EUVIMEDEuropean Health Evidence
Uhr 7/7Sources Journal Tree
Easy Demo

EUVIMED Themenbrowser · Onkologie · Seite 28

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

Themen erkunden

Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

ACR Open Rheumatology

Fracture Risk Associated With Long‐Term Discontinuation of Postmenopausal Osteoporosis Treatment: A French Population‐Based Study Using National Claims Data (Système National des Données de Santé)

Audrey Lajoinie, Meriem Benmerad, Magali Laborey, Pascale Samama, Gaëlle Désaméricq, Leila Chelbani, Karine Briot

Objective This retrospective cohort study evaluated the long‐term discontinuation (LTD) of osteoporosis treatments in postmenopausal women in France and associated fracture risk and economic burden. Methods From the national French health care database (Système National des Données de Santé), we included postmenopausal women aged ≥60 years initiating oral bisphosphonates, intravenous bisphosphonates, or denosumab between 2012 and 2015 with three or more (bisphosphonates) or two or more (denosumab) years of continuo …

01.09.2026journal-article

Cancer Reports

AZD6738 (Ceralasertib) Enhances Trifluridine's Antitumor Effect in 5‐ FU –Resistant Colorectal Cancer Cells

Shuhei Uehara, Takuya Suzuki, Junki Kato, Hiroyuki Asai, Akira Kato, Shinnosuke Harata, Hajime Ushigome, Yushi Yamakawa, Takahisa Hirokawa, Hiroki Takahashi, Yoichi Matsuo, Shuji Takiguchi

ABSTRACT Background Resistance to 5‐fluorouracil (5‐FU) remains a major obstacle in colorectal cancer (CRC) treatment. Trifluridine (FTD), the active component of TAS‐102, exerts cytotoxicity through DNA incorporation and reportedly remains active in 5‐FU‐resistant tumors, though with limited clinical efficacy. Aims We investigated whether AZD6738, an inhibitor of ataxia telangiectasia and Rad3‐related kinase (ATR) that regulates the G2/M checkpoint, could enhance FTD efficacy in 5‐FU‐resistant CRC. Methods and Res …

02.09.2026journal-article

The Oncologist

15 Defining Systemic and Tumor-Intrinsic Biomarkers of Immune Suppression in Renal Cell Carcinoma

Giuliana Mognol, Erpei Wang, William Harris, Tami Von Schalshcha, Rayan Jouny, Birkley Lim, Ahmed Abdelhak, Rana McKay, Judith Varner

Abstract Background Renal cell carcinoma (RCC) is characterized by a highly immunosuppressive tumor microenvironment enriched in tumor-associated macrophages (TAMs) and regulatory T cells (Tregs), both of which correlate with poor clinical outcomes. TAMs in RCC commonly exhibit an immunosuppressive phenotype, marked by production of TGFb, IL-10 and IL-6, which suppress cytotoxic T cell responses and promote tumor progression. Despite advances in immunotherapy, metastatic RCC remains highly lethal, underscoring the …

02.09.2026journal-article

MedComm

Early Local Treatment Delays Multiple Metastases in Non‐Small Cell Lung Cancer With Solitary Distant Metastasis: A Multicenter Retrospective Cohort Study

Kang Miao, Siyu Lei, Xiaobin Zheng, Shanshan Yang, Yujing Li, Sihui Chen, Qian Miao, Longfeng Zhang, Zihua Zou, Haipeng Xu, Gen Lin

ABSTRACT Solitary distant metastasis (SDM) is a distinct oligometastatic subtype associated with a relatively favorable prognosis. This multicenter retrospective study including 139 non‐small cell lung cancer (NSCLC) patients with SDM (2019–2024) was conducted to investigate prognostic factors for multiple metastases and identify the critical time window for local treatment. Statistical analyses included Cox regression, Kaplan–Meier survival analysis, and restricted mean survival time (RMST). Results showed that dr …

