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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

The Oncologist

45 Targeting Lysyl Oxidase Inhibits Tumor Progression in Clear Cell Renal Cell Carcinoma

Burge Ulukan, Ozge Saatci, Ariel Madrigal, Minjun Kim, Wensheng Tian, Mustafa Soytas, Zohreh Mehrjoo, Ozlem Sahin, Kukkamadi Sreenivas, Chintada Nageswara Rao, Tamiko Nishimura, Virginie Pillon, Jean-Sebastian Anoma, Elizabeth Hill, Janusz Rak, Campbell McInnes, Morag Park, Fadi Brimo, Simon Tanguay, Ryan Charles Russell, Hamed Najafabadi, Yasser Riazalhosseini, Ozgur Sahin

Abstract Background Clear cell renal cell carcinoma (ccRCC) is defined by constitutive pseudohypoxia driven by von Hippel-Lindau (VHL) loss, pronounced intratumoral heterogeneity, and aberrant hypervascularity, features that collectively promote tumor progression and limit therapeutic durability. Although VEGF-targeted therapies and HIF-2α inhibitors have improved clinical outcomes, resistance frequently emerges, including mutations in the PAS-B binding pocket that impair drug efficacy. However, the mechanisms that …

01.09.2026journal-article

ACS Applied Nano Materials

Smart Hydrogel-Nanoparticle Platforms for Precision Drug Delivery and Tumor Microenvironment Modulation in Breast Cancer

Poulami Dutta, Dhruvi Dipakbhai Patel, Halak Shukla, Dewang Limaye, Jothiswaran VV, Juni Banerjee, Sonu Gandhi, Shuvomoy Banerjee

Abstract Breast cancer accounts for one in four cancers diagnosed in women and remains the leading cause of cancer-related mortality among women worldwide. The drug delivery system (DDS) has created an effective approach in cancer treatment. The current advancement is a combination of nanomaterials with modern nanotechnological strategies, revolutionizing the DDS. Hydrogels provide an exciting route for innovative DDS to deliver various molecules, including peptides, via transdermal, vaginal, nasal, ocular, oral, a …

01.09.2026journal-article

JAIDS Journal of Acquired Immune Deficiency Syndromes

Hepatitis B and C Prevention, Screening, and Diagnostic Services at HIV Treatment Sites: International Epidemiology Databases to Evaluate AIDS

Mark H. Kuniholm, Gad Murenzi, Niharika Samala, Evy Yunihastuti, Gilles Wandeler, H. Nina Kim, Marie K. Plaisy, Hugo Perazzo, Christella Twizere, Francesca Odhiambo, Rohan Bopage, Guy Muula, Vincent Lo Re, Albert Minga, Alvaro López-Iñiguez, Dominique M. Nsonde, Charles Kasozi, Dewi K. Wati, Matthew P. Fox, Gregory D. Kirk, Eugene Messou, Carina Cesar, Peter V. Ebasone, Helen Byakwaga, Jeremy Ross, Cleophas Chimbetete, George A. Yendewa, Antoine Jaquet, Regina C. M. Succi, Fernanda Maruri, Ellen Brazier, on behalf of IeDEA

Background: Prevention, screening, and diagnostic services for hepatitis B virus (HBV) and hepatitis C virus (HCV) can prevent morbidity and mortality in people receiving HIV care. However, there is limited information about the availability of HBV and HCV services at HIV clinics globally. Methods: The International epidemiology Databases to Evaluate AIDS (IeDEA) conducted surveys of service delivery and practices at participating HIV treatment centers from 7 regions. We used 2023 survey data to measure availabilit …

01.09.2026journal-article

RETINAL Cases & Brief Reports

FULMINANT CLOSTRIDIUM SEPTICUM ENDOGENOUS ENDOPHTHALMITIS PRESENTING WITH INTRAOCULAR GAS IN A PATIENT WITH METASTATIC ENDOMETRIAL CANCER

