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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Ege Tıp Dergisi

Development of an extracellular vesicle-based shRNA delivery system to overcome cisplatin resistance in non-small cell lung cancer by targeting STAT3

Mustafa Kotmakçı, Vildan Bozok

Aim: Cisplatin resistance remains a major clinical challenge in non-small cell lung cancer, frequently driven by STAT3 activation. This study aimed to engineer an autologous extracellular vesicle (EV) formulation loaded with anti-STAT3 shRNA-encoding plasmid DNA to resensitize cisplatin-resistant Calu1 lung cancer cells.Materials and Methods: EVs were isolated from parental Calu1 cell culture supernatants via modified differential ultracentrifugation and characterized using electron microscopy, atomic force microsc …

03.09.2026journal-article

Frontiers in Oncology

A collision tumor of buccal squamous cell carcinoma and diffuse large B-cell lymphoma: a case report and literature review

Xiao Pang, Ying Long, Hui Wang, Zhang Zhang

Background Collision tumors are rare entities in which two histologically distinct malignancies coexist in close proximity without histological admixture or transition. The coexistence of buccal squamous cell carcinoma (SCC) and diffuse large B-cell lymphoma (DLBCL) in the oral region is exceptionally uncommon. Because the clinical and radiological findings may overlap, such cases can pose substantial diagnostic and therapeutic challenges. Case presentation We report a case of a 66-year-old man with a long history …

03.09.2026journal-article

Frontiers in Dental Medicine

Case Report: Dental treatment under general anesthesia for a child with Ullrich congenital muscular dystrophy

SokIok Cheang, WeiYun Chen, Shuang Wang, XinXin Wang, Kuo Wan, Lin Ma

Background Ullrich congenital muscular dystrophy (UCMD) is a rare inherited myopathy caused by mutations in the COL6 gene and is frequently associated with multisystem complications affecting the respiratory and skeletal systems, which may increase airway and anesthetic risks during dental treatment. Case report This report describes a 4-year-old girl with UCMD who presented with pain in the left lower molar. After a comprehensive multidisciplinary evaluation by the Department of Stomatology, Anesthesiology, and Pe …

03.09.2026journal-article

Journal of Palliative Medicine

Palliative Surgery to Restore Function and Dignity: A Case of Massive Breast Tumor Debulking in Rural Uganda

Simran Kripalani, Howard Eison, Goretti Nassali, Prossy Nafula, Benjamin Schwarz, Randi Diamond

Background: Palliative surgery plays a critical role in alleviating symptom burden and thus improving quality of life in patients with advanced disease. Case Presentation: This is a case of a 23-year-old female in rural Uganda with an untreated, massive right breast mass present since infancy and progressive abdominal distention of unclear etiology. Over time, the breast mass impaired her mobility, rendering her largely homebound and dependent on others for basic movement. Despite evidence of profound malnutrition, …

03.09.2026journal-article

Petroleum Engineering

INVESTIGATION OF THE FRACTIONAL COMPOSITION OF RESIN COMPONENTS OF HEAVY OIL UNDER STEAM-THERMAL TREATMENT

I.I. Mukhamatdinov, G.Kh. Sitdikova

In recent decades, the extraction and processing of heavy high-viscosity oil has become an urgent task for the oil industry. Such raw materials require additional preparation, including destruction of high molecular weight components to increase the yield of light fractions. The main share in it is occupied by resins and asphaltenes, the study of the structure of which is important both for understanding the processes of oil formation and for optimizing production, transport and processing. The paper studied the fr …

03.09.2026journal-article

Frontiers in Genetics

Integrated transcriptomics approach identifies the upregulated SLC7A5, and associated pathways across different thyroid cancer cell types

Muhammad Naeem, Nan Wu, Yang Wu, Shahid Nawaz, Ren Jing, Yuanbin Luo, Shijian Yi

Thyroid cancer is the most common type of endocrine malignancy, and its aggressive types are diagnosed at advanced stage due to limited treatment options. This study aimed to identify upregulated SLC7A5 across thyroid cancer cell types using an integrated transcriptomics approach. Total RNA was extracted from different samples. Differential expression analysis was performed through DESeq2. Functional enrichment analyses were performed to explore key pathways. The PPI network was built using the STRING database to i …

03.09.2026journal-article

BMC Public Health

Awareness level of cancer risk factors and warning signs among adults in Mansoura District, Egypt

