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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

npj Aging

Aging-related transcriptomic signatures associated with recurrence following resection of stage I lung adenocarcinoma

Fares Darawshy, Cigdem Sevim Bayrak, Xianxiao Zhou, Kendrew Wong, Imran Sulaiman, Benjamin Kwok, Cecilia Chung, Alena Lukovnikova, Sofia Roldan, Benjamin G. Wu, Matthias C. Kugler, Yonghua Li, Rosemary Schluger, Destiny Collazo, Yaa Kyeremateng, Ray Pillai, Matthew Blaisdsell, Michelle Fridman, Alexander Bain, Marcus D. Goncalves, Chandra Goparaju, Daniel Sterman, Anil Vachani, Gregory David, Aristotelis Tsirigos, Bin Zhang, Christian V. Forst, Harvey Pass, Leopoldo N. Segal, Jun-Chieh J. Tsay

Abstract Age is an independent prognostic factor in early-stage non-small cell lung cancer, yet age-associated molecular differences and their association with cancer recurrence remain poorly understood. We investigated transcriptomic differences associated with aging and recurrence in stage I lung adenocarcinoma (LUAD). Bulk RNA sequencing was performed on tumor and adjacent normal lung tissue (NAT) from 126 patients with resected stage I LUAD. Differential expression, pathway enrichment, and multiscale embedded g …

28.08.2026journal-article

European Geriatric Medicine

A survey among geriatricians on geriatric oncology and geriatric surgical oncology models in Europe

Paula Sobrini-Morillo, Isabelle Moens, Alfonso Cruz-Jentoft, Andrea Sebastiano Ciccone, Jugdeep K. Dhesi, Nicolas M. Gonzalez-Senac, Marije Hamaker, Cecilia Lund, Francesco Mattace-Raso, Nina Neuendorff, Siri Rostoft, David Shipway, Giuseppe Dario Testa, Anja Velghe, Harmke A. Polinder-Bos, on behalf of the SIG Perioperative Geriatric Medicine and the SIG Gero-Oncology of the European Geriatric Medicine Society

Abstract Purpose To provide an up-to-date overview of geriatricians’ involvement in oncological and onco-surgical care for older adults across Europe. Methods An anonymous 35-item online survey was distributed via (inter)national societies between 10 April and 23 May 2025. The responses were summarized, and associations between comprehensive geriatric assessment (CGA) outputs, participation in oncological multidisciplinary team (MDT) meetings, and involvement in treatment decision-making were explored. Results A to …

28.08.2026journal-article

The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences

Cross-National Comparison of the Association between Adult Child Educational Attainment and Older Parents’ Functional Health

Yulin Yang, Karla Renata Flores Romero, Sirena Gutierrez, Ah-Reum Lee, Emma Nichols, Jacqueline Torres

Abstract Background Mounting evidence points to the protective role of adult child education in older parents' health, including their risk of ADL and IADL difficulties. Yet, little is known whether this association varies cross-nationally due to contextual differences in intergenerational transfers, family dynamics, and other factors. This study examines the relationship between adult child education and parents’ functional health outcomes across countries, using comparable population-based datasets. Methods We us …

28.08.2026journal-article

British Journal of Clinical Pharmacology

Potential drug–drug interactions and clinical outcomes among people living with HIV with comorbidities: A multicentre retrospective cohort study

Chanadda Wuttikul, Noppaket Singkham, Chadathorn Hongsudta, Jindarat Danpan, Chontawan Wannagon, Wuttikrai Chaimipak, Prakaikaew Jaiwanglok, Puttasorn Detmon, Sirayut Phattanasobhon

Aims This study aimed to determine the prevalence and patterns of potential drug–drug interactions (pDDIs), identify associated factors among people living with HIV (PLWH) with comorbidities and examine associations with clinical outcomes. Methods This multicentre retrospective study was conducted across three healthcare tiers in Thailand during 2023–2024. pDDIs were identified using Lexicomp (categories A–X). Multivariable logistic regression identified factors associated with pDDIs and assessed associations with …