Young Je Choi, Min Jeong Kwon, Hyun Goo Kang, Kang Hyun Kim, Min Kim

Purpose: To report a rare and fulminant case of Clostridium septicum endogenous endophthalmitis. Methods: A case report of a 52-year-old woman with metastatic endometrial cancer who developed sudden vision loss in the left eye 10 hours after presenting with dizziness, moderate fever, and a normal brain computed tomography scan. Results: The left eye had no light perception. Slit-lamp examination revealed corneal edema and mild anterior chamber inflammation. Owing to a limited fundus view, B-scan ultrasonography was …

01.09.2026journal-article

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH

Improving Diagnostic and Treatment Precision for Negative Symptoms of Schizophrenia using Quantitative Electroencephalography and Transcranial Direct Current Stimulation: A Case Report

Deepan Raj, Srinivas Rajkumar, Priya Sivashankar

Schizophrenia is a major mental illness associated with significant disability. Negative symptoms represent a key determinant of longterm morbidity and poor functional outcomes. This is a case report of a 22-year-old male presenting with poor functional recovery despite apparent resolution of psychotic symptoms (hallucinations and delusions) on antipsychotics. In follow-up his antipsychotic dose was up titrated along addition of anti-depressants with suspicion of primary negative vs depressive symptoms. He did not …

01.09.2026journal-article

Mathematics

Advancing the Numerical Treatment of Caputo Fractional Lotka–Volterra Systems Through Non-Polynomial Spline Approximation and Neural Network Verification

Majeed Ahmad Yousif, Karwan S. Mohammed, Faraidun K. Hamasalh, Pshtiwan Othman Mohammed

This paper presents a modified non-polynomial fractional cubic spline (MNPFCS) method for solving fractional Lotka–Volterra prey–predator systems governed by the Caputo fractional derivative. The proposed method integrates non-polynomial spline interpolation with fractional calculus to obtain accurate numerical approximations for nonlinear coupled systems. The stability and convergence of the method are established theoretically. To further verify its effectiveness, the numerical solutions are compared with those p …

01.09.2026journal-article

Journal of Comparative Effectiveness Research

Zanubrutinib versus fludarabine, cyclophosphamide and rituximab in fit, treatment-naïve patients with chronic lymphocytic leukemia: a matching-adjusted indirect comparison

Talha Munir, Lianne Barnieh, Leyla Mohseninejad, Sheng Xu, Milica Jevdjevic, Walter Bouwmeester, Keri Yang

Aim: Fludarabine, cyclophosphamide and rituximab (FCR) is a first-line therapy for fit treatment-naive patients with chronic lymphocytic leukemia (CLL); however, its hematotoxicity and related infections necessitate more efficacious, safer treatments. Zanubrutinib is a highly potent and selective next-generation Bruton tyrosine kinase inhibitor approved for treatment-naive patients with CLL and small lymphocytic lymphoma. Given the absence of clinical trials providing head-to-head comparisons, the aim of this analy …

01.09.2026journal-article

Asia-Pacific Journal of Clinical Oncology

CDK4/6 Inhibitors in the Management of Hormone Receptor‐Positive (HR+)/Human Epidermal Growth Factor Receptor 2‐Negative (HER2−) Advanced Breast Cancer in Indonesia: Challenges, Opportunities, and Recommendations

Sonar Soni Panigoro, Samuel J. Haryono, Prihantono Prihantono, Dedy Hermansyah, Sumadi Lukman Anwar, Yohana Azhar, Febriyanto Kurniawan, Putu Anda Tusta Adiputra, Kristanto Yuli Yarso, Asdi Wihandono

ABSTRACT Breast cancer (BC) is the most prevalent cancer affecting women globally, with Asia accounting for nearly half of all cases. BC represents a major public health issue, particularly in Indonesia, where it is the leading cancer type among women. Indonesia faces high rates of late‐stage diagnoses and poor survival outcomes, largely driven by socioeconomic disparities, limitations in healthcare infrastructure, and delays in detection; challenges also encountered across comparable resource‐constrained settings. …

01.09.2026journal-article

University of Bisha Journal for Basic and Applied Sciences

TiO2 Quantum Dots Supported on Poly(Chloroaniline): Enhanced Photocatalytic Degradation and Recyclability for Wastewater Treatment

