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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Oncology

Gap analysis of breast cancer care at tertiary facilities in Armenia

Ani Arzoumanian, Sione Markarian, Anja Johnson, Emma Mastro, Sira Jil-Agopian, Catherine Duggan, Marine Hovhannisyan, Henry Louis, Shant Shekherdimian

Breast cancer is the leading cause of cancer mortality among women globally. Armenia has one of the highest breast cancer mortality rates in the world, with an age standardized mortality-to-incidence ratio of 0.41, indicating that two in five breast cancer patients die from the disease. The factors contributing to this disproportionate mortality burden are poorly understood. The present study utilized a validated survey across four high-capacity cancer facilities to produce a national gap analysis of breast cancer …

03.09.2026journal-article

Frontiers in Oncology

Case Report: Solitary right thigh skin metastasis of bladder cancer misdiagnosed as erysipelas with literature review

Zhaonan Hou, Mingfeng Ji, Fang Peng, Yihao Chen, Zhiyu Liu, Zhihong Dai

Background Cutaneous metastasis from bladder carcinoma is an uncommon clinical manifestation and may be misdiagnosed as a benign inflammatory dermatosis, such as erysipelas, causing diagnostic delay and missed opportunities for timely systemic treatment. Case presentation We report a case of a 70-year-old man with a history of muscle-invasive bladder carcinoma treated with radical cystectomy and bilateral cutaneous ureterostomies, who presented 6 years later with a maculopapular rash on his right thigh. The lesion …

03.09.2026journal-article

Frontiers in Immunology

The ALP score: a novel composite index for prognostic risk stratification to chemo-immunotherapy in advanced non-small cell lung cancer

Yize Wang, Xiaolong Zhou, Yan Huang, Ting Zhong, Huan Yan, Juan Liang, Lianxi Song

Objective This study aimed to investigate the value of a novel composite index, the ALP score (calculated as the product of lymphocyte count and serum albumin), in predicting the risk of early progression to chemotherapy combined with immune checkpoint inhibitors (ICIs) in patients with driver mutation-negative advanced non-small cell lung cancer (NSCLC). Methods Clinical data from 433 patients with advanced NSCLC who received first-line chemoimmunotherapy were retrospectively collected. Independent risk factors fo …

03.09.2026journal-article

Journal of Hepato-Biliary-Pancreatic Sciences

Pretreatment Contrast‐Enhanced Harmonic EUS Predicts Pathological Response and Recurrence‐Free Survival After Multimodal Treatment in Resectable Pancreatic Cancer

Yuichi Kano, Takuya Ishikawa, Kentaro Yamao, Yasuyuki Mizutani, Tadashi Iida, Yoshihisa Takada, Ryohei Kumano, Takeshi Yamamura, Kazuhiro Furukawa, Hiroki Kawashima

ABSTRACT Objectives Recurrence remains common in resectable pancreatic cancer (PC) despite multimodal treatment. We evaluated whether pretreatment contrast‐enhanced harmonic endoscopic ultrasonography (CH‐EUS) predicts pathological response and recurrence‐free survival (RFS). Methods We retrospectively analyzed 52 patients with resectable PC who underwent CH‐EUS before standardized multimodal treatment (neoadjuvant chemotherapy, surgery, and adjuvant chemotherapy). Associations between CH‐EUS enhancement patterns ( …

03.09.2026journal-article

Frontiers in Microbiology

Klebsiella pneumoniae in inflammatory bowel disease and rectal cancer: from gut inflammation to a potential driver of carcinogenesis

Shuxin Xiong, Rui Yao

The gut microbiota is a critical modulator of intestinal inflammation and colorectal cancer (CRC), yet the specific microbial drivers that bridge inflammatory bowel disease (IBD) to rectal carcinogenesis remain poorly defined. Klebsiella pneumoniae ( K. pneumoniae ) has recently emerged as a compelling candidate at this nexus; however, several critical questions remain unresolved: (i) whether K. pneumoniae colonization is a cause or a consequence of rectal carcinogenesis; (ii) how strain level heterogeneity determi …

03.09.2026journal-article

Annals of Surgery

Cancer Surgery Outcomes After Implementation of a Global Budget Model in Rural Hospitals

Jacob Whitman, Eric T. Roberts, Jonathan G. Yabes, Donald Bourne, Zhaojun Sun, Manisha Bhattacharya, Jeremy M. Kahn, Bruce L. Jacobs, Lindsay M. Sabik

Objective: To evaluate the association between the implementation of the Pennsylvania Rural Health Model (PARHM), a global budget program for rural hospitals, and short-term outcomes for rural residents undergoing cancer surgery. Background: Rural hospitals play a critical role in delivering surgical care but face ongoing financial instability. Global budget models aim to stabilize hospitals and preserve access to care. While designed to stabilize finances and improve population health, its impact on quality of car …

