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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Public Health

The effectiveness of the intervention model based on cognitive behavioral therapy in reducing risky sexual behaviors among MSM

Xiaochen Xiang, Xiaobing Zhai, Yumeng Lei, Jialu Feng, Qiang Wang

Methods Based on CBT theory and the Internet, we established an intervention model targeting high-risk sexual behavior patterns in MSM. We then conducted a randomized controlled trial ( n = 50) to assess the impact of the CBT-based intervention on high-risk sexual behaviors and gut microbiota changes in this population. Results Prior to the implementation of the intervention, 44% of the participants engaged in high-risk behaviors despite having better cognitive levels. However, preliminary findings from post-interv …

03.09.2026journal-article

Frontiers in Public Health

Physical exercise therapy for autism spectrum disorder: a scoping review of systematic reviews

Fei Fan, Ji Li, Xuan Zhang, Bo Wang, Zilin Chen, Yuchen Hu, Fei Han

Background Physical exercise therapy (PET) is used as a non-pharmacological intervention for individuals with autism spectrum disorder (ASD). However, the overall evidence landscape remains unclear. Methods This scoping review adhered to the Joanna Briggs Institute methodology and the PRISMA-ScR checklist. Searches were conducted in MEDLINE, EMBASE, Web of Science, and Cochrane Library from database inception to December 4, 2025. Included were systematic reviews that investigated PET for individuals with ASD. Two r …

03.09.2026journal-article

DRUG CONTROL

Pseudo-Rehabilitation of Drug Addicts (Issues of Countering Criminal Business)

Ivan L. Tretyakov

Purpose: the Author studied the state of the problem associated with the criminal activity of peoplehiding their real purposesunder the guise of highly professional specialists who allegedly can helpdrug addicts. Research methods: the complex of criminal law, criminological, socio-psychological and organizational approaches used to establish the causes of this phenomenon constituted the theoretical and methodological basis of this Study. The use of the system analysis enabled the Author to develop effective recomme …

03.09.2026journal-article

Haematologica

Efficacy and safety of bridging therapy prior to CAR T-cell therapy in relapsed or refractory multiple myeloma

Marie Christine Wesener, Uta Margareta Demel, Thomas Pabst, Raphael Teipel, Anca-Maria Albici, Bastian Von Tresckow, Marcel Teichert, Amelie Boquoi, Tobias Holderried, Friederike Schmitz, Fabian Müller, Friedrich-Linus Rößiger, Michele Hoffmann, Natalie Schub, Natalia Tovar, Aina Oliver-Caldes, Nicolaus Kröger, Ben-Niklas Baermann, Stephan Bohl, David Fandrei, Vladan Vucinic, Irene Strassl, Friedrich Stölzel, Carlos Fernández De Larrea, Ulrich Keller, Antonia Busse, Maximilian Merz, Nico Gagelmann

Disease burden at the time of BCMA-directed chimeric antigen receptor (CAR) T-cell infusion is a key determinant of outcome in relapsed or refractory multiple myeloma (RRMM). Bridging therapy is frequently administered between leukapheresis and infusion to prevent disease progression, yet its clinical impact remains unclear. We conducted a multicenter real-world cohort study of 399 patients with RRMM treated with BCMA-directed CAR T-cell therapy, including 348 (87%) who received bridging therapy. Bridging therapy r …

03.09.2026journal-article

Frontiers in Neurology

Paired vagus nerve stimulation for post-stroke shoulder motor recovery: corticospinal–C5 motor network plasticity and rehabilitation applications

Xiang Ji, Weiran Zheng, Wei Ma, Jiaying Liu, Guizhi Xu

Shoulder motor impairment after stroke restricts reaching, self-care, balance reactions, and the use of mobility aids. Paired vagus nerve stimulation (pVNS), in which brief cervical vagus nerve stimulation is temporally coupled to task-specific rehabilitation, improves overall upper-extremity impairment and activity in selected people with chronic ischemic stroke. Its shoulder-specific effects, however, remain uncertain. This Mini Review evaluates pVNS through a corticospinal–C5 motor-network frameworkthat links mo …

03.09.2026journal-article

Signal Transduction and Targeted Therapy

CDK12/13 inhibition overcomes platinum resistance by impairing RNA metabolism

Ilenia Pellarin, Valentina Rossi, Riccardo Giuseppe Margiotta, Javad Karimbayli, Alessio Polacchini, Ashwani Bahl, Milena Nicoloso, Maura Sonego, Sara D’Andrea, Laura Sala, Simone Canesi, Andrea Favero, Anna Nespolo, Danilo Licastro, Michele Bartoletti, Fabio Puglisi, Antonino Ditto, Vincenzo Canzonieri, Monica Schiappacassi, Iain McNeish, Guido Sanguinetti, Barbara Belletti, Gustavo Baldassarre