01.09.2026journal-article

Revista Ibero-Americana de Humanidades, Ciências e Educação

TRATAMENTO LAPAROSCÓPICO VERSUS CIRURGIA ABERTA NA ÚLCERA PÉPTICA PERFURADA: COMPARAÇÃO DOS DESFECHOS PÓS-OPERATÓRIOS

Leonardo Schaucoski Cizeski, Ana Caroline Gomes de Miranda Linhares, Caio Ferraz Gomes Barros, Eduarda Siqueira Cesário, Lucas Venancio Tavares, Pedro Henrique Borges Silvestre, Sayd Abrantes de Lima Pereira

A úlcera péptica perfurada constitui uma emergência cirúrgica associada a elevada morbimortalidade, decorrente principalmente de peritonite, sepse e deterioração fisiológica progressiva. Embora a cirurgia aberta permaneça amplamente utilizada, o tratamento laparoscópico vem ganhando espaço devido ao potencial de reduzir trauma cirúrgico e complicações pós-operatórias. O objetivo deste estudo foi comparar os principais desfechos pós-operatórios associados ao tratamento laparoscópico e à cirurgia aberta na abordagem …

01.09.2026journal-article

Cancer Medicine

Effect of Tertiary Lymphoid Structures on Immune Cell Infiltration in the Tumor Microenvironment and Prognosis in Lung Adenocarcinoma

Sihong Le, Weidan Fang, Yitao Le, Ling Zhang

ABSTRACT Tertiary lymphoid structures (TLSs) modulate immune responses in various solid tumors, but their comprehensive role in lung adenocarcinoma (LUAD) remains unclear. In this study, we analyzed RNA‐seq data from 539 LUAD patients in The Cancer Genome Atlas (TCGA) and microarray data from 223 samples from the Gene Expression Omnibus (GEO, GSE13213, and GSE37745). TLS signatures were evaluated via unsupervised consensus clustering based on 12 chemokine transcriptome signatures. The relationships between TLS and …

01.09.2026journal-article

Blood Advances

Life-years saved by advances in blood cancer therapy: a retrospective analysis

Dennis C Chang, Ann-Kathrin Eisfeld, Lee M Greenberger, E Anders Kolb

The impact of research and the development of therapeutics for blood cancer must be measured to direct future studies. Here, we used a life-years saved (LYS) methodology to quantify that impact. We estimate 25.8 million cumulative LYS across major blood cancer types in the US since 1949. The majority of LYS (~20 million) were for Hodgkin lymphoma (HL), acute lymphoblastic leukemia (ALL), and non-Hodgkin lymphoma (NHL). NHL stands out due to a high incidence, while HL and ALL have accumulated LYS over the longest pe …

01.09.2026journal-article

Journal of Biomolecular Techniques

Beyond Infrastructure: Shared Resources as Drivers of Impact and Collaboration in the NCI Cancer Center Community

Brian C. Springer, Nicholas P. Ambulos, David M. Gosky

Shared Resources (SRs) are essential to advancing team science in NCI-Designated Cancer Centers by providing access to specialized expertise, advanced technologies, and state-of-the-art instrumentation. Effective SRs rely on strategic planning, continuous evaluation, infrastructure investment, and user feedback to remain responsive to evolving scientific needs. Beyond technical support, SRs strengthen institutional research capacity by fostering collaboration, leveraging resources, supporting external partnerships, …

01.09.2026journal-article

BMJ Open

Evaluating an innovative support programme for older long-term cancer survivors (IMPULS-A): protocol for a randomised controlled trial

Till Johannes Bugaj, Charlotte Flock, Elena Scapinello, Joachim Wiskemann, Dirk Jäger, Jürgen M. Bauer, Beate Wild, Eva Winkler, Volker Arndt, Julien Frick, Daniela Doege, Katja Mehlis, Sarina Carter, Annette Eidam, Martin Bongartz, Rea Kuehl, Tabea Bertram, Sabrina Scherbarth, Bernhard Ortseifen, Imke Veit-Schirmer, Mechthild Hartmann, Hans-Christoph Friederich

Introduction More than 5 million people in Germany are living with cancer or a history of cancer, 40% of them aged 75 years or older. Cancer and its treatment may lead to reduced physiological reserves, multiple somatic comorbidities and a combination of functional and psychosocial health problems in addition to the long-term and late effects of cancer and its treatment. Therefore, providing tailored care and support through an interdisciplinary care network is crucial. The aim of the IMPULS-A (Implementation of a …

