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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

Journal of Alzheimer’s Disease

APOE ε4 and peripheral metabolic network architecture in older adults

Dae Jong Oh, Ji Won Han, Tae Hui Kim, Kyung Phil Kwak, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Seok Woo Moon, Joon Hyuk Park, Seung-Ho Ryu, Dong Woo Lee, Seok Bum Lee, Jung Jae Lee, Jin Hyeong Jhoo, Ki Woong Kim

Background Whether apolipoprotein E ( APOE ) ε4 status shapes the organization of modifiable peripheral metabolic risk pathways for dementia prevention remains unclear. Most prior studies have focused on individual APOE -by-biomarker interactions rather than the broader conditional dependency structure among metabolic variables. Objective We aimed to examine whether APOE ε4 is conditionally connected to metabolic factors and whether network architecture differs by genotype. Methods In 2454 participants from the Kor …

28.08.2026journal-article

International Journal of Molecular Sciences

Liposomal Helix aspersa Snail Mucus: A Biomacromolecular Platform for Attenuating Chronological Skin Aging Through Modulation of miR-34a-Associated Senescence and Extracellular Matrix Remodeling

Esraa M. Mosalam, Hend Mohamed Abdel-Bar, AbdElhafez R. AbdElhafez, Mai El-Sayed Ghoneim, Ebtehal M. Metwally, Amany Ebrahim Nofal, Aya Ibrahim Elberri

Chronological skin aging is a complex biological process characterized by progressive collagen degradation and cellular senescence. Among the molecular regulators implicated in these hallmarks, miR-34a has emerged as a critical mediator linking inflammation and senescence pathways. Consequently, this study aimed to investigate the anti-aging potential of Helix aspersa snail mucus, with particular emphasis on its modulation of miR-34a-associated molecular mechanisms, and to explore liposomal encapsulation as a strat …

28.08.2026journal-article

Current Neuropharmacology

Statin Therapy for Primary Prevention in Adults Aged 80 Years and Older: A Systematic Review Conducted in Accordance with PRISMA 2020

Francisco Epelde

Introduction: Statins are well established for the primary prevention of cardiovascular disease (CVD) up to approximately 75 years of age; however, direct evidence in adults aged 80 years and older remains limited. Extrapolation from younger populations is uncertain because advanced age is associated with greater competing mortality, frailty, multimorbidity, polypharmacy, and a shorter remaining time in which benefit can accrue. Methods: We conducted a systematic review in accordance with PRISMA 2020. A prespecifie …

28.08.2026journal-article

Frontiers in Genetics

Homeostatic conflict as a driver for brain aging

Cristian A. Wulkop-Gil, Michael Petrascheck

Mammalian tissue function depends on the balance between proliferative, mitotic cell populations and irreplaceable post-mitotic cells. Throughout life, aging progressively disrupts cell type balance and thus tissue function through opposing forces on different cell types. Aging promotes the aberrant proliferation or entry into pro-inflammatory senescent states of mitotic cells, while contributing to the functional erosion and, in vulnerable populations, loss of post-mitotic irreplaceable cells. The divergent age-as …

28.08.2026journal-article

Frontiers in Sports and Active Living

Lower limb exoskeletons for older adults: key assistance parameters and evaluation of ankle assistive strategies via musculoskeletal modelling

Josée Mallah, Luigi G. Occhipinti

Aging comes with physiological changes resulting in alterations to gait, decline of muscle function, and balance that contribute to reduced mobility, increased metabolic cost of walking, and elevated fall and injury risks in older adults. Wearable lower-limb exoskeletons have emerged as a promising strategy to support healthy aging; however, identifying optimal assistance strategies remains challenging due to the complexity and cost of experimental testing. In this study, we combined musculoskeletal modelling and s …

28.08.2026journal-article

European Journal of Health Research

HIV-Associated Dementia: Current Diagnostic Challenges and Implications for Comprehensive Care. A Narrative Review

Alfredo Duvergel Moreira, Juan Carlos de la Cruz González, Mohamed Azis Pérez-Caldevilla

Introduction: HIV-associated dementia (HAD) has become less frequent in the antiretroviral therapy era, but its diagnosis and management pose new challenges because of aging, multimorbidity, and the diverse causes of cognitive impairment among people with HIV. Objective: To characterize HAD in the current context, considering its clinical, neurocognitive, and psychosocial features, as well as current diagnostic challenges and implications for comprehensive care. Methods: The review followed SANRA criteria. Searches …

