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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

Nanotechnology

Targeted therapy of colon cancer with aptamer-functionalized albumin nanoparticles loaded with disulfiram

Yacong An, Zhen Yu, Ting Li, Xundou Li, Qiping Jiang

Abstract Chemotherapy remains the primary treatment for most patients with metastatic colorectal cancer (mCRC), yet its efficacy is often limited by severe adverse effects. Drug repurposing offers a promising strategy to accelerate oncology drug development. Disulfiram (DSF), a licensed anti-alcoholism agent, has demonstrated broad-spectrum anticancer activity in preclinical models. However, its clinical translation for oncology is hindered by poor aqueous solubility, rapid metabolism, and lack of tumor selectivity …

01.09.2026journal-article

Cancer Reports

An In Vitro and In Vivo Assessment of the Anti‐Breast Cancer Activity of Erythrina excelsa Baker (Fabaceae) Bark Extracts

Jonas Walantini, Marius Trésor Kemegne Sipping, Merline Nguedia Ymele, Roland Nhouma Rebe, Joël Abel Gbaweng Yaya, Derek Tantoh Ndinteh, Dieudonné Njamen, Stéphane Zingue

ABSTRACT Background Breast cancer remains a topic of interest due to its high mortality rate among Cameroonian women. The barks of Erythrina excelsa are traditionally used for medicinal purposes in the management of various conditions including cancer. Aims This study evaluated the phytochemical composition, antioxidant properties, and anticancer effects of Erythrina excelsa bark extract in vitro and in vivo. Methods and Results Phytochemical profiling and antioxidant assays (DPPH, FRAP) were conducted to determine …

01.09.2026journal-article

Peer Review

Are fluoroquinolones still viable for empirical UTI treatment? Evidence from southeastern Brazil

Patrícia Guedes Garcia, Janita Soraia de Oliveira Da Silva, Natália Maria da Silva Fernandes, Lucas Fernandes Suassuna, Luciana Debortoli de Carvalho, Taleessa Vieira Gomes, Ana Carolina Apolonio, André Luiz Silva Alvim, Marcio Roberto Silva

Urinary tract infections frequently require empirical antimicrobial therapy, although increasing fluoroquinolone resistance may limit their use. This retrospective cross-sectional study evaluated local susceptibility patterns and factors associated with resistance in urine cultures from outpatients attending a university hospital in southeastern Brazil during 2024. Of 1,958 cultures, 418 (21.35%) showed significant bacterial growth. Escherichia coli was the predominant pathogen (48.3%), followed by Klebsiella spp. …

01.09.2026journal-article

npj Systems Biology and Applications

Encapsulated multicellular breast cancer spheroids exhibit behavioural plasticity under non-negotiable mechanical stress

Sukanya Gayan, Saili S. Shinde, Asadullah, Anisha Karmakar, Shamik Sen, Tuli Dey

Abstract Cancerous growth, along with other known biological and biochemical signals, also depends on the biomechanical pressure wielded by the adjacent extracellular matrix (ECM). The dynamic relationship between the growing tumor and the ECM influences tumor growth, aggressiveness, and dormancy. Additionally, with time, the stroma also becomes subject to tumor-mediated remodeling through deformation and deposition cycles. In recent years, many studies have identified the dialog between the ECM and the tumor as on …

02.09.2026journal-article

Journal for ImmunoTherapy of Cancer

Targeting the PD-L1-induced PDK4/GLS metabolic axis overcomes anti-PD-1 resistance in non-small cell lung cancer

Wenxin Lian, Hui Yang, Yuqi Zhang, Chenchen Liu, Chunyao Fang, Mengyue Xu, Yixing Yang, Yan Wang, Runqiu Jiang, Jing Xu, Wen Gao

Background Metabolic reprogramming within the tumor microenvironment is a pivotal barrier to effective immune checkpoint blockade (ICB). While programmed death ligand 1 (PD-L1) is well characterized as a ligand inhibiting T-cell function, its intrinsic ‘reverse signaling’ role in regulating tumor metabolism and shaping the immune landscape remains poorly understood. Here, we investigated the metabolic determinants of resistance to anti-programmed cell death protein 1 (anti-PD-1) therapy and the underlying molecular …

03.09.2026journal-article

Journal of Applied Clinical Medical Physics

Evaluation of inter‐fractional anatomical variations due to compression belt placement reproducibility using MR‐guided radiotherapy treatment fraction images

Olivia Shay, David Solis, Morgan Aire, Christopher Schneider, Krystal Kirby

Abstract Background Abdominal compression (AC) using a belt‐based system is widely employed in radiation therapy to limit respiration‐induced target motion for abdominal and hepatic malignancies. While AC has demonstrated efficacy in reducing intrafraction motion amplitude, the interfractional anatomical consequences of daily compression belt (CB) placement variability remain poorly characterized. A clearer understanding of this variability is necessary to determine whether online adaptive radiotherapy (oART) is re …