01.09.2026journal-article

Journal of Computer Assisted Tomography

Prediction of Ki-67 Status in Breast Cancer Using a Habitat-Guided 2.5D Multiparametric MRI Deep Learning Model

Zeyang Miao, Run Xu, Mengyao Guo, Hong Chen, Xuting Fang, Qiong Li, Peng Luo, Guanwu Li

Objective: Intratumoral heterogeneity may limit the representativeness of biopsy-based Ki-67 assessment in breast cancer. We therefore developed and validated a habitat-guided 2.5D deep learning (DL) model based on multiparametric MRI for noninvasive preoperative prediction of high versus low Ki-67 expression. Methods: This retrospective study enrolled 333 patients with invasive breast carcinoma from 2 distinct MRI vendor cohorts (Siemens, training set, n=233; United Imaging, independent test set, n=100). All patie …

01.09.2026journal-article

ASM Case Reports

Treatment of multidrug-resistant tuberculosis with bedaquiline, pretomanid, linezolid, and moxifloxacin following near-total gastrectomy

Ihab Weheba, Sarah K. Brode, Melissa Richard-Greenblatt, Natasha F. Sabur

ABSTRACT Background Patients with a history of gastrectomy are at increased risk of developing pulmonary tuberculosis due to nutritional deficiencies and potential immune impairment. Altered gastrointestinal anatomy can affect oral drug absorption and treatment pharmacokinetics, making management of drug-resistant tuberculosis in this population challenging. Case Summary We describe a case of a woman with a history of gastric adenocarcinoma treated with chemotherapy, followed by near-total gastrectomy and Roux-en-Y …

01.09.2026journal-article

AMK : Abdi Masyarakat UIKA

Empowering Women of Reproductive Age (WUS) through Implementation of the 'AYU CARE' Model in Independent Early Breast Cancer Screening at Puskesmas Rambah

Joko Prasetyo, Romy Wahyuny

Breast health promotion in primary care requires cadres who are able to convey warning signs, support breast awareness, and connect women with health workers. This community service activity involved 23 female cadres in Rambah Tengah Utara, Rokan Hulu, in July 2026. The series of activities included participant registration, distribution of breast-health leaflets, interactive education, visual demonstration, guided breast self-examination (BSE) practice, use of supporting digital media, mentoring, discussion, and a …

01.09.2026journal-article

Frontiers in Pediatrics

Case Report: Selumetinib as a neoadjuvant treatment for the removal of a PN

Ciavarelli Patricia, Mezmezian Mónica Beatriz, Daniel Yedlin, Paloma Amarillo

Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder that presents with benign tumors of the peripheral nerve sheath, named plexiform neurofibromas. Progressive tumor growth may cause pain, physical disfigurement, and compression of adjacent structures, potentially impairing normal development during childhood. We report the case of a 13-year-old patient with a plexiform neurofibroma in the right foot, which had been growing since the first months of life and compromised the talocalcaneal joint, …

01.09.2026journal-article

Frontiers in Surgery

Arthroscopic-assisted uniportal spinal surgery for the treatment of rare T10/T11 thoracic disc herniation: a case report

De Meng, GuoFang Meng, ShenRong Jiang, Yuan Zhong

Background Thoracic disc herniation (TDH) is rare, with an estimated incidence of 1 per 1,000,000 individuals. Surgical treatment is indicated for those suffering from myelopathy and/or intractable neurological deficit. Open surgical approaches including transthoracic and retropleural access carry substantial perioperative risks. Contemporary minimally invasive endoscopic techniques reduce tissue dissection and manipulation of the thecal sac, yet they are associated with a steep learning curve and limited intraoper …

01.09.2026journal-article

Energy & Fuels

Evolution of Pore-Fracture Structure and Coupled Damage–Seepage Characteristics of Coal Induced by LCO2 Phase-Transition Treatment: A 3D Digital Core Study

