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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
29.08.2026journal-article

Antimicrobial Resistance & Infection Control

Antimicrobial therapy among hospitalized older adults with suspected infection and negative blood cultures

Galadriel Pellejero-Sagastizabal, Elena Morte-Romea, José Antonio Girón Ortega, José Ramón Paño-Pardo, Raquel Fernández Guerrero, Francisca Guerrero, Montserrat Montes de Oca, Silvia Jiménez-Jorge, Zaira R. Palacios-Baena, Jesús Rodríguez-Baño, Pilar Retamar-Gentil, NO-BACT Team, Montserrat Montes de Oca Arjona, Fátima Galán Sánchez, María Eugenia Rodríguez Mateos, José Antonio Girón-González, Andrés Martín Aspas, Claudio Sánchez Tembleque, Francisca María Guerrero Sánchez, Pilar Luque Gómez, José Luis Sierra, Santiago Letona Gimenez, Pilar Palacián, Nora Mariela Rodriguez, Mercedes Arenere Mendoza, Maria Ángeles Allende Bandrés, Raquel Fresquet Molina, Irene Navarro Pardo, Raquel Fernández Guerero, Zaira Palacios-Baena, Marina de Cueto, Margarita Beltrán García, María Luisa Cantón Bulnes, Lorenzo Roberto Suarti

Abstract Background Managing infections in older adults is challenging due to their unique characteristics, which often drives empirical antimicrobial use, increasing risks of adverse outcomes and antimicrobial resistance (AMR). Data on antimicrobial adequacy in older patients with suspected infection but negative blood cultures (BC) remain scarce, despite this being a common clinical scenario. Methods In this multicenter prospective cohort study (NO-BACT project) across three Spanish hospitals (2018–2019), we comp …

29.08.2026journal-article

Polymers

Towards Sustainable Utilization of Rejuvenated Bitumen: A Review with Emphasis on Secondary Aging, Aging Resistance, and Multiple Rejuvenation

Hongbin Zhu, Naisheng Guo, Yuanyuan Li, Shisong Ren, Fu Wang, Jun Zhang, Zhi Zheng, Hang Su, Zenggang Zhao, Ke Zhang

To further advance the recycling of pavement waste, the secondary-aging and multiple-rejuvenation processes of bitumen are first systematically reviewed. Beginning with primary-aging mechanisms, rejuvenator classification and physicochemical properties are summarized to aid elucidation of primary rejuvenation. Secondary-aging evolution of technical and physicochemical properties of rejuvenated bitumen (RB) is critically analyzed. The aging resistance of virgin bitumen and RB is quantitatively compared via extensive …

29.08.2026journal-article

International Forum of Allergy & Rhinology

Impact of Highly Effective Modulator Therapy on Olfactory‐Specific Gene Expression in People With Cystic Fibrosis

Michael R. Xiang, Ankit Chauhan, Gina Hong, Denis Hadjiliadis, Daniel Dorgan, Michael M. Rey, Samantha Kane, James N. Palmer, Nithin D. Adappa, Noam A. Cohen, Michael A. Kohanski, Jennifer E. Douglas

ABSTRACT Background Chronic rhinosinusitis is common in people with cystic fibrosis (PwCF). Highly effective modulator therapy (HEMT) has been shown to improve sinonasal outcomes. However, prior studies failed to show improvement in objective olfaction with HEMT, and the impact of HEMT on olfactory‐specific quality of life has yet to be studied. Furthermore, the underlying changes in gene expression within the olfactory epithelium (OE) of PwCF remains poorly understood. Methods Single‐center cross‐sectional cohort …

29.08.2026journal-article

Revista Brasileira de Sexualidade Humana

INSTRUMENTOS PARA AVALIAÇÃO DA SEXUALIDADE EM IDOSOS/AS LATINO-AMERICANOS/AS

Rita de Cássia Paulino da Silva, Jaine de Jesus Vasconcelos, Rosalba Maria dos Santos, Fernando Soares da Silva Neto

