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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Psychiatry

Clinical characteristics and neuropsychiatric profiles of young-onset dementia: a retrospective cross-sectional study at a tertiary care center in Northern Thailand

Sirivipa Jekpoo, Kittithatch Booncharoen, Supisara Prompila, Tinakon Wongpakaran, Huali Wang, Nahathai Wongpakaran

Background Data on young-onset dementia (YOD) in Thailand remain limited. We aimed to describe clinical presentation, general cognitive performance, neuropsychiatric symptoms, neuroimaging features, and selected laboratory findings across YOD subtypes in a tertiary-care cohort in Northern Thailand. Methods We conducted a retrospective cross-sectional study of 295 individuals with YOD (symptom onset < 65 years) treated at Chiang Mai University Hospital (2010–2025). Data extracted included demographics, presenting co …

03.09.2026journal-article

Psicologia: Reflexão e Crítica

Spanish version of the personal experience of aging scale: psychometric analyses from classical and network psychometrics approaches in a Chilean sample

Oscar Terán-Mendoza, Vicente Cancino

Abstract Background How people experience aging is linked to health, well-being, and engagement in later life, but Spanish-language measures for capture self-perceptions of aging in Latin America remain limited. Objective To adapt the Personal Experience of Aging Scale (PEAS) into Spanish and evaluate its psychometric properties in Chilean adults aged 50 and older. Methods The instrument was translated into Spanish, and content validity was examined by expert judges. Two independent community samples from Chile (ex …

03.09.2026journal-article

Frontiers in Psychiatry

Prevalence, role impairment, and mental health service utilization of depressive disorders among community-dwelling older adults in China

Dandan Wang, Xiaofei Hou, Zhaorui Liu, Yueqin Huang, Shuiyuan Xiao, Lingjiang Li, Tingting Zhang, Jie Yan, Yaqin Yu, Xiufeng Xu, Zhizhong Wang, Yifeng Xu, Tao Li, Xiangdong Xu, Limin Wang, Yongping Yan, Minghui Li, Guangming Xu, Huifang Yin

Background Depressive disorders pose a significant public health burden, particularly among older adults. However, their prevalence, associated factors, role impairment, and mental health service utilization patterns among community-dwelling older ay -30dults in China remain understudied. Methods The data for this study were obtained from the China Mental Health Survey (CMHS) among participants aged 60 years and older. The World Health Organization Composite International Diagnostic Interview Version 3.0 (CIDI 3.0) …

03.09.2026journal-article

BMC Geriatrics

Challenges and solutions to family engagement in the medication management of older adults during transitions of care: a qualitative exploratory study

Caitlin Deery, Kerry Hwang, Grace Marconi, Maneesh Prasad, Kelly Ottosen, Stephanie Garratt, Pauline Wong, Elizabeth Manias

Abstract Background The presence of multimorbidity and polypharmacy in older adults (aged 65 years and older) increases their susceptibility to medication harm, particularly during transitions of care. Family members are a source of continuity throughout transitions of care, but their medication competence remains largely underutilized. We sought to explore family members’ perspectives regarding the challenges and possible solutions for improving their engagement in the medication management of older adults during …

03.09.2026journal-article

Science

Longitudinal dynamics of gene expression and metabolomics in an aging population cohort

Julia S. El-Sayed Moustafa, Anna Ramisch, Yasrab N. Raza, Gwenael G. R. Leday, Yunlong Jiao, Dongmeng Wang, Michael Stevens, Amy L. Roberts, Max Tomlinson, Xinyu Yan, Elizabeth Ing-Simmons, Samuel Wadge, Moustafa Abdalla, Mario Falchi, Christopher C. Holmes, Cristina Menni, George Nicholson, Mark I. McCarthy, Emmanouil T. Dermitzakis, Sylvia Richardson, Tim D. Spector, Kerrin S. Small