01.09.2026journal-article

Cancer Diagnosis & Prognosis

Malignant Myoepithelioma Arising from the Upper Arm With Brachial Plexus Involvement: A Rare Case

HAYATO TATSUMI, TOSHIHIRO MATSUO, TAKASHI NISHISAKA, YUI HATTORI, KOJI NISHIDA, RYOUSUKE MATSUSHITA, MASAHIRO YOSHIKAWA, SATOSHI AKI, NOBUO ADACHI

Background/Aim: Malignant myoepitheliomas (MMs) are infrequent, and the site of upper arm is extremely rare. To our knowledge, only two cases occurred in the upper arms according to previous reports. Case Report: A 73-year-old male presented with a growing mass in his left upper arm one year prior to surgery. After a needle biopsy, histopathological analysis revealed the mass to be a myxoid sarcoma but did not reach to definite diagnosis. The tumor was excised from the brachial plexus. The brachial artery and vein …

04.09.2026journal-article

Journal of Primary Care & Community Health

Perceived Feasibility and Acceptability of a Self-Collected HPV DNA Testing Policy for Cervical Cancer Screening in Thailand

Chayanis Kositamongkol, Euarat Mepramoon, Sukrit Kanchanasurakit, Pattarawalai Talungchit, Pattama Chaopotong, Kirati Kengkla, Thanet Chaisathaphol, Surasak Saokaew, Pochamana Phisalprapa

Objectives Although cervical cancer screening is available to all Thai women, incidence and mortality remain high because uptake remains low. The national health benefits package now covers self-collected human papillomavirus (HPV) DNA testing, which may reduce barriers. We explored the perceived feasibility and acceptability of self-collected HPV DNA testing within Thailand’s national cervical cancer screening policy. Methods We conducted individual, in-depth interviews with 40 participants to explore their perspe …

01.09.2026journal-article

Nutrition Reviews

Validity of Nutrition Screening Tools for Risk of Malnutrition Among Pediatric Oncology Populations: A Systematic Review and Meta-Analysis

Melda Kangalgil, Buket Meral, Ebru Küçük Erdöl

Abstract Context The lack of standardized procedures for malnutrition risk screening in the pediatric oncology population. Objective This systematic review and meta-analysis aimed to evaluate the validity of nutritional screening tools for identifying the risk of malnutrition in pediatric oncology patients. Data sources A systematic review of studies identified in 4 databases (Web of Science, Scopus, OVID and CINAHL) were searched from inception to April 2025. Data Extraction Two reviewers independently screened st …

01.09.2026journal-article

PLOS Medicine

Effect of a person-centered care intervention on return and sustained reengagement after treatment interruptions from HIV care in Zambia: A post-hoc analysis of a stepped-wedged cluster randomized trial

Aaloke Mody, Kombatende Sikombe, Sandra Simbeza, Njekwa Mukamba, Laura K. Beres, Jake M. Pry, Anjali Sharma, Jacob Mutale, Alida Zulu Dube, Musunge Mulabe, Lloyd Mulenga, Suilanji Sivile, April Ratliff, Charles W. Goss, Charles B. Holmes, Carolyn Bolton Moore, Izukanji Sikazwe, Elvin H. Geng

Background Poor client-provider interactions lead to reinforcing cycles of treatment interruptions (TIs) from HIV care and fear of return, undermining sustained retention. We previously demonstrated a multi-component person-centered care intervention (PCC) targeting healthcare worker (HCW) behavior improved client experience and retention in HIV care. To understand mechanisms of improved retention, we evaluated the effect of the PCC intervention on return after TIs and sustained retention after return in a post-hoc …

01.09.2026journal-article

Current Oncology

Post-Treatment Trajectories of Retained Totally Implantable Venous Access Ports After Anticancer Therapy: A Conditional Landmark Cohort Study

Zeyang Fan, Tiantian Li, Kai Yang

Background: Retained totally implantable venous access ports (TIVAPs) pose a clinical management challenge after completion of intravenous anticancer therapy, particularly when future treatment needs remain uncertain. We aimed to characterize longitudinal post-treatment TIVAP trajectories after a day-90 conditional landmark, with elective removal prespecified as the primary first event. Methods: This retrospective cohort study included patients who were alive and event-free, retained the original TIVAP, had no docu …

01.09.2026journal-article

Journal for ImmunoTherapy of Cancer

Normal-immunopeptidome denominator: a safety atlas for immunotherapies targeting non-canonical and aberrantly expressed tumor antigens