Abstract Epithelial ovarian cancer (EOC) is a highly lethal disease characterized by a high rate of platinum (PT)-resistant recurrence. Dysregulation of transcriptional and alternative splicing (AS) has been suggested as a possible mechanism of PT resistance involving transcriptional cyclin-dependent kinases (CDKs). We report that pharmacological CDK12/CDK13 inhibition (CDK12i) synergistically enhances PT-induced cytotoxicity in a large number of PT-sensitive and PT-resistant EOC models. CDK12i effectively delayed …

03.09.2026journal-article

Frontiers in Neurology

Efgartigimod-alfa therapy in acetylcholine receptor antibody myasthenia gravis: Romanian experience

Nicolae Grecu, Oana Antonia Mihalache, Eugenia Irene Davidescu, Rodica Bălașa, Mihaela Simu, Vitalie Văcăraș, Ileana-Maria Vodă, Andreea-Ioana Mușuroi, Andra Mădălina Ene, Diana Mihaela Petrescu, Cristina Elena Mitu, Lorena Furnică, Amalia Cornea, Romana Homorodean, Crisanda Vîlciu, Cristina Tiu

Background Efgartigimod alfa, the first neonatal Fc receptor inhibitor approved for the treatment of acetylcholine receptor antibody (AChR)-positive generalized myasthenia gravis (MG), has demonstrated efficacy in randomized controlled trials. However, real-world data, particularly from Eastern Europe, remain limited. Methods This prospective, multicenter study enrolled AChR-positive generalized MG patients treated with efgartigimod across six Romanian university hospitals between March 2024 and September 2025. Out …

03.09.2026journal-article

Frontiers in Oncology

Case Report: Neuroretinitis following combination checkpoint inhibition therapy with nivolumab and ipilimumab for stage IIIC melanoma

Nuha S. Arefin, Jared Moon, Aaron B. Roller, Moe H. Aung

Purpose Neuroretinitis is a very rare but recognized immune-related adverse event (irAE) of immune checkpoint inhibitor (ICI) therapy. We present a case of likely ICI-associated neuroretinitis following combination nivolumab and ipilimumab treatment for stage IIIC cutaneous melanoma. Observations Our patient is a 48-year-old woman with stage IIIC melanoma who developed acute left eye vision loss approximately three months after initiating nivolumab and ipilimumab, near the end of a corticosteroid taper for a concur …

03.09.2026journal-article

Frontiers in Rehabilitation Sciences

Functional recovery and mortality after intensive inpatient rehabilitation for severe acquired brain injury in older adults: a retrospective cohort study

Valeria Pingue, Chiara Pavese, Jasmine Invernizzi Descalzi, Loretta Fiorina, Vittorio Gabba, Gianluca Bellaviti, Antonio Nardone

Background Severe acquired brain injury (sABI) is a major cause of mortality and long-term disability. Although its prevalence is increasing among older adults (≥65 years), evidence on independent determinant of rehabilitation outcomes in this population remains limited. This study aimed to identify early factors associated with poor functional outcomes and mortality in younger and older patients undergoing intensive inpatient rehabilitation following severe acquired brain injury (sABI). Methods In this single-cent …

02.09.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Impact of Diabetes Mellitus on Drug-Induced Liver Injury during Antituberculosis Therapy: A Prospective Cohort Study

Ruina Chen, Yu Wu, Xiaoyan Xu, Jingru Cheng, Yan Jiang, Xiaomin He, Hongqiu Pan, Meiling Zhang, Lihuan Lu, Honggang Yi, Shaowen Tang

ABSTRACT. Drug-induced liver injury (DILI) is a significant concern during antituberculosis (anti-TB) treatment, and its association with diabetes mellitus (DM) remains inconsistent. This study investigated whether DM influences anti-TB DILI occurrence in Chinese patients. A prospective cohort study enrolled patients receiving anti-TB treatment at four hospitals. Patients were grouped by DM status and followed up until treatment completion. Propensity score matching (PSM) was performed at a 1:1 ratio to ensure comp …

02.09.2026journal-article

JOSPT Open

Persistent Shoulder Instability and Retained Primitive Reflexes. Addressing a Potential Gap in Adult Musculoskeletal Rehabilitation Care

Ellie Richardson, Ramni Acharya, Peter C Goodwin, Jeremy Lewis

Using a case of recalcitrant type III shoulder instability, this editorial explores the potentially overlooked link between retained primitive reflexes and persistent musculoskeletal conditions. We explore how incomplete primitive reflex integration may disrupt motor control, compromise dynamic stability, and interact with neurodevelopmental traits like generalized joint hypermobility. Addressing a potential gap in adult musculoskeletal care, we establish a theoretical framework and foundational justification for f …