03.09.2026journal-article

Frontiers in Public Health

The impact of oral health literacy on oral health in lung cancer patients: the mediating role of psychosocial factors

Nan Zhang, Yingao Liu, Tiane Fa

Background Lung cancer patients often have poor oral health due to treatment toxicities, increasing risks of oral mucositis, and pulmonary infection. Oral health literacy (OHL) is a key determinant, and psychosocial factors such as anxiety and family support also play roles. However, prior studies examined only single dimensions, not underlying mechanisms. This study aims to build a mediation model linking OHL, psychosocial factors, and oral health status in lung cancer patients, providing exploratory evidence for …

03.09.2026journal-article

Frontiers in Cellular and Infection Microbiology

Gut microbiome-mediated primary and acquired resistance to immune checkpoint inhibitors in MSI-H/dMMR colorectal cancer: mechanisms, biomarkers, and therapeutic implications-a narrative review

Marko Marjanović, Nemanja Maletin, Biljana Kukić, Ivan Nikolić, Nemanja Petrović, Jelena Radić, Aleksandar Đurić, Milica Knezević, Božidar Dejanović, Vanja Ćalić

Introduction Immune checkpoint inhibitors (ICIs) have transformed the management of microsatellite instability-high/deficient mismatch repair (MSI-H/dMMR) colorectal cancer (CRC). However, a substantial proportion of patients exhibit primary resistance or eventually develop acquired resistance, highlighting the need for a better understanding of the biological mechanisms influencing therapeutic response. Increasing evidence suggests that the gut microbiome–immune axis is an important regulator of antitumor immunity …

03.09.2026journal-article

Frontiers in Public Health

A co-production study of an art-based media campaign intervention to encourage early breast cancer screening uptake among Black women in England

Tarela Juliet Ike, Dung Ezekiel Jidong, Mieyebi Lawrence Ike, Evangelyn Ebi Ayobi, Peremi Richmond Ike, Oluwakorede Florence Adebowale, Gabriella Rooks, Nusrat Husain

Background Breast cancer is one of the most common cancers that affects women globally. Of central concern are Black women in the United Kingdom who are disproportionately affected, present late and suffer higher mortality due to poor early screening uptake. Informed by an interpretative phenomenological analytical lens, this study makes an original and significant contribution to address the gap by working with 15 Black women from the north of England to co-produce an art-based media campaign intervention designed …

03.09.2026journal-article

Frontiers in Medicine

Neoadjuvant pembrolizumab-based therapy versus dual HER2 blockade in early breast cancer: comparable surgical complication rates in a real-world cohort

Kerstin Wimmer, Katharina Kantner, Ruth Exner, Rupert Bartsch, Zsuzsanna Bago-Horvath, Stefan Konrad, Florian Fitzal, Maximilian Marhold

Background Neoadjuvant systemic therapy (NST) has become a cornerstone in the management of aggressive early breast cancer (BC) subtypes, including triple-negative (eTNBC) and HER2-positive disease. Immune checkpoint inhibition with pembrolizumab represents an active immunotherapeutic approach, whereas dual HER2 blockade with trastuzumab and pertuzumab constitutes passive immunotherapy in early HER2-positive BC. Although both strategies demonstrate substantial antitumor efficacy, real-world data directly comparing …

03.09.2026journal-article

Frontiers in Medicine

Metachronous bilateral diabetic mastopathy mimicking breast cancer in a woman with long-standing type 2 diabetes: a case report

Zhixiang Kuang, Wei Ding, Li Li

Background Diabetic mastopathy is an uncommon benign fibroinflammatory disorder of the breast that often resembles malignancy on clinical examination and imaging. Most reports involve younger women with long-standing type 1 diabetes. Metachronous bilateral disease in an older woman with type 2 diabetes is less often described. Case presentation A 69-year-old woman with a 38-year history of type 2 diabetes treated with self-administered insulin had previously undergone partial excision of a suspicious right-breast m …

03.09.2026journal-article

Frontiers in Oncology

Molecular classification of endometrial cancer in fertility-sparing-treatment: toward a personalized clinical approach

Filippo Alberto Ferrari, Giorgio Bogani, Matteo Pavone, Elena Olearo, Andrea Puppo, Marcello Ceccaroni

Molecular classification has emerged as a promising tool to improve patient selection and prognostic stratification in fertility sparing treatment (FST) for endometrial cancer (EC). Although FST is currently considered a valid option for carefully selected patients with early stage, low grade endometrioid EC, recurrence rates remain substantial and conventional clinicopathologic criteria inadequately capture tumor biological heterogeneity. Current evidence suggests that NSMP tumors represent the most favorable subg …

03.09.2026journal-article

Frontiers in Immunology

Integrated single-cell analysis characterizes malignant epithelial programs and context-dependent immune associations of MP7/SERINC2 in colorectal cancer

