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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

University of Bisha Journal for Basic and Applied Sciences

TiO2 Quantum Dots Supported on Poly(Chloroaniline): Enhanced Photocatalytic Degradation and Recyclability for Wastewater Treatment

Ibrahem A. Ibrahem

A poly(chloroaniline)/TiO2 quantum-dot (ClAn/TiQD) hybrid photocatalyst was prepared by in situ oxidative polymerization to address the limited visible-light utilization and charge recombination commonly associated with TiO2-based systems in dye-bearing wastewater treatment. Structural and spectroscopic analyses confirmed retention of anatase TiO2 after hybrid formation, preservation of the conjugated polymer backbone, and interfacial coupling between TiQD and ClAn. TEM showed ClAn particles of 33–42 nm, TiQD domai …

01.09.2026journal-article

Slovenian Journal of Public Health

A Comparative Analysis of the Economic Burden of Breast, Colorectal and Lung Cancer-Related Premature Mortality in Slovenia: Value-Added Decomposition by Occupation-Gender Groups

Tjaša Redek, Tanja Istenič, Petra Došenović Bonča, Ivica Ratoša, Andraž Perhavec, Daša Farčnik

Abstract Introduction This paper aims to estimate the value-added loss attributable to premature deaths from breast, colorectal and lung cancer in Slovenia using a novel methodology using linked employer-employee data, enabling value-added decomposition by occupation-gender groups. Methods The analysis is based on population-level microdata for the 2016–2022 period matched from several sources. Premature mortality costs are estimated using occupation- and gender-specific output losses rather than assuming uniform p …

01.09.2026journal-article

Journal of Medical Imaging and Radiation Oncology

Volumetric and Geometric Assessment of Offline Adaptation in Cervical Cancer External Beam Radiotherapy

Pereshin Moodaley, Karen Lim, Viet Do, Joseph Descallar

ABSTRACT Introduction Offline adaptive replanning is an appealing strategy in cervical cancer external beam radiotherapy (EBRT) to account for tumour shrinkage. It remains unclear whether volume reduction with adaptation improves geometric coverage in the presence of daily pelvic variation. This study evaluated the volumetric and geometric impact of offline EBRT adaptation in this setting. Methods Seventeen patients who completed definitive radio(chemo)therapy and brachytherapy were retrospectively assessed. An MRI …

01.09.2026journal-article

Cancer Plus

Malnutrition in pediatric oncology critical care: Mechanisms, assessment, and nutrition support

Peiyu Huang, Zhixuan Deng

Children with cancer who require pediatric intensive care encounter overlapping metabolic insults from cancer biology, anticancer treatment, and critical illness. These insults may produce a dynamic malnutrition phenotype characterized by impaired intake or absorption, rapid lean-mass loss, micronutrient and electrolyte depletion, and assessment confounded by inflammation and fluid shifts. In this narrative review, we conducted a systematic search on PubMed/MEDLINE through August 11, 2026 and prioritize evidence in …

01.09.2026journal-article

Turkish Journal of Mathematics

A delayed SIAMR prostate cancer model with vertical transmission and treatment: stability analysis and numerical simulation

HÜSEYİN DEMIR, İNCİ ÇİLİNGİR SÜNGÜ, İBRAHİM KELES

​In this paper, we propose and analyse a delayed-compartmental mathematical model of prostate cancer dynamics that incorporates vertical transmission and therapeutic intervention. The population is stratified into five compartments: susceptible (S), infected/virally activated (I), asymptomatic infectious under treatment (A), malignant untreated (M), and recovered (R). A discrete time delay τ > 0 is introduced in the force-of-infection term to model the age-dependent onset of susceptibility in middle-aged adult male …

02.09.2026journal-article

Supportive Care in Cancer

The impact of financial toxicity on adolescent/young adult cancer survivors (AYACS): A mixed methods study

