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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
30.08.2026journal-article

Journal of Asian Medical Students' Association

Comparative Efficacy and Safety of Dual Orexin Receptor Antagonists (DORAs) Versus Z-Drugs for Insomnia in Older Adults : A Systematic Review

Given Anugraha Wijaya, Frederick Karel Himawan, Jason Conrad Tanely

Introduction Insomnia affects up to 48% of older adults globally, often treated with Z-drugs that increase the risk of cognitive impairment and falls.1,4 Dual Orexin Receptor Antagonists (DORAs) offer a targeted alternative by specifically suppressing wakefulness-promoting pathways to minimize these adverse effects.7,8 Method This systematic review of Randomized Controlled Trials was conducted using the PRISMA guideline with references found in multiple online databases including PubMed, ScienceDirect, Proquest and …

30.08.2026journal-article

European Journal of Preventive Cardiology

Fitness does not retire: cardiorespiratory fitness and risk of major adverse cardiovascular events in older adults

Sindre Midttun, Håvard Dalen, Einar Lund, Elisabeth K Vesterbekkmo, Inger-Lise A Aksetøy, Leonard Kaminsky, Jeff S Coombes, Ulrik Wisløff, Dorthe Stensvold

Abstract Aims To evaluate the association between cardiorespiratory fitness (CRF), directly measured as peak oxygen uptake (VO2peak), and the risk of major adverse cardiovascular events (MACE) in older Norwegian adults. Methods and results A total of 1547 individuals aged 70–77 years (784 women) from the Generation 100 Study, examined in 2012 and 2013, were studied. We defined MACE as the first occurrence of acute myocardial infarction, stroke, heart failure, or cardiovascular death. Sex- and cohort-specific VO2pea …

30.08.2026journal-article

Diabetic Medicine

DiaActive protocol: A randomized controlled trial of cognitive‐motor multicomponent exercise to reduce fall rate in older adults with diabetes

Aksayan Arunanthy Mahalingasivam, Asger Ahlmann Bech, Peter Vestergaard, Martin Grønbech Jørgensen, Nicklas Højgaard‐Hessellund Rasmussen

Abstract Introduction Older adults with diabetes have an increased risk of falls due to neuropathy, impaired bone health and cardiovascular disease, resulting in significant morbidity and mortality. Conventional fall‐prevention programmes primarily target strength and balance, while cognitive‐motor integration, essential for safe mobility in complex environments, is often overlooked. Multicomponent exercise combining physical and cognitive training may therefore provide additional benefits in this population. Metho …

30.08.2026journal-article

Journal of Alzheimer’s Disease

Depressive symptoms and low cognitive performance in Chinese older adults: A severity-graded epidemiological analysis and a BARNN-inspired prospective risk-prediction framework with strict participant-level temporal validation

Qiang Zhang, Xiao Cai, Yifan Zhao, Xinsong Ren, Dongwei Yan

Background Late-life depression is robustly associated with subsequent cognitive impairment, yet the dose-response gradient and temporally validated, uncertainty-aware prediction tools remain understudied in Chinese older adults. Objective To characterize the severity-graded epidemiological association between depressive symptoms and low cognitive performance, and to develop and validate a prospective risk-prediction framework with explicit uncertainty estimation. Methods We analyzed 31,570 observations from 12,494 …

30.08.2026journal-article

Journal of the American Geriatrics Society

Preoperative Moderate–Severe Excessive Daytime Sleepiness Is Associated With Postoperative Cognitive Dysfunction in Older Surgical Patients

Michael J. Devinney, Jeffry Takla, Keith VanDusen, Mary C. Wright, Andrew R. Spector, Jake Thomas, Pallavi Avasarala, Ashley Hall, Ayesha Syed, Melissa Adams, Eugene Moretti, Jennifer E. Dominguez, Patrick J. Smith, Megan K. Wong, Victor Cai, Sarada Eleswarpu, Jeffrey N. Browndyke, Harvey J. Cohen, Heather E. Whitson, Sigrid C. Veasey, Miriam Treggiari, Kaj Blennow, Henrik Zetterberg, Joseph P. Mathew, Miles Berger, the INTUIT Study Investigators

ABSTRACT Background Excessive daytime sleepiness may reflect increased vulnerability to postoperative neurocognitive disorders given its association with neurodegenerative disease, cognitive decline, and dementia. However, the role of excessive daytime sleepiness in postoperative neurocognitive disorders is unknown. Here, we investigated whether preoperative moderate–severe excessive daytime sleepiness is associated with postoperative neurocognitive disorder severity. Methods This prospective observational cohort s …

30.08.2026journal-article

Journal of Alzheimer’s Disease

A hippocampal vascular–glymphatic model of brain maintenance and cognitive resilience in Alzheimer's disease and post-stroke dementia

