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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

Journal of the American Veterinary Medical Association

American Association of Veterinary Parasitologists Hookworm Task Force review on best practices for diagnosis and treatment of multidrug-resistant hookworms

Ray M. Kaplan, Pablo D. Jimenez Castro, Antoinette E. Marsh, Jeba R. J. Jesudoss Chelladurai, John S. Gilleard

Abstract Ancylostoma caninum , the canine hookworm, is the most common and clinically important gastrointestinal nematode parasite infecting dogs in the US. Common clinical signs associated with acute infections include anemia, melena, hematochezia, dehydration, and poor weight gain or weight loss. In the past few years, multiple anthelmintic drug resistance to fenbendazole, moxidectin, and pyrantel pamoate has been documented in A caninum in the US, and cases of drug-resistant canine hookworms are increasingly bei …

1 Zitationen
01.09.2026journal-article

Journal of Korean Neurosurgical Society

Treatment of Brain Abscess in Patient with Eisenmenger Syndrome

Su Jeong Sung, Dae Lim Koo, Songyi Park, Dong Hoon Shin, Haechan Cho, You Jung Ok, Jin-Young Hwang, Hack-Lyoung Kim, Yoon Hwan Byun

Eisenmenger syndrome (ES) is a complex multisystem disorder caused by untreated congenital heart disease. Management of brain abscess in ES is challenging, as treatment decisions must balance infection control with altered cardiopulmonary physiology, necessitating a multidisciplinary approach. We present a case of a 45-year-old male with ES and symptomatic brain abscess treated successfully with abscess aspiration under monitored anesthesia care and appropriate antibiotic therapy. We share our experience, outline k …

01.09.2026journal-article

Pediatrics in Review

Beyond Survival: Outpatient Treatment for Functional Recovery After Brain Injury

Emily Kivlehan, Uchenna Ewulonu Pelzer, Sophie Leib, Brian D. Wishart

Abstract Acquired brain injuries (ABIs), including hypoxic-ischemic and traumatic injuries, are leading causes of long-term disability in children. While acute treatment has advanced, many survivors face persistent cognitive, emotional, and physical challenges that require coordinated outpatient care. This review aims to equip pediatric providers with the knowledge and tools necessary to provide longitudinal, comprehensive, and family-centered outpatient care for children recovering from ABIs. This review begins wi …

01.09.2026journal-article

S.S. Korsakov Journal of Neurology and Psychiatry

Ketogenic diet in the treatment of drug-resistant epilepsy in children: Assessment of clinical efficacy, health care resource consumption, and direct medical costs

E.G. Lukyanova, A.G. Tolkushin, S.O. Ayvazyan, K.V. Osipova, E.A. Pyrieva, A.I. Krapivkin, V.A. Zhestkov

Objective. To evaluate the impact of the ketogenic diet (KD) on clinical outcomes, health resource consumption, including medication burden, hospitalization rates, and outpatient care, and direct medical costs (DMCs) in pediatric patients with drug-resistant epilepsy (DRE). Material and methods. A retrospective, non-interventional observational study was conducted at a specialized medical center. Data were collected from 58 children diagnosed with DRE: 29 patients received the ketogenic diet, while 29 patients comp …

01.09.2026journal-article

Cancers

Interpreting Mutation Co-Occurrence in Cancer Genomics Under Biological Context

Yong Hun Jang, Woochang Hwang

Somatic mutation patterns observed in cancer genomes are widely used to generate hypotheses about functional relationships among cancer genes and signaling pathways. However, mutation co-occurrence and mutual exclusivity are assessed at multiple levels, including cohorts, bulk specimens, lesions, regions, clones, and individual cells, although each observational level supports a different scope of inference. In this structured narrative review, we clarify these inferential boundaries and distinguish marginal from c …

01.09.2026journal-article

Cancers

Comorbidity Burden and Survival After Primary Surgery for Oral Cavity Squamous Cell Carcinoma: Tumor Stage as an Effect Modifier

Mateusz Szewczyk, Krzysztof Przybylski, Bartosz Nowak, Bartosz Wojtera, Dominika Wojnar, Damian Rusek, Jakub Pazdrowski

