraldi

Abstract Purpose Population-based studies overall report no excess mortality among patients with prolactinoma compared with the general population. However, since prolactinomas are clinically heterogeneous, mortality may not be uniform across data-driven patient profiles. Methods We analyzed 3,378 adult prolactinoma cases (26,118 person-years) from the Surveillance, Epidemiology, and End Results database (2004–2022). Standardized mortality ratios (SMRs) were calculated using US life tables matched by age, sex, cale …

03.09.2026journal-article

Chinese Medicine and Culture

China's Most Beautiful Imperial Illustration-Colored Manuscript :A History of the Overseas Dissemination and Global Circulation of Ben Cao Pin Hui Jing Yao (《本草品汇精要》Collected Essentials of Species of Materia Medica)

Hui Cao, Qing Wu

Abstract: Ben Cao Pin Hui Jing Yao (《本草品汇精要》 Collected Essentials of Species of Materia Medica ) is an official materia medica text that was compiled and revised by Tai Yi Yuan (太医院the Imperial Academy of Medicine), completed in the eighteenth year of the Hongzhi era (1505 AD) under Emperor Xiaozong (孝宗) in Ming Dynasty. As the last pharmacopoeia in ancient China, it was even earlier than the Nuremberg Pharmacopoeia issued by the European Nuremberg Senate in 1546 AD. However, the book was not published, because Emp …

03.09.2026journal-article

The Prison Journal

Pathways to Homicide: Trauma, Mental Health and Reintegration Challenges Among Incarcerated Women in India

Pooja Tyagi, Meenu Sharma, Rajni Sharma, Mehek Arora, Raj Ratan

This qualitative study examines the trauma histories, mental health profiles, socioeconomic circumstances and reintegration concerns of 50 women incarcerated for homicide in four North Indian prisons. Applying a feminist pathways framework, semistructured interviews were analysed using reflexive thematic analysis. Four themes emerged: cumulative victimisation, untreated psychological distress, structural entrapment and reintegration precarity, reflecting widespread domestic violence, psychological distress, poverty …

03.09.2026journal-article

Wilderness & Environmental Medicine

Effects of Metal Climbing Gear and Lightning Safety Position During Simulated Lightning

Mathias Maurer, Wolfgang Lederer, Benjamin Treichl, Markus Isser, Sandra Bauchinger, Stephan Pack

Introduction When trapped in a climbing route during a thunderstorm, it is generally recommended that climbers should maintain a maximum distance from rock formations and water accumulations. It is common practice for climbers to untie themselves from the rope and deposit metal equipment a few meters away. Methods In an experimental study, the formation of upward leaders from metal gear attached to a climbing harness and the number of lightning strikes to rope, metal gear, and subject were evaluated. A lightning im …

03.09.2026journal-article

BMC Microbiology

First identification and characterization of a plasmid co-harbouring poxtA and cfr in a clinical linezolid-resistant Staphylococcus aureus isolate

Kang Xu, Kaixin Zhou, Linlin Xu, Qing Chen, Lianyan Xie, Feifei Gu, Aikuang Ma, Shuzhen Xiao, Jingyong Sun, Dongan Zhu

Abstract Background Linezolid remains an important treatment option for serious infections caused by Gram-positive pathogens; however, acquired oxazolidinone resistance genes carried by mobile genetic elements are an increasing clinical concern. In Staphylococcus aureus , cfr and poxtA have previously been reported together in the chromosomal mosaic transposon Tn 6349 , whereas complete plasmid-borne structures co-harbouring these genes remain poorly defined. Methods Isolate D2958 was identified by matrix-assisted …

03.09.2026journal-article

Japan Journal of Nursing Science

Nurses' Visual Attention During Initial Observation of Patients With Suspected Pneumonia: An Observational Pupillometry Study

Shoya Kamijo, Shinji Matsutani, Eijun Nakayama, Naoya Ohtani

ABSTRACT Aim Observation requires selective attention to visual information acquired through gaze. Measuring pupil diameter, an index of attention, we examined skilled and novice nurses during the initial assessment of a patient urgently admitted with suspected community‐acquired pneumonia. Methods This observational study was conducted in a simulated environment. Participants comprised skilled nurses with advanced practice training and novice nurses. During a 120‐s initial assessment of a mock patient with suspect …

03.09.2026journal-article

Neurocritical Care

Time-Stamped Annotations in High-Frequency Physiological Data: Evaluating an Approach for Assessing Annotation Plausibility in the CENTER-TBI Dataset

Sara Turella, Erta Beqiri, Stefan Yu Bögli, Bogdan Ianosi, Ihsane Olakorede, Tommaso Zoerle, Jeanette Tas, Raimund Helbok, Peter Smielewski, the Smart Neuromonitoring to Support Precision Medicine in Acute Central Nervous Injury (SOPRANI) collaborators and the CENTER-TBI High-Resolution Sub-Study Participants and Investigators, Audny Anke, Ronny Beer, Bo-Michael Bellander, David Nelson, Andras Buki, Giorgio Chevallard, Arturo Chieregato, Giuseppe Citerio, Endre Czeiter, Bart Depreitere, George Eapen, Shirin Frisvold, Stefan Jankowski, Daniel Kondziella, Lars-Owe Koskinen, Geert Meyfroidt, Kirsten Moeller, Anna Piippo-Karjalainen, Rahul Raj, Andreea Radoi, Juan Sahuquillo, Arminas Ragauskas, Saulius Rocka, Jonathan Rhodes, Rolf Rossaint, Ana Stevanovic, Oliver Sakowitz, Nina Sundström, Riikka Takala, Tomas Tamosuitis

