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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
31.08.2026journal-article

Journal of Electrodiagnosis and Neuromuscular Diseases

First Korean Case of DOK7 Congenital Myasthenic Syndrome Responsive to Ephedrine Therapy

Sangwon Joe, Moonjeong Choi, Yunjung Choi, Soo-Hyun Kim, Hyung Jun Park

Congenital myasthenic syndromes (CMSs) are a heterogeneous group of genetic neuromuscular disorders caused by pathogenic variants in genes encoding proteins essential for neuromuscular junction development and function. Downstream of tyrosine kinase 7 (DOK7)-related CMS has been reported frequently in Europe, North America, and Japan, but not in Korea. A 7-year-old girl presented with gait disturbance, frequent falls, and difficulty climbing stairs, which had begun at 4 years of age. Examination revealed mild symme …

31.08.2026journal-article

Advanced Composites and Hybrid Materials

A catalytic-immune OGP peptide-crosslinked 3D-printed hydrogel scaffold for concurrent antitumor therapy and bone regeneration

Jiachen He, Jianjun Wu, Lin Wang, Siwei Yin, Kun Yu, Yanyun Liu, Dejia Xu, Tuo Ji, Yuzhi Gao, Yikuan Du, Xuzhu Gao, Limin Cai, Chaoming Xie, Xiong Lu

Abstract Resection of bone-metastatic tumors is often accompanied by severe bone erosion and structural defects. Three‐dimensional (3D) printed hydrogel scaffolds with tailorable architectures and mechanical robustness are increasingly employed to restore bone integrity after tumor removal. Here, a 3D-printed sodium alginate/GelMA hydrogel scaffold is engineered to remodel the local microenvironment for simultaneous tumor ablation and bone repair, aiming to overcome the persistent challenge of functionally modifyin …

31.08.2026journal-article

Frontiers in Public Health

The mediating role of digital health literacy in the relationship between social support and health-promoting lifestyle among occupational populations: a cross-sectional study

Yun Pan, Tantan Cheng, Tianyu Sha, Jiakui Zhao, Yeqing Gu

Background In the digital age, health-promoting lifestyle (HPL) among occupational populations is critical for chronic disease prevention. Social support has been recognized as a key facilitator of HPL, yet the underlying mechanisms remain unclear. Digital health literacy (DHL)—the ability to access, understand, and apply online health information—may serve as a potential mediator. However, empirical evidence on this mediation model in occupational settings is limited. This study aims to examine the mediating role …

31.08.2026journal-article

JOURNAL OF BONE MARROW TRANSPLANTATION AND CELLULAR THERAPY

Consensus on graft-versus-host disease

Vaneuza Araújo Moreira Funke, João Victor Piccolo Feliciano, Giancarlo Fatobene, Maria Cláudia Rodrigues Moreira, Antonio Vaz de Macedo, Rita de Cássia Barbosa da Silva Tavares, Marcia de Matos Silva, Marcos Paulo Colella, Morgani Rodrigues, Luis Fernando da Silva Bouzas, Afonso Celso Vigorito

Graft-versus-host disease (GvHD) remains the mainly cause of late non-relapse mortality following allogeneic hematopoietic cell transplantation. Advancements in novel immunosuppressive therapies and prophylactic regimens necessitate an update to current clinical guidance. This consensus provides updated evidence-based recommendations for GVHD prophylaxis, alongside the treatment of acute and chronic disease.

31.08.2026journal-article

Jurnal Keperawatan Jiwa

The Implementation of Art Drawing Therapy in Patient Nn. F with Schizophrenia and Primary Problem of Suicide Risk at RSKD Duren Sawit

Jeni Nur Aini, Jesika Pasaribu

Severe mental disorders such as schizophrenia are often accompanied by depressive symptoms, hallucinations, and an increased risk of suicide. Patients with limited verbal communication require safe and supportive non-pharmacological interventions to express their emotions. Art Drawing Therapy is an art-based therapeutic approach that facilitates non-verbal emotional expression through drawing activities. This study aimed to describe the implementation of Art Drawing Therapy in a patient with schizophrenia whose pri …

31.08.2026journal-article

Fluctuation and Noise Letters

DMAWNet: Multi-Objective Based Distributed Attention Enabled WNet Framework for Speech Enhancement

Anil Garg, Ankur Singhal, Deepti Chaudhary, Priyanka Jangra, Poonam Rani, Ajay Jangra

Speech enhancement is significant with the advancement of communication systems, and in real-world circumstances, ambient noise is often present in speech data, emphasizing the vital role of enhancement techniques. The existing methods employed for enhancement are susceptible to various drawbacks, including the lack of interpretation of noise characteristics, failure to extract spectral details in different environments, and the required high time consumption, which leads to high cost. Moreover, the models either f …