28.08.2026journal-article

Pharmacoepidemiology and Drug Safety

Dementias in Older Women With Early‐Stage HER2 ‐Negative Breast Cancer Treated With Anthracycline Plus Taxane Versus Taxane‐Based Chemotherapy Regimens

Nguyen Le, Nirupama Anne, Chan Shen, Ratnakishore Pallapothu, Yan Liu, Chanhyun Park

ABSTRACT Background Anthracycline plus taxane (ATAX) regimens are associated with improved survival in HER2‐negative breast cancer (HBC) compared to taxane‐based (TAX) regimens. However, anthracyclines are known for their cardiotoxicity, which could increase the risk of neurocognitive deficits, raising concerns about neurocognitive safety, particularly in older adults. Limited evidence exists comparing neurocognitive outcomes between these two regimens. Objective To compare the incidence of Alzheimer's disease and …

28.08.2026journal-article

Research on Aging

Constraint or Warning? Health Shocks and Dietary Habits Among Older Adults in China

Keshan Liu, Yiwei Liu

Health shocks may reshape health behaviors in later life, yet their implications for dietary habits remain insufficiently understood. Using six waves of the Chinese Longitudinal Healthy Longevity Survey from 2002 to 2018, this study examines the association between serious illness episodes and dietary diversity among Chinese older adults. The results show that health shocks are significantly associated with lower dietary diversity. This association remains stable across sensitivity analyses. Heterogeneity analyses …

28.08.2026journal-article

Frontiers in Physiology

Wearable-derived heart rate variability responses to a mind-body exercise intervention in older people from high southern latitudes (Chilean Patagonia, ~53°S)

Diego Mabe-Castro, Ruby Méndez-Muñoz, Pablo Sanhueza, Matías Castillo-Aguilar, Ginés Viscor, Antonio Zamuner, Cristian Núñez-Espinosa

Background High southern latitudes expose older adults to chronic cold and marked seasonal light variability, potentially challenging physiological resilience. Yet, few interventions have examined stress-related autonomic regulation in these geographically extreme contexts, and wearable-derived heart rate variability (HRV) frameworks remain insufficiently tested. Objective To evaluate a wearable-derived HRV framework, including signal quality control and Bayesian multivariate modeling, to characterize resting and e …

28.08.2026journal-article

Journal of Clinical Psychology in Medical Settings

Treating Multiple Chemical Sensitivity as a Specific Phobia Using Cognitive Behavioural Therapy: A Case Study in an Older Adult

Matthew Wilcock, Alice Loyal, David Hitt

Abstract Multiple Chemical Sensitivity (MCS) is a poorly understood condition characterised by physical symptoms triggered by minimal exposure to odorous or chemical agents, often without identifiable organic pathology. This case study describes cognitive behavioural therapy (CBT) for MCS in an older adult referred to a respiratory team after developing persistent, generalised reactions to odours following an acute toxic inhalation. Symptoms led to severe avoidance, functional impairment and suicidal ideation. Foll …

28.08.2026journal-article

JMIR Aging

Assessing a Digital Platform (KOKU-Nut) to Improve Nutrition in Older Adults: Mixed Methods Feasibility Randomized Controlled Trial

Chloe French, Sorrel Burden, Jaheeda Gangannagaripalli, Emma Stanmore

Abstract Background Keep-on-Keep-up Nutrition (KOKU-Nut) is a free, tablet-based digital platform that focuses on increasing physical activity and improving the dietary intake of older adults. Objective The aim of this study was to assess the feasibility of using KOKU-Nut among community-dwelling older adults. Feasibility was assessed by considering recruitment and retention rates, acceptability of the intervention, and study design. Methods Participants (community-dwelling adults aged ≥65 years) were randomized 1: …

28.08.2026journal-article

Frontiers in Child and Adolescent Psychiatry

Co-designing and piloting adolescent-adapted social rhythm therapy for young people with unipolar and bipolar depression: a mixed-methods feasibility case series