Abstract Background/Objective High-resolution neuromonitoring data with time-stamped clinical annotations offer valuable insights into treatment responses, though reliability is limited by manual documentation. This study aims to develop and demonstrate a three-step methodological framework to evaluate the plausibility of time-stamped clinical annotations using a high-frequency dataset. The framework integrates visual inspection of reference annotations and automated classification based on predefined physiological …

03.09.2026journal-article

BMC Oral Health

Knowledge of medical students regarding the cariogenic potential of paediatric liquid medications: a cross-sectional study

Laura Marqués-Martínez, Cristina Olano-López, Juan Ignacio Aura-Tormos, Carla Borrell-García, Paula Boo-Gordillo, María Carmona-Santamaría, Clara Guinot-Barona, Esther García-Miralles

Abstract Background Paediatric liquid medications may contain sucrose, acidulants, and other formulation characteristics that create a cariogenic and erosive oral environment. This generates a therapeutic paradox: medicines prescribed to restore systemic health may also contribute to preventable dental disease when used frequently or without preventive guidance. Because prevention can begin at the point of prescription, future prescribers’ knowledge of medication excipients is relevant to paediatric oral-health pro …

03.09.2026journal-article

Frontiers in Pediatrics

Clinical utility of renal and urinary tract point-of-care ultrasound in the neonatal intensive care unit: insights from a case series

Gayatri Morajkar, Sujata Deshpande, Sachin Verma, Vivek Goyal, Jayanta Hazarika, Prasoon Bansal, Yogen Singh, Pradeep Suryawanshi

Background Clinical decision-making in acutely ill neonates often depends on the timely identification of the underlying pathology. Bedside point-of-care ultrasound (POCUS), performed by the treating clinician, allows immediate correlation of imaging findings with evolving clinical status. However, its role in evaluating renal and urinary tract abnormalities in neonates remains relatively underexplored and is not yet widely integrated into routine practice. Methods This multicenter case series included data from fo …

03.09.2026journal-article

Frontiers in Public Health

Fusing meteorological factors and baidu search index with an adapted deformtime model to predict influenza-like illness in Beijing

Lingling Shen, Yajun Xiong, Zhaobin Sun

Background Influenza-like illness (ILI) poses a significant burden on public health systems, particularly in densely populated megacities. Accurate and timely forecasting is crucial for early warning and resource allocation. While deep learning models have shown promise, capturing the complex, non-linear coupling between environmental drivers and human behavior remains a challenge. Methods We used weekly ILI% surveillance data from Beijing (2010–2019), complemented by 20 meteorological variables and 322 Baidu Searc …

03.09.2026journal-article

Frontiers in Public Health

Beyond visual comfort: comparing pupillometry and subjective measures of cognitive strain in workplace lighting

D-Filipa Ferreira, Ana-Carolina Fonseca, Simão Ferreira, Luís Pinto-Coelho, Matilde A. Rodrigues

Introduction This study evaluated the discriminative sensitivity of pupillometry, relative to subjective self-report measures, as an objective indicator of cognitive load during screen-based tasks performed under two workplace illuminance levels (300 and 500 lux). Inadequate workplace illuminance is associated with visual fatigue, stress, and impaired attention, yet its effect on cognitive strain during screen-based tasks remains underexplored through objective physiological indicators, particularly given the confo …

03.09.2026journal-article

Frontiers in Public Health

Safety of Sabin-derived inactivated poliovirus vaccine in adult booster recipients: a systematic review and meta-analysis

Muhammad Hussain, Muhammad Hassan, Abdul Hannan, Arham Kamil, Muhammad Tayyab Azam, Zain Ul Abideen Shahid, Hasibullah Aminpoor, Suhaylah Gore, Faizan Ahmed, Anna Guseva

Background Poliomyelitis remains a public health concern in select regions. Sabin strain-derived inactivated poliovirus vaccine (sIPV) offers a potentially safer and cost-effective alternative to conventional IPV (cIPV) for adult booster immunization. Objective To systematically review and meta-analyze evidence on the safety of sIPV in adults. Methods We searched PubMed, Embase, Cochrane, and Scopus through January 2026 for randomized controlled trials comparing sIPV with cIPV/w-IPV or placebo in adults. Safety out …

03.09.2026journal-article

Frontiers in Public Health

Association between physical fitness and myopia among school-entry students: a school-based cross-sectional study

ChengChao Duan, Yi Ba, Honglin Song, Yaqi Xue

Objective We examined whether school physical-fitness performance was associated with screening-defined current myopia in primary grade 1 and junior middle grade 1 students. We also explored item-level fitness profiles in relation to current myopia status. Methods We analyzed routine health-screening records collected in 2025 from three schools in Xicheng District, Beijing. Screening-defined current myopia required unaided visual acuity <5.0 together with a non-cycloplegic spherical equivalent ≤ −0.50 D in the same …

03.09.2026journal-article

Journal of Palliative Medicine

Liminal Personhood and Continuity of Moral Identity in Clinical Care

Harvey Max Chochinov, Marianne Sofronas, Joseph J. Fins

Capacity-based frameworks of personhood risk marginalizing individuals whose agency, cognition, or consciousness are diminished by illness, brain injury, or proximity to death. This article introduces the concept of liminal personhood , which describes the persistence of moral and relational identity even as conventional markers of personhood fade. Drawing on ethical, philosophical, and neuroethical scholarship, the paper argues that failing to recognize enduring personhood can fracture patient identity and erode c …