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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

F1000Research

Effect of Passive Versus Active Aquatic Therapy Over Conventional Physiotherapy in Patients With Chronic Low Back Pain: A Randomized Crossover Trial — Study Protocol

Ammar Mohamed, Watson Arulsingh, Praveen Kumar Kandakurti, Ramprasad Muthukrishnan

Background Chronic low back pain (CLBP) is a highly prevalent musculoskeletal disorder worldwide, often associated with long-term disability and reduced quality of life. 1,2 Conventional physiotherapy continues to be the cornerstone of management; however, alternative approaches such as aquatic therapy have gained increasing attention in recent years due to their surging therapeutic benefits. 3,4 Within aquatic rehabilitation, various methods including passive aquatic therapy (Watsu) and active aquatic therapy are …

03.09.2026journal-article

Herz

Predicting LDL-cholesterol reduction variability on statin–ezetimibe therapy: insights from “Jena auf Ziel”

Umidakhon Makhmudova, Dieter Lütjohann, Franz Haertel, Anja Kerksiek, Robert Römer, Pellumb Haxhikadrija, Aurel Maloku, Beasat Samadifar, Sylvia Otto, P. Christian Schulze, Oliver Weingärtner

Abstract Background and aims Low-density lipoprotein cholesterol (LDL-C) is a causal risk factor for atherosclerotic cardiovascular disease (ASCVD). ESC/EAS guidelines recommend reducing LDL-C < 1.4 mmol/L and > 50% from baseline in patients with myocardial infarction. “Jena auf Ziel” (JaZ) is a prospective cohort study in which early combination therapy with atorvastatin 80 mg and ezetimibe 10 mg was initiated on admission in patients with ST-elevation myocardial infarction (STEMI) to reduce LDL‑C levels early and …

03.09.2026journal-article

Pediatric Blood & Cancer

Safety and Effectiveness of a High‐Dose, Tailored Tissue Plasminogen Activator Therapy Protocol: A Joint Pediatric Hematology and Cardiac ICU Quality Improvement Initiative Analysis

Eran Shostak, Oded Gilad, Yael Feinstein, Sigal Nakav, Ofer Schiller, Joanne Yacobovich

ABSTRACT Background Pediatric thromboembolism is increasingly encountered in critical care. Systemic thrombolysis with tissue plasminogen activator (tPA) facilitates vessel or valve patency, yet pediatric‐specific protocols remain undefined, and safety concerns persist. Objective To evaluate the efficacy and safety of a tailored, prolonged systemic tPA protocol for vessel thrombosis and mechanical valve obstruction in infants and children, and to characterize D‐dimer kinetics by indication. Methods This retrospecti …

03.09.2026journal-article

Revista Portuguesa de Doenças Infecciosas (RPDI)

Protocolo de utilização de soluções de bloqueio com antibiótico em cateter venoso central

Luisa Graça, Betânia Abreu Faria, Joana Laranjinha, Charlene Viana, Catarina Silva, Marcelo Costa, Sandra Teixeira, Susana Ribeiro, Diana Gaspar, Joana Alves, Ana Cláudia Carvalho

Introdução: Perante uma infeção associada a cateter venoso central, a remoção do cateter é a opção privilegiada para o controlo do foco. Quando tal não é possível, o uso de soluções de bloqueio de altas concentrações de antibiótico (ou lock) associa-se a uma melhor resposta do que a antibioterapia sistémica isoladamente. A eficácia desta técnica está dependente do agente de infeção e das soluções utilizadas. Objetivos: Uniformizar a prescrição e aplicação da solução de bloqueio com antibiótico e, assim, maximizar a …

03.09.2026journal-article

Journal of NeuroEngineering and Rehabilitation

Potential modulation of cortical oscillations by temporal interference stimulation in the primary somatosensory cortex

Koshi Iimuro, Naofumi Otsuru, Yusuke Akazawa, Ilkka Laakso, Hitomi Ikarashi, Sota Inoue, Kazuaki Nagasaka, Ryoki Sasaki, Hiroshi Shirozu, Hideaki Onishi, Akimasa Hirata

Abstract Background Temporal interference stimulation (TIS) is a promising non-invasive technique for reaching deep brain regions that are difficult to modulate with conventional transcranial electrical stimulation. A critical question is whether TIS can reliably induce neural modulation at its envelope frequency in humans. Objective As an initial step toward applications targeting deeper structures, we investigated whether TIS can modulate cortical oscillations at the envelope frequency within the primary somatose …

03.09.2026journal-article

Frontiers in Public Health

Knowledge, attitudes, and practice regarding rehabilitation among postoperative patients with spinal degenerative diseases: a cross-sectional study