02.09.2026journal-article

Pathogens

Partial Oral Antibiotic Therapy for Infective Endocarditis: A Practical Review of Current Evidence and Guidelines

Thomas Roland, Jean Cyr Yombi

Infective endocarditis (IE) is associated with an in-hospital mortality rate of 15–30%. Standard treatment requires 2 to 6 weeks of intravenous (IV) antibiotic therapy, resulting in prolonged hospitalization with its attendant risks, including catheter-related complications, increased length of stay, and cost. This review summarizes the current evidence, eligibility criteria, antibiotic regimen selection, and practical aspects of partial oral antibiotic therapy (POAT) for IE. Oral treatment is already recommended f …

02.09.2026journal-article

International Journal of Sports Physical Therapy

Utilization of the Functional Lower Extremity Evaluation (FLEE) in Return-to-Sport Rehabilitation Protocol Following Hip Arthroscopy in Collegiate Athletes: A Case Series

Yazdan Raji, Rebecca E. Luft, Kinsley J. Pierre, Floyd VitoCruz, Marc R. Safran

Background The Functional Lower Extremity Evaluation (FLEE) is a validated assessment tool designed to assess lower limb function and symmetry. There is a gap in knowledge in return to sport (RTS) regarding the application of the FLEE in RTS rehabilitation protocols following hip arthroscopy. The purpose of this case series was to assess the utility of the FLEE in guiding RTS rehabilitation protocols for collegiate athletes after hip arthroscopy and to evaluate lower limb symmetry using FLEE components. Hypothesis …

02.09.2026journal-article

Journal of Nursing, Midwifery and Allied Health Sciences

Measurement Equivalence between Pidgin English and Igbo Versions of the Birth Satisfaction Scale–Revised among Postpartum Women in Owerri, Nigeria

Anne Chidinma Nwogu, Ayishetu Musa-Maliki, Yarhere Iroro, Joy Chiamaka Samuel, Josephine Nonye Amadi

Birth satisfaction is an indicator of the quality of intrapartum care, yet evidence on measurement equivalence of birth satisfaction instruments across Nigerian languages remains limited. In multilingual settings such as Nigeria, where Nigerian Pidgin is widely used alongside indigenous languages such as Igbo, establishing cross-language equivalence of patient-reported outcome measures is essential to ensure valid comparison of maternal birth experiences. This study assessed measurement equivalence between the Nige …

02.09.2026journal-article

Journal of Language Teaching and Research

Linguistic Foundations for Constructing Speech Synthesis in the Kazakh Language

Fazylzhan A.M., Bazarbayeva Z.M., Amanbayeva A.Zh., Zhumabayeva Zh.T., Ospangaziyeva N.B., Karshigayeva A.А.

The article is devoted to the problem of correctly recognizing and pronouncing, in accordance with orthoepic norms, shortened words and abbreviations, numerical symbols, mathematical operations, formulas, and conventional signs within the Kazakh-language text-to-speech system. The main objective of the study is to identify the linguistic features of fully expanding shortened words and abbreviations in texts processed by the speech synthesis system, as well as of representing mathematical expressions in written form …

02.09.2026journal-article

Transgender Health

Alterations in Breast Tissue Morphology and Androgen Receptor Expression Following Masculinizing Gender-Affirming Hormone Therapy in Transgender Men

Poonpissamai Suwajo, Thawin Techapongsatorn, Adiluck Pisutpunya, Kasama Nilprapha, Jiraroch Meevassana, Apichai Angspatt, Kroonpong Iampenkhae, Saranpong Pornsinsirirak

Purpose: This study aimed to evaluate histological alterations and androgen receptor (AR) expression within breast tissue associated with masculinizing gender-affirming hormone therapy (GAHT) exposure of different duration in transgender men. Methods: A retrospective review of breast histopathological specimens obtained from 81 transgender men following gender-affirming mastectomy between 2017 and 2023 was conducted. Histological features and AR expression were compared between individuals with and without prior GA …

02.09.2026journal-article

Pediatric Rheumatology

Long-term outcome of bisphosphonate therapy in paediatric CNO: a single-centre cohort study

Sarah Remtoula, Federica Anselmi, Justin Ulm, Linda Rossi-Semerano, Caroline Galeotti, Sandrine Chilloh, Vanessa Lapierre, Ines Mannes, Marie Robert, Perrine Dusser