Ibrahem A. Ibrahem

A poly(chloroaniline)/TiO2 quantum-dot (ClAn/TiQD) hybrid photocatalyst was prepared by in situ oxidative polymerization to address the limited visible-light utilization and charge recombination commonly associated with TiO2-based systems in dye-bearing wastewater treatment. Structural and spectroscopic analyses confirmed retention of anatase TiO2 after hybrid formation, preservation of the conjugated polymer backbone, and interfacial coupling between TiQD and ClAn. TEM showed ClAn particles of 33–42 nm, TiQD domai …

01.09.2026journal-article

Slovenian Journal of Public Health

A Comparative Analysis of the Economic Burden of Breast, Colorectal and Lung Cancer-Related Premature Mortality in Slovenia: Value-Added Decomposition by Occupation-Gender Groups

Tjaša Redek, Tanja Istenič, Petra Došenović Bonča, Ivica Ratoša, Andraž Perhavec, Daša Farčnik

Abstract Introduction This paper aims to estimate the value-added loss attributable to premature deaths from breast, colorectal and lung cancer in Slovenia using a novel methodology using linked employer-employee data, enabling value-added decomposition by occupation-gender groups. Methods The analysis is based on population-level microdata for the 2016–2022 period matched from several sources. Premature mortality costs are estimated using occupation- and gender-specific output losses rather than assuming uniform p …

01.09.2026journal-article

Journal of Medical Imaging and Radiation Oncology

Volumetric and Geometric Assessment of Offline Adaptation in Cervical Cancer External Beam Radiotherapy

Pereshin Moodaley, Karen Lim, Viet Do, Joseph Descallar

ABSTRACT Introduction Offline adaptive replanning is an appealing strategy in cervical cancer external beam radiotherapy (EBRT) to account for tumour shrinkage. It remains unclear whether volume reduction with adaptation improves geometric coverage in the presence of daily pelvic variation. This study evaluated the volumetric and geometric impact of offline EBRT adaptation in this setting. Methods Seventeen patients who completed definitive radio(chemo)therapy and brachytherapy were retrospectively assessed. An MRI …

01.09.2026journal-article

Cancer Plus

Malnutrition in pediatric oncology critical care: Mechanisms, assessment, and nutrition support

Peiyu Huang, Zhixuan Deng

Children with cancer who require pediatric intensive care encounter overlapping metabolic insults from cancer biology, anticancer treatment, and critical illness. These insults may produce a dynamic malnutrition phenotype characterized by impaired intake or absorption, rapid lean-mass loss, micronutrient and electrolyte depletion, and assessment confounded by inflammation and fluid shifts. In this narrative review, we conducted a systematic search on PubMed/MEDLINE through August 11, 2026 and prioritize evidence in …

01.09.2026journal-article

Turkish Journal of Mathematics

A delayed SIAMR prostate cancer model with vertical transmission and treatment: stability analysis and numerical simulation

HÜSEYİN DEMIR, İNCİ ÇİLİNGİR SÜNGÜ, İBRAHİM KELES

​In this paper, we propose and analyse a delayed-compartmental mathematical model of prostate cancer dynamics that incorporates vertical transmission and therapeutic intervention. The population is stratified into five compartments: susceptible (S), infected/virally activated (I), asymptomatic infectious under treatment (A), malignant untreated (M), and recovered (R). A discrete time delay τ > 0 is introduced in the force-of-infection term to model the age-dependent onset of susceptibility in middle-aged adult male …

02.09.2026journal-article

Supportive Care in Cancer

The impact of financial toxicity on adolescent/young adult cancer survivors (AYACS): A mixed methods study

Pooja Rao, Kristin Bingen, Katie A. Devine, Joel E. Segel, Emily Wasserman, Courtney Rumbaugh, Tonya S. King, Heather J. Costigan, Allison M. Scott, Smita Dandekar, Kevin Rakszawski, Natthapol Songdej, George F. Blackall, Eugene J. Lengerich, Lauren J. Van Scoy

Abstract Purpose Financial toxicity (the financial burden that accompanies a cancer diagnosis) uniquely affects adolescent/young adult cancer survivors (AYACS). The objective of this study was to use a mixed-method approach to understand AYACS’ perspectives on financial consequences of cancer treatment, to complement quantitative measures of financial toxicity. Methods In this convergent mixed methods study, data from AYACS participants ( n = 35) were collected. Financial toxicity was measured quantitatively using …