Xianke Wang, Yonggang Qiao, Nan Fan, Danping Yuan, Shida Zhang, Yongliang Mu

Abstract This study combines micro-CT scanning with Avizo-based three-dimensional reconstruction technology to quantitatively characterize the evolution of pore-fracture structures in coal during LCO2 phase-transition treatment and systematically investigates the coupled response of damage evolution and seepage behavior under different stress conditions based on digital coal core models. Results show that LCO2 phase-transition treatment significantly reconstructs the coal pore-fracture network, promoting the develo …

02.09.2026journal-article

Journal of Coloproctology

Adenoma Detection Rate in Sedated Colonoscopies Performed at Mehrgan Hospital, Kerman (2020–2024): Association with Demographic Factors and Colorectal Cancer Occurrence

Sadreddin Lahsaee, Mohammad RezazadehKermani, Shahnaz ShahabiNasab, Zahra Sarabandi, Fatemeh Asadi, Fatemeh Ahmadi

Abstract Colorectal cancer (CRC) is the third most commonly diagnosed malignancy and the second leading cause of cancer-related death worldwide. The adenoma detection rate (ADR), based on pathology-confirmed adenomas, is a key quality indicator for colonoscopy and a surrogate marker for its effectiveness in CRC prevention. We conducted a retrospective cross-sectional study of all sedated colonoscopies performed at Mehrgan Hospital, Kerman, Iran, between 1399 and 1403 (2020–2024). Patient demographic data (age, sex) …

01.09.2026journal-article

Current Bioactive Compounds

Antitumor Potential of Extracts Derived from Aerial Parts of Sigesbeckia orientalis L.: Cytotoxic Activities In Vitro and DMBA-induced Tumor Model in Swiss Mice

Thuy Nguyen Thi, Le Ba Vinh, Thanh Tung Bui, Van Khanh Nguyen, Huyen Nguyen Thi, Hong Khanh Do Thi, Hong Minh Phan, Van Anh Bui Thi, Nguyen Thuc Thu Huong, Phuong Thanh Mai

Background: Sigesbeckia orientalis L., a member of the Asteraceae family, is an annual herb traditionally used to treat various ailments, such as rheumatism and joint pain. Recent studies have increasingly focused on its potential pharmacological effects through various in vitro, in silico, and in vivo models. However, there are limited reports on its potential anti-tumor applications. Objective: This study aimed to investigate the cytotoxic effects of various extracts of S. orientalis on cancer cell lines and to e …

01.09.2026journal-article

Frontiers in Environmental Chemistry

Vetiver biochar application for heavy metal sequestration in water treatment: bridging perfumery waste and environmental sustainability

Sameer Neve, Viravid Na Nagara, Zhiming Zhang, Rupali Datta, Dibyendu Sarkar

Converting industrial byproducts into functional adsorbents supports circular and sustainable approaches to water treatment. This study evaluated biochar derived from spent vetiver ( Chrysopogon zizanioides ) roots, a byproduct of the perfumery essential-oil industry, for the competitive adsorption of copper (Cu), cadmium (Cd), zinc (Zn), and lead (Pb). Vetiver root biochar produced at 500 °C for 60 min exhibited a high surface area of 308.2 m 2 /g and a yield of 53.8%. Batch adsorption experiments were performed i …

01.09.2026journal-article

Nature Communications

Global incidence of esophageal cancer by histological and anatomical subtypes

Claire Chenwen Zhong, Junjie Huang, Zehuan Yang, Zhaojun Li, Lin Zhang, Xu Lin, Don Eliseo Lucero-Prisno, Wanghong Xu, Minmin Wang, Yinzi Jin, Zhi-Jie Zheng, Mellissa Withers, Martin CS Wong

Abstract Esophageal cancer is a major contributor to the global cancer burden, yet comprehensive global assessments of its burden across subtypes are lacking. This study examines the incidence, risk factors, and trends of esophageal cancer by histological and anatomical subtypes, with stratification by sex and age across different countries, using GLOBOCAN 2022 estimates, Cancer Incidence in Five Continents data, and country-level socioeconomic, lifestyle, and metabolic risk-factor indicators. Here we show that Eas …

01.09.2026journal-article

Metabolites

Advances in Exercise-Mediated Regulation of the Gut Microbiota via the Muscle–Gut Axis: Implications for Tumor Immunity and Treatment Responses

