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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

Frontiers in Rehabilitation Sciences

Market shaping via digital public infrastructure for assistive technology in low- and middle-income countries

Will Wade, Sijung Hu, James Fleming

Digital assistive technology (AT) is now delivered through a variety of platforms, including smartphones, cloud services, dedicated devices, and embedded systems rather than a single dominant form factor. However, in low- and middle-income countries (LMICs), affordability, connectivity, electrical reliability, service capacity, and uneven language infrastructure continue to determine which digital pathways can be deployed and maintained at scale. This perspective argues that market-shaping strategies should priorit …

01.09.2026journal-article

Journal Human Research in Rehabilitation

Psychological Dimensions of Organizational Culture in Healthcare Institutions

Sasa Stepanovic, Branka Radojevic, Ana Grbic

Organizational culture represents a complex system of shared values, professional beliefs, and behavioral patterns that shape employees’ cooperation, decision-making, and work performance within healthcare institutions. The quality of organizational culture directly influences employees’ motivation, job satisfaction, and readiness to accept changes in contemporary healthcare systems. This study examines the relationship between the psychological dimensions of organizational climate and employees’ innovation readine …

01.09.2026journal-article

American Journal of Physical Medicine & Rehabilitation

Adaptive Sports Exposure Across Physical Medicine and Rehabilitation Residency and Sports Medicine Fellowship Programs: A National Cross-Sectional Website Analysis

Chantal Nguyen, Emily Moya, Mehul Chowdarapu, Durga Monica Ghosh, Miriam Agaibi, Jacob Nguyen, Molly Timmerman

Adaptive sports improve health and quality of life for people with disabilities, yet the extent of adaptive sports exposure in physical medicine and rehabilitation (PM&R) training is unclear. This cross-sectional study reviewed the public websites of 115 accredited physical medicine and rehabilitation residency programs and 26 sports medicine fellowship programs for any mention of adaptive sports, characterizing exposure type, target populations, and associated program characteristics. Adaptive sports were mentione …

01.09.2026journal-article

Molecular Medicine

GPR65 protects adipose-derived stem cell therapy against acidosis in hindlimb ischemia

Wenhao Niu, Shilei Wan, Wenyue Cao, Huilong Qu, Huihui Yuan, Kun Huang, Jianxiang Wu, Jan Nilsson, Ru Ding, Chun Liang, Yihong Chen

Abstract Background Critical limb ischemia is the end stage of lower extremity peripheral artery disease (PAD) with few available pharmacological and endovascular approaches. Stem cell-based therapy represents a promising therapeutic strategy for angiogenesis; however, its clinical benefits have not yet met expectations. Tissue acidosis is a central challenge in stem cell transplantation, and poor cell survival and function of the transplanted cells caused by acidosis-mediated injury limit the therapeutic potential …

01.09.2026journal-article

Frontiers in Neuroscience

On the meaning of “plasticity” in neuroscience and mental health research and its relation to the action of psychedelic therapy

R. L. Carhart-Harris, R. J. Zeifman, L. Pasquini, B. Nandi, C. Rohani-Shukla, S. Suseelan, P. Mediano, F. Rosas, C. Timmermann, H. Kettner, P. A. McConnell

First-line dictionary definitions of “plasticity” describe it as the ability (of a thing) to be shaped or molded; we call this “plasticity proper” (PP). In neuroscience, however, “neural plasticity” or “neuroplasticity” is defined as an induced change in brain function or structure. These two plasticities are not the same. Several popular biomarkers of neuroplasticity index part of an evoked process, often linked to learning. Paradoxically, these processes often bias phenotypic canalization, the opposite of phenoty …

02.09.2026journal-article

The Oncologist

18 Prediction of Immune-Related Adverse Events (irAEs) with Hematologic Markers in Patients Receiving First-Line Immune Checkpoint Inhibitor (ICI)-Based Therapy in Metastatic Renal Cell Carcinoma (mRCC)

Rahul Winayak, Xiaochen Li, Vitor Abreu de Góes, Ali Moradi, Salvador Jaime Casas, Koral Shah, Nicholas Salgia, Benjamin Mercier, Michelle Li, Jadon Fann, George Zhang, Ruchi Agarwal, JoAnn Hsu, Hedyeh Ebrahimi, Alexander Chehrazi-Raffle, Sumanta Pal