A sexualidade se caracteriza como uma parte vital e subjetiva de todo ser humano, a qual tem continuidade no envelhecimento, todavia, assumindo diferentes formas e significados conforme as vivências e realidades. Apesar de sua importância, ainda há escassez de instrumentos específicos para avaliar a sexualidade de idosos/as. Diante desse cenário, objetiva-se mapear os instrumentos utilizados para avaliar a sexualidade de idosos/as em contextos socioculturais e clínicos da América Latina. Trata-se de uma revisão de …

29.08.2026journal-article

Veredas do Direito

ADVANCING PLANT DISEASE DETECTION THROUGH STATE-OF-THE-ART DEEP LEARNING MODELS LEVER-AGING EFFICIENTNETV2, VISION TRANSFORMER, AND ENSEMBLE TECHNIQUES

Najaf Ali, Ferdi Sonmez

Plant diseases are still posing a challenge to the productivity, quality of crops, and food security, especially in locations where field diagnosis is based on manual visual inspec-tion. This paper assesses deep learning network-based automated classification of plant leaf diseases on public RGB leaf-image datasets, such as the Kaggle New Plant Diseases Dataset (Augmented) and PlantVillage images. They investigated four archi-tectures: EfficientNetV2B0, ResNet152V2, DenseNet201, and one hybrid Vision Trans-former ( …

29.08.2026journal-article

Metabolites

Determinants of Metabolic Syndrome in Virally Suppressed People Living with HIV: A Single-Center Comparative Analysis of Antiretroviral Regimens

Michał Biały, Małgorzata Inglot

Background: Metabolic complications and weight gain have emerged as primary concerns among virologically suppressed and immunologically competent people living with HIV. Particularly integrase strand transfer inhibitors (INSTIs) and tenofovir alafenamide (TAF) are being connected with this issue. Objectives: This study aimed to evaluate the prevalence of metabolic syndrome (MetS) and its components within a highly homogeneous, virologically suppressed cohort, assessing the impact of antiretroviral therapy (ART) and …

29.08.2026journal-article

BMC Geriatrics

A mixed-methods feasibility study of dog-assisted exercise therapy in geriatric inpatients

Lilly Joschko, Eva Jansen, Stefanie Weinert, Maximilian Hinse, Roland Zerm, Harald Matthes

Abstract Background Animal-assisted therapy (AAT) is a promising complementary approach in geriatric rehabilitation, but evidence on feasibility and patient experiences remains limited. Methods This exploratory, mixed-methods, two-arm randomized controlled parallel-group design (RCT) compared dog-assisted exercise therapy (intervention) to standard exercise therapy (active control) in geriatric inpatients during a two-week rehabilitation program. Quantitative data on mobility (TUG), depression (HADS-D) symptoms, mo …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Cytomegalovirus Modulation of CD8 T Cell Phenotype and Function in People Living with HIV-1

Brandi L Clark, E Kaitlynn Allen, Stefan A Schattgen, Lee-Ann Van de Velde, Kim Allison, Ronald Dallas, Adrienne English, Kim DeLuca, Robert C Mettelman, Aditya Gaur, Patricia Flynn, Paul G Thomas, Jeremy C Crawford, Amanda M Green

Abstract Background Both human immunodeficiency virus 1 (HIV-1) and cytomegalovirus (CMV) cause lifelong infections that cannot be cured by antiviral chemotherapy due to persistent viral reservoirs. There is mounting evidence that chronic CMV alters immune responses to various subsequent infections, and that large clonal expansions of CMV-specific CD8 T cells in elderly persons denote immune senescence. We propose that CMV co-infection may contribute to dysregulated HIV-1 control. Methods Longitudinal peripheral bl …

29.08.2026journal-article

Trials

Process evaluation of the randomized trial—“Care management for older people with cognitive impairment during and after hospitalisation in Germany (intersec-CM)”