Background/Objectives: To evaluate the association between comorbidity burden, quantified using the Charlson Comorbidity Index (CCI), and overall survival (OS) and disease-free survival (DFS) in patients treated surgically for oral cavity squamous cell carcinoma (OCSCC), and to determine whether this association is modified by tumor stage. Methods: We retrospectively analyzed 325 patients treated with primary surgery for OCSCC at a single institution (2009–2021). CCI was scored excluding the index malignancy compon …

01.09.2026journal-article

Frontiers in Oncology

AI-enabled D-dimeromics in precision breast oncology: a transformative framework for the identification, stratification, and prognostication of ultra-high-risk disease phenotypes

Emmanuel Ifeanyi Obeagu

Breast cancer is a highly diverse ailment marked by various molecular subtypes, differing clinical paths, and unique treatment reactions. Notwithstanding considerable progress in precision oncology, the prompt detection of patients with ultra-high-risk breast cancer phenotypes continues to be a significant clinical hurdle. Growing evidence suggests that hypercoagulability linked to cancer and thromboinflammation are vital in tumour advancement, metastatic spread, evasion of immunity, and resistance to treatment. D- …

01.09.2026journal-article

CVIR Oncology

Percutaneous CT-guided cryoablation of desmoid tumors: single-center experience with volumetric midterm outcome

Moritz Schaaf, Tim Sattler, Johann Spatz, Stefanie Surwald, Julian Schraut, Tobias F. Jakobs

Abstract Purpose Desmoid tumors are rare mesenchymal neoplasms with a propensity for local recurrence and significant morbidity. Percutaneous cryoablation has emerged as a promising treatment option, yet data on volumetric outcomes remain limited. This small study evaluated the safety and preliminary efficacy of percutaneous CT-guided cryoablation of desmoid tumors with systematic volumetric assessment of tumor volume. Materials and methods A retrospective single-center analysis was performed on 13 consecutive pati …

02.09.2026journal-article

The Oncologist

62 Patient Experience with Clinical Trials: Results from the International Kidney Cancer Coalition Global Patient Survey

Eric Jonasch, Stênio de Cássio Zequi, Axel Bex, Deborah Maskens, Margaret Hickey, Karin Kastrati, Christine Collins, Michael Jewett

Abstract Background Clinical trials are essential for advancing cancer care, yet patient participation remains suboptimal worldwide. While structural and clinician-reported barriers are well described, patient perspectives across diverse geographic and socioeconomic settings are less understood. The International Kidney Cancer Coalition (IKCC) conducts a biennial Global Patient Survey (GPS) to assess patient and caregiver experiences with kidney cancer, including clinical trials, to identify unmet needs and inform …

01.09.2026journal-article

Journal of Obstetrics and Gynaecology Research

DNA Methylation Testing in Cervical Cancer: A Triage Tool for HPV ‐Based Screening and Post‐Treatment Surveillance

Yuance Xu, Xiaoting Zhou, Lina Guo, Rongjun Lyu

ABSTRACT Background High‐risk HPV screening achieves high sensitivity but low specificity, resulting in excessive colposcopy referrals. DNA methylation biomarkers could refine risk stratification across the cervical cancer care continuum. Objective To evaluate the diagnostic performance and clinical implementation of DNA methylation testing in HPV‐positive triage and post‐treatment surveillance. Methods Narrative review of prospective cohorts and randomized trials (2013–2024) evaluating methylation markers in cervi …

01.09.2026journal-article

Cancer Medicine

Eosinophil Proportion May Serve as a Candidate Biomarker for Adverse Events in Patients With Urothelial Carcinoma Treated With Enfortumab Vedotin

Kunihiro Odagiri, Toshiharu Morikawa, Taku Naiki, Yosuke Sugiyama, Yoshihiko Tasaki, Yoshihisa Mimura, Aya Naiki‐Ito, Takashi Nagai, Toshiki Etani, Keitaro Iida, Daiki Ishikawa, Yusuke Noda, Nobuhiko Shimizu, Maria Aoki, Masakazu Gonda, Rika Banno, Hiroki Kubota, Ryosuke Ando, Yukihiro Umemoto, Noriyasu Kawai, Yoko Furukawa‐Hibi, Takahiro Yasui