Álvaro Ruiz-García, Blanca Díaz-Benito, Mariana Muñoz-García

Individuals with comparable burdens of brain pathology often follow markedly different cognitive trajectories. This heterogeneity is captured by three partly dissociable constructs—brain reserve, cognitive reserve, and brain maintenance—here grouped under the superordinate term cognitive resilience. Cognitive reserve has traditionally been indexed by education, occupational complexity, and lifelong cognitive engagement, yet its biological substrates remain incompletely defined. We propose that hippocampal vascular …

30.08.2026journal-article

Life

Effects of Mind–Body Exercise on Pulmonary Function and Functional Exercise Capacity in Older Adults with COPD: A Three-Level Meta-Analysis

Weiping Du, Songnian Han, Xiaodan Niu, Aiping Chi, Jianhua Zhou

Background/Objectives: Mind–body exercise may improve pulmonary function and exercise capacity in older adults with chronic obstructive pulmonary disease (COPD), but its overall effects and potential variation by exercise modality and intervention duration remain uncertain. This study evaluated its effects on pulmonary function and six-minute walk distance (6MWD) in COPD samples with a mean age of ≥60 years. Methods: PubMed, Web of Science Core Collection, Embase, the Cochrane Library, CNKI, and Wanfang Data were s …

30.08.2026journal-article

Agriculture

The Impact of Rural Population Aging on Food Prices: Empirical Evidence from China

Zhen Nie, Zhenzhen Liu, Wen Li, Qiongyao Liu, Jiaxing Pang

Stabilizing food prices is essential for ensuring food security in an aging society. Using panel data from 30 Chinese provinces spanning 2005 to 2022, this study employs a nonlinear panel model and a Spatial Durbin Model (SDM) to analyze the impact of rural population aging on food prices and its spatial spillover effects. This study derives the following findings based on empirical research: (1) Rural population aging exhibits a significant inverted U-shaped relationship with food prices, with an inflection point …

30.08.2026journal-article

Journal of Korean Society of Dental Hygiene

Association between food-derived water intake and oral health indicators among Korean older adults living alone: a cross-sectional study using data from the 2020–2024 Korea National Health and Nutrition Examination Survey

Ji-Young Lee, Da-Jeong Kim, Yu-Rin Kim

Objectives: To compare food-derived water intake and oral health between Korean older adults living in single-person households (SG) and those living in multi-person households (MG), and to examine the association between food-derived water intake and oral health among those living alone using data from the 2020–2024 Korea National Health and Nutrition Examination Survey (KNHANES). Methods: This cross-sectional study included 8,164 adults aged ≥65 years (SG=2,158; MG=6,006). Food-derived water intake was categorize …

30.08.2026journal-article

Physiological Reports

Impact of aging on neck vasculature and brain biochemistry in female mice

Allison R. Jones, Amin Jarrahi, Kylee Karpowich, EllaGrey Moody, Lily Renner, Lindsay P. Brown, Caitlin M. Tressler, A. Colleen Crouch

Abstract Age‐related changes in large‐vessel biomechanics may contribute to neurovascular dysfunction and region‐specific biochemical remodeling in the brain, with important implications for female health. This study investigated the impact of aging on neck vasculature and brain lipid biochemistry in female C57BL/6NHsd mice by comparing young (12 weeks; n = 10) and middle‐aged (52 weeks; n = 10) cohorts using ultrasound imaging, histology, and mass spectrometry. In vivo ultrasound quantified carotid and jugular hem …

30.08.2026journal-article

International Journal of Geriatric Psychiatry

Beyond Caregiving: Recovery and Growth Among Primary Caregivers Following the Loss of a Family Member Living With Dementia

Wen‐Ying Chang, Shan‐Mei Chang, Wen‐Jiuan Yen, Wei‐Fen Ma

ABSTRACT Background Caring for a family member with dementia places long‐term emotional, physical, and social strain on primary caregivers. Although extensive research has examined the caregiving phase, relatively few studies have explored caregivers' recovery experiences following bereavement, particularly in Chinese cultural contexts. Objectives To explore the post‐bereavement recovery among primary family caregivers of individuals with dementia, with specific attention to emotional adjustment, life transitions, …

30.08.2026journal-article

Vaccines

Adverse Events Following Yellow Fever Vaccination in Older Adults in Colombia, 2024–2025: A National Pharmacovigilance Analysis

Heriberto Vásquez-Serna, Carlos Eduardo Jiménez-Canizales, Carlos Alexander Huertas-Caro, Diana Urrego-Ricaurte, Johan Estiven Vargas-Vargas, Luis Gabriel Forero Gutiérrez, Laura Rodríguez, Olga Corredor, Gina Hurtado, Lysien I. Zambrano, Alfonso J. Rodríguez-Morales