N. Chikhradze, A. Hannich, IC. Otte, T. S. Busse, A. Suslow, A. Nikelski, F. Schumacher-Schoenert, S. H. Kreisel, M. Boekholt, J. R. Thyrian, W. Hoffmann, H. C. Vollmar

Abstract Background Effective care of people with cognitive impairment and their families depends, among other things, on the cooperation of the professionals involved in their care. An effective dementia care management support model for people with dementia and their families for the outpatient sector has been further developed for ambulatory and hospital settings. The intersec-CM randomized controlled trial (RCT) implemented this intersectoral care management (iCM) model into routine care in three hospitals in B …

29.08.2026journal-article

Scientific Reports

Nutritional literacy as a potential moderator of the intrinsic capacity–frailty relationship in older adults: a cross-sectional study

Afsaneh Bakhtiari, Neda Ahmadzadeh Tori, Melika Gorji, Zahra Geraili

Abstract Intrinsic capacity (IC) and frailty are two interrelated constructs that shape the functional trajectory of aging. Although both are influenced by multiple lifestyle and health-related factors, limited evidence exists on how nutritional literacy (NL), the nutrition-specific knowledge and skills required making informed dietary decisions, may modify this relationship. This cross-sectional study was conducted in 2024 among 250 community-dwelling older adults aged 60 years and above. Data were collected using …

28.08.2026journal-article

Frontiers in Medicine

Feasibility and acceptability of two remote physical activity programs for older Latino adults: the C.E.R.E.B.R.O. study, a pilot randomized trial

Jocelyn Ocampo-Mota, Yuliana Soto, Miguel A. Negrete, Eduardo Cardiel, Brynne Karlinsey Skidmore, Mariana Pinto, David X. Marquez

Introduction Expanding access to culturally relevant physical activity (PA) programs is key to supporting healthy brain aging among older Latinos. The C.E.R.E.B.R.O. study compared two Spanish-language PA programs delivered remotely to Latinos with subjective cognitive impairment. BAILAMOS™ was a 6-month Latin dance-based intervention, and ¡En Forma y Fuerte! (Fit & Strong!) was a 3-month multicomponent program. Methods This pilot randomized trial took place remotely via Zoom. Participants were healthy, inactive, a …

28.08.2026journal-article

BMC Public Health

Exploring how and why people who drink alcohol at high-risk levels use alcohol-free and low-alcohol drinks when cutting down: a qualitative focus group study

Parvati Perman-Howe, Laura Fenton, Rachel O’Donnell, Rebecca Howell, Inge Kersbergen, Zoe Clarke, John Holmes

Abstract Background Alcohol-free and low-alcohol drinks are becoming increasingly popular in high-income countries. However, there is limited evidence on their use among general population samples. Drawing on social practice theory, this study aimed to examine how and why people who drink at high-risk levels embed alcohol-free and low-alcohol drinks into their everyday practices when trying to reduce their alcohol consumption. Methods Four online focus groups were conducted with a total of 31 adults from England an …

28.08.2026journal-article

Aging Cell

Oxygenaging: A Physiological Framework for Geroscience

Stefano Donega, Kenneth W. Fishbein, Paolo Dominelli, Allison B. Herman, Rafael de Cabo, Myriam Gorospe, Luigi Ferrucci

ABSTRACT The stepwise movement of oxygen from the atmosphere to the mitochondria, the “oxygen cascade”, is one of the most tightly regulated systems in physiology. Despite decades of mechanistic study, it has remained quite unexplored in Geroscience. This oversight should be reconsidered. In young organisms, hypoxic stress (whether environmental or tissue‐specific) activates a complex adaptive response to preserve energetic stability via restraining anabolic pathways, optimizing mitochondrial performance, and reinf …

28.08.2026journal-article

Innovation in Aging

Response consistency and response time across later life stages: Evidence from a factorial survey on housing decisions