ABSTRACT Enfortumab vedotin (EV) is a crucial treatment for patients with metastatic urothelial carcinoma (mUC). However, a significant proportion of patients experience adverse events (AEs). The identification of biomarkers for AEs is imperative for the detection and treatment of AEs at an early stage. In this exploratory study, we aimed to identify biomarkers of AEs in patients with mUC treated with EV. We retrospectively examined 10 factors identified from the data of 116 patients with mUC treated with EV to ide …

01.09.2026journal-article

International Journal of Health Management Review

SURGICAL AND ORTHODONTIC TREATMENT OF TEMPOROMANDIBULAR JOINT ANKYLOSIS

Giacomo Gobbo Trojan, Pamela Rufina Stefanello Wideck, Isabella Rayane de Souza Torres, Lívia Numeriano de Sá Gomes Vilarim, Victoria Carminatti Silveira, Rene Rodrigues Vieira, Maria Eduarda Cardoso Malheiros de Sena, Rebeca Pires de Castro, Laís Gomes do Nascimento

Temporomandibular joint (TMJ) ankylosis is characterized by the bony, fibrous, or fibro-osseous fusion of articular surfaces, resulting in severe limitation of mouth opening and compromising masticatory and phonatory functions, as well as oral hygiene. When it manifests during childhood or persists for extended periods, it can lead to craniofacial developmental disorders, such as facial asymmetry, micrognathia, retrognathism, and malocclusions. This study aimed to analyze the main surgical and orthodontic approache …

01.09.2026journal-article

The Professional Medical Journal

Metronomic capecitabine in metastatic triple negative breast cancer.

Asima Luqman, Sarah Khan

Objective: To evaluate the efficacy and safety of metronomic capecitabine in patients with metastatic TNBC (mTNBC), with progression free survival (PFS) as primary end point and toxicity profile as secondary endpoint. Study Design: Retrospective study. Setting: Department of Radiotherapy, Quaid e Azam Medical College, Bahawalpur, Pakistan. Period: 1st January 2022 to 30th October 2025. Methods: The study included patients with mTNBC of any age who were metastatic at presentation. All patients received first-line ch …

01.09.2026journal-article

Radiology: Imaging Cancer

HPV-associated Oropharyngeal Squamous Cell Carcinoma: An Imaging Framework for AJCC Version 9 TNM Staging

Pranjal Rai, Adam L. Holtzman, Alok A. Bhatt

The American Joint Committee on Cancer/ Union for International Cancer Control version 9 TNM staging system for human papillomavirus (HPV)–associated oropharyngeal squamous cell carcinoma provides an updated framework for radiology reporting, incorporating cautious assessment of unequivocal imaging-detected extranodal extension and acknowledging the emerging, complementary role of circulating tumor tissue–modified viral HPV DNA in surveillance.

01.09.2026journal-article

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH

Dentoalveolar and Smile Aesthetic Changes Following Fixed Orthodontic Treatment in Adults with Varying Anterior Overjet: A Retrospective Study

Radha Manoj Paturkar, Chaitra Mastud, Rajaganesh Gautam, Sonali Deshmukh, Asmita Kharche, PV Swathi

Introduction: Anterior overjet is a key determinant of dentofacial aesthetics and occlusal function, and its correction is a primary objective of fixed orthodontic therapy. It is still unclear how baseline overjet magnitude affects dentoalveolar adaptation during orthodontic treatment in adults. Although fixed appliance therapy routinely addresses excessive overjet, no single study has directly compared whether patients grouped by initial overjet category respond differently- or whether any such differences carry t …

01.09.2026journal-article

Journal of Clinical Oncology

Polatuzumab Vedotin Plus Rituximab, Gemcitabine, and Oxaliplatin in Relapsed or Refractory Diffuse Large B-Cell Lymphoma: Results From the Phase III, Randomized POLARGO Trial