Pooja Rao, Kristin Bingen, Katie A. Devine, Joel E. Segel, Emily Wasserman, Courtney Rumbaugh, Tonya S. King, Heather J. Costigan, Allison M. Scott, Smita Dandekar, Kevin Rakszawski, Natthapol Songdej, George F. Blackall, Eugene J. Lengerich, Lauren J. Van Scoy

Abstract Purpose Financial toxicity (the financial burden that accompanies a cancer diagnosis) uniquely affects adolescent/young adult cancer survivors (AYACS). The objective of this study was to use a mixed-method approach to understand AYACS’ perspectives on financial consequences of cancer treatment, to complement quantitative measures of financial toxicity. Methods In this convergent mixed methods study, data from AYACS participants ( n = 35) were collected. Financial toxicity was measured quantitatively using …

01.09.2026journal-article

PAIN, JOINTS, SPINE

Changes In Individual Functional Assessment Of Cancer Therapy–General Items Following a 12-Week Tele-Rehabilitation Program In Oncology: a Secondary Analysis

Preksha Jain, Dr. Jafar Khan, Dr. Manoj U. Mahajan, Dr. Veenodini Warhade, Dr. M.S Satish, Dr. k m Annamalai

Introduction: Health-related quality of life (HRQOL) is a multidimensional outcome frequently used to evaluate rehabilitation interventions in oncology. Most tele-rehabilitation studies report improvements using total or domain-level scores of the Functional Assessment of Cancer Therapy–General (FACT-G) questionnaire; however, little is known about which individual patient-reported concerns are most responsive to structured tele-rehabilitation. Understanding item-level response patterns may provide clinically meani …

02.09.2026journal-article

The Oncologist

42 Spatial Mapping of the Sarcomatoid Transition in Chromophobe Renal Cell Carcinoma Reveals a Reprogrammed Tumor-Immune Interactome

Yan Tang, Tiegang Han, Katrina Collins, Joelle Chami, Michel Alchoueiry, Michelle S Hirsch, Elizabeth P Henske

Abstract Background Chromophobe Renal Cell Carcinoma (ChRCC), derived from the intercalated cells of the collecting duct, typically follows an indolent clinical course. However, approximately 5–8% of cases undergo sarcomatoid transformation (sChRCC), a high-grade dedifferentiation resulting in a spindle-cell morphology and a rapid, metastatic trajectory. This transition represents a profound clinical shift; while classic ChRCC (cChRCC) is often surgical, sChRCC is notoriously refractory to anti-angiogenic agents an …

03.09.2026journal-article

Cancer Reports

A Novel BRCA1 Pathogenic Variant in Tunisian Patient With High Grade Ovarian Cancer: Favorable Therapeutic Response to Olaparib

Nihel Ammous‐Boukhris, Rania Abdelmaksoud‐Dammak, Ameni Feki, Souhir Khemiri, Slim Charfi, Tahia Sallemi‐Boudawara, Jamel Daoud, Afef Khanfir, Raja Mokdad Gargouri

ABSTRACT Background Ovarian cancer is one of the leading causes of death from gynecological cancer worldwide. Genetic mutations in genes involved in key cellular functions such as BRCA1/2 play a central role in tumorigenesis and have major implications for targeted therapeutic strategies, especially the use of poly (ADP‐ribose) polymerase (PARP) inhibitors. Case Herein, we described a case of a 50‐year‐old woman diagnosed with severe anemia secondary to heavy menometrorrhagia. Initial gynecological evaluation, incl …

01.09.2026journal-article

Journal of Acute Care Pharmacotherapy

Remdesivir versus usual care in the treatment of patients with COVID-19

Ivette M. Solís-Nolasco, Ian Murphy, Michael McAlister, Cara Slaton

Background Remdesivir was approved by the Food and Drug Administration in 2020 for treating hospitalized COVID-19 patients and those at high risk of severe disease. Although studies have shown a reduced risk of severe outcomes during the Omicron era compared to earlier variants, data on the effectiveness of remdesivir during this period remains limited. Objective To evaluate the clinical benefit of remdesivir in comparison to no antiviral therapy for the treatment of more recent COVID-19 infections. Methods This re …