28.08.2026journal-article

Hacettepe University Faculty of Health Sciences Journal

Examining the Relationship Between Occupational Balance, Spirituality, and Quality of Life in Older Adults

Yasin Tekeci, Mustafa Cemali, Berkan Torpil

Introduction: This study aimed to examine the relationships between occupational balance, spiritual well-being, and quality of life (QoL) in older adults, and to evaluate the effects of these variables on occupational balance.Methods: This cross-sectional study included 156 volunteers aged 65 years and older without cognitive impairment. Data were collected using the Occupational Balance Questionnaire, the Spiritual Well-Being Scale and the WHOQOL-BREF Quality of Life Scale. Pearson correlation and multiple linear …

28.08.2026journal-article

Frontiers in Psychology

How people evaluate anti-corona measures II—Lessons for future crises from a longitudinal study and qualitative analysis

Hendrik Godbersen, Susana Ruiz-Fernández

The COVID-19 pandemic represents an unprecedented health crisis in modern times. The pandemic itself and governmental counter-measures severely affected the individual and social lives of people around the globe. Against this backdrop, we examined how people evaluated the main anti-corona measures — restrictions on outdoor activities, tips for hygiene, and tips for mental health — with regard to the elements of the Theory of Planned Behavior (attitude, subjective norm, and perceived behavioral control) and four soc …

28.08.2026journal-article

Current Aging Science

Brain Dynamics During Delirium: An Exploratory Study

Alice Greenwood, Johan van der Meer, Sarah Ward, Michael Breakspear, Eamonn Eeles

Objective: Disrupted Brain dynamics are implicated in delirium. We aimed to better understand the characteristics of functional brain activity as a model for delirium. Methods: Measurement of functional brain connectivity at rest and during task-based activities in acutely delirious patients in a convenience sample of patients with delirium versus controls. Dynamic jumps between discrete brain states were modelled using the hidden Markov modelling (HMM), an analytical framework that posits the existence of distinct …

28.08.2026journal-article

Science Advances

Development of mitochondrial mutator pigs exhibiting increased mitochondrial DNA mutations and premature aging via prime editing

Fangbing Chen, Yanhui Liang, Wei Zheng, Aobo Yao, Ning Wang, Huangyao Chen, Zhenpeng Zhuang, Meng Lian, Yu Zhao, Zhen Ouyang, Zhaohai Zhou, Weikai Ge, Qishuai Liu, Yinghua Ye, Liangxue Lai, Kepin Wang

The accumulation of mitochondrial DNA (mtDNA) mutations is a primary driver of mitochondrial dysfunction, which is intrinsically linked to aging and various pathologies. POLG, the catalytic subunit of DNA polymerase gamma, is essential for mtDNA replication; notably, a deficiency in its proofreading function precipitates the accumulation of mtDNA mutations. In this study, by combining prime editing with somatic cell nuclear transfer technology, we successfully generated a mitochondrial mutator pig model expressing …

28.08.2026journal-article

American Journal of Physiology-Renal Physiology

Renal Single-Nucleus Transcriptomic of a New Model of Cardiovascular-Kidney-Metabolic (CKM) Syndrome in Aging Swine

Alfonso Eirin, Sathesh K. Sivasankaran, Rhys Sitz, Elizabeth A. McCarthy, Samuel Anthony Martin, Alejandro R. Chade

CKM syndrome entails pathophysiological interactions among the heart, the kidneys, and metabolic derangements. The specific cell populations implicated in renal injury have yet to be identified. We leveraged a new model of CKM syndrome in aging swine and single-nucleus RNA sequencing (snRNA-seq) to investigate the renal cell-specific transcriptomic profile and set the stage for future testing of potential new targets. Aging pigs with CKM syndrome were studied for 14 weeks. Kidneys were harvested, nuclei isolated, s …

28.08.2026journal-article

JMIR Research Protocols

Prevalence of Periodontitis and Tooth Loss Among Older Adult Women With Low Bone Mineral Density: Protocol for a Cross-Sectional Study

Shirmila Syamala, Sukumaran Anil, Jafar Alabdallah, Seham Alyafei, Yasmine Eid, Aishah Althuwaini, Yasemin Sezgin

Abstract Background Periodontitis and low bone mineral density (BMD) are both highly prevalent among older women and share inflammatory and metabolic pathways, yet their co-occurrence and combined impact on tooth loss remain insufficiently characterized, particularly in Middle Eastern populations. Active matrix metalloproteinase-8 (aMMP-8), measured by point-of-care testing (PoCT) in oral rinse, is a candidate biomarker that may support periodontal screening in geriatric settings. Objective The primary objective is …