31.08.2026journal-article

Retina

Treatment of foveal-involving tractional retinal detachments from proliferative diabetic retinopathy with intravitreal anti-VEGF therapy

Nihaal Mehta, G. Baker Hubbard

Purpose: To report the outcomes of patients with fovea-off tractional retinal detachment (TRD) from proliferative diabetic retinopathy (PDR) treated with serial anti-VEGF therapy. Methods: We reviewed the medical records of patients with fovea-off TRD from PDR treated with serial anti-VEGF therapy. Outcome measures included visual acuity, foveal reattachment, need for vitrectomy, number of intravitreal injections, and average interval between injections. Results: 12 eyes of 10 patients were included. 75% of eyes (n …

31.08.2026journal-article

Annals of Rehabilitation Medicine

M-Wave and F-Wave Parameters in Relation to Recording Electrode Placement

Masataka Kurobe, Naoki Kado, Toshiaki Suzuki

Objective: To clarify the influence of recording electrode placement on F-wave parameters, we investigated F-wave parameters recorded from the abductor pollicis brevis muscle using different recording electrode positions.Methods: Thirteen healthy volunteers participated. Recording electrodes were placed at four locations (20, 30, 40, and 50 mm from the reference electrode). The stimulating electrode was positioned over the median nerve at the wrist, and the reference electrode was placed on the distal tendon of the …

31.08.2026journal-article

International Journal of Innovative Technologies in Social Science

THE EFFICACY AND SAFETY OF LASER THERAPY AS A METHOD OF DIRECT HAIR REMOVAL IN HIRSUTISM: SUMMARY OF FINDINGS

Aleksandra Wiśniewska, Julia Marek, Szymon Daniszewski, Izabela Czerny

Introduction: Hirsutism, which affects approximately 5–15% of women during their reproductive years, is defined by the emergence of coarse terminal hair in androgen-sensitive regions typically associated with male distribution patterns. The clinical presence of visible terminal hair frequently precipitates significant psychological morbidity, including elevated levels of anxiety, clinical depression, and a compromised sense of femininity, which collectively diminish overall quality of life. Empirical data from clin …

31.08.2026journal-article

Annals of Rehabilitation Medicine

Digital Health Approaches to Geriatric Rehabilitation: A Narrative Paper

Changwon Moon, Pamela Bregasi, Aminreza Khandan, Bijan Najafi

Rapid population ageing is widening the gap between geriatric rehabilitation needs and constrained care capacity. Digital health offers new ways to deliver rehabilitation beyond traditional settings, but its role and limitations in geriatric practice remain unclear. To provide a narrative synthesis of how digital health can support geriatric rehabilitation, highlighting advances, challenges, and future directions. We conducted a narrative review of digital health approaches in geriatric rehabilitation, informed by …

31.08.2026journal-article

Annals of Rehabilitation Medicine

Immediate Effects of Manual Muscle Stretching on Respiratory Capacity, Heart Rate Variability, and Diaphragmatic Function in Patients With COPD

Hsin-Lun Yang, Jian-Cheng Peng, Yu-Ting Huang, Hui-Ching Cheng, Ching-Hsia Hung, Chiung-Zuei Chen, Sheng-Yuan Wang, Chin-Wei Kuo, Kun-Ling Tsai

Objective: To investigate the acute physiological responses following a single session of manual muscle stretching in patients with moderate to severe chronic obstructive pulmonary disease (COPD).Methods: A single-group pre–post design was used. Nineteen participants with moderate to severe COPD received one session of manual stretching, incorporating passive stretching and muscle energy techniques targeting the anterior scalene, upper trapezius, pectoralis, and diaphragm muscles. Primary outcomes included spiromet …

31.08.2026journal-article

Journal of Sleep Medicine

The Relationship Between Caffeine Intake and Cognitive Behavioral Therapy for Insomnia Efficacy in Patients With Chronic Insomnia

Yeonsoo Kim, Tae-Joon Kim, JaeWook Jeong, Jung-Won Shin

Objectives: Cognitive behavioral therapy for insomnia (CBT-I) is the first-line treatment for chronic insomnia; however, individual responses vary. Although caffeine disrupts sleep, its effect on CBT-I outcomes remains unclear. This study investigated the relationship between caffeine consumption and efficacy of CBT-I.Methods: This retrospective study included 37 adults with chronic insomnia who completed a standardized 4-week CBT-I program. The participants were classified into the caffeine (n=19) and non-caffeine …

31.08.2026journal-article

Bioinformation

Metformin and nano-metformin gels as adjuncts to periodontal therapy: A split-mouth trial