Gonzalo Salazar de Pablo, Claudia Aymerich, Zahra Kamran, Cecilia Sanjuan-Ortiz, Nuria Laherran-Cantera, Shantal Zeb, Eleonora Armyra, Allan H. Young, Aditya Sharma, Cornelius Ani, Manasi Kumar, Holly A. Swartz

Objective Depressive and bipolar disorders commonly emerge during adolescence and are associated with disturbances in sleep, daily routines and social rhythms, as well as functional impairment. Social Rhythm Therapy (SRT) targets these processes. However, adult-derived rhythm protocols do not adequately reflect adolescents’ school and family schedules, developmental autonomy, social and digital routines, or preferences regarding monitoring. Direct youth co-design is therefore needed to improve developmental fit, en …

28.08.2026journal-article

Health Affairs Scholar

Primary Care Physician Characteristics and Potentially Inappropriate Medications in Older Adults

Yuki Tatsuno, Catherine A Sarkisian, John N Mafi, Kei Kitajima, Daichi Sato, Yusuke Tsugawa, Atsushi Miyawaki

Abstract Background Potentially inappropriate medications (PIMs) are a growing public health concern. While research in North America suggests physician characteristics were associated with PIM prescription, their generalizability to other countries remains understudied. Methods We conducted a cross-sectional study using a nationwide electronic health record database of primary care clinics in Japan. We analyzed patients aged ≥75 years who visited solo-practice physicians at least quarterly during October 2022 to S …

28.08.2026journal-article

Medicine

The platelet-to-high-density lipoprotein cholesterol ratio as a potential biomarker linking tobacco exposure to accelerated reproductive aging in women

Jie Liao, De Qiong, Dawa Zhuoma, Weiwei Ning, Da Ga, Silang Quncuo, Jing Jing, Lingxiu Li, Yalan Li, Xin Li, Bin Lv, Hengxi Chen

Female reproductive aging, commonly reflected by menopausal age and reproductive lifespan, is influenced by environmental exposures and metabolic health, and tobacco exposure has been associated with earlier menopause and shortened reproductive lifespan. Because this association may involve inflammatory activation and lipid-metabolic alterations, the platelet-to-high-density lipoprotein cholesterol ratio (PHR) may provide a useful composite marker for evaluating tobacco-related reproductive aging. We analyzed data …

28.08.2026journal-article

Journal of Clinical Medicine

Balance and Mobility Impairment in Older Adults with Cardiovascular Disease Before and After Rehabilitation: A Narrative Review

Zhengyang Song, Sasha Douglas, Imran Khan Niazi, Yanxin Zhang, Jocelyne Benatar, Paul W. Marshall

Balance impairment threatens mobility and independence in older adults with cardiovascular disease, yet cardiac rehabilitation (CR) has traditionally prioritised aerobic capacity and cardiovascular outcomes. This narrative review examines the mechanisms and assessment of balance impairment, balance recovery within CR, and implications for clinical practice. Balance impairment reflects interactions among musculoskeletal, sensory, cognitive–motor, and cardiovascular constraints that affect different domains of postur …

28.08.2026journal-article

Current Alzheimer Research

Psychotropic Polypharmacy in Alzheimer’s Disease: A Potentially Inappropriate Medication Perspective in Older Adults

Kang-Jinyuan Gou, Yuhao Chen, Zehu Sheng, Weihua Yu, Lanyang Wang, Yang Lü

Neuropsychiatric symptoms (NPS) are highly prevalent in Alzheimer’s disease (AD). Consequently, potentially inappropriate medication (PIM) use is particularly common among older adults with AD. Psychotropic polypharmacy may increase the risk of various adverse outcomes beyond cognitive decline. Although geriatric prescribing criteria and dementia-care guidelines offer important safety recommendations, a clinically integrated framework for potentially inappropriate psychotropic medication use in older adults with AD …

28.08.2026journal-article

Middle East Current Psychiatry

Impact of Menopausal Hormone Therapy on cognitive function and dementia Risk: A systematic review and meta-analysis focusing on the timing hypothesis and administration route