01.09.2026journal-article

PAIN, JOINTS, SPINE

Changes In Individual Functional Assessment Of Cancer Therapy–General Items Following a 12-Week Tele-Rehabilitation Program In Oncology: a Secondary Analysis

Preksha Jain, Dr. Jafar Khan, Dr. Manoj U. Mahajan, Dr. Veenodini Warhade, Dr. M.S Satish, Dr. k m Annamalai

Introduction: Health-related quality of life (HRQOL) is a multidimensional outcome frequently used to evaluate rehabilitation interventions in oncology. Most tele-rehabilitation studies report improvements using total or domain-level scores of the Functional Assessment of Cancer Therapy–General (FACT-G) questionnaire; however, little is known about which individual patient-reported concerns are most responsive to structured tele-rehabilitation. Understanding item-level response patterns may provide clinically meani …

02.09.2026journal-article

The Oncologist

42 Spatial Mapping of the Sarcomatoid Transition in Chromophobe Renal Cell Carcinoma Reveals a Reprogrammed Tumor-Immune Interactome

Yan Tang, Tiegang Han, Katrina Collins, Joelle Chami, Michel Alchoueiry, Michelle S Hirsch, Elizabeth P Henske

Abstract Background Chromophobe Renal Cell Carcinoma (ChRCC), derived from the intercalated cells of the collecting duct, typically follows an indolent clinical course. However, approximately 5–8% of cases undergo sarcomatoid transformation (sChRCC), a high-grade dedifferentiation resulting in a spindle-cell morphology and a rapid, metastatic trajectory. This transition represents a profound clinical shift; while classic ChRCC (cChRCC) is often surgical, sChRCC is notoriously refractory to anti-angiogenic agents an …

03.09.2026journal-article

Cancer Reports

A Novel BRCA1 Pathogenic Variant in Tunisian Patient With High Grade Ovarian Cancer: Favorable Therapeutic Response to Olaparib

Nihel Ammous‐Boukhris, Rania Abdelmaksoud‐Dammak, Ameni Feki, Souhir Khemiri, Slim Charfi, Tahia Sallemi‐Boudawara, Jamel Daoud, Afef Khanfir, Raja Mokdad Gargouri

ABSTRACT Background Ovarian cancer is one of the leading causes of death from gynecological cancer worldwide. Genetic mutations in genes involved in key cellular functions such as BRCA1/2 play a central role in tumorigenesis and have major implications for targeted therapeutic strategies, especially the use of poly (ADP‐ribose) polymerase (PARP) inhibitors. Case Herein, we described a case of a 50‐year‐old woman diagnosed with severe anemia secondary to heavy menometrorrhagia. Initial gynecological evaluation, incl …

01.09.2026journal-article

Journal of Acute Care Pharmacotherapy

Remdesivir versus usual care in the treatment of patients with COVID-19

Ivette M. Solís-Nolasco, Ian Murphy, Michael McAlister, Cara Slaton

Background Remdesivir was approved by the Food and Drug Administration in 2020 for treating hospitalized COVID-19 patients and those at high risk of severe disease. Although studies have shown a reduced risk of severe outcomes during the Omicron era compared to earlier variants, data on the effectiveness of remdesivir during this period remains limited. Objective To evaluate the clinical benefit of remdesivir in comparison to no antiviral therapy for the treatment of more recent COVID-19 infections. Methods This re …

01.09.2026journal-article

Dietetics

Microbiota-Directed Therapies for the Treatment of Small Intestinal Bacterial Overgrowth: A Systematic Review and Meta-Analysis

Diego Fernández Lázaro, Isabel Mínguez-De La Concha, Carla Cucalón Solanot, Evelina Garrosa, Marina Seco-Casares, Enrique Roche

Small intestinal bacterial overgrowth (SIBO) is characterized by an excessive proliferation of bacteria within the small intestine, resulting in chronic gastrointestinal symptoms, impaired quality of life, and frequent recurrence. Although rifaximin remains the cornerstone of treatment, increasing interest has focused on microbiota-directed therapeutic strategies aimed at restoring intestinal homeostasis and addressing mechanisms beyond bacterial eradication. This systematic review and meta-analysis evaluated the e …