01.09.2026journal-article

Scientific Reports

A methodological approach for creating virtual patient cohorts reflecting real-world diabetes treatment outcomes

Ernesto Estremera, Aleix Beneyto, Alvis Cabrera, Ivan Contreras, Josep Vehí

Abstract Virtual patients (VPs) are widely used to evaluate the performance, scope, and robustness of glycemic-control strategies. However, existing virtual cohorts often include too few subjects or fail to reflect the diversity of the intended clinical population. Generating new VPs that reproduce real-patient (RP) characteristics is therefore crucial for advancing diabetes therapies. We present a data-driven method to construct VP cohorts matched to individual RPs using routine therapy and outcome data. Starting …

01.09.2026journal-article

Revista Vértices

Psilocibina e neuroplasticidade: novas perspectivas terapêuticas para depressão resistente

Leticia Almeida Castro, André Luiz Anjos Simões Júnior, Guilherme Gianizeli Corradi Simões, Vagner Rocha Simonin Souza, Lucas Luís Meigre Dias Pereira, Ariely Lirio Sousa Lacerda, Cristiane Lyrio Silva

Depression is a multifactorial mental disorder and a leading cause of global disability. A subset of patients does not respond to conventional antidepressants, characterizing treatment-resistant depression (TRD). This study aimed to investigate the therapeutic potential of psilocybin in TRD, focusing on its effects on neuroplasticity. An integrative literature review was conducted using PubMed, Scielo, and Cochrane Library, including studies published between 2019 and 2026. Findings indicate that psilocybin increas …

01.09.2026journal-article

Annals of Gastroenterological Surgery

Mac‐2 Binding Protein Glycosylation Isomer ( M2BPGi )–Based Risk Stratification Refined by Tumor Metabolic Activity in Hepatocellular Carcinoma

Kojiro Shirabe, Junya Mita, Shinji Itoh, Takeo Toshima, Yoshiyuki Kitamura, Norifumi Iseda, Takuro Isoda, Kousei Ishigami, Tomoharu Yoshizumi

ABSTRACT Aim To evaluate the prognostic significance of preoperative Mac‐2 binding protein glycosylation isomer (M2BPGi) and determine whether tumor metabolic activity provides additional risk stratification after hepatic resection for hepatocellular carcinoma (HCC). Methods We retrospectively analyzed 291 patients with HCC who underwent hepatic resection at a single Japanese institution between 2015 and 2023 and had available preoperative M2BPGi and 18F‐fluorodeoxyglucose positron emission tomography/computed tomo …

01.09.2026journal-article

Cancer Prevention Research

Precision Cancer Prevention Needs Both Implementation Science and Ethics

Alexandra Wicker, Amanda Courtright-Lim, Lila J. Finney Rutten, Steven W. Ressler, Jon C. Tilburt, Jessica D. Austin

Abstract As technological and genomic innovations continue to advance precision cancer prevention, psychosocial, ethical, and operational complexities increasingly accompany their development. Addressing these challenges will require intentional cross-disciplinary collaboration. We argue that the distinct yet complementary lenses of bioethics and implementation science will be crucial as precision cancer prevention technologies move toward clinical integration. We provide a framework for how this joint effort can b …

01.09.2026journal-article

Journal of Orthopaedic & Sports Physical Therapy

Musculoskeletal Treatment Mechanisms: A Puzzle That May Never Be Fully Solved

Chad E. Cook, Damian L. Keter

SYNOPSIS: Musculoskeletal treatments often appear simple, yet the mechanisms underlying their effects remain difficult to explain. Patients and clinicians routinely ask why exercises, manual techniques, or psychologically informed interventions help, but current evidence rarely supports the intuitive explanations offered in practice. Although mechanistic research promises more precise and individualized care, most studies isolate single pathways under controlled conditions that fail to reflect the complexity of hum …