Shih-Shuan Fang, Sheng-Han Chen

Abstract Background The relationship between menopausal hormone therapy (MHT) and the trajectory of cognitive function in midlife and later life remains one of the most consequential and contested questions in women’s health. The “critical window” or timing hypothesis posits that the cognitive consequences of exogenous estrogen depend on when therapy is initiated relative to the menopausal transition, and on which formulation, route, dose, and duration are used. After two decades of randomised trials and large phar …

28.08.2026journal-article

BMC Geriatrics

Direct-access model for dysphagia management in community-dwelling older adults: retrospective analysis of 120 patients

Raymond Fong, Connie C. Y. Kwan, S. F. Yu, Mavis S. M. Chan, Yuki Y. Y. Choi, Phoenix Y. F. Wei, Wency W. S. Ho

Abstract Background Oropharyngeal dysphagia is a significant geriatric syndrome linked to severe clinical complications, yet community-dwelling older adults frequently normalize symptoms, leading to under-reporting and delayed care. While hospital-based management is highly protocolized, routine community screening remains low. This study evaluates a community-integrated service model designed as an alternative to traditional medical gatekeeping through public health literacy outreach and direct patient access. Met …

28.08.2026journal-article

Wellcome Open Research

Development and External Validation of a Treatment-Adjusted Machine Learning Model to Support Risk-Informed Group-Based Depression Care for People Living with HIV in Uganda

Shakira Babirye, Rongjie Huang, Chengbo Zeng, Jeremiah Mutinye, Barbara Kemigisha, Kizito Wamala, Rosco Kasujja, Kenneth Kalani, Raquel Andres Martinez, Etheldreda Nakimuli-Mpungu

Background Group-based depression care is widely used in HIV services in Uganda, yet some patients remain symptomatic following treatment. We developed and externally validated a treatment-adjusted machine learning model to support risk-informed group-based depression care for people living with HIV (PLWH). Methods We analyzed data from 1,140 adults living with HIV and significant depression symptoms enrolled across 30 HIV clinics in the SEEK-GSP trial (PACTR201608001738234). Participants received either Group Supp …

28.08.2026journal-article

Journal of Head Trauma Rehabilitation

Multidimensional Preinjury Health and 6-month Outcome After Traumatic Brain Injury in Older Adults Presenting With Mainly GCS 13–15

Roy Tzemah-Shahar, Yael Rosen Lang, Ava M. Puccio, Esther L. Yuh, Domenico Lombardi, Michele Diaz Nelson, John Boscardin, J. Russell Huie, Kristine Yaffe, David O. Okonkwo, Ramon Diaz Arrastia, Geoffrey T. Manley, Raquel C. Gardner, the TRACK-TBI Investigators

Objective: To test the accuracy of existing traumatic brain injury (TBI) outcome prediction models in older adults with TBI (oaTBI), to determine the independent association of 5 different measures of preinjury health with 6-month outcome, and to investigate whether these preinjury health measures improve outcome prediction. Setting: Two level 1 trauma centers. Participants: A total of 112 adults aged ≥65 years who underwent head computed tomography after acute TBI (95% with Glasgow Coma Scale (GCS) score 13–15, 66 …

28.08.2026journal-article

Nutrients

Association Between Oral Frailty and Body Mass Index in Late-Stage Older Adults Stratified by Sarcopenia Status

Masaki Hayase, Kazuhito Miura, Kimiya Ozaki, Yasushi Tamada, Maki Shirobe, Keiko Motokawa, Misato Hayakawa, Hirohiko Hirano, Takahiro Ono, Eri Arai, Masanori Iwasaki, Akira Adachi, Takao Watanabe, Shigekazu Komoto, Yutaka Watanabe

Objectives: Oral frailty is associated with sarcopenia and underweight; however, its relationship with sarcopenic obesity remains unclear. This cross-sectional study investigated the associations between oral frailty and body mass index (BMI) categories (underweight/obesity), stratified by sarcopenia status. Methods: Data were obtained from dental checkups for 3829 older adults in Tottori, Japan (1489 men and 2340 women, mean age: 80.1 ± 4.3 years). Participants were divided into sarcopenia risk and non-sarcopenia …