Matthew Matasar, Zhiming Li, Theodoros P. Vassilakopoulos, Juan-Manuel Sancho, Andreas Viardot, Andrew McMillan, Mehmet Sinan Dal, Juliana Pereira, Jin Seok Kim, Lugui Qiu, Connie Lee Batlevi, Rania Ibrahim, Juana Hernandez, Bruce McCall, Yanwen Jiang, Mark Yan, Will Harris, Lisa Musick, Corinne Haioun

PURPOSE Patients with relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL) face an unfavorable prognosis once first-line treatment fails; therefore, there is an unmet need for new treatment options. We evaluated the efficacy and safety of polatuzumab vedotin plus rituximab, gemcitabine, and oxaliplatin (Pola-R-GemOx) as an alternative therapy in patients with transplant-ineligible R/R DLBCL. METHODS The phase III POLARGO trial was a randomized, open-label, global study. Following a Pola-R-GemOx safety …

1 Zitationen
01.09.2026journal-article

Frontiers in Pharmacology

Preclinical pharmacokinetic modeling and clinical translation of SIG001, a novel anti-cancer therapeutic antibody targeting on cancer-derived sialylated IgG

Qingyu Yao, Chen Liu, Shenghua Zhang, Yaou Liu, Ying Zhou, Xiaoyan Qiu

Introduction Sialylated immunoglobulin G (SIA-IgG) has emerged as a novel therapeutic target selectively overexpressed in epithelial-derived malignancies. The humanized monoclonal antibody SIG001 binds specifically to tumor-associated SIA-IgG and is regarded as a promising first-in-class candidate for the broad-spectrum treatment of epithelial cancers. Methods The pharmacokinetic (PK) behavior of SIG001 was evaluated in both cynomolgus monkeys and mice following intravenous administration. Utilizing modeling approa …

01.09.2026journal-article

Slovenian Journal of Public Health

Why Organised Cancer Screening Works: Lessons from Slovenia and the Next Phase of Evidence-Based Implementation

Mateja Krajc, Urška Ivanuš

Abstract Slovenia's experience shows that cancer screening becomes effective only when a test is embedded in an organised, population-based programme that reaches the target population equitably, assures quality across the whole pathway and uses individual- and programme-level data for improvement. Since the national roll-out of Programme ZORA for cervical cancer screening in 2003, followed by DORA for breast cancer screening in 2008 and Programme Svit for colorectal cancer screening in 2009, Slovenia has built a c …

01.09.2026journal-article

Medical Journal of Australia

Patterns of Osteoporosis Treatment Initiation Following Low‐Trauma Fracture: A Population‐Based Retrospective Cohort Study in New South Wales, Australia, Using Linked Administrative Health Data

Mike Lin, Huy Nguyen, Thach Tran, Robert D. Blank, Dana Bliuc, Jacqueline R. Center

ABSTRACT Objectives To characterise osteoporosis medicine prescribing patterns following low‐trauma fractures and identify predictors of early treatment initiation. Study Type Retrospective population‐based cohort study. Setting New South Wales, Australia, using statewide linked administrative health data. Participants Adults aged ≥ 50 years with an incident low‐trauma fracture between January 2011 and June 2019. Main Outcome Measures Primary outcomes were osteoporosis treatment prescribing patterns and timing of i …

01.09.2026journal-article

ACR Open Rheumatology

Fracture Risk Associated With Long‐Term Discontinuation of Postmenopausal Osteoporosis Treatment: A French Population‐Based Study Using National Claims Data (Système National des Données de Santé)

Audrey Lajoinie, Meriem Benmerad, Magali Laborey, Pascale Samama, Gaëlle Désaméricq, Leila Chelbani, Karine Briot

Objective This retrospective cohort study evaluated the long‐term discontinuation (LTD) of osteoporosis treatments in postmenopausal women in France and associated fracture risk and economic burden. Methods From the national French health care database (Système National des Données de Santé), we included postmenopausal women aged ≥60 years initiating oral bisphosphonates, intravenous bisphosphonates, or denosumab between 2012 and 2015 with three or more (bisphosphonates) or two or more (denosumab) years of continuo …