Li-zhen Chen

Proteogenomic cancer antigen discovery now extends beyond somatic mutations to include unmutated, aberrantly expressed, and non-canonical sources. We distinguish two orthogonal dimensions: molecular origin (canonical or non-canonical) and normal-tissue distribution (tumor-specific antigen, tumor-associated antigen, or lineage-specific antigen). Importantly, non-canonical origin does not imply tumor specificity. For human leukocyte antigen (HLA)-restricted immunotherapy, selectivity must be established at the level …

01.09.2026journal-article

Ophthalmology Research: An International Journal

Anti-Vascular Endothelial Growth Factor Treatment Outcomes in Patients with Visual Impairment in Ahmadu Bello University Teaching Hospital, Zaria: A Retrospective Analysis

Aishah Ukashat, Kehinde Oladigbolu, Kashetu Suleiman Bello, Mubarak Bello

Aim: To assess treatment outcomes in eyes that received an anti-VEGF injection in the medical retina unit of Ahmadu Bello University Teaching Hospital (ABUTH), Zaria, Nigeria, in terms of visual acuity and central macular thickness. Study Design: A retrospective descriptive study. Place and duration of study: Medical Retina Record Unit, Department of Ophthalmology, ABUTH, Zaria, from January to April 2025. Methodology: We reviewed the records of patients who received intravitreal anti-VEGF injections for retinal di …

01.09.2026journal-article

ASM Case Reports

Mycobacterium bovis BCG infection of the brain following intravesical BCG treatment

Sierra Amaya, Steven N. Schwartz, James E. Kirby, Hemant Varma

ABSTRACT Background Intravesical Bacille Calmette-Guerin (BCG) therapy with live-attenuated form of Mycobacterium bovis ( M. bovis ) is used as a treatment of early-stage bladder cancers. Documented adverse reactions are usually local and time limited, with severe central nervous system (CNS) complications being exceedingly rare. We report an 88-year-old patient with papillary urothelial carcinoma who presented with recurring neurological complications for over a year after treatment with intravesical BCG therapy. …

01.09.2026journal-article

Current Issues in Molecular Biology

Ferrostatin-1 Attenuates CLP-Induced Colonic Injury: Associations with Ferroptosis-Related Alterations, Oxidative Stress, Inflammation, and Treatment Timing

Mehmet Tolga Kafadar, Eda Yıldızhan

Fecal peritonitis induces severe oxidative and inflammatory injury and may involve ferroptosis-related mechanisms. This study investigated the effects of Ferrostatin-1 (Fer-1) on cecal ligation and puncture (CLP)-induced colonic injury, with emphasis on oxidative stress, inflammation, ferroptosis-related alterations, and treatment timing. Thirty-five male Wistar rats were randomly assigned to five groups: Sham, CLP, CLP + dimethyl sulfoxide (DMSO), CLP + Fer-1 (30 min), and CLP + Fer-1 (2 h). Fer-1 (5 mg/kg, intrap …

01.09.2026journal-article

BMC Oral Health

Preferences for orthodontic treatment attributes among young adult malocclusion patients in Anhui, China: a discrete choice experiment

Fangyu Song, Dandan Yu, Shan Jiang, Yihui Li, Yuguang Liu, Wang Yao, Han Cheng, Jianguang Xu, Wenhua Xu, Lidan Wang, Yuanyuan Gu

Abstract Background Malocclusion is a common dental condition that affects both oral function and facial appearance, with substantial implications for psychological well-being and oral health-related quality of life. Despite continuing advances in orthodontic technology, evidence on patient preferences for the available treatment options remains limited. This study aimed to quantify preferences and willingness to pay (WTP) for key orthodontic treatment attributes among young adults with malocclusion in China. Metho …

01.09.2026journal-article

JNCI: Journal of the National Cancer Institute

Cancer rarity and mortality: Evidence from a nationwide cohort study

Simon M Kønig, Søren Friis, Trille K Kjær, Jane Christensen, Mia Klinten Grand, Susanne O Dalton, Jan Wohlfahrt

Abstract Background Patients with rare cancers have consistently been reported to have poorer survival than patients with common cancers. We hypothesized that the excess mortality could be attributable to differences in tumor histology and stage at diagnosis and, explored whether it reflected a broader relationship between cancer incidence and mortality. Methods In a nationwide, population-based cohort study, we included adults diagnosed with a first primary solid malignant tumor in Denmark between 2004 and 2023. C …

01.09.2026journal-article

Cancer Reports

Age‐Associated Four‐Gene Prognostic Signature in Breast Cancer

Shiro Uchida

ABSTRACT Background Young‐onset breast cancer is associated with inferior disease‐free survival (DFS), but the contribution of additional molecular heterogeneity remains unclear. Aims To identify an exploratory age‐associated gene expression signature linked to recurrence‐related outcomes and evaluate its prognostic association. Methods and Results We analyzed clinicopathological and RNA‐sequencing data from 821 patients with Stages I–III invasive ductal or lobular carcinoma in The Cancer Genome Atlas, including 14 …