Multiomic profiling provides a comprehensive physiological overview at the molecular level, but understanding of its spatiotemporal dynamics remains limited in human populations. We profiled longitudinal whole-blood gene expression and metabolite levels in 335 females over 8 years. Levels of 5061 genes and 181 metabolites changed over time, with individual trajectories often diverging from population-level trends. Longitudinally variable genes showed cell type specificity and enrichment for aging-relevant pathways, …

03.09.2026journal-article

Medicina

Pre-Thrombolysis Biological Correlates of Admission Glasgow Coma Scale in Older Adults with Acute Ischemic Stroke: A Retrospective Single-Center Cohort Study

Sorina Nicoleta Munteanu, Adrian Stan, Aurel Nechita, Dorel Firescu, Mihai Cristian Marinescu, Claudiu Elisei Tanase, Ioana Navalici, Dana Tutunaru, Mihaela Moisei, Aurelia Romila

Background and Objectives: Biological correlates of baseline clinical responsiveness remain incompletely characterized in older adults with acute ischemic stroke treated with intravenous thrombolysis. We evaluated associations between admission Glasgow Coma Scale (GCS) and pre-thrombolysis hematologic, inflammatory, iron-status, and micronutrient parameters. Materials and Methods: This retrospective single-center cohort included 95 unique patients aged ≥65 years, all treated with intravenous alteplase between 2020 …

03.09.2026journal-article

Obesities

Fluid Distribution Index and Bioelectrical Impedance Analysis in Adolescents and Adults: Reference Values in People Residing in Mexico

Carlos Abraham Herrera-Amante, César Octavio Ramos-García, Rodrigo Yáñez Sepúlveda, Wiliam Carvajal-Veitía, José Francisco Tornero-Aguilera, Vicente Javier Clemente-Suárez, Cristhian Mauricio Zapata Valencia, Boryi A. Becerra-Patiño, Daniel Rojas Valverde, José Francisco López-Gil

Background: Bioelectrical impedance vector analysis (BIVA) allows assessment of body composition and fluid distribution without relying on predictive equations. However, recent evidence shows that reference values from three decades ago are outdated and population-specific references are required. No large-scale BIVA references exist for populations residing in Mexico. Objectives: (1) to establish sex-stratified BIVA tolerance ellipses in a large sample of adolescents and adults (16–60 years) from Guadalajara; (2) …

03.09.2026journal-article

The Economic and Labour Relations Review

When work hurts: The health consequences of job stress and part-time work among a longitudinal sample of older European workers

Sabela Siaba, Berta Rivera, Luis Currais

Abstract In the context of population ageing and extended working lives, understanding how employment quality affects older workers’ health is of growing policy relevance. Although previous research has linked working conditions to health, significant gaps remain in panel designs, unobserved heterogeneity, measurement validity, and sample representativeness. Using longitudinal microdata from the Survey of Health, Ageing, and Retirement in Europe (SHARE), we estimate individual fixed-effects models over a 12-year pe …

03.09.2026journal-article

Current Issues in Sport Science (CISS)

Is Poor Sleep Associated with Lower Physical Function in Older Adults?

Michelle Slunecko, Barbara Wessner, Robert Csapo

Introduction & Purpose Poor sleep is a major contributor to mortality and many diseases. Epidemiological data suggests that sleep disturbances affect overall health and physical function [1] and growing evidence points to an association of sleep quality with muscle health and body composition across the lifespan [2]. Effective prevention and treatment programs rely on understanding the role of sleep in the development of sarcopenia and obesity. This project investigated the association of sleep quality with BMI and …

03.09.2026journal-article

Frontiers in Immunology

HIV associated immune aging among people living with HIV: implications for long-term antiretroviral therapy and potential HIV cure interventions in sub-Saharan Africa

Praiscillia Kia, Edward Kankaka, Patricia Kankundiye, Marcel Tongo, Rose Nabatanzi, Tokameh Mahmoudi, Damalie Nakanjako

Background Clinical and biological consequences of accelerated immune aging are substantial, with growing evidence of increased risk of non-communicable diseases (NCD) among people living with HIV (PLHIV). However, there is limited understanding of reliable biomarkers of immune aging, singly or in combination, that can be used for monitoring HIV treatment in large longitudinal cohorts in sub-Saharan Africa (SSA). This review describes candidate biomarkers of immune aging during HIV treatment and their potential cli …