Introduction: Yellow fever re-emerged as a major public health threat in the Americas during 2024–2025, with increasing numbers of cases and deaths, predominantly among unvaccinated individuals. Although the live-attenuated 17D yellow fever vaccine is highly effective, adults aged ≥60 years have an increased risk of serious adverse events following immunization (AEFIs). We assessed the safety profile of yellow fever vaccination in Colombia, with particular emphasis on older adults, and contextualized the observed r …

30.08.2026journal-article

Aging Cell

SIRT1 Silences L1 Retrotransposons by Stabilizing Heterochromatin‐Modifying Complexes

Xiaona Wang, Tianbo Li, Huanyin Tang, Meng Xiao Liu, Qinghua Peng, Xiao Huang, Zhiyong Mao, Ying Jiang, Anke Geng

ABSTRACT SIRT1, a sirtuin family member, has been extensively documented to be closely linked to aging and aging‐related disease. Cellular senescence is a state of irreversible cell cycle arrest that functions as a key driver of aging. During cellular senescence, LINE‐1 (L1) retrotransposable elements become transcriptionally activated and stimulate a type‐I interferon (IFN‐I) response. L1 activity has been strongly linked to aging and a variety of age‐related disorders. However, whether SIRT1 influences cellular s …

30.08.2026journal-article

Revista ft

Hipertensão arterial e doença renal crônica em idosos: revisão das evidências sobre evolução clínica e tratamento

Beatriz Aguiar Medeiros, Julia Gauer Gomides Tavares, Nicolly Cristine Nobre Bredun, Michel Hosananh Vasconcelos

Systemic arterial hypertension (SAH) and chronic kidney disease (CKD) are among the most prevalent chronic conditions in the elderly, frequently coexisting and mutually exacerbating their outcomes. This interaction compromises quality of life and increases the risk of cardiovascular and renal complications, making its management a significant challenge. This study analyzed the influence of hypertension on the progression of kidney disease in the elderly and evaluated the effectiveness of available therapeutic strat …

30.08.2026journal-article

Aging Cell

Higher Frontal Cortex Angiotensin Type 2 Receptor‐Interacting Protein ( ATIP ) Levels Are Associated With a Lower Amyloid‐Beta Burden in Postmortem Brains of Older Adults With Alzheimer's Disease

Caglar Cosarderelioglu, Simion Kreimer, Alma I. Plaza‐Rodriguez, Pablo A. Iglesias, C. Conover Talbot, Helmy M. Siragy, Ceereena Ubaida‐Mohien, Francine Grodstein, Luigi Ferrucci, David A. Bennett, Jeremy Walston, Peter Abadir

ABSTRACT Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by amyloid‐β (Aβ) and tau accumulation. Dysregulation of the brain renin‐angiotensin system, particularly hyperactivation of the angiotensin II type‐1 receptor, contributes to AD pathogenesis. In contrast, activation of the angiotensin II type‐2 receptor (AT 2 R) has been linked to neuroprotection and reduced Aβ accumulation. However, the underlying mechanisms of AT 2 R‐related Aβ reduction and the role of AT 2 R‐interacting pro …

30.08.2026journal-article

Veterinary Record Case Reports

Treatment of separation anxiety and fear of noises, confinement and unfamiliar people in a dog using escitalopram and clonidine

Erica Grier

Abstract A 3‐year‐old, 8.9 kg, neutered male dachshund was presented for fear and anxiety that significantly affected his daily quality of life. Distressing situations included being separated from his owner, confined in crates, exposed to noises and introduced to unfamiliar people. Clinical signs frequently included trembling, barking, hypersalivation, urination and attempts to escape or hide, with a recovery time of 20–40 minutes. Previous treatment with fluoxetine, a cannabidiol supplement and trazodone, alongsi …

30.08.2026journal-article

Wilderness & Environmental Medicine

Read It and Weep: An Evaluation of People Involved in Avalanches and Their Forecast Reading Habits

Sarah Petelinsek, Rowan Kelner, Jamal Jones, Nikki Champion, Michael Morgan, Patrick G. Hughes

Introduction The aim of this investigation is to gain insight into how humans interact with the avalanche forecast and better understand the role that the avalanche forecast plays in prevention of human-triggered avalanche incidents. Methods Using a 5-y cross-sectional study of self-reported survey data of participants involved in avalanches, we performed a secondary analysis to identify trends and patterns in avalanche forecast reading habits. The study assessed avalanche forecast reading habits, perceptions, and …

29.08.2026journal-article

The FASEB Journal

Identification of Ferro‐Aging‐Related Biomarkers for Ulcerative Colitis Through Integrated Machine Learning, Single‐Cell Analysis, and Spatial Transcriptomics