Manuela Schulz, Christiane Gross, Andrea Teti

Abstract Background and Objectives Factorial surveys are increasingly used in gerontological research to study complex decision-making in later life. While prior work has demonstrated their feasibility among older adults, less is known about how response behaviour varies across later-life stages and how response time relates to response consistency, particularly among the oldest old. Research Design and Methods Data are drawn from a factorial survey on housing decisions conducted with a convenience sample of adults …

28.08.2026journal-article

Frontiers in Aging Neuroscience

Astragaloside IV attenuates hypoxia-reoxygenation-induced endothelial senescence and vascular inflammation by modulating the NOTCH1/VCAM-1 axis

Dehui Huang, Rongjing Zhou, Jun Ling

Objective Alzheimer's disease (AD) progression involves cerebral microvascular endothelial cell senescence induced by brain hypoperfusion, which contributes to blood-brain barrier (BBB) dysfunction. While Notch1 signaling is known to exacerbate endothelial senescence and neuroinflammation via vascular cell adhesion molecule-1 (VCAM-1), the mechanism by which it mediates hypoxia-induced endothelial aging in AD remains unclear. Furthermore, although Astragaloside IV (AS-IV) has been shown to alleviate cerebral hypope …

28.08.2026journal-article

International Journal of Molecular Sciences

The Zinc–Senescence Axis in Skin Aging and Wound Healing: A Narrative Review

Kerim Mutig, Prim B. Singh, Dulat Azhibek, Svetlana Lebedeva

Approximately one billion people worldwide are affected by acute or chronic skin wounds, placing a substantial burden on healthcare systems. This burden is further increased by population aging, as wound healing is impaired in older individuals due to age-related changes in tissue repair. Structural and functional skin alterations associated with aging and wound healing have been extensively described, including cellular senescence and inflammaging. However, less is known about zinc homeostasis in aged skin and its …

28.08.2026journal-article

Environmental Science & Technology

Influence of Fragmentation Techniques on the Biotic Aging of Test Microplastics

Barbara Klun, Serena Ducoli, Mark Starin, Janja Novak, Filippo Vaccari, Edoardo Puglisi, Ula Rozman, Nataša Čelan Korošin, Gabriela Kalčíková, Stefania Federici

Abstract This study investigates how mechanical fragmentation techniques─ultracentrifugal and mixer milling─affect the biotic aging of polystyrene (PS) and polypropylene (PP) microplastics in freshwater, focusing on biofilm formation, microbial colonization, and changes in their physicochemical properties. Both polymer type and fragmentation methods significantly affected biofilm development. Mixer-milled PP supported greater biofilm accumulation than ultracentrifugally milled PP, while the latter exhibited higher …

28.08.2026journal-article

Frontiers in Sustainable Cities

Measuring neighbourhood walkability for older adults: development and pilot validation of a multidimensional scale

Akshatha Rao, Nandineni Rama Devi, Shriharsh Ashok Dixit, Roshan S. Shetty, Kailas Mallaiah, John Benette John

Introduction While there is a growing recognition of walkable neighbourhoods in promoting the health and well-being of older adults, there is limited evidence of a validated, multidimensional measurement scale tailored for Indian context that integrates policy antecedents, built environment attributes, and behavioural outcomes. This study aims to develop and pilot-validate such a scale for assessing neighbourhood walkability among older adults. Methods A three-phase scale development process was adopted. First, an …

28.08.2026journal-article

Población y Salud en Mesoamérica

Interrelationships between the meaning of life, physical activity, social support network, age, and gender in older adults

Diego Rodríguez-Méndez, Luis Solano-Mora, María Antonieta Corrales-Araya, Edgar Murillo-Campos, Brynel Cortés-Gómez

Introduction: Older adults attending daycare centers are in an environment in which different variables are interrelated and could shape their meaning of life, among other aspects. Objective: To analyze the associations between the meaning of life, physical activity, social support network, age, and gender in seven-day centers in the province of Heredia, Costa Rica. Methodology: This is a cross-sectional quantitative study. Seventy-seven older adults were recruited from seven-day centers. The variables investigated …