Abstract Objectives Chronic non-bacterial osteomyelitis (CNO) is a rare autoinflammatory bone disorder affecting mainly children. While non-steroidal anti-inflammatory drugs (NSAIDs) are the first-line therapy, bisphosphonates (BPs) are frequently used in refractory cases despite limited evidence. This study evaluated the clinical, laboratory, and radiological outcomes of BPs therapy in children affected by CNO. Methods We conducted a single-centre retrospective study of 30 children with CNO treated with intravenou …

02.09.2026journal-article

Epilepsy Currents

The Odd Couple: Replacement Therapy for Citrate Transporter Deficiency in the Brain and the Liver

Sara Eyal

AAV-mediated gene therapy in a model of SLC13A5 citrate transporter disorder rescues epileptic and metabolic phenotypes Bailey LE, Adams RM, Schackmuth MK, Garza IT, Knight K, Holmes SK, Eller MM, Lee M, and Bailey RM. J Clin Invest . 2026 Feb 19;136(8):e197503. doi: 10.1172/JCI197503. PMID: 41712282; PMCID: PMC13078891. SLC13A5 citrate transporter disorder is a rare epileptic encephalopathy caused by loss-of-function pathogenic variants in the SLC13A5 gene. Loss of sodium/citrate cotransporter function causes a se …

02.09.2026journal-article

Arthroscopy, Sports Medicine, and Rehabilitation

Arthroscopic Suprapectoral Biceps Tenodesis Using a Standard Suture Anchor Is Safe and Effective

Xavier A. Duralde, Caroline A. Heramb, Jennifer N. Blanda

Purpose To evaluate the safety and efficacy of an arthroscopic technique of suprapectoral biceps tenodesis using a standard absorbable double‐loaded suture anchor. Methods This retrospective study includes all patients who underwent arthroscopic biceps tenodesis by the senior author between December 2017 and June 2020. Biceps tenodesis was performed in patients who had failed conservative management and exhibited evidence of biceps pathology at the time of surgery that appeared to be contributing to the patient's p …

02.09.2026journal-article

BMC Sports Science, Medicine and Rehabilitation

Categorizing race profiles in professional men’s and women’s road cycling races using clustering

Annemiek J. Roete, Marije T. Elferink-Gemser, Robert P. Lamberts, Matthias Kempe

Abstract Background Professional road cycling races differ in physiological demands because race profiles vary. Yet no standardized method exists to categorize race profiles across professional road cycling races. Organizer labels are inconsistent or missing. Systematic categorization would enable large-scale analysis of race demands. This study develops a categorization of race profiles in men’s and women’s professional road cycling. Methods The dataset comprised international men’s and women’s races from 2024 sup …

02.09.2026journal-article

BMC Musculoskeletal Disorders

Effectiveness of dynamic neuromuscular stabilization exercises on clinical variables in postoperative rehabilitation of patients with lumbar disc herniation: a randomized controlled trial

Burak Buğday, Büşra Arısüt, Elif Esma Bayraktar, Ömer Şevgi̇n

Abstract Purpose This study evaluates the effects of an 8-week Dynamic Neuromuscular Stabilization (DNS) program on disability, physical activity, and fear-avoidance behaviors in postoperative lumbar disc herniation (LDH) patients. Method The study was designed as a randomized controlled trial. Participants of both sexes, aged 35–50 years, were recruited from a single-center postoperative outpatient physiotherapy setting and randomized into DNS (intervention) and standard care (control) groups. The DNS program emph …

02.09.2026journal-article

Stem Cell Research & Therapy

Extracellular vesicles from specific muscle progenitor cells as a novel therapeutic strategy for sarcopenia

Bi Zhao, Yao Yao, Hong Shi, Srinivas M. Tipparaju, Muhammad Ashraf, Wanling Xuan

Abstract Background Sarcopenia, characterized by age-related loss of skeletal muscle mass and function, poses a significant challenge to lifelong health and wellbeing. Currently, no effective therapeutic interventions exist. In previous work, we developed specialized muscle progenitor cells (MPCs), termed Givi-MPC, from human induced pluripotent stem cells (hiPSCs). These cells demonstrated robust regenerative capacity in both sarcopenic and dystrophic muscle models. However, the potential of extracellular vesicles …

02.09.2026journal-article

Australian Occupational Therapy Journal

Exploring successful implementation of occupational therapy led home fall‐hazard reduction interventions

Susan Melchert, Richard Franklin, Daniel Lowrie

Abstract Introduction Falls among older adults are a major cause of death, injury, and loss of independence. High‐certainty evidence demonstrates that comprehensive, occupational therapy–led home fall‐hazard reduction interventions can reduce the number of falls among older adults at high risk. Despite this evidence, these interventions are not routinely implemented in practice. Current literature provides limited insight into the factors that influence successful implementation of home fall‐hazard reduction interv …