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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Journal of Hospital Medicine

National trends in pathogen‐specific diagnoses and outcomes among hospitalizations for infectious diarrhea

David Wong Arias, Spencer R. Goble, Mauricio Torrealba

Abstract Background The diagnostic evaluation of infectious diarrhea has evolved with increasing adoption of multiplex gastrointestinal nucleic acid amplification tests and changing diagnostic strategies for Clostridioides difficile . Objectives We aimed to assess changes in inpatient pathogen‐specific documentation rates and clinical outcomes on a national level. Methods We performed a retrospective cross‐sectional study using the National Inpatient Sample from 2016 to 2023. Adult hospitalizations with a primary d …

03.09.2026journal-article

Journal of Hospital Medicine

Reducing inpatient falls with a mobility‐first, multidisciplinary intervention at a VA Medical Center

Ryan Duffy, Padideh Imenikashani, Tymeeka Davis, Steven Fairbanks, Folake Ogunmola, Laura Previll, Brian Schneider

Abstract Inpatient falls are a common and preventable source of harm among hospitalized patients. At a Veterans Health Affairs medical center, we implemented a mobility‐first, multidisciplinary intervention using sequential Plan‐Do‐Study‐Act cycles, including redesigned activity orders to “mobilize unless contraindicated,” physical therapist‐led education, and interdisciplinary fall huddles with rapid feedback. Over 18 months, total falls decreased by 34%, from 7.6 to 5.0 per 1000 bed‐days, and injurious falls decr …

03.09.2026journal-article

Frontiers in Surgery

Giant adrenal pseudocyst with unclear preoperative origin: a case report and literature review

Shouyi Long, Bin Xiong, Zhen Long, Bo Li, Xiujun Yuan, Shulian Chen

Introduction Adrenal cysts are relatively rare, and most are nonfunctional and lack specific clinical manifestations, often being discovered incidentally during imaging examinations. For giant adrenal cysts with a maximum diameter exceeding 10 cm, especially when accompanied by degenerative changes such as hemorrhage, fibrosis, and calcification, compression of adjacent organs and obscuration of anatomical planes may increase the difficulty of determining the origin preoperatively, and they may even be misdiagnosed …

03.09.2026journal-article

Measurement Science and Technology

Hybrid loss-driven source-free domain adaptation with post-hoc explainability for bearing fault diagnosis

Chenghao Yan, Dongsheng Liu, Tong Wu, Renjie Sun, Yahui Chen, Wenjun Huang, Zhongqiu Liu

Abstract While conventional fault diagnosis excels in steady-state scenarios, reliable detection under variable operating conditions remains a critical challenge in modern industrial drive systems. Although domain adaptation techniques address cross-domain distribution shifts, their deployment is often hindered by data privacy concerns and the impracticality of labeling massive target data in real-world factories. Furthermore, standard methods typically require concurrent access to source and target data, which vio …

03.09.2026journal-article

European Heart Journal: Acute Cardiovascular Care

Electrocardiographic Principles for the Diagnosis of Occlusion Myocardial Infarction

Hans C Helseth, Pedro Mansur, Mazen El-Baba, Jesse T T McLaren, José Nunes de Alencar, Stephen W Smith

Abstract The ECG is the only rapid, noninvasive diagnostic test that can identify coronary occlusion warranting reperfusion therapy at the bedside. The diagnostic paradigm of STEMI/NSTEMI is based on millimeter ST Elevation (STE) criteria as stated in the 4th Universal Definition of MI. It has identified candidates for emergent reperfusion for decades, but is limited by the low sensitivity and specificity of STE for acute coronary occlusion. A paradigm shift to Occlusion MI/Non-Occlusion MI (OMI/NOMI) has been prop …

03.09.2026journal-article

Journal of Imaging Informatics in Medicine

Long-PVSUNet: A Longitudinal Deep Learning Framework for Count-Oriented Perivascular Space Segmentation in Brain MRI

Shizuka Hayashi, Lei Fan, Jiyang Jiang, Yang Song, Dadong Wang, Henry Brodaty, Perminder S. Sachdev, Wei Wen

Abstract Enlarged perivascular spaces (ePVS) are small, sparse MRI-visible markers of cerebral small vessel disease and brain ageing. Their size, low contrast, and severe foreground–background imbalance make automated segmentation challenging. Existing methods are mainly cross-sectional and do not model temporal consistency, limiting their utility for tracking longitudinal change. We developed Long-PVSUNet, a two-timepoint framework for count-oriented ePVS segmentation on paired baseline/follow-up T1-weighted and F …

03.09.2026journal-article

Journal of Medicine and Health Research

Psychiatric Morbidity among Fresher Medical Students in a Nigerian Tertiary Institution: A Mixed-Methods Study