Mingming Liu, Xiaoye Guo, Yutong Bi, Doudou Chen, Qiao Chen, Jinqing Zhang, Ying Han, Bing Han

Background This study aimed to investigate postoperative patients’ knowledge, attitudes, and practice (KAP) regarding spinal degenerative diseases and rehabilitation training. Methods This single-center cross-sectional study was conducted from July 1, 2025, to September 30, 2025, at Beijing Jishuitan Hospital, Capital Medical University. The questionnaire was developed through two rounds of Delphi consultation with seven experts, pilot-tested in 35 patients, and evaluated using confirmatory factor analysis (CFA). R …

03.09.2026journal-article

Frontiers in Immunology

Predictive value of serum HBcrAg in antiviral therapy for chronic hepatitis B

Shiyu Wang, Hongxiao Hao, Wen Deng, Lu Zhang, Weihua Cao, Ziyu Zhang, Xinxin Li, Yaqin Zhang, Xin Wei, Linmei Yao, Zixuan Gao, Shuojie Wang, Minghui Li

Chronic hepatitis B (CHB) remains a significant global public health challenge. The goals of its antiviral therapy are gradually shifting from long-term viral suppression toward achieving safer treatment discontinuation, more accurate risk stratification, and deeper functional cure. Traditional serological markers, such as HBV DNA and HBsAg, remain clinically important in CHB. However, their ability to reflect residual viral activity and long-term outcomes is limited after long-term nucleos(t)ide analog (NA) therap …

03.09.2026journal-article

Frontiers in Immunology

Mapping the research landscape of antibody therapy for Ebola virus disease: a bibliometric analysis

Zengwei Kou, Yunsheng Liu, Wujie Qian, Sihan Zhang, Shulei Lou, Da Shao

Background Antibody-based therapies have become a cornerstone of Ebola virus disease (EVD) treatment and prevention, particularly following the successful clinical development of monoclonal antibody therapeutics against Zaire ebolavirus. However, despite substantial advances, the global research landscape, collaboration patterns, and evolving thematic trends of Ebola antibody therapy have not been systematically characterized. The ongoing 2026 Bundibugyo ebolavirus outbreak, for which no licensed vaccines or therap …

03.09.2026journal-article

Frontiers in Psychiatry

Psychosocial recovery and nutritional rehabilitation in residential treatment for anorexia nervosa: an exploratory longitudinal multi-frequency bioelectrical impedance analysis study

Francesco Monaco, Annarita Vignapiano, Stefania Landi, Rossella Bonifacio, Daniela Falchetta, Emanuela Ferrara, Ernesta Panarello, Bruno Attianese, Annaluce Caputo, Luca Steardo, Gennaro Sosto, Giulio Corrivetti

Background Nutritional rehabilitation is widely considered a prerequisite for recovery in anorexia nervosa (AN), given the profound effects of malnutrition on cognitive, emotional, and behavioral functioning. However, whether psychiatric improvement during residential treatment is directly coupled with the degree of nutritional restoration remains insufficiently understood. This study investigated longitudinal changes in body composition and psychosocial outcomes during residential psychiatric rehabilitation for AN …

03.09.2026journal-article

Occupational Medicine

Non-pharmacological intervention for shift nurses’ sleep: systematic review and meta-analysis

A Y L Lee, L A Tse

Abstract Background Nurses working rotating shifts often experience poor sleep quality due to circadian rhythm disruption. Previous reviews primarily focused on managerial changes to improve nurses’ alertness during night shifts. Although some studies found that individual-level non-pharmacological interventions may significantly alleviate sleep problems, past reviews focused only on aromatherapy. Aims To understand current trends and synthesise the effectiveness of non-pharmacological interventions for improving s …

03.09.2026journal-article

LABOR LAW IN RUSSIA AND ABROAD

Occupational Safety and Technological Development: Legal Aspects

Yulia S. Sergeenko

The author of the article explores the issues of occupational safety and technological development. The analysis of the International Labour Organization Conventions, legal acts of the Russian Federation devoted to occupational safety is carried out. Legal aspects are highlighted in the topic under consideration.