Ahmed M. Eid, Abeer M. Kamal, Asmaa Elsayed, Rahma M. Almetwaly, Basma Kamel, Naira A. Shoman, Aya M. Abdelmohsin, Sara H. Elhendawy, Yasmeen A. State, C. A. collaboration team, Abdallah Gamal, Menna S. Sellow, Nourhan R. Elbatal, Mohamed A. Abdelaziz, Ahmad M. Gewili, Mariam B. Elbialy, Nouran K. Mashaly, Rania S. Omar, Abdelrahman M. Darweesh, Abdelsmad Elhalwaty, Hager S. Elhebeshy, Moustafa Y. Nassar, Hanin Fadl, Ahmed H. Maarouf, Omar M. Eid, Sama Mahmoud Abo Younis, Ashraf Alaziz, Mokhtar M. Elkerdawey, Ahmed Mohamed Zayed, Abdel-Hady El-Gilany

Abstract Background Cancer remains a leading cause of mortality worldwide, with prevention and early detection dependent on the public awareness of its risk factors and warning signs. However, knowledge of cancer-related symptoms and modifiable risk factors remains limited in many populations, particularly in low- and middle-income countries. Limited research exists examining general cancer awareness in Egypt's general population. Objective To assess public knowledge of cancer's early warning signs, risk factors, a …

03.09.2026journal-article

Frontiers in Oncology

Prediction of overall survival in primary lung adenocarcinoma using machine learning and deep learning: a cohort study in Latin America country cancer center

Javier H. Gil-Gómez, Carlos Carvajal-Fierro, Ricardo Bruges-Maya, Ixchel Rodríguez Parada, Andrés Mosquera-Zamudio, Julián Riaño-Moreno, José Fernando Polo, Marcela Gómez-Suárez, John Jaime Sprockel, Rafael Parra-Medina

Background Lung adenocarcinoma is the most common subtype of non-small cell lung cancer and a leading cause of cancer-related mortality worldwide. Its marked clinical heterogeneity results in variable outcomes and poor prognosis for many patients. This study aimed to develop and compare statistical, machine learning, and deep learning models for predicting overall survival (OS) in patients with primary lung adenocarcinoma. Methods This retrospective cohort study included patients with primary lung adenocarcinoma. M …

03.09.2026journal-article

Frontiers in Oncology

Case Report: Long-term remission of metastatic pancreatic ductal adenocarcinoma after surgery and high-dose nicotinamide supplementation

Hubert Kolb, Werner Hartwig, Torsten Beyna, Daniela auf der Horst, Kerstin Kempf, Stephan Martin, Kerstin Struse-Soll, Markus Dommach

Background Pancreatic ductal adenocarcinoma carries a poor prognosis, with the worst outcomes observed in UICC stage IV disease characterized by hepatic—and less frequently pulmonary—metastases. Considerable genetic heterogeneity, including mutations in KRAS , BRCA1/2 , and ERBB2 , enables the development of individualized therapeutic strategies. We report here a patient with KRAS - and BRCA1/2 -wild-type but mutant TP53 and ERBB2 disease who achieved apparent remission of hepatic metastases. Case presentation A 78 …

03.09.2026journal-article

Frontiers in Oncology

APIM-guided dyadic nursing after colorectal cancer surgery: a propensity score-matched cohort study

Huili Du, Jing Wang

Background Recovery after colorectal cancer surgery is influenced not only by patient symptoms but also by caregiver capacity, psychological distress, self-efficacy, and dyadic coping. However, real-world evidence on Actor–Partner Interdependence Model (APIM)-guided dyadic nursing in routine postoperative care remains limited. Objective To examine the association between documented exposure to APIM-guided dyadic nursing and 6-month postoperative outcomes among colorectal cancer patient–caregiver dyads, and to explo …

03.09.2026journal-article

Frontiers in Oncology

Prognostic utility of perineural invasion in individuals with rectal cancer receiving neoadjuvant chemoradiotherapy: a meta-analysis

Meiyu Chen, Haoyu Yuan, Chunfang Xu

Objective This study aimed to systematically examine the prognostic role of post-neoadjuvant chemoradiotherapy (nCRT) perineural invasion (yPNI) in patients with locally advanced rectal cancer (LARC) treated with nCRT. Methods This study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang Data, VIP Chinese Science and Technology Journal Database …

03.09.2026journal-article

Frontiers in Public Health

Declining trends but persistent disparities in cervical cancer mortality in the United States, 1999–2023

Jie Liu, Yonglin Liu, Yanjiao Jiang, Xuefeng Wang, Xianwei Zhou

Background Cervical cancer is largely preventable through effective screening and human papillomavirus (HPV) vaccination; however, mortality disparities remain a persistent public health challenge in the United States. This study aimed to examine long-term trends and socio-demographic and geographic inequalities in cervical cancer mortality. Methods We conducted a population-based study of cervical cancer mortality among U.S. women aged ≥25 years from 1999 to 2023 using national mortality data from the CDC WONDER d …