Adeoye Oyewole, Adedotun Oyewole, Samson Ojedokun, Chukwunonso Ndulue

Background: The transition into medical school represents a major developmental, academic, and psychosocial challenge for young adults. These challenges may be particularly significant among freshers. The study aimed to determine the prevalence and predictors of psychiatric morbidity among freshers in the medical school of a public university in Nigeria. Methods: A convergent mixed-methods design was used for the study. The quantitative component involved a cross-sectional survey of first-year medical students usin …

03.09.2026journal-article

Frontiers in Medicine

Syphilis causing elevation of anti-CCP: a case report of medical mimicry

Tara Subrahmanyan, Ashley Martinez, Justin Baik, Matthew Kelly

Introduction Infection with Treponema pallidum, or syphilis, is often called the “Great Imitator” because of its propensity for atypical presentations and non-specific symptoms. In addition, syphilis has been shown to create false-positive results for common tests, including Lyme disease, HIV, and multiple autoimmune conditions. One that has not been documented is anti-cyclic citrullinated peptide (anti-CCP). Anti-CCP is a highly specific test for Rheumatoid Arthritis. However, in this case, syphilis led to false-e …

03.09.2026journal-article

Frontiers in Psychiatry

Psychiatric comorbidities in hoarding disorder: a structured clinical interview study

Nami Nishida, Keitaro Murayama, Hirofumi Tomiyama, Kenta Kato, Kang Mingi, Kou Matsukuma, Makoto Kawahito, Kana Tsunoda, Takuro Kamio, Ayaka Shuto, Tomohiro Nakao

Objective Hoarding disorder (HD) is a psychiatric condition characterized by persistent difficulty in discarding possessions, leading to significant clutter and functional impairment. HD is often comorbid with other psychiatric disorders, but previous findings of these comorbidities are inconsistent due to limited structured assessments. This study investigates the psychiatric comorbidities in individuals with HD using structured, clinician-administered interviews. Methods Between 2016 and 2022, 68 individuals diag …

03.09.2026journal-article

Frontiers in Surgery

A transformer-based multi-modal fusion framework for laryngeal lesion classification using contact endoscopy

Yunjing Duan, Wei Li

Purpose This study introduces a novel multi-modal transformer-based framework that integrates clinical data, radiomic features, and deep learning representations for automated classification of laryngeal lesions from contact endoscopy images. Methods We retrospectively enrolled 300 patients with laryngeal lesions from three independent medical centers (Centers A, B, and C), acquiring 7,847 contact endoscopy images with narrow band imaging. Clinical variables (18 features), radiomic features extracted using PyRadiom …

03.09.2026journal-article

Frontiers in Neurology

Brain-computer interface for post-stroke upper-limb recovery: a systematic review integrating clinical efficacy with neuroplasticity evidence

Yu Wu, Feilong Zhu, Qiumeng Dong, Ming Zhang

Objective Over 20 systematic reviews have evaluated brain-computer interface (BCI) training for post-stroke upper-limb rehabilitation, but published syntheses have focused predominantly on clinical efficacy, and the neuroplasticity mechanisms remain comparatively underexplored. This review integrates pooled clinical efficacy with a structured synthesis of neuroplasticity evidence from the same trials. Methods PubMed, Embase, CINAHL via EBSCO, Web of Science, Scopus, and Cochrane CENTRAL were searched from inception …

03.09.2026journal-article

European Journal of Clinical Microbiology & Infectious Diseases

Comparative efficacy of oral antibiotics against intracellular populations of uropathogenic Escherichia coli and bladder cell inflammatory response

Michelle Kalu, Peter Jorth, Annie Wong-Beringer

Abstract Predisposing risks to recurrent urinary tract infections caused by uropathogenic Escherichia coli (UPEC) include the formation of intracellular bacterial communities (IBCs) as a reservoir for persistence within bladder epithelial cells and sustained elevation of proinflammatory mediators that interfere with wound healing. Here we investigated the efficacy of oral agents (nitrofurantoin, doxycycline, and gepotidacin) in intracellular bacterial clearance and proinflammatory signaling in bladder epithelial ce …

03.09.2026journal-article

Lupus

Clinical characteristics of patients with primary antiphospholipid syndrome and “single” antiphospholipid antibody: Retrospective results from the APS ACTION clinical database and repository (“registry”)