01.09.2026journal-article

Revista Vértices

Psilocibina e neuroplasticidade: novas perspectivas terapêuticas para depressão resistente

Leticia Almeida Castro, André Luiz Anjos Simões Júnior, Guilherme Gianizeli Corradi Simões, Vagner Rocha Simonin Souza, Lucas Luís Meigre Dias Pereira, Ariely Lirio Sousa Lacerda, Cristiane Lyrio Silva

Depression is a multifactorial mental disorder and a leading cause of global disability. A subset of patients does not respond to conventional antidepressants, characterizing treatment-resistant depression (TRD). This study aimed to investigate the therapeutic potential of psilocybin in TRD, focusing on its effects on neuroplasticity. An integrative literature review was conducted using PubMed, Scielo, and Cochrane Library, including studies published between 2019 and 2026. Findings indicate that psilocybin increas …

01.09.2026journal-article

Cell Biology International

Sotagliflozin, a Dual SGLT1/2 Inhibitor, Modulates DNMT1 and Class I/II HDAC Expression in Association With Anticancer Effects in Breast and Lung Cancer Cells

P. K. Hima, K. Aswathy, Govinda Rao Duddukuri

ABSTRACT Sodium–glucose cotransporter (SGLT) inhibitors are increasingly recognised for anticancer activity beyond their established glycaemic effects. While selective SGLT2 inhibitors have been reported to suppress tumour cell proliferation and modulate AMPK/mTOR and PI3K/AKT signalling, whether dual SGLT1/2 inhibition is associated with modulation of epigenetic regulators has remained largely unexplored. Here, we investigated the anticancer effects of sotagliflozin, a dual SGLT1/2 inhibitor, in breast (MCF‐7) and …

01.09.2026journal-article

Cancer Prevention Research

Precision Cancer Prevention Needs Both Implementation Science and Ethics

Alexandra Wicker, Amanda Courtright-Lim, Lila J. Finney Rutten, Steven W. Ressler, Jon C. Tilburt, Jessica D. Austin

Abstract As technological and genomic innovations continue to advance precision cancer prevention, psychosocial, ethical, and operational complexities increasingly accompany their development. Addressing these challenges will require intentional cross-disciplinary collaboration. We argue that the distinct yet complementary lenses of bioethics and implementation science will be crucial as precision cancer prevention technologies move toward clinical integration. We provide a framework for how this joint effort can b …

01.09.2026journal-article

Annals of Gastroenterological Surgery

Mac‐2 Binding Protein Glycosylation Isomer ( M2BPGi )–Based Risk Stratification Refined by Tumor Metabolic Activity in Hepatocellular Carcinoma

Kojiro Shirabe, Junya Mita, Shinji Itoh, Takeo Toshima, Yoshiyuki Kitamura, Norifumi Iseda, Takuro Isoda, Kousei Ishigami, Tomoharu Yoshizumi

ABSTRACT Aim To evaluate the prognostic significance of preoperative Mac‐2 binding protein glycosylation isomer (M2BPGi) and determine whether tumor metabolic activity provides additional risk stratification after hepatic resection for hepatocellular carcinoma (HCC). Methods We retrospectively analyzed 291 patients with HCC who underwent hepatic resection at a single Japanese institution between 2015 and 2023 and had available preoperative M2BPGi and 18F‐fluorodeoxyglucose positron emission tomography/computed tomo …

01.09.2026journal-article

Scientific Reports

A methodological approach for creating virtual patient cohorts reflecting real-world diabetes treatment outcomes

Ernesto Estremera, Aleix Beneyto, Alvis Cabrera, Ivan Contreras, Josep Vehí

Abstract Virtual patients (VPs) are widely used to evaluate the performance, scope, and robustness of glycemic-control strategies. However, existing virtual cohorts often include too few subjects or fail to reflect the diversity of the intended clinical population. Generating new VPs that reproduce real-patient (RP) characteristics is therefore crucial for advancing diabetes therapies. We present a data-driven method to construct VP cohorts matched to individual RPs using routine therapy and outcome data. Starting …