03.09.2026journal-article

Frontiers in Oncology

Factors influencing oncologists’ decisions for germline BRCA testing and adjuvant therapy selection in HER2-negative early breast cancer

Qixin Li, M. Janelle Cambron-Mellott, Xiaoqing Xu, Nicole Kashine-Tack, Jennifer F. Hayes, Kathryn Emily Mishkin, Alexandra Gordon, Oliver Will, Lauren A. Howell, Alejandro Noval, Kathleen Beusterien

Introduction With advances in targeted early breast cancer (eBC) treatment, research is needed to understand the factors influencing biomarker testing and respective treatment selection among physicians in routine clinical practice. The purpose of this study was to evaluate factors influencing oncologist decisions for germline BReast Cancer gene (BRCA) mutation (gBRCAm) testing and adjuvant therapy in human epidermal growth factor receptor 2-negative (HER2-) early breast cancer (eBC). Materials and methods US oncol …

03.09.2026journal-article

Frontiers in Oncology

Case Report: Intra-procedural fatal cerebral lipiodol embolism without angiographically visible shunting during right inferior phrenic artery TACE

Yannan Xie, Chunyu Zhang, Chaofeng Tang, Bendong Chen

Background CLE can occur during right inferior phrenic artery TACE despite negative angiographic findings. Negative angiography should not be interpreted as excluding occult embolic pathways, and radiologic clearance of intracranial Lipiodol should not be equated with neurological recovery. Case presentation A 51-year-old man with clinically diagnosed malignant liver tumor who developed fatal CLE during the fourth liver-directed procedure. During selective right inferior phrenic artery transarterial chemoembolizati …

03.09.2026journal-article

Frontiers in Psychiatry

Language-informed treatment recommendations in psychiatry: bridging the gap in individual predictability

Ruyi Shui, Xu Zhang, Zheya Cai, Kangrui Zhao, Michael Siniatchkin, Jiaojiao Hou

Treatment recommendation systems in psychiatry perform suboptimally, largely due to low individual-level predictability from conventional clinical predictors. We argue that language captured through clinical interviews and electronic health records provides a rich, workflow-native substrate for estimating individualized treatment effects. We highlight opportunities for language-informed systems using modern language models and outline key challenges that must be addressed for safe and scalable deployment.

03.09.2026journal-article

Frontiers in Oncology

Case Report: Ulcerative breast cancer occurring 20 years after breast augmentation with Amazingel injection

Tian Li, Yun Tong, Mengyao Luo

Background Polyacrylamide hydrogels (PAAG), commercially known as Amazingel, have been widely used for injectable breast augmentation in China since the early 2000s. Because PAAG is non-degradable, long-term retention in the body may lead to complications, including infection, granuloma formation, and induration. Concerns regarding its potential long-term carcinogenicity have also emerged. However, breast cancer developing after PAAG injection has rarely been reported, and cases occurring more than 20 years after i …

03.09.2026journal-article

Exploration of Neuroscience

Colon cancer in a patient with a mosaic monoallelic germline pathogenic NF1 gene variant

Feras Alsabagh, Karam M. Chaaban, Marlene Girardo, Ehab Harahsheh, Misha B. Asif, Dusica Babovic-Vuksanovic, Mohamad Bassam Sonbol, Mayowa A. Osundiji

Pathogenic variants in the tumor suppressor gene NF1 cause neurofibromatosis type 1 (NF1), one of the most common hereditary cancer predisposition syndromes. Pathogenic NF1 variants have been associated with an increased risk of several cancers; however, the relationship between NF1 variation and colon cancer remains underreported. We report a 41-year-old woman with a mosaic monoallelic germline pathogenic NF1 variant, NM_000267.3:c.1756_1759del (p.Thr586Valfs*18), previously detected on germline multigene panel te …

03.09.2026journal-article

Frontiers in Immunology

The ALP score: a novel composite index for prognostic risk stratification to chemo-immunotherapy in advanced non-small cell lung cancer

Yize Wang, Xiaolong Zhou, Yan Huang, Ting Zhong, Huan Yan, Juan Liang, Lianxi Song

Objective This study aimed to investigate the value of a novel composite index, the ALP score (calculated as the product of lymphocyte count and serum albumin), in predicting the risk of early progression to chemotherapy combined with immune checkpoint inhibitors (ICIs) in patients with driver mutation-negative advanced non-small cell lung cancer (NSCLC). Methods Clinical data from 433 patients with advanced NSCLC who received first-line chemoimmunotherapy were retrospectively collected. Independent risk factors fo …