01.09.2026journal-article

Cancer Reports

AZD6738 (Ceralasertib) Enhances Trifluridine's Antitumor Effect in 5‐ FU –Resistant Colorectal Cancer Cells

Shuhei Uehara, Takuya Suzuki, Junki Kato, Hiroyuki Asai, Akira Kato, Shinnosuke Harata, Hajime Ushigome, Yushi Yamakawa, Takahisa Hirokawa, Hiroki Takahashi, Yoichi Matsuo, Shuji Takiguchi

ABSTRACT Background Resistance to 5‐fluorouracil (5‐FU) remains a major obstacle in colorectal cancer (CRC) treatment. Trifluridine (FTD), the active component of TAS‐102, exerts cytotoxicity through DNA incorporation and reportedly remains active in 5‐FU‐resistant tumors, though with limited clinical efficacy. Aims We investigated whether AZD6738, an inhibitor of ataxia telangiectasia and Rad3‐related kinase (ATR) that regulates the G2/M checkpoint, could enhance FTD efficacy in 5‐FU‐resistant CRC. Methods and Res …

02.09.2026journal-article

The Oncologist

15 Defining Systemic and Tumor-Intrinsic Biomarkers of Immune Suppression in Renal Cell Carcinoma

Giuliana Mognol, Erpei Wang, William Harris, Tami Von Schalshcha, Rayan Jouny, Birkley Lim, Ahmed Abdelhak, Rana McKay, Judith Varner

Abstract Background Renal cell carcinoma (RCC) is characterized by a highly immunosuppressive tumor microenvironment enriched in tumor-associated macrophages (TAMs) and regulatory T cells (Tregs), both of which correlate with poor clinical outcomes. TAMs in RCC commonly exhibit an immunosuppressive phenotype, marked by production of TGFb, IL-10 and IL-6, which suppress cytotoxic T cell responses and promote tumor progression. Despite advances in immunotherapy, metastatic RCC remains highly lethal, underscoring the …

02.09.2026journal-article

MedComm

Early Local Treatment Delays Multiple Metastases in Non‐Small Cell Lung Cancer With Solitary Distant Metastasis: A Multicenter Retrospective Cohort Study

Kang Miao, Siyu Lei, Xiaobin Zheng, Shanshan Yang, Yujing Li, Sihui Chen, Qian Miao, Longfeng Zhang, Zihua Zou, Haipeng Xu, Gen Lin

ABSTRACT Solitary distant metastasis (SDM) is a distinct oligometastatic subtype associated with a relatively favorable prognosis. This multicenter retrospective study including 139 non‐small cell lung cancer (NSCLC) patients with SDM (2019–2024) was conducted to investigate prognostic factors for multiple metastases and identify the critical time window for local treatment. Statistical analyses included Cox regression, Kaplan–Meier survival analysis, and restricted mean survival time (RMST). Results showed that dr …

01.09.2026journal-article

Revista Ibero-Americana de Humanidades, Ciências e Educação

TRATAMENTO LAPAROSCÓPICO VERSUS CIRURGIA ABERTA NA ÚLCERA PÉPTICA PERFURADA: COMPARAÇÃO DOS DESFECHOS PÓS-OPERATÓRIOS

Leonardo Schaucoski Cizeski, Ana Caroline Gomes de Miranda Linhares, Caio Ferraz Gomes Barros, Eduarda Siqueira Cesário, Lucas Venancio Tavares, Pedro Henrique Borges Silvestre, Sayd Abrantes de Lima Pereira

A úlcera péptica perfurada constitui uma emergência cirúrgica associada a elevada morbimortalidade, decorrente principalmente de peritonite, sepse e deterioração fisiológica progressiva. Embora a cirurgia aberta permaneça amplamente utilizada, o tratamento laparoscópico vem ganhando espaço devido ao potencial de reduzir trauma cirúrgico e complicações pós-operatórias. O objetivo deste estudo foi comparar os principais desfechos pós-operatórios associados ao tratamento laparoscópico e à cirurgia aberta na abordagem …