Wei Ying, Yuhan Zhang, Shirong Wu, Rui Wu, Xiaoxia Li

Introduction Colorectal cancer (CRC) comprises heterogeneous malignant epithelial states, but it remains unclear which transcriptional programs recur across patients and how these programs relate to the immune context. Methods We integrated five public single-cell RNA-sequencing datasets comprising 425,402 cells from 119 patients using scVI, defined malignant epithelial cells with inferCNV, and characterized their states and transcriptional programs using cNMF, pySCENIC, and CytoTRACE2. Program recurrence was asses …

03.09.2026journal-article

Frontiers in Oncology

Leptomeningeal metastasis from colon cancer: a case report and review of literature

Chao Wang, Daixi Wu, Aolin Wang, Xiaojia Zhang, Jianghui Duan, Mingrui Dong, Mingxiao Li, Zhirong Qi, Huijuan Cui

Background Leptomeningeal metastasis from colorectal cancer (LM-CRC) is a rare condition characterized by poor outcomes and no established standard of care. Case description We report a 60-year-old female patient who presented with constipation and abdominal pain. Eight months prior, she had been diagnosed with poorly differentiated adenocarcinoma of the sigmoid colon with focal signet-ring cell features, proficient mismatch repair, and a KRAS mutation. She had received treatment with FOLFOX/FOLFIRI ± bevacizumab. …

03.09.2026journal-article

Frontiers in Oncology

MRI-derived features reveal recurrence heterogeneity in VI-RADS 2 non-muscle-invasive bladder cancer

Junpeng Sun, Ziyong Wang, Maofa Yang, Zijian Tan, Hong Sun, Xusong Pang, Longguo Dai, Siting Wang, Kun Zhang, Tenglu Ma, Zhao Cao, Hong Yang

Objectives To characterize recurrence heterogeneity among patients with VI-RADS 2 non-muscle-invasive bladder cancer (NMIBC) and to develop and internally validate a recurrence-free survival (RFS) prediction model incorporating quantitative MRI features. Methods This retrospective study included 342 patients with pathologically confirmed VI-RADS 2 NMIBC, who were randomly divided into training and internal validation cohorts. Clinical and quantitative MRI variables were evaluated using Cox regression, least absolut …

03.09.2026journal-article

Current Opinion in Oncology

Implementing liquid biopsy in HR+/HER2− metastatic breast cancer: challenges and opportunities

Valentina Frescura, Massimo Cristofanilli, Carolina Reduzzi, Letizia Pontolillo, Eleonora Nicolò

Purpose of review Liquid biopsy (LB) is rapidly transforming the management of hormone receptor-positive/HER2-negative (HR+/HER2−) metastatic breast cancer (mBC). In this review, we discuss the most recent findings on circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs), exploring their roles across the treatment continuum, from treatment selection to resistance monitoring. Recent findings ctDNA-based detection of actionable mutations – including ESR1 and PIK3CA – achieved regulatory validation as a pri …

03.09.2026journal-article

Frontiers in Oncology

Clinical and genomic characterization of KRAS G13X non-small cell lung carcinoma

Benjamin J. Staum, Rachaita Lakra, Aditya Ravindra, Sarah L Mott, Deqin Ma, William Zeitler, Margaret Byrne, Nirmal Choradia, Abdul Rafeh Naqash, Raid Aljumaily, Muhammad Furqan

Background KRAS mutations (KRAS m )represent the most common oncogenic drivers in non–small cell lung cancer (NSCLC). However, molecular features and clinical implications of the less common, codon 13 mutations ( KRAS G13X) remain poorly characterized. We conducted a retrospective study to characterize KRAS G13X-positive NSCLC. Methods We reviewed patients’ charts with KRAS m NSCLC treated at University of Iowa Health Care. Based on intent of therapy, patients were assigned to curative-intent (CI) or palliative-int …

03.09.2026journal-article

Frontiers in Oncology

Treatment and outcomes of hepatoblastoma in a tertiary care pediatric institution: a single-center experience

Aleksandar Sretenović, Srđa Janković, Nada Krstovski, Polina Pavićević, Jelena Lazić, Goran Milošević, Marija Ćazić, Jelena Krcunović, Branislav Jovanović, Tijana Radović, Đorđe Pavlović, Dubravka Milutinović, Jelena Pejanović Jovanović, Ivana Dašić, Sofija Cvejić, Jovana Svorcan Pavlović, Predrag Rodić

Introduction Hepatoblastoma is the most prevalent pediatric malignant liver neoplasm, and despite substantial advances in multimodal treatment, outcome data from Southeast European pediatric centers remain limited. The aim of this study was to evaluate the clinical characteristics, treatment approaches, surgical management, and outcomes of children treated for hepatoblastoma at a tertiary pediatric institution over a 17-year period. Methods This retrospective single-center cohort study included 24 pediatric patient …