28.08.2026journal-article

Vaccines

Vaccination Uptake and Pandemic-Related Healthcare Experiences Among People Living with HIV in Romania: A Cross-Sectional Study

Adrian Gabriel Marinescu, Aida-Isabela Adamescu, Cătălin Tilișcan, Daniela Pițigoi, Sebastian Ciobanu, Laurențiu Mihăița Stratan, Carmen Cristina Vasile, Victor Daniel Miron, Mariana Mardarescu, Dalila Toma, Andreea Iuliana Ciobanu, Victoria Aramă, Ștefan Sorin Aramă

Background: The COVID-19 pandemic exposed major vulnerabilities in healthcare accessibility and may have influenced preventive attitudes among people living with HIV (PLWH). However, the relationship between pandemic-related healthcare experiences and vaccination uptake remains insufficiently understood. Materials: A cross-sectional survey was conducted among 203 adults living with HIV receiving follow-up care in Romania between October 2025 and March 2026. The questionnaire evaluated vaccination uptake, vaccine-re …

28.08.2026journal-article

Antioxidants

Natural-Product-Derived Antioxidants and DNA Methylation-Based Epigenetic Aging: A Systematic Review of Human Intervention Studies

Fatemeh Taktaz, Salar Hafez-Ghoran

DNA methylation clocks provide a tractable molecular readout for testing whether nutritional and natural-product interventions can modify biological aging. Natural-product-derived antioxidants are biologically plausible candidates because they influence redox signaling, inflammation, mitochondrial function, microbial metabolism and epigenetic regulation, yet their effects on DNA methylation-based aging remain difficult to interpret. Here, we systematically synthesize human intervention studies evaluating antioxidan …

28.08.2026journal-article

PLOS Aging and Health

Middle-aged chair stands predict mortality risk

Nicolle A. Mode, Alan B. Zonderman, Michele K. Evans

The five chair stand test (CST-5) has been used for decades in the elderly to assess physical performance and predict future fall and mortality risk, but its use is less common for middle-aged adults. We examined longitudinal measures of the CST-5, a 60-second assessment of leg strength, endurance, and balance by five repeated stands from a seated position, in a cohort of middle-aged adults and their relation to mortality risk. This longitudinal prospective cohort study examined CST-5 at four visits and mortality o …

28.08.2026journal-article

Frontiers in Public Health

Public–private partnerships for UAV-assisted emergency medical services in aging communities: an evolutionary game approach

Jingling Zhong, Yali Gao

Objective To analyze the current “market failure” in the large-scale deployment of UAV-assisted automated external defibrillator (AED) delivery networks for aging communities, and to explore innovative “Public–Private Partnership” (PPP) business models to overcome the “cold-start” institutional deadlock. Methods This study introduces a three-party evolutionary game model comprising community representatives, medical institutions, and UAV operators. By integrating principles of “health economics,” we simulated the i …

28.08.2026journal-article

Frontiers in Public Health

Fear of dementia in adults without diagnosed dementia: an updated systematic review of prevalence, measurement, and correlates

Feng Chen, Sixian Li, Kuai In Tam, Huimin Su

Background Dementia is a major public health concern. Adults, particularly older adults may experience fear of dementia due to concerns about current and future cognitive decline, loss of independence, or increased burden on their families. Previous reviews have mainly focused on concepts, measurement, or assessment tools. Therefore, it is necessary to summarize current evidence on fear of dementia among adults without a diagnosis of dementia. Objective To primarily synthesize the reported prevalence or levels, mea …

28.08.2026journal-article

Diabetes Obesity and Cardiometabolic CARE

Determinants of Cognitive Change Over 1 Year in Older Adults With Type 1 Diabetes

Miranda Zuniga-Kennedy, Justin Gillette, Hariharan Malmurugan, Jacob Satake, Anjali Sharma, Anika Bilal, Anna Casu, Robert J. Henderson, Yogish C. Kudva, Richard Pratley, Naomi Chaytor

OBJECTIVE Older adults with type 1 diabetes (T1D) have a greater risk for cognitive decline, highlighting the need to identify risk factors for meaningful cognitive change using brief screening tools suitable for annual wellness examinations. RESEARCH DESIGN AND METHODS This study examined determinants of 1-year cognitive change in 74 older adults with T1D (mean age 70 ± 4 years; 47% female). Cognitive outcomes included the Montreal Cognitive Assessment (MoCA) and the Processing Speed Index (PSI) from the Wechsler …