03.09.2026journal-article

Pilot and Feasibility Studies

FASTINA – protocol for a randomised feasibility trial of time-restricted eating to improve response to multiple myeloma therapy

Anna Franziska Hamm, Jan Vorwerk, Mona Maria Merz, Martin Smollich, Christina Schwitlick, Kay Horn, Inke Regina König, Theo Leitner, Lorenz Oelschläger, Helal Ahmed, Felix Sommer, Nikolas von Bubnoff, Cyrus Khandanpour

Abstract Multiple myeloma (MM) is an incurable plasma cell malignancy with relapses and diminishing response durations. Preclinical studies suggest that time-restricted eating (TRE)-related metabolic changes may enhance chemosensitivity by exploiting cancer cell vulnerabilities to nutrient deprivation. Clinical data in solid tumours remain limited and heterogeneous, mainly supporting feasibility and possible toxicity reduction rather than definitive efficacy. While efficacy has been explored in breast cancer patien …

03.09.2026journal-article

Cell and Gene Therapy Insights

Accelerating AAV biosafety and characterization decisions with validated NGS workflows

Andrew Hillhouse

Confirming product identity, genome integrity and freedom from adventitious agents requires a single test to hold up across genomes as small as an AAV vector and as large as a human genome, against regulatory guidance that continues to evolve (ICH Q5A(R2)). Here is how FUJIFILM Biotechnologies built validated NGS workflows covering library preparation, genome integrity, sensitivity testing and adventitious agent detection, cutting biosafety testing turnaround from up to 8 weeks to 1–2 weeks.

03.09.2026journal-article

Frontiers in Medicine

Impact of antiplatelet therapy on erectile dysfunction following percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction

Joongwon Choi, Chung Un Lee, Hyun Woong Park, Jung Hoon Kim, Yong Seong Lee, Jong-Hwa Ahn, Jin Sin Koh, Min Gyu Kang, Weon Kim, Udaya S. Tantry, Paul A. Gurbel, Jin-Yong Hwang, Young-Hoon Jeong

Background: Acute myocardial infarction (AMI) is strongly associated with erectile dysfunction (ED). This study evaluated the association between P2Y 12 receptor inhibitor type and ED, and factors associated with moderate-to-severe ED in high-risk patients with AMI. Methods The HEALING-AMI trial randomized patients with naïve ST-segment elevation myocardial infarction (STEMI) to dual antiplatelet therapy (DAPT) with either ticagrelor or clopidogrel. This substudy included 59 male patients who completed 6 months of …

03.09.2026journal-article

Lire Journal (Journal of Linguistics and Literature)

<b>ADHERENCE TO LEECH'S (2014) POLITENESS MAXIMS IN ILLOCUTIONARY SPEECH ACTS IN THE MINANGKABAU FILM ONDE MANDE!</b>

Fatimah Azzahra, Djatmika, Miftah Nugroho

This study examines the forms of adherence to Leech's (2014) politeness maxims as realized through illocutionary speech acts in the Minangkabau regional film Onde Mande!. The study is motivated by the limited application of Leech's (2014) revised framework in existing literature, particularly in the context of regional Indonesian cinema. Employing a qualitative descriptive approach with a single case study design, this study draws on a pragmatic framework that integrates illocutionary speech act theory with Leech's …

03.09.2026journal-article

Media and Communication

Threat and Remedy: AI’s Technological and Normative Role in Democratic Discourse and Counter Speech

Diana Rieger, Mario Haim

Artificial intelligence (AI) has fundamentally transformed online discourse, serving simultaneously as a source of and a potential solution to threats to democracy. This article conceptually examines AI’s multifaceted role in digital public spheres, beginning with an analysis of how AI shapes democratic processes online, ranging from information curation and political participation to dialogue facilitation and the construction of epistemic infrastructures. We identify several key risks: AI amplifies harmful content …

03.09.2026journal-article

LABOR LAW IN RUSSIA AND ABROAD

Implementation of ILO Convention No. 187 "Concerning the Promotional Framework for Occupational Safety and Health" (2006) into Russian Legislation: Problems of a Systemic Approach to Occupational Safety Management

Mikhail A. Afanasyev

The article presents a comparative legal analysis of the provisions of ILO Convention No. 187 "Concerning the Promotional Framework for Occupational Safety and Health" (2006) and the norms of Russian legislation regulating occupational safety. The author examines the basic principles and requirements of the Convention and identifies existing problems and gaps in the legal framework that impede the full implementation of international standards. The focus is on the systemic approach to occupational safety management …

03.09.2026journal-article

BUSINESS LAW

Why Is the New Rehabilitation (Sanation) Mechanism a Step Forward?