01.09.2026journal-article

Hemato

Acute Myeloid Leukemia in Older Adults: A Comprehensive Narrative Review of Risk Stratification and Treatment Advances

Ahmed S. Mohamed, Shraboni Dey, Shibhani Rajanna, Marina Basta, Shareif Abdelwahab, Maggie James, Mohammed A. Saafan, Tarneem Deyab, Sameh Elias

Acute myeloid leukemia (AML) is predominantly a disease of older adults, with a median age at diagnosis of 68–72 years. Management in this population is complicated by adverse cytogenetic and molecular features, higher rates of secondary disease, and patient-specific factors such as comorbidity and frailty. This narrative review synthesizes the current evidence on risk stratification and treatment of AML in adults aged 60 years and older, with dedicated attention to patients aged 60–75 (“fit” older adults) and thos …

01.09.2026journal-article

Cell Biology International

Sotagliflozin, a Dual SGLT1/2 Inhibitor, Modulates DNMT1 and Class I/II HDAC Expression in Association With Anticancer Effects in Breast and Lung Cancer Cells

P. K. Hima, K. Aswathy, Govinda Rao Duddukuri

ABSTRACT Sodium–glucose cotransporter (SGLT) inhibitors are increasingly recognised for anticancer activity beyond their established glycaemic effects. While selective SGLT2 inhibitors have been reported to suppress tumour cell proliferation and modulate AMPK/mTOR and PI3K/AKT signalling, whether dual SGLT1/2 inhibition is associated with modulation of epigenetic regulators has remained largely unexplored. Here, we investigated the anticancer effects of sotagliflozin, a dual SGLT1/2 inhibitor, in breast (MCF‐7) and …

01.09.2026journal-article

Scientific Reports

Altered ANG/TIE gene expression in advanced ovarian cancer is not accompanied by disproportionate body water accumulation relative to perioperative fluid balance

Sarah Reifenhaeuser, Katrin Stein, Stilla Frede, Eva K. Egger, Alexander Mustea, Mark Coburn, Sven Klaschik, Martin Soehle, Tobias Hilbert

Abstract Abdominal cytoreductive surgery due to advanced-stage ovarian cancer (OC) often requires extensive fluid administration to stabilize hemodynamic conditions. Recently, systemic changes in the expression profile of Angiopoietin (ANG)/TIE axis genes have been demonstrated in those patients, raising the question whether they exhibit an inherent clinical phenotype associated with vascular dysfunction and leakage that may explain the significant perioperative fluid demands. Abdominal muscle tissue gene expressio …

01.09.2026journal-article

Dietetics

Microbiota-Directed Therapies for the Treatment of Small Intestinal Bacterial Overgrowth: A Systematic Review and Meta-Analysis

Diego Fernández Lázaro, Isabel Mínguez-De La Concha, Carla Cucalón Solanot, Evelina Garrosa, Marina Seco-Casares, Enrique Roche

Small intestinal bacterial overgrowth (SIBO) is characterized by an excessive proliferation of bacteria within the small intestine, resulting in chronic gastrointestinal symptoms, impaired quality of life, and frequent recurrence. Although rifaximin remains the cornerstone of treatment, increasing interest has focused on microbiota-directed therapeutic strategies aimed at restoring intestinal homeostasis and addressing mechanisms beyond bacterial eradication. This systematic review and meta-analysis evaluated the e …

01.09.2026journal-article

ACS Applied Bio Materials

Gelatin–PVA Hydrogel Composite-Based Immunosensing Interface for Early Detection of HPV16-Driven Cervical Cancer