03.09.2026journal-article

Frontiers in Neurology

Robot-assisted gait training in people with subacute and chronic stroke: a randomized controlled trial

Michaela Stampfer-Kountchev, Sarah Mildner, Isabella Hotz, Janice Habig, Markus Pröglhöf, Johanna Panzl, Christian Brenneis, Barbara Seebacher

Introduction The effectiveness of robot-assisted gait training (RAGT) after stroke remains uncertain, particularly regarding its role across different recovery stages. This single-blind, randomized, parallel-group trial examined whether a 4-week inpatient program of end-effector-based RAGT plus conventional physiotherapy (RAGT+CPT) improved walking ability and basic activities of daily living (ADL) more than conventional physiotherapy alone (CPT), and whether effects differed by stroke phase. Methods One hundred pe …

03.09.2026journal-article

Frontiers in Aging

Peripheral adaptive immune remodeling associated with severe hearing loss in older adults: a single-center flow-cytometry study with mouse cochlear transcriptomic context

Qunhui Zhang, Wei Liu, Meijun Shao, Jinyu Wang, Qianyi Zhong, Linlan Jiang

Objective To investigate the association between severe hearing loss and systemic immune aging in older adults using participant-level clinical immunophenotyping, and to explore potential inflammatory pathways and cellular contexts using public mouse cochlear transcriptomic data. Methods We analyzed a single-center cohort of 76 older adults, classified into normal hearing (NH), mild-to-moderate hearing loss (MMHL), or severe-to-profound hearing loss (SPHL) groups. Age- and sex-adjusted models were used to assess im …

03.09.2026journal-article

Current Issues in Sport Science (CISS)

Digital Solutions in Exercise Therapy for Diabetes & Obesity: Using Smart Technology to Get People Moving

Othmar Moser

Physical activity and structured exercise are essential components of the management of diabetes and obesity (Moser et al., 2020)(Davies et al., 2022). Nevertheless, many people do not achieve recommended activity levels, and the translation of exercise recommendations into everyday life remains challenging. Digital solutions may help to overcome this gap by providing personalised guidance, continuous feedback and scalable support beyond traditional clinical settings (Moser et al., 2025). This keynote will explore …

03.09.2026journal-article

Journal of Experimental Political Science

Shared Discrimination’s Effect on Solidarity between People of Color Is Uniform Across Major Racial, Political, and Social Differences

Kasheena Rogbeer, Emily Ortiz, Efrén Pérez

Abstract Solidarity between people of color (PoC) is key to understanding multiracial coalition-building in the United States. However, limited statistical power has constrained research on whether shared discrimination’s effect on solidarity is reliably moderated by differences in race, political orientation, and social background, which structure the internal diversity of racially stigmatized subgroups within the mega-category, PoC. We report a preregistered meta-analysis of eight published experiments ( N = 5,81 …

03.09.2026journal-article

Frontiers in Medicine

Development and validation of a nomogram prediction model for perioperative delirium in older patients with osteoporotic fractures based on LASSO regression and multiple parameters

Ni Hua, Hongmei Yuan, Yanhong Wei, Zhenqi Wei, Yanping Feng, Yong Liu, Tongguang Xu, Suliang Zhao, Li Zhang, Xiaohong He

Background Perioperative delirium (POD) is a severe postoperative complication in older patients with osteoporotic fractures. This study aimed to establish a nomogram prediction model incorporating multisystem stress, inflammation and frailty-related biomarkers for risk prediction. Methods This retrospective cohort study included 176 older patients (≥65 years) with osteoporotic fractures. Potential predictors, including the rate-pressure product (RPP), systemic inflammation response index (SIRI) and prognostic nutr …

03.09.2026journal-article

Brain Sciences

Cognitive Stimulation and Training in People with Mild-to-Moderate Alzheimer’s Disease: A Scoping Review