28.08.2026journal-article

BMC Geriatrics

Distinct factors associated with past-year fall occurrence and fall-related injury among community-dwelling older adults: a cross-sectional analysis

Junwoo Park, Kitaek Lim, Soyeon Yoon, Donggeon Kim, Sungmin Chun, Jongwon Choi, Woochol Joseph Choi

Abstract Background Current fall prevention strategies have been built predominantly on the factors associated with fall occurrence rather than fall-related injury, and the determinants of these two outcomes may be distinct. This study aimed to identify distinct factors associated with past-year fall occurrence (non-fallers vs. fallers) and fall-related injury (non-injurious vs. injurious fallers) in community-dwelling older adults. Methods In this cross-sectional, secondary analysis, 9,950 community-dwelling older …

28.08.2026journal-article

Journal of Oral Rehabilitation

Cross‐Sectional Survey of Dental Treatment Needs Among Older Adults Receiving Home‐Visit Dental Care for Eating‐Related Problems in Acute, Convalescent and Community‐Based Care Phases

Naoki Todayama, Hiroyuki Suzuki, Chiaki Matsubara, Yasuyuki Iwasa, Yoko Wakasugi, Akira Goda, Shuhei Takeuchi, Yasushi Tamada, Koichiro Matsuo, Haruka Tohara, Junichi Furuya

ABSTRACT Background Oral health in older adults is often compromised by age‐related changes, such as oral frailty and systemic comorbidities. Consequently, older patients requiring home‐visit dental care, mostly due to eating‐related problems, may show stage‐dependent differences in oral conditions and dental care priorities. Objective To clarify care phase‐specific dental care needs among older patients receiving home‐visit dental care. Methods This multicenter cross‐sectional study included 356 older patients who …

28.08.2026journal-article

Frontiers in Public Health

Indirect association of kinesiophobia with physical activity through pain self-efficacy in older women with primary osteoporosis

Qian-Lian Zheng, Yue-Hua Zhang, Fu-You He, Yu-Mei Yang, Jun-Min Chen, Ling-Min Zhang, Yao Chen, Jiao Zhong, Yu-Xiang Yang, Lei Sun

Background Physical activity is a core component of osteoporosis management, yet many older women with primary osteoporosis remain insufficiently active. Kinesiophobia, pain self-efficacy, and physical activity are theoretically linked, but their cross-sectional inter-relationships in this population remain unclear. Methods This multi-center cross-sectional study recruited older women with primary osteoporosis and chronic musculoskeletal pain from outpatient clinics at three tertiary hospitals in China between Marc …

28.08.2026journal-article

European Journal of Investigation in Health, Psychology and Education

Resilience and Protective Factors Associated with Well-Being Among Older Informal Caregivers: A Convergent Segregated Mixed Studies Systematic Review

Alba Peraza Delgado, Yurena María Rodríguez Novo, Miguel López Martínez, Mercedes Novo Muñoz

Background: Population aging has led to an increasing proportion of older adults (aged 65 and older) acting as informal caregivers. These caregivers face risks of burden, stress, and depression. While research frequently documents negative psychological outcomes, resilience represents a crucial protective process. This systematic review synthesizes and maps the empirical evidence regarding the association between the socio-ecological resilience process and the well-being of older informal caregivers. Methods: Follo …

28.08.2026journal-article

JMIR Aging

A Smart Wheeled Walker With Integrated Physiological Monitoring to Improve Mobility in Older Adults: Randomized Crossover Trial

Phurichaya Werasirirat, Pornpimol Muanjai, Oranat Sukkho, Nongnuch Luangpon, Audrius Snieckus, Juntip Namsawang

Abstract Background Mobility limitations in older adults are associated with an increased physiological cost of walking, reduced functional independence, and elevated fall risk. Conventional wheeled walkers improve stability but lack real-time physiological monitoring and safety feedback. Digital health–enabled assistive devices integrating physiological monitoring and fall detection may enhance mobility performance and safety. Objective This study aimed to evaluate the short-term effects of a smart wheeled walker …