28.08.2026journal-article

The Anáhuac Journal

El empaque como detonante de valor en jóvenes: percepciones, significados en la decisión de compra

Erika Dolores Ruiz, Adriana Paloma Manzo Martínez, Erika Murillo Ramón

El propósito del estudio fue analizar la percepción del empaque en sus dimensiones visuales, simbólicas y de sostenibilidad, y su influencia en la decisión de compra de consumidores jóvenes. Se basó en una metodología cuantitativa, no experimental y transversal, con un alcance correlacional-explicativo. Se trató de muestra estadística, aleatoria simple, integrada por 374 jóvenes de Veracruz, México. Se utilizó una encuesta de tipo Likert, validada estadísticamente. Se aplicaron análisis descriptivos y la prueba de …

28.08.2026journal-article

Creative Science

A health planning expert system for promoting quality of life among older adults in Buriram province

Wilairat Yathongchai, Chusak Yathongchai, Phuangphet Ratchaprakhon

This study aimed to (1) develop a knowledge base for health planning among older adults and (2) develop and transfer an expert system to support personalized health planning and promote the quality of life of older adults in Buriram Province, Thailand. This applied research adopted the System Development Life Cycle (SDLC), comprising five main phases: Knowledge Acquisition and Contextual Requirements Analysis; Ontology Design and Knowledge Base Construction; System Analysis, Design, and Development based on object- …

28.08.2026journal-article

Scientific Notes of Junior Academy of Sciences of Ukraine

Development of software and scientific–methodological tools for researching environmental awareness among young people: architecture, questionnaire and data analysis algorithm in Python

K. О. Malinina, O. М. Shylo

This article presents an original scientific, methodological and curricular framework designed for a comprehensive study of environmental awareness among young people in the context of contemporary social transformations and Ukraine’s post-war reconstruction. The relevance of the study stems from the need to create a coherent, theoretically sound, psychometrically robust and reproducible set of tools capable of ensuring the unity of the conceptual model, empirical data collection procedures and algorithms for their …

28.08.2026journal-article

Journal of Alzheimer’s Disease

APOE ε4 and peripheral metabolic network architecture in older adults

Dae Jong Oh, Ji Won Han, Tae Hui Kim, Kyung Phil Kwak, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Seok Woo Moon, Joon Hyuk Park, Seung-Ho Ryu, Dong Woo Lee, Seok Bum Lee, Jung Jae Lee, Jin Hyeong Jhoo, Ki Woong Kim

Background Whether apolipoprotein E ( APOE ) ε4 status shapes the organization of modifiable peripheral metabolic risk pathways for dementia prevention remains unclear. Most prior studies have focused on individual APOE -by-biomarker interactions rather than the broader conditional dependency structure among metabolic variables. Objective We aimed to examine whether APOE ε4 is conditionally connected to metabolic factors and whether network architecture differs by genotype. Methods In 2454 participants from the Kor …

28.08.2026journal-article

International Journal of Molecular Sciences

Liposomal Helix aspersa Snail Mucus: A Biomacromolecular Platform for Attenuating Chronological Skin Aging Through Modulation of miR-34a-Associated Senescence and Extracellular Matrix Remodeling

Esraa M. Mosalam, Hend Mohamed Abdel-Bar, AbdElhafez R. AbdElhafez, Mai El-Sayed Ghoneim, Ebtehal M. Metwally, Amany Ebrahim Nofal, Aya Ibrahim Elberri

Chronological skin aging is a complex biological process characterized by progressive collagen degradation and cellular senescence. Among the molecular regulators implicated in these hallmarks, miR-34a has emerged as a critical mediator linking inflammation and senescence pathways. Consequently, this study aimed to investigate the anti-aging potential of Helix aspersa snail mucus, with particular emphasis on its modulation of miR-34a-associated molecular mechanisms, and to explore liposomal encapsulation as a strat …