Silvia Grazietta Foddai, Irene Cecchi, Massimo Radin, Laura Bertolaccini, Danieli de Andrade, Maria Tektonidou, Vittorio Pengo, Chary Lopez-Pedrera, Diana Paredes-Ruiz, Howard Michael Belmont, Paul R. Fortin, Denis Wahl, Ware Branch, Maria Gerosa, Guilherme de Jesus, Zhouli Zhang, Tatsuya Atsumi, Maria Efthymiou, Laura Andreoli, Esther Rodriguez, Michelle Petri, Ricard Cervera, Bahar Artim-Esen, Rosana Quintana, Jason S. Knight, Rohan Willis, Reyhan Kose Cobanoglu, Hannah Cohen, Doruk Erkan, Savino Sciascia

Objective While triple antiphospholipid antibody (aPL) positivity is associated with a higher risk of thrombosis, the clinical significance of single aPL positivity remains unclear. This study aimed to assess the prevalence, clinical characteristics, and cardiovascular disease (CVD) risk profile of persistently single aPL-positive primary antiphospholipid syndrome (PAPS) patients. Methods We conducted a retrospective analysis for APS patients from the APS ACTION registry with confirmed persistent single aPL positiv …

03.09.2026journal-article

South Asian Journal of Cancer

AsiaPacific Geriatric Oncology Society (AGOS; virtual tumour board no 9) real world consensus for management of endometrial cancer with multiple co-morbidities and polypharmacy in the older patient

Purvish M Parikh, Nikhil Ghadyalpatil, Dharshitha Varigonda, TVSVGK Tilak, Bipinesh Sansar, Karishma De, Mosale Venkatesha Chandrakant, VenkataSampath Vankamamidi, Steve Paul Manjaly, Athika Shaik, Madhusudhan Perumandla

The AsiaPacific Geriatric Oncology Society (AGOS) conducts a monthly virtual tumour board. One of the cases discussed was a 70-year-old female with Stage IIIA endometrial cancer, multiple co-morbidities and polypharmacy. A group of experts discussed the challenges in the real world with specific reference to improving Timed Up and Go (TUG) score, managing the effect of co-morbidities, preventing risk due to drug-drug interactions and evaluating the risk of delaying anti-cancer therapy in an attempt to improve patie …

03.09.2026journal-article

Journal of Intensive Care Medicine

Maternal Sepsis for the Intensivist: Recognition, ICU Triage, and Pregnancy-Adapted Management

Felicia Chen

Sepsis in pregnancy and the puerperium is a leading, and often preventable, cause of maternal critical illness. This narrative review summarizes pregnancy-adapted physiology, epidemiology, clinical recognition, intensive care unit triage, and management, with particular emphasis on decision-making around ICU admission and the practical delivery of organ support for intensivists who do not routinely manage obstetric patients.

03.09.2026journal-article

ANZ Journal of Surgery

Negative Pressure Wound Therapy Does Not Reduce Wound Complications Following Simple Mastectomy: A Retrospective Cohort Study

Robert Torode, David Walsh, Jonathan Fong

ABSTRACT Background Negative pressure wound therapy (NPWT) reduces wound complications following oncoplastic breast surgery, yet there is limited evidence supporting its use in mastectomy without reconstruction. This study evaluated the effect of NPWT on post‐mastectomy wound complications in a rural Australian centre. Methods A single centre retrospective cohort study assessed simple mastectomy outcomes between 2020 and 2025. Wounds were grouped by post‐operative dressing type (NPWT vs. no NPWT). The primary outco …

03.09.2026journal-article

Journal of Public Health and Preventive Medicine

Research Progress on the Impacts of Social Isolation and Loneliness on the Health of the Elderly

Elisa M. Carter, Ryan D. Simmons, Megan L. Henderson, Julia A. Bennett

Social isolation and loneliness have emerged as critical public health concerns affecting older adults worldwide. Despite being distinct concepts—social isolation referring to the objective lack of social connections and loneliness representing the subjective distress of feeling alone—both conditions are associated with profound adverse effects on physical and mental health. This narrative review synthesizes current research on the conceptual definitions, measurement tools, health impacts, intervention strategies, …

03.09.2026journal-article

Frontiers in Medicine

Facial discoid lupus erythematosus complicated by a Candida tropicalis fungal granuloma in a patient with rhupus syndrome: a case report of successful treatment with oral itraconazole

Lingling Dong, Ting Zhang, Tong Hua, Yan Wang, Zhenhua Nie, Qingkang Lyu, Zuotao Zhao

Discoid lupus erythematosus (DLE) is a chronic cutaneous subtype of lupus erythematosus characterized by inflammatory lesions that are highly susceptible to secondary infection, particularly in immunocompromised individuals. Cutaneous fungal granulomas caused by Candida tropicalis and superimposed on pre-existing DLE lesions are exceedingly rare and pose substantial diagnostic challenges. We report the case of a 48-year-old female patient with a 2-year history of rheumatoid arthritis (RA), who presented with facial …

03.09.2026journal-article

International Journal of Science, Strategic Management and Technology

White Spot Lesions Following Orthodontic Treatment: Contemporary Management

Y.Muni Akash

White spot lesions (WSLs) often develop after fixed orthodontic treatment. They appear as milky white spots on teeth due to enamel demineralization. These lesions are a common aesthetic concern, affecting 45.8% to 97% of orthodontic patients [1]. Today, dentistry focuses on non-invasive remineralization therapies to treat WSLs and prevent their progression.