Tao Pang, Xinyi Zhou, Zhe Ge

The gut microbiota can influence tumor immunity and treatment responses through microbial metabolism, intestinal barrier regulation, and immune–inflammatory signaling, but whether exercise engages these mechanisms through the muscle–gut axis remains uncertain. This review integrates evidence from exercise physiology, microbial metabolism, and tumor immunology to examine how exercise-associated host signals may reshape the intestinal ecological niche and microbial function. Three candidate muscle–gut axes are propos …

01.09.2026journal-article

Frontiers in Immunology

Intrathecal IgG synthesis as a biomarker for CNS involvement in anti-GQ1b antibody syndrome: a case report and hypothesis-generating treatment framework

Han Zhou, Xiuming Guo

Anti-GQ1b antibody syndromes span a clinical continuum from peripheral Guillain-Barré syndrome (GBS) to central Bickerstaff brainstem encephalitis (BBE), but reliable biomarkers of central nervous system (CNS) involvement that could guide treatment intensity are lacking. We report a 37-year-old woman with a relapsing GBS–Miller Fisher syndrome (MFS)–BBE overlap phenotype. In the first episode (March 2024), plasma exchange, intravenous methylprednisolone and IVIG were administered after anti-GD1a IgG was detected. A …

02.09.2026journal-article

Therapeutic Advances in Infectious Disease

Doravirine and islatravir for HIV-1 treatment: A systematic review and meta-analysis with GRADE assessment

Muhammad Tayyab Azam, Muhammad Hussain Azam, Muhammad Arif Khan, Muhammad Hassan Azam, Zain Ul Abideen Shahid, Shahzad Ashraf, Syeda Momina Umer, Rabeea Arshad, Hasibullah Aminpoor, Hammad Javaid

Background Two-drug antiretroviral regimens are increasingly explored to simplify HIV-1 treatment while maintaining durable viral suppression. Doravirine combined with Islatravir (DOR/ISL) represents a novel non-integrase strand transfer inhibitor (non-INSTI) regimen. However, comprehensive synthesized evidence remains limited. Objectives To systematically evaluate the efficacy and safety of fixed-dose Doravirine (100 mg) plus Islatravir (0.25 or 0.75 mg) for HIV-1 treatment in adults. Design Systematic Review and …

01.09.2026journal-article

Welding Journal

Examining Stress Modification in Dissimilar and Similar Metal Welds through Ultrasonic Impact Treatment

American Welding Society, HAMID EISAZADEH, JEFFREY R. BUNN, ANDREW PAYZANT, PARIS CORNWELL, DARYUSH K. AIDUN

Residual stress (RS) from welding poses major challenges, especially in dissimilar joints such as 1018 steel and 304 stainless steel, where thermal expansion mismatches intensify tensile stress. Conventional post-weld heat treatments, although effective for homogeneous materials, often require substantial energy, specialized equipment, and extensive processing time, making them less practical for dissimilar metal weld applications. This study explores an alternative, energy-efficient method — ultrasonic impact trea …

01.09.2026journal-article

Tributaries journal for Studies and Researches In sports sciences

أثر برنامج علاجي في تحسين وظائف الركبة وجودة الحياة لدى المصابات بهشاشة العظام

امال محمد إبراهيم بابكر, عاتقة الأمين, رحمة إبراهيم

تهدف هذه الدراسة إلى التعرف على أثر برنامج علاجي حركي لمدة ثمانية أسابيع في تحسين وظائف مفصل الركبة وجودة الحياة لدى النساء المصابات بهشاشة مفصل الركبة (Osteoporosis). استخدمت الدراسة المنهج شبه التجريبي بتطبيق القياس القبلي والبعدي على عينة مكوّنة من (30–40) سيدة تتراوح أعمارهن بين (45–65) عامًا، والمشخّصات بهشاشة مفصل الركبة من الدرجة الأولى أو الثانية. اشتمل البرنامج العلاجي على تمارين للمرونة، وتمارين تقوية العضلات، وتمارين التوازن، إضافة إلى تمارين وظيفية موجهة للمفصل، بواقع ثلاث جلسات أسبوعيًا. أظهرت النتائج …