03.09.2026journal-article

Journal of Hepato-Biliary-Pancreatic Sciences

Pretreatment Contrast‐Enhanced Harmonic EUS Predicts Pathological Response and Recurrence‐Free Survival After Multimodal Treatment in Resectable Pancreatic Cancer

Yuichi Kano, Takuya Ishikawa, Kentaro Yamao, Yasuyuki Mizutani, Tadashi Iida, Yoshihisa Takada, Ryohei Kumano, Takeshi Yamamura, Kazuhiro Furukawa, Hiroki Kawashima

ABSTRACT Objectives Recurrence remains common in resectable pancreatic cancer (PC) despite multimodal treatment. We evaluated whether pretreatment contrast‐enhanced harmonic endoscopic ultrasonography (CH‐EUS) predicts pathological response and recurrence‐free survival (RFS). Methods We retrospectively analyzed 52 patients with resectable PC who underwent CH‐EUS before standardized multimodal treatment (neoadjuvant chemotherapy, surgery, and adjuvant chemotherapy). Associations between CH‐EUS enhancement patterns ( …

03.09.2026journal-article

Frontiers in Oncology

Gap analysis of breast cancer care at tertiary facilities in Armenia

Ani Arzoumanian, Sione Markarian, Anja Johnson, Emma Mastro, Sira Jil-Agopian, Catherine Duggan, Marine Hovhannisyan, Henry Louis, Shant Shekherdimian

Breast cancer is the leading cause of cancer mortality among women globally. Armenia has one of the highest breast cancer mortality rates in the world, with an age standardized mortality-to-incidence ratio of 0.41, indicating that two in five breast cancer patients die from the disease. The factors contributing to this disproportionate mortality burden are poorly understood. The present study utilized a validated survey across four high-capacity cancer facilities to produce a national gap analysis of breast cancer …

03.09.2026journal-article

Frontiers in Oncology

Case Report: Solitary right thigh skin metastasis of bladder cancer misdiagnosed as erysipelas with literature review

Zhaonan Hou, Mingfeng Ji, Fang Peng, Yihao Chen, Zhiyu Liu, Zhihong Dai

Background Cutaneous metastasis from bladder carcinoma is an uncommon clinical manifestation and may be misdiagnosed as a benign inflammatory dermatosis, such as erysipelas, causing diagnostic delay and missed opportunities for timely systemic treatment. Case presentation We report a case of a 70-year-old man with a history of muscle-invasive bladder carcinoma treated with radical cystectomy and bilateral cutaneous ureterostomies, who presented 6 years later with a maculopapular rash on his right thigh. The lesion …

03.09.2026journal-article

Frontiers in Psychiatry

A critical appraisal of integrating family constellation therapy with pharmacological treatment for depression

Wenhao Zhong, Mei Rao, Qian Zhou, Zeying Leng, Bing Zhang, Zhijian Lin

Depression remains a leading cause of disability worldwide, driven by a complex interplay of biological, psychological, and social factors. While pharmacotherapy, particularly selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors, provides essential symptom control, its limitations—including delayed onset, variable response, and side effects—underscore the need for complementary approaches that address systemic and relational roots of the disorder. This narrative review synthesize …

03.09.2026journal-article

Annals of Surgery

Cancer Surgery Outcomes After Implementation of a Global Budget Model in Rural Hospitals

Jacob Whitman, Eric T. Roberts, Jonathan G. Yabes, Donald Bourne, Zhaojun Sun, Manisha Bhattacharya, Jeremy M. Kahn, Bruce L. Jacobs, Lindsay M. Sabik

Objective: To evaluate the association between the implementation of the Pennsylvania Rural Health Model (PARHM), a global budget program for rural hospitals, and short-term outcomes for rural residents undergoing cancer surgery. Background: Rural hospitals play a critical role in delivering surgical care but face ongoing financial instability. Global budget models aim to stabilize hospitals and preserve access to care. While designed to stabilize finances and improve population health, its impact on quality of car …

03.09.2026journal-article

Frontiers in Microbiology

Klebsiella pneumoniae in inflammatory bowel disease and rectal cancer: from gut inflammation to a potential driver of carcinogenesis

Shuxin Xiong, Rui Yao

The gut microbiota is a critical modulator of intestinal inflammation and colorectal cancer (CRC), yet the specific microbial drivers that bridge inflammatory bowel disease (IBD) to rectal carcinogenesis remain poorly defined. Klebsiella pneumoniae ( K. pneumoniae ) has recently emerged as a compelling candidate at this nexus; however, several critical questions remain unresolved: (i) whether K. pneumoniae colonization is a cause or a consequence of rectal carcinogenesis; (ii) how strain level heterogeneity determi …