Dipannita Ghosh, Damini Verma, Devesh Bhimsaria, Gopinath Packirisamy

Abstract Viral oncoprotein HPV16 E6 is a critical mediator of cervical malignancy and a promising biomarker for early-stage detection of cervical cancer. Current diagnostic approaches centered around morphology-based screening and DNA-based assays emphasize the need for noninvasive, affordable, and highly sensitive urine-based detection methods targeting HPV16 E6 oncoprotein for early diagnosis. This study introduces a noninvasive diagnostic strategy using a gelatin–PVA (G-PVA) hydrogel composite-based electrochemi …

01.09.2026journal-article

Journal of Oncology Pharmacy Practice

Establishing comprehensive oncology-haematology pharmacy care for paediatric bone marrow transplantation in sickle cell disease: Procedural insights from a Delphi study conducted in Tanzania

Kauke Bakari Zimbwe, David Simon Shau, Yusto Julius Yona, Ibrahim Philemon Bura, Mkapa Faustine Madebele

Background Hematopoietic stem cell transplantation (HSCT) is vital for treating blood disorders, yet Low- and Middle-Income Countries (LMICs) often lack adequate Bone Marrow Transplant (BMT) pharmacy services. This study aims to reach consensus among oncology pharmacy experts on the essential staff, infrastructure, supplies, and safety/control measures required to establish BMT pharmacy services in LMICs. Methodology The Delphi method was employed to evaluate and achieve consensus on BMT pharmacy services at Benjam …

01.09.2026journal-article

Mathematical and Computational Applications

Modeling the Impact of Treatment Adherence on Hepatitis C Transmission Dynamics Among Intravenous Drug Users

Mlyashimbi Helikumi, Tinashe Victor Mupedza, Shingirai Tangakugara Murambiwa, Moster Zhangazha, Adquate Mhlanga

Hepatitis C virus (HCV) infection remains highly prevalent among people who inject drugs (PWID), where treatment effectiveness is strongly influenced by adherence and behavioral relapse. In this study, we develop and analyze a deterministic compartmental model to examine the impact of treatment adherence, relapse, and risk-reduction behaviors on HCV transmission dynamics. The model incorporates key behavioral pathways, including treatment initiation, partial adherence, and relapse to high-risk behavior. Analytical …

01.09.2026journal-article

Frontiers in Pharmacology

Microbiota-driven metabolic–immune crosstalk in breast cancer

Jie Guan, Qian Zhou, Jun Chen, Jinnan Zhang, Shuyi Yang, Qingquan Xiong, Jiaan Ye, Yun Zeng, Guang-Hui Ren, Meng Zhang

Cancer continues to pose a significant risk to women’s health globally, as its progression and treatment resistance arise from an intricate interplay between metabolic reprogramming, immunological evasion, and the tumor microbiome. Augmented glycolysis has emerged as a pivotal element in cancer pathogenesis, altering the tumor microenvironment via the buildup of immune-regulated metabolites that directly influence the activation of the cGAS-STING pathway. This pathway is regarded as a significant modulator of cance …

01.09.2026journal-article

Cancer Research

Targeting GEM Reprograms Macrophages and Overcomes Immunotherapy Resistance in Esophageal Squamous Cell Carcinoma

Linfeng Wu, Changhao Ren, Yifei Zhang, Gaojia Wang, Kai-Qian Zhou, Kechen Guo, Zhiwang Zhao, Dongxian Jiang, Yanbo Liu, Yuning Zhou, Yanjun Zhou, Mengting Wang, Han Ding, Yuanyuan Ruan, Pinghong Zhou, Yiqun Zhang

Abstract Esophageal squamous cell carcinoma (ESCC) exhibits heterogeneous responses to immune checkpoint blockade, highlighting the need to define tumor-intrinsic mechanisms driving resistance to PD-L1 inhibition. In this study, we identified GTP-binding protein overexpressed in skeletal muscle (GEM) as a tumor cell–intrinsic regulator associated with poor response to anti–PD-L1 therapy in ESCC. GEM expression in tumor cells drove tumor-associated macrophage–mediated immunosuppression, leading to reduced CD8+ T-cel …