01.09.2026journal-article

Diagnostics

Urinary Biomarkers in Urological Oncology: From Biological Origin to Clinical Decision-Making—A Narrative Review

Aliya Nurmukhanbetova, Kassymkhan Sultanbekov, Khussan Umurzakov, Zie Gassanov, Altyn Duisenbayeva, Alimkhan Talas, Lazzat Shaikenova, Aidos Bolatov

Urinary biomarkers are promising tools in urological oncology because urine can be collected non-invasively and repeatedly during diagnosis, treatment, and surveillance. Despite extensive biomarker discovery, their adoption in routine practice remains limited. Biomarker performance depends not only on analytical accuracy but also on the clinical decision, anatomical route into urine, biological source of the signal, specimen fraction, and timing and conditions of sampling. This review evaluates urinary biomarkers a …

01.09.2026journal-article

Journal of Cell Science

CCT8 associates with the MYO10 motor domain and regulates filopodia and breast cancer cell invasion

Ana Popović, Marjaana Ojalill, Christine Touma, Neil J. Ball, Mitro Miihkinen, Omkar Joshi, Michal Dibus, Joanna Pylvänäinen, Johanna Ivaska, Benjamin T. Goult, Guillaume Jacquemet

Cancer cells utilize filopodia to explore, adhere to, and invade their surrounding microenvironment, yet the protein networks that organize these protrusions remain incompletely defined. To uncover the molecular machinery underlying MYO10-positive filopodia, we targeted the fast biotin ligase TurboID to the motor protein MYO10. Proximity biotinylation in two cell types revealed hundreds of potential MYO10 interactors. A targeted microscopy and siRNA screen identified MINK1, SCRIB, CSNK1A1, and CCT8 as new regulator …

01.09.2026journal-article

Journal of Iranian Medical Council

Changes in Lactobacillus and Bifidobacterium Load in a Population of Iranian People with Papillary Thyroid Cancer: The Effect of Radioactive Iodine therapy

Sakineh Moghadam Shiri, Nahid Hashemi-Madani, Sara Cheraghi, Babak Fallahi, Sara Minaeian, Maryam Honardoost, Fereshteh Shahrabi, Mohammad E. Khamseh

Background: To investigate the changes in Lactobacillus and Bifidobacterium load in a population of Iranian people with Papillary Thyroid Carcinoma (PTC) before and following Radioactive Iodine (RAI) therapy. Methods: This longitudinal cohort study included 28 healthy individuals and 30 PTC patients referred for RAI therapy. A total of 90 stool samples from the same 30 patients with PTC were collected one day before RAI therapy, two weeks and two months following RAI therapy. As a control group, 28 stool samples we …

01.09.2026journal-article

European Journal of Nuclear Medicine and Molecular Imaging

Comparative analysis of PSMA-RADS Version 2.0 versus bone uptake metastatic probability (BUMP) score for characterising focal bone uptake on [18F]PSMA-1007 PET/CT in prostate cancer – a multicentre evaluation

James Cairns, Salman Arain, Amarnath Challapalli, Amalia Stavropoulos, Tamir Ali, Daniel Ward, John Sage, Georgia Ionescu, Julien M. Y. Willaime, Russell Frood, Amit Bahl, George Petrides, Andrew Scarsbrook

Abstract Purpose Prostate-specific membrane antigen (PSMA) PET/CT is widely used in prostate cancer management, but unspecific bone uptake (UBU) remains a diagnostic challenge particularly with [18F]PSMA-1007. Bone uptake metastatic probability (BUMP) score - a composite imaging-clinical model, was compared with PSMA Reporting and Data System (PSMA-RADS, Version 2) for predicting skeletal metastases in UBU. Methods A real-world cohort of [18F]PSMA-1007 PET/CT scans performed at three tertiary cancer centres was ret …

01.09.2026journal-article

Frontiers in Oncology

Case Report: Metastatic melanoma with initial ctdna decline and radiographic response during self-directed antiparasitic use: treatment effect or spontaneous regression?

Ricky Cheng, Daniel V. Araujo

A 74-year-old man with nodular melanoma of the right lateral neck presented with nodal and hepatic metastases at staging. He declined guideline-directed therapy and instead pursued lifestyle modifications alongside self-administered ivermectin and fenbendazole. On serial imaging, his disease initially demonstrated reduced metabolic activity and size without new sites of involvement, paralleled by a decline in tumor-informed ctDNA (Signatera) from 2.04 to 0.18 MTM/mL. Both subsequently worsened, with ctDNA rising to …