Rohit Ranjan

Chronic periodontitis produces persistent periodontal inflammation, pocket formation, attachment loss and intrabony defects, while scaling and root planing alone may have limited access in deep and anatomically complex sites. Thirty systemically healthy participants contributed 90 intrabony defect sites in a split-mouth randomized design allocated to SRP with placebo gel, SRP with 1% metformin gel, or SRP with 1% nano-metformin gel; plaque index, gingival index, probing pocket depth and clinical attachment level we …

31.08.2026journal-article

International Journal of Innovative Technologies in Social Science

A COMPREHENSIVE REVIEW OF CAR-T CELL THERAPY ACROSS RHEUMATIC DISEASES

Mateusz Miluski, Dorota Szydłowska, Mikołaj Jońca, Natasza Kurys, Adam Kubisa, Aleksandra Dybcio, Szymon Paruszewski, Julia Kupczak, Mikhail Kazachok, Katarzyna Kupczyk

Background: Autoimmune rheumatic diseases (ARDs) are characterized by a failure of immune tolerance, leading to chronic inflammation, autoantibody production, and progressive organ damage. Conventional therapies often fail to induce long-term, drug-free remission in refractory patients. Chimeric antigen receptor (CAR) T-cell therapy, originally developed for hematological malignancies, has appeared as a promising strategy to achieve the sustained depletion of pathogenic immune cells in rheumatology. Objective: This …

31.08.2026journal-article

Asian Journal of Medical Sciences

Local-Regional Therapy Response in Hepatocellular Carcinoma: A Clinical Evaluation

Navaneetha Kumar Govarthanan, Meyyappan M, Biji Babu, Dirisala Anudeep, Anita S

Background: Accurate assessment of treatment response after locoregional therapy is essential in hepatocellular carcinoma (HCC). European Association for the Study of Liver (EASL), modified response evaluation criteria in solid tumors (mRECIST), and liver imaging and reporting data system (LI-RADS) treatment response (LI-RADS TR) are widely used imaging-based criteria with potential differences in response categorization. Aims and Objectives: The aim of the study is to evaluate the treatment response of HCC followi …

31.08.2026journal-article

DA'WA: Jurnal Bimbingan Penyuluhan & Konseling Islam

<i>Acceptance and Commitment Therapy</i> (ACT) dalam Konseling Pesantren: Eksplorasi Pengalaman Santri dalam Menghadapi <i>Experiential Avoidance</i><b></b>

Heri Fadli Wahyudi, Musyfiquddin, Syaifatul Jannah, Bagus Amirullah

Kecenderungan menghindari pengalaman psikologis yang tidak menyenangkan (experiential avoidance) sering muncul pada remaja dalam situasi yang memunculkan tekanan emosional maupun evaluasi sosial. Di pesantren, kondisi ini dapat memengaruhi keberanian santri dalam berinteraksi, berpartisipasi dalam kegiatan publik serta menghadapi tuntutan akademik. Oleh karena itu, diperlukan pendekatan konseling yang mampu membantu santri mengelola pengalaman internal secara lebih adaptif. Penelitian menggunakan pendekatan kualita …

31.08.2026journal-article

Bioinformation

Patient preference between implant therapy and conventional prosthesis

Veena Kalburgi

The replacement of missing teeth is a dilemma, as patient preferences are shaped by both clinical and personal considerations. This cross-sectional comparative survey involved 350 patients to evaluate preferences between implant therapy and traditional prostheses, as well as to discover factors influencing treatment selection. The research employed a structured questionnaire to document demographic information, awareness, treatment preferences, and factors influencing decision-making. Implant therapy was preferred …

31.08.2026journal-article

Toxics

Temporal Variability of Urinary Organophosphate Flame Retardant Metabolites Among E-Waste Workers in France: A Pilot Study to Inform Occupational Biomonitoring Sampling Design

Baninia Habchi, Guillaume Antoine, Aurélie Martin Remy, François Zimmermann, Marie-Thérèse Lecler, Williams Esteve, Claude Emond, Nathalie Grova, Sophie Ndaw

Workers in the e-waste industry are exposed to chemical hazards, including organophosphate esters (OPEs) used as flame retardants (FRs). Assessing exposure through spot urine metabolite analysis is challenging due to limited knowledge of the toxicokinetics and urinary excretion patterns of OPEs. This pilot study investigates the temporal variability of seven organophosphate flame retardants (OPFRs) in urine samples from e-waste workers over five workdays to identify the most representative spot urine sample for acc …