Rosa Martins, Nélia Carvalho, Ricardo Loureiro, Joana Bernardo Loureiro

Background/Objectives: Cognitive stimulation and cognitive training are used as non-pharmacological approaches to support people living with Alzheimer’s disease, but Alzheimer-specific evidence is dispersed across heterogeneous intervention formats. This scoping review mapped structured cognitive stimulation and training interventions evaluated in people with mild-to-moderate Alzheimer’s disease and summarized the cognitive, emotional, functional, and follow-up outcomes reported. Methods: The review was conducted u …

03.09.2026journal-article

Journal of Alzheimer’s Disease

Differential associations of individual- and neighborhood-level socioeconomic status with mortality in dementia: Findings from the Mayo Clinic Study of Aging

Jie Lin, Maria Vassilaki, Jennifer St. Sauver, Ronald C. Petersen, Chung Il Wi, Young J. Juhn, Jun Chen, Yuk Sham, Sunghwan Sohn

Background Alzheimer's disease (AD) and related dementias are leading causes of death worldwide. While socioeconomic status (SES) is a critical determinant, its impact on mortality after diagnosis remains understudied. Objective To investigate the roles of neighborhood-level and individual-level SES in predicting mortality risk among older adults with incident dementia. Methods We analyzed data from 924 participants with incident dementia from the Mayo Clinic Study of Aging (N = 6909), a cohort with clinical follow …

03.09.2026journal-article

Nutrition and Health

Antioxidant status and dehydroepiandrosterone sulfate in aging: Evidence from MIDUS 3 biomarkers cohort

Laith Ashour, Leen Altiti, Rand Khawaldeh, Batool Abuqudaira, Rakan Hani Wadi, Mera Jaber, Basae'r Najadat, Shaima Jaber, Rand Ibrahim Awwad, Tuqa Waleed Smadi, Sara Jamal Mohammad

Background Dehydroepiandrosterone sulfate (DHEAS) has been consistently linked to cardiovascular and skeletal health; however, the relationship between circulating antioxidant concentrations, including vitamins, and DHEAS levels in older adults has been insufficiently examined. Aim To assess associations between serum DHEAS and five antioxidants: β-cryptoxanthin, total lycopene, α-tocopherol, γ-tocopherol, and retinol. Methods Data from the Midlife in the United States (MIDUS3) Biomarker Project (2017–2022) were an …

03.09.2026journal-article

AIDS and Behavior

Self-reported and Point-of-Care Biomarkers of Substance Use Measures Among Older Adults with HIV from Low- and Middle-Income Countries

Kathryn E. Lancaster, Melissa A. Stockton, Judith A. Hahn, Thida Chanyachukul, Ivan Marbaniang, Dhanushi Rupasinghe, Hai Thi Thanh Nguyen, Edith Kwobah, Helen Byakwaga, Aggrey Semeere, Suzanne Goodrich, Patrizia Carrieri, Gad Murenzi, Hugo Perazzo, Brenda Crabtree Ramírez, Jessica Mejía, Andreas D. Haas, Ardele Mandiriri, Albert Minga, Marie Plaisy, Antoine Jaquet, Angela M. Parcesepe, the Sentinel Research Network of the International epidemiology Databases to Evaluate AIDS, Rohidas T. Borse, Vidya Mave, Smita Nimkar, Thach Ngoc Pham, Dung Thi Hoai Nguyen, Dung Thi Nguyen, Jeremy L. Ross, Kathy Petoumenos, Rodrigo Moreira, Sandra W. Cardoso, Valdilea G. Veloso, Beatriz Grinsztejn, Paola Alarcón-Murra, Alvaro López-Iñiguez, Jessica Mejía-Castrejón, Sharon Ortiz-Valdespino, Jessica Castilho