03.09.2026journal-article

Frontiers in Oncology

Deep learning model using contrast-enhanced CT imaging features and clinical variables to predict surgical risk after hepatic resection for hepatocellular carcinoma

Kimika Kato, Yasuhito Mitsuyama, Hiroji Shinkawa, Takuma Okada, Atsushi Sugimoto, Ryota Tanaka, Sadaaki Nishimura, Jun Tauchi, Masahiko Kinoshita, Genki Watanabe, Kohei Nishio, Takeaki Ishizawa

Background Accurate preoperative risk assessment is crucial for patients undergoing hepatic resection for hepatocellular carcinoma (HCC). Conventional prediction methods are limited by the inability to capture complex relationships among multiple factors, and existing deep learning (DL) approaches focus on individual surgical outcomes. In this study, we developed and evaluated a DL model that integrates preoperative contrast-enhanced computed tomography (CT) imaging features and clinical variables to predict intrao …

03.09.2026journal-article

Journal of Dance Medicine & Science

Dance as Rehabilitation in Parkinson’s Disease: A Scoping Review of Motor, Non-Motor, and Cognitive Outcomes

Simran Rooprai, Nicholas Ramcharran, Caitlin van den Hoorn, Jenna Smith-Turchyn, Nicole D. Anderson, Joseph FX DeSouza

Introduction: Dance is a multimodal experience, integrating movement and music, with cognitive and psychosocial effects, potentially providing a non-pharmacological care approach for persons with Parkinson’s disease (PwPD). While numerous studies have investigated motor outcomes following dance interventions, less is known about the degree to which cognitive and non-motor outcomes are explored. The objective of this scoping review was to explore the scope and characteristics of dance-based interventions for PD, foc …

03.09.2026journal-article

Current Opinion in Otolaryngology & Head & Neck Surgery

Tympanomastoidectomy canal wall reconstruction with mastoid obliteration

Adam S. Vesole, Ravi N. Samy

Purpose of review To describe the various techniques in performing a tympanomastoidectomy canal wall reconstruction with mastoid obliteration for surgical management of chronic otitis media and cholesteatoma, and to assess the outcomes and complications compared to the more traditional canal wall up and canal wall down surgical techniques. Additionally, the purpose of this review is to highlight the versatility and novelty of this approach in addressing other middle ear pathologies such as glomus tympanicum. Recent …

03.09.2026journal-article

Global Spine Journal

Characteristics of Patients Achieving Clinically Meaningful Improvement in Neuropathic Pain After Surgery for Degenerative Cervical Myelopathy

Narihito Nagoshi, Junichi Yamane, Toshiki Okubo, Hitoshi Kono, Kentaro Fukuda, Takeshi Fujii, Yosuke Horiuchi, Yasuhiro Kamata, Norihiro Isogai, Takahito Iga, Kazuki Takeda, Masahiro Ozaki, Satoshi Suzuki, Morio Matsumoto, Masaya Nakamura, Kota Watanabe

Study Design Retrospective analysis of a prospectively maintained multicenter cohort. Objectives To identify clinical characteristics associated with clinically meaningful improvement in neuropathic pain and to evaluate its relationship with postoperative functional outcomes in patients with degenerative cervical myelopathy (DCM). Methods Among 816 patients with complete Neuropathic Pain Symptom Inventory (NPSI) data, 597 with baseline total NPSI scores ≥7 were included in the primary analysis because they were eli …

03.09.2026journal-article

European Journal of Trauma and Emergency Surgery

Repeated scoring with the adult appendicitis score improves the sensitivity and the specificity of appendicitis diagnosis in patients with early equivocal signs of appendicitis: a secondary analysis

Kirsi S. Lastunen, Ari K. Leppäniemi, Panu J. Mentula

Abstract Purpose The utilization of computed tomography in the early stage of acute appendicitis may result in overdiagnosis and unnecessarily expose patients to ionising radiation. The Adult Appendicitis Score (AAS) can be used to select patients for imaging. Observation and re-scoring in the DIAMOND trial reduced the need for imaging. Now, we wanted to determine if the change in AAS (∆AAS) can serve as a diagnostic tool to select patients for imaging even more precisely. Methods Eighty-eight patients with early e …