28.08.2026journal-article

Adolescent Research Review

Parents’ and Caregivers’ Understanding of Self-Harm in Young People: A Systematic Review

Heather Boughey, Jason Poole, Barbara Mezes

Abstract Self-harm among young people is a global concern. Parents and caregivers play a central role in supporting young people who self-harm, however, many report difficulties in understanding the behaviour and its meaning. This systematic review, therefore, aimed to identify variations in how self-harm is defined within studies and synthesize qualitative evidence on parents’ and caregivers’ understanding of self-harm in young people. Four electronic databases were searched to December 2024, alongside hand-search …

28.08.2026journal-article

International Journal of Innovative Technologies in Social Science

DIGITAL HEAT-HEALTH EARLY WARNING SYSTEMS FOR OLDER ADULTS: CLINICAL EVIDENCE, HEALTH EQUITY, AND PUBLIC POLICY IMPLICATIONS OF PERSONALIZED CLIMATE-HEALTH TECHNOLOGIES

Maria Woźniak, Zuzanna Zalewska, Julia Szymkowiak, Karolina Reczka

Extreme heat poses an increasingly serious threat to public health, particularly among older adults, for whom age-related impairment of thermoregulation, chronic diseases, polypharmacy, social isolation, energy poverty, and poor housing conditions increase the risk of heat-related morbidity and mortality. The aim of this review article is to provide a comprehensive overview of the evidence regarding digital early warning systems for heat-related effects in older adults, with particular emphasis on their clinical ba …

28.08.2026journal-article

People and Nature

Resilience‐as‐doing: A relational model for living practice

Katie Moon

Abstract Dominant frameworks treat resilience as a capacity to withstand disturbance and recover, something systems, communities or individuals either have or lack. This paper proposes a different understanding, grounded in relational onto‐epistemology and first‐person, practice‐based, autoethnographic inquiry situated within a household garden. I develop a conceptual model of resilience‐as‐doing: situated participation within an entangled, more‐than‐human relational field, rather than a property to be built or mea …

28.08.2026journal-article

Bolu Abant Izzet Baysal Universitesi Tip Fakultesi Abant Tip Dergisi

The Role of HbA1c, CRP/Albumin, and Neutrophil/Lymphocyte Ratio in Predicting Mortality in Geriatric Patients with Diabetic Foot Ulcers

Kübra Erdoğan, Arife Polat Düzgün

Objectives: This study aimed to evaluate the association between laboratory-based metabolic, inflammatory, and nutritional markers and in-hospital mortality among patients aged 65 years and older with diabetic foot ulcers. Materials and Methods: The retrospective study included 110 patients who were followed up for diabetic foot ulcers. Demographic characteristics, comorbidities, Wagner stage, length of stay, and routine laboratory parameters were recorded. The association of HbA1c, leukocyte count, neutrophil/lymp …

28.08.2026journal-article

Frontiers in Nutrition

Data-driven dietary patterns in relation to psychological distress and psychological quality of life among community-dwelling older adults in Shanghai, China: a cross-sectional study

Haonan Shi, Zuowei Wang, Jia Zhu, Miqiong Li, Wang Li, Weiyun Xu, Ziyi Sun, Cheng Chen, Chuan Zhang, Tingting Wang, Xuan Yao

Objectives: Evidence linking overall dietary patterns with psychological health in older adults remains inconsistent, particularly in urban China. We derived dietary patterns among community-dwelling older adults in Shanghai and examined their associations with multiple psychological outcomes. Methods We analyzed cross-sectional baseline data from adults aged ≥60 years recruited at two community health service centers in Shanghai. Previous-month diet was assessed using a modified quantitative 25-item food-frequency …

28.08.2026journal-article

Foods

Six Bioactive Small Molecules from Tremella fuciformis with Potential for Healthy Aging

Feifei Wang, Yuxuan Duan, Ziying Cai, Shidong Lin, Lingjun Yu, Yongbiao Zheng

Six representative small-molecule constituents were isolated and structurally characterized from the edible mushroom Tremella fuciformis: cis-oleic acid (1), 1-oleoylglycerol (2), cerevisterol (3), a cerebroside (4), trans-homoaconitic acid (5), and uridine (6). Compound 5, a tricarboxylic acid derivative, is reported for the first time as abundantly accumulated in this fungus. Aging-relevant assays showed that 1 potently inhibited α-glucosidase (IC50 = 0.02 mM, surpassing acarbose) and moderately inhibited acetylc …