Arina S. Lyamkina

The article is devoted to the analysis of the reformed rehabilitation mechanism as a key stage in the development of corporate restructuring law in Russia. The current model remains ineffective due to the opportunism of creditors, the threat of out-of-court agreements being challenged, and the absence of incentives for preventive financing. The novelty of the reform is seen in the creation of a balanced comprehensive rehabilitation agreement, which permits the compulsory extension of its terms to nonparticipating c …

03.09.2026journal-article

Frontiers in Oncology

Adjuvant therapy in chromophobe renal cell carcinoma: current evidence and unmet needs

Niovi Bejjani, Joseph Kattan

Objectives Chromophobe renal cell carcinoma (chRCC) is a rare subtype of kidney cancer with biological and clinical features that differ significantly from clear cell renal cell carcinoma (ccRCC). While adjuvant treatments have evolved for ccRCC, chRCC has been excluded or understudied in clinical trials, which has led to insufficient histology-specific data to guide postoperative treatment. This research aimed to summarize and critically appraise the current evidence regarding adjuvant therapies for chRCC, highlig …

03.09.2026journal-article

Journal of Dance Medicine & Science

Dance as Rehabilitation in Parkinson’s Disease: A Scoping Review of Motor, Non-Motor, and Cognitive Outcomes

Simran Rooprai, Nicholas Ramcharran, Caitlin van den Hoorn, Jenna Smith-Turchyn, Nicole D. Anderson, Joseph FX DeSouza

Introduction: Dance is a multimodal experience, integrating movement and music, with cognitive and psychosocial effects, potentially providing a non-pharmacological care approach for persons with Parkinson’s disease (PwPD). While numerous studies have investigated motor outcomes following dance interventions, less is known about the degree to which cognitive and non-motor outcomes are explored. The objective of this scoping review was to explore the scope and characteristics of dance-based interventions for PD, foc …

03.09.2026journal-article

Frontiers in Immunology

Combination of tofacitinib and tacrolimus therapy in refractory interstitial lung disease associated with anti-synthetase syndrome: a case series of six patients

Qiuyu Fan, Wei Huang, Shaohui Song, Huiqin Yang, Ya Liu, Chao Jia, Yu Xiao, Liang Zou

Objective This study aimed to assess the efficacy and safety of tofacitinib and tacrolimus (TAT) combination therapy for treating refractory interstitial lung disease (ILD) associated with anti-synthetase syndrome (ASyS-ILD). Method Patients with refractory ASyS-ILD who were treated with TAT at Wuhan No. 1 Hospital were included in the study from January 2020 to May 2024. A retrospective analysis of the clinical data from these patients is presented. Result A total of six patients, one male patient and five female …

03.09.2026journal-article

International Journal of Biomathematics

Mathematical modeling of anti-PD-1 and ascorbic acid combination therapy for lymphoma based on tumor–immune interactions

Chenghang Li, Haifeng Zhang, Jinzhi Lei

Lymphoma is a malignant tumor originating from the lymphohematopoietic system. As lymphocytes are vital components of the immune system, their malignant transformation closely links lymphoma development to immune dysregulation. Recent studies suggest that combining ascorbic acid with anti-PD-1 may have significant anti-tumor potential. In this study, we developed a mathematical model to quantitatively characterize tumor–immune interactions and evaluate the therapeutic effect of this combination in lymphoma treatmen …

03.09.2026journal-article

Frontiers in Pharmacology

Comparative effectiveness of genotype-guided and empirical bismuth-containing quadruple therapy for Helicobacter pylori eradication: a retrospective study

Pan Wang, Mengyuan Yang, Xiaolin Zhao, Haiou Ding, Jianping Cheng

Objective To compare the efficacy of genotype-guided versus empirical bismuth-containing quadruple therapy (BQT) for Helicobacter pylori ( H. pylori ) eradication and to identify factors influencing treatment success. Methods This single-center retrospective study included 616 patients with H. pylori infection who received 14-day BQT. All regimens comprised bismuth potassium citrate 2.6 g, a proton pump inhibitor (PPI, esomeprazole 20 mg or ilaprazole 5 mg) or a potassium-competitive acid blocker (P-CAB, keverpraza …

03.09.2026journal-article

Journal of Associated Medical Sciences

Impact of self reflection training using Kawa model on quality of life and Academic performance among occupational therapy students

Associate professor, Saveetha College of Occupational Therapy, Saveetha Institute of Medical and Technical Sciences , Chennai, Tamilnadu, India., Punitha P, Sofia Williams, Occupational therapist, Saveetha College of Occupational Therapy, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamilnadu, India.

Background: Self-appraisal and reflection are crucial for occupational therapy students (OT) and practitioners, fostering learning and professional growth. The Kawa model, typically used clinically, may aid self-reflection by helping students recognize their strengths and challenges. However, while the model has been extensively studied in clinical settings, research on its application as a self-reflection tool for OT students remains limited. Objectives: This study aimed to evaluate the impact of self-reflection t …