31.08.2026journal-article

Journal of Medicinal Chemistry

A 177Lu-Labeled Circular Bivalent Aptamer for PTK7-Targeting Radionuclide Therapy in Ovarian Cancer and Orthotopic Hepatoblastoma

Xiaoning Tong, Yi He, Heng Liu, Wenjie Guo, Wen-Guo Huang, Peng Li, Luoan Wang, Yuntian Zhu, Le Cai, He-Qing Yi, Xue-Qiang Wang, Weihong Tan

Abstract Targeted radionuclide therapy (TRT) is a promising strategy for precision oncology but is limited by the lack of high-performance targeting ligands. Here, we report a lutetium-177 (177Lu)-labeled PTK7-targeted cyclized bivalent aptamer (CBSgc8) for treating an orthotopic hepatoblastoma. The cyclized multivalent design enhances biostability and binding affinity, while 177Lu labeling preserves its functional properties. The resulting 177Lu-CBSgc8 exhibited high serum stability, strong specificity for PTK7-po …

31.08.2026journal-article

Journal of Sleep Medicine

Successful Positive Health Impact of Nasal Surgery on Comorbid Difficult-to-Treat Chronic Rhinosinusitis and Severe Obstructive Sleep Apnea After Failed Medical Therapy

Jin-Ing Lin

Obstructive sleep apnea (OSA) is a common contributor to hypertension and is strongly associated with chronic rhinosinusitis (CRS) development. OSA and CRS have a bidirectional causality. OSA causes systemic tissue hypoxia and increases liability to infection and chronic inflammation. CRS reduces nasal nitric oxide release and pulmonary vasodilation and increases pulmonary arterial pressure. Our patient had obstruction at two subsites of the upper airway: static intranasal obstruction caused by CRS with an exophyti …

31.08.2026journal-article

Revista de Geopolítica

AVALIAÇÃO DOS IMPACTOS EMOCIONAIS EM CASAIS HETEROSSEXUAIS EM TERAPIA: UM ESTUDO TRANSVERSAL SOBRE ANSIEDADE, DEPRESSÃO E DESESPERANÇA

Hernani Souza Silva

Este trabalho investiga os impactos emocionais da crise conjugal sobre os níveis de ansiedade, depressão e desesperança em casais heterossexuais que estão em terapia. O objetivo principal é confirmar a hipótese de que casais em crise apresentam níveis significativamente elevados dessas emoções. Para alcançar esse objetivo, foram analisados 40 casais, utilizando questionários padronizados que medem tanto a percepção da crise quanto os níveis emocionais dos participantes. Os resultados revelaram uma média de percepçã …

31.08.2026journal-article

Periodontology 2000

Factors influencing the effectiveness of surgical therapy of peri‐implantitis

Ausra Ramanauskaite, Wenije Zhou, Emilio A. Cafferata, Frank Schwarz

Abstract Background Surgical therapy is required in the majority of peri‐implantitis cases due to the inconsistent efficacy of non‐surgical approaches. Although surgical treatment generally offers higher predictability, reported success rates vary widely. Aim To review the available evidence on the factors influencing the outcomes of peri‐implantitis surgical therapy, including surgical technique, implant‐site characteristics, and patient‐related conditions. Materials and Methods This narrative review is based on a …

31.08.2026journal-article

Journal of Mechanisms and Robotics

On the Kinematic Synthesis of a Hand Rehabilitation System: A Case Study to Implement Spasticity Effect on Low-Velocity Physical Therapy

Mertcan Kocak, Özgün Başer, Erkin Gezgin

Abstract This work presents a kinematic synthesis methodology that is developed to implement a simple linear stiffness element into an existing single degree of freedom hand rehabilitation system without altering its mobility in order to render the system mechanically capable of replicating spasticity behaviour during low-velocity rehabilitation treatments. Due to velocity dependent nature of the spasticity, replicating its effects during these treatments conducted below certain velocity thresholds, where sudden in …

31.08.2026journal-article

Advanced Science

Engineered Cyanobacteria‐Hydrogel Microecological System for Oxygen Reprogramming Synergizes Immunomodulation With Anabolism in Osteoarthritis Therapy

Lerong Yang, Chong Shen, Hongjun Huang, Siyi Liu, Zeyu Huang, Licheng Xi, Huan Cao, Li Zheng, Zainen Qin

ABSTRACT Osteoarthritis remains a major clinical challenge due to its complex pathophysiology involving chronic inflammation and progressive cartilage degradation. Current treatments largely fail to address the dual demands of synovial anti‐inflammation and cartilage anabolism, particularly under the critical yet often overlooked influence of oxygen zonation within articular tissues. In this study, we propose a novel microorganism oxygen metabolism engineering strategy using an injectable cyanobacteria‐laden hydrog …