Abstract Measuring alcohol and other drug (AOD) use remains challenging in HIV care in low- and middle-income countries, where self-report and point-of-care (POC) urine biomarkers capture different time windows. Among 2,059 people with HIV aged 40 years or older across eight IeDEA clinics (2020 to 2022), we examined what self-reported AOD use (AUDIT, ASSIST) and POC urine tests (uEtG for alcohol; 5-panel drug screen) each capture. Self-report identified more use than urine testing (unhealthy alcohol 19.7% versus uE …

03.09.2026journal-article

Dementia

Social Interactions Between People Living With Dementia and Staff in Health and Social Care Settings: A Scoping Review

Stephanie Janka-Spurlock, Georgia Page, Gary Hodge, Helen Lloyd, Susie Pearce

Dementia is an umbrella term for progressive conditions affecting memory, thinking, communication and other cognitive functions. These changes can make social interaction challenging, particularly in unfamiliar or overstimulating environments . Although social interactions between staff and people living with dementia are recognised as an aspect of care, existing literature across health and social care settings largely focuses on general care needs and experiences rather than social interaction specifically. Conse …

03.09.2026journal-article

Vaccines

A Randomized Phase 3 Study to Evaluate the Safety, Tolerability, and Immunogenicity of the Bivalent RSVpreF Vaccine in Older Adults in Korea

Won Suk Choi, Karen Quan, James A. Baber, Anna Jaques, Karla Janse van Rensburg, Wen Li, Mark W. Cutler, Elena V. Kalinina, Annaliesa S. Anderson, Kena A. Swanson, Alejandra Gurtman, Iona Munjal

Background/Objectives: The bivalent RSVpreF vaccine is effective at preventing respiratory syncytial virus (RSV)-associated lower respiratory tract illness in adults. However, data regarding safety and immunogenicity of RSVpreF in Korean populations are limited. Methods: This was a phase 3, multicenter, placebo-controlled, randomized (2:1), double-blind study in Korean adults 60 years of age and older. Participants received a single 120-μg dose of RSVpreF or matching placebo. Safety endpoints included local reactio …

03.09.2026journal-article

Frontiers in Endocrinology

Joint trajectories of loneliness and depressive symptoms and risk of incident osteoporosis among middle-aged and older adults: a prospective cohort study

Dongnan Chen, Lincheng Duan, Xiaoxue Huang, Jingyu Li, Dan Wu

Background Loneliness, depressive symptoms, and osteoporosis are major public health concerns in ageing populations worldwide. Although the interplay between mental and physical health is well recognized, evidence remains limited regarding whether long-term joint patterns of loneliness and depressive symptoms are prospectively associated with incident osteoporosis. This study aimed to investigate the prospective associations between joint trajectories of loneliness and depressive symptoms and incident osteoporosis …

03.09.2026journal-article

European Journal of Ageing

Self-reported social and motivational factors in health-related future intentions amongst older adults

Maria A. Nygaard, Eva Rubínová, Julia L. Allan, Júlia Stasová, Louise H. Phillips

Abstract Prospective memory (PM), the ability to form a specific intention and remember to carry it out at an appropriate future time, is critical in health-related contexts and has been found to decline significantly with age. Further, motivation plays a vital role in PM and previous research indicated that older adults are particularly motivated by the social relevance of PM tasks. However, little is known about the role of perceived social impact in older adults’ health intentions. The current study aimed to exp …

03.09.2026journal-article

European Review of Aging and Physical Activity

Predictive value of physical activity and walking time for dual cognitive-physical decline: a multinational cohort study using temporal deep learning and explainable AI

Zhenhao Lin, Haonan Liu, Young-Je Sim, Dong Li, Zhonghua Sun, Jingbo Zhang, Yuwen ShangGuan, Litao Yan

Abstract Objective To develop an interpretable deep-learning framework to identify risk factors for dual cognitive-physical decline in older adults and evaluate the impact of physical activity (PA) on functional trajectories. Methods Using HRS ( n = 11,574) for discovery and ELSA ( n = 3,810) for external validation, we employed a Temporal Attention Network (TAN) to screen 15 core variables. Six conventional machine-learning algorithms and TAN were compared, with SHAP used to interpret the best-performing model. PA …