Qianwen Wang, Na Wang, Honglin Yan, Jingping Yuan

ABSTRACT Ulcerative colitis (UC) is characterized by chronic mucosal inflammation, epithelial injury, oxidative stress, and marked molecular heterogeneity. Ferro‐aging has recently been proposed as an ACSL4‐associated, iron‐dependent aging‐related state in primates, but whether its associated transcriptional features are relevant to chronic mucosal inflammatory disease remains unclear. Here, we integrated bulk transcriptomics, machine learning, single‐cell RNA sequencing, spatial transcriptomics, and immunohistoche …

29.08.2026journal-article

Discover Medicine

Navigating the sedation challenge in frail older patients undergoing endoscopic retrograde cholangiopancreatography: a narrative review

Koji Takahashi, Nana Yamada, Terunao Iwanaga, Takafumi Sakuma, Hidehiro Kamezaki

Abstract The global increase in life expectancy has resulted in a higher volume of endoscopic retrograde cholangiopancreatography (ERCP) procedures among frail older patients. Frailty, a multidimensional syndrome characterized by decreased physiological reserve, presents significant risks for sedation-related adverse events. Current sedation practices frequently rely on data derived from younger cohorts, often failing to account for the distinct pharmacokinetic and pharmacodynamic profiles associated with frailty. …

29.08.2026journal-article

Journal of Applied Polymer Science

The Effects and Mechanisms of Thermal Oxygen Aging on Trap Characteristics and Electrical Performance of Functional Group‐Grafted Materials for HVDC Cable Insulation

Xu Yang, Jingyang Sun, Jun You, Zhe Fu, Yuan Gao, Hong Zhao, Xuan Wang

ABSTRACT In this study, N‐allylaniline (NA), a functional monomer possessing both deep trap‐inducing and antioxidant capabilities, was grafted onto cross‐linked polyethylene (XLPE) to prepare XLPE‐g‐NA. Both XLPE and XLPE‐g‐NA were subjected to thermo‐oxidative aging, and their physicochemical and electrical properties before and after aging were systemically investigated. For pure XLPE, carbonyl groups introduced during thermo‐oxidative aging formed electron traps, which reduced the conductance current at low temp …

29.08.2026journal-article

International Journal of Public Health and Nursing

The Prevalence of Asymptomatic Bacteriuria among People Living in Public Compounds at Obinze Community of Imo State

E. Emeka Ikechukwu, E. Inya Joseph, J. Ofoegbu Chukwudi, E. Ogbonna Chinazom, H. Njoku Akudo, Chukwuemeka Njemanze Canice

The study was conducted between November 2024 and March 2025 using a well-structured questionnaire. Urine samples were collected after engaging Two Hundred (200) persons living in public compounds at Obinze, Imo State. The selected study group was given questionnaires to fill. The samples were collected with suitable sterile urine bottles and transported to the Microbiology Unit of Science Laboratory Technology Department FUTO, where they were processed and inoculated on cysteine lactose electrolyte-deficient media …

29.08.2026journal-article

Molecular Neurodegeneration

Lipid-driven membrane remodeling engages a lysosome-dependent adaptive repair program during retinal aging

Emily Tom, Fangyuan Gao, Carolina N. Franco, Adrian Wong, Nathan Kemmerer, Zichen Wang, Amit Jairaman, Qianlan Xu, Yinyin Zhuang, Samuel W. Du, Grazyna Palczewska, Krzysztof Palczewski, Itay Budin, Shivashankar Othy, Xiaoyu Shi, Vera L. Bonilha, Johannes Schoeneberg, Karl J. Wahlin, Lauren V. Albrecht, Dorota Skowronska-Krawczyk

Abstract Age-associated remodeling of membrane lipid composition has been implicated in cellular dysfunction, yet the mechanisms linking lipid changes to membrane integrity and disease remain poorly defined. In the retinal pigment epithelium (RPE), lipid dysregulation is strongly associated with aging and age-related macular degeneration (AMD), a neurodegenerative disease of the central nervous system, but the causal pathways remain unclear. Here, we identify reduced activity of the lipid elongase ELOVL2 as a centr …

29.08.2026journal-article

Applied Research in Quality of Life

Trajectories of Parent-Child Relationship Quality and Cognitive Function among Older Adults: Differences between Mothers and Fathers

Jeenkyoung Lee

Abstract The present study examined heterogeneity in trajectories of positive and negative parent–child relationship quality (RQ) and their associations with older parents’ cognitive function. Data came from 7,217 older adults ( M age = 73.57, SD = 9.38; 62% women) in the Health and Retirement Study, using pooled samples (2006/2008, 2010/2012, 2014/2016, 2018/2020). Growth mixture modeling identified five latent trajectory groups for both positive and negative RQ: high-stable (69%/5%), moderate (16%/23%), increasin …