03.09.2026journal-article

Frontiers in Physiology

Fusion color space analysis of tongue image characteristics in different stages of metastatic colorectal cancer and three-class model construction

Zhenyi Lin, Fan Chen, Zhenzheng Zhu, Dingxuan Wu, Weiwei Zhou, Shuning Ding, Leitao Sun, Guanjun Jiang

Objective Color spaces were used to analyze the color characteristics of tongue image in different stages of metastatic colorectal cancer (mCRC), and a three-class model was constructed to predict the different tongue characteristics during the mCRC progression. Methods Tongue images of CRC patients were collected and classified into non-metastatic, oligometastatic, and extensive metastatic groups according to tumor metastasis. The color components in HSB, Lab, and YCrCb color spaces were measured from tongue image …

03.09.2026journal-article

Frontiers in Pharmacology

Lipid-dependent regulation of Kv10.1 in cancer: implications of membrane remodeling for channel function and pharmacology

Nguyen Van Phuong, Anna Stary-Weinzinger

The voltage-gated potassium channel Kv10.1 (Eag1), which is abnormally overexpressed across a wide range of tumor types, is a promising therapeutic target for cancer treatment. However, the clinical development of Kv10.1 inhibitors is currently constrained by severe off-target cardiotoxicity resulting from unintended inhibition of the structurally homologous Kv11.1 (hERG) channel. In this review, we examined cancer-associated membrane lipid remodelling and its implications for the lipid-dependent regulation of both …

03.09.2026journal-article

Ege Tıp Dergisi

Real-world outcomes of first-line carboplatin–etoposide–atezolizumab in extensive-stage small-cell lung cancer

Abdülkadir Koçanoğlu, Oktay Ünsal, İbrahim Karadağ, Fırat Şirvan, Serdar Karakaya

Aim: The addition of atezolizumab to platinum-etoposide chemotherapy has become the standard first-line treatment for extensive-stage small-cell lung cancer (ES-SCLC). However, real-world data regarding treatment outcomes and prognostic factors remain limited. This study evaluated the effectiveness of first-line carboplatin-etoposide-atezolizumab and investigated clinical and PET/CT-derived prognostic factors in patients with ES-SCLC.Materials and Methods: We retrospectively analyzed 59 consecutive patients with ES …

03.09.2026journal-article

Cancers

Identification of Factors That Determine Adherence for Total Neoadjuvant Therapy in Locally Advanced Rectal Cancer

Cynthia Araradian, Emmett Hunnicutt, Siting Chen, Shawna Rivedal, Shelby Willis, Maura Walsh, Vassiliki Liana Tsikitis, Sandy Hwang Fang

Background: Locally advanced rectal cancer (LARC) treatment has shifted from the utilization of neoadjuvant chemoradiation (NACRT), followed by total mesorectal excision (TME) and adjuvant chemotherapy (AC) to the implementation of total neoadjuvant therapy (TNT). This transition was influenced by data from multiple studies reporting suboptimal compliance rates to adjuvant chemotherapy. As a result, a paradigm shift to TNT occurred, consisting of chemoradiation with chemotherapy, based on the RAPIDO and PRODIGE-23 …

03.09.2026journal-article

Interactions

Predictive analysis of wear rate in SUP9 spring steel under controlled heat treatment cooling rates

Mamookho Elizabeth Makhatha, Sergei Sherbakov, Daria Podgayskaya, Pawan Kumar

Abstract In the present work, SUP9 spring steel specimens were reheated to 1000 °C in a controlled muffle furnace to obtain a homogeneous austenitic structure. The specimens were then cooled at different rates (0.1, 5, 100, 375, and 650 °C) to generate varied microstructures. Increasing the cooling rate refined the pearlitic microstructure, resulting in a finer and more uniform grain structure. These heat-treated specimens were then subjected to the wear test to study the influence of cooling rate ( dT/dt ), load ( …

03.09.2026journal-article

Frontiers in Oncology

Case Report: Radical nephroureterectomy after toripalimab plus disitamab vedotin in biomarker-non-enriched upper tract urothelial carcinoma

Guohui Cheng, Quan Zhang, Rundong Li, Zhongze Zhou, Xiangbin Kong, Zhilong Dong

Upper tract urothelial carcinoma (UTUC) is uncommon and aggressive, and evidence for perioperative antibody-drug conjugate or immunotherapy remains limited. We report a 59-year-old man with biomarker-non-enriched high-risk ureteral UTUC treated with four cycles of toripalimab plus disitamab vedotin before planned surgery. Magnetic resonance urography, urine cytology, and ureteroscopic biopsy supported high-grade UTUC with glandular differentiation; CDX-2, villin, and β-catenin positivity prompted exclusion of a gas …