Abstract Background First-line therapies with combinations of ICI-ICI and ICI-tyrosine kinase inhibitor (TKI) are commonplace in mRCC. Frequency of irAEs in patients receiving first-line ICI-based therapies is high, with grade ≥ 2 (G ≥ 2) typically warranting active management. Although prognostication based on irAEs has been demonstrated, prediction of irAE occurrence in mRCC remains a challenge. We investigated the role of baseline hematologic markers to predict G ≥ 2 irAE occurrence with first-line ICI-based the …

01.09.2026journal-article

Veterinary and Comparative Oncology

Combination of Hypofractionated Radiation Therapy and Gilvetmab for the Treatment of Cutaneous or Subcutaneous Mast Cell Tumours in Dogs

Tiffany W. Martin, Douglas H. Thamm, Kristen M. Weishaar

ABSTRACT Gilvetmab is a caninised monoclonal antibody against canine PD‐1. Concurrent or sequential administration of anti‐PD‐1 antibodies and radiation therapy (RT) improves survival time in various species. Eighteen dogs with mast cell tumours (MCTs) were prospectively treated with 24 Gy of RT over Days 0, 7 and 21 and gilvetmab every 2 weeks beginning on the second fraction of RT (Day 7) for up to 10 doses. Best tumour response was complete in one (6%), partial in eight (44%) and stable disease in nine dogs (50% …

01.09.2026journal-article

Pediatric Annals

Hemoglobinopathies and Cellular Therapy: What Pediatricians Need to Know About Indications and Counseling

Obadah Alquadan, Rasha Deebaja, Avanti Gupte, Eman T. Al-Antary

Hemoglobinopathies are inherited disorders of hemoglobin structure or production. Sickle cell disease (SCD) results from a beta-globin mutation causing hemoglobin polymerization, red blood cell sickling, vaso-occlusion, and hemolytic anemia. Thalassemia results from reduced or absent alpha- or beta-globin synthesis, ranging from asymptomatic carrier states to transfusion-dependent anemia. This article summarizes the pathophysiology, diagnosis, management, and curative options for SCD and transfusion-dependent thala …

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01.09.2026journal-article

Otolaryngology–Head and Neck Surgery

Contralateral Hearing Status as a Determinant of Cochlear Implant Device Engagement and Rehabilitation Trajectory

Stephanie Younan, Lourdes Kaufman, Pearl Doan, Connie Chang‐Chien, Christina Im, Kara Ushijima, Eliot D. Lee, Nicole T. Jiam

Abstract Objective To compare device utilization, speech recognition trajectories, and predictive validity of early postactivation performance across 3 contralateral hearing status groups: single‐sided deafness (SSD), asymmetric hearing loss (AHL), and bilateral nonserviceable hearing loss (BSHL). Study Design Retrospective longitudinal cohort study. Setting Tertiary academic medical center. Methods Retrospective review of 360 adult cochlear implant recipients implanted 2018 to 2024, classified by contralateral pur …

01.09.2026journal-article

Asian/Pacific Island Nursing Journal

Maintenance of the Self-Reported Behavior Change Stage Among Male Bus Drivers Using Longitudinal Occupational Health Checkup Data: Retrospective Cohort Study

Eiko Nakanishi, Reiko Sakashita, Masakazu Morimoto, Manabu Nii

Abstract Background Public bus drivers experience prolonged sitting, irregular shifts, limited breaks, and disrupted meals and sleep, making the maintenance of a healthy lifestyle difficult. Although occupational health checkups identify health risks, little is known about the duration of maintenance of self-reported stages of behavior change or their association with physiological markers. Objective This study examined the duration of maintenance of the self-reported stage of behavior change and its association wi …

01.09.2026journal-article

Jornadas de Automática

Control semántico de un robot rehabilitador mediante modelos de lenguaje

Pablo Romero-Sorozábal, Iñaki Dellibarda Varela, Rafael Sendra-Arranz, Juan Miguel Valverde-García, Annemarie F. Laudanski, Eduardo Rocon

Large Language Models (LLMs) offer new possibilities for simplifying interaction with robotic rehabilitation platforms, whose low-level parameterisation represents a recognised barrier to clinical usability. This work proposes an architecture for the semantic control of the Discover2Walk platform, a cable-driven robotic system for paediatric gait rehabilitation. An LLM-based agentic layer interprets natural language commands issued by the clinician and generates a structured action plan. A deterministic safety laye …

01.09.2026journal-article

Frontiers in Oncology

BCG after trimodality therapy: managing non-muscle-invasive recurrence in the irradiated bladder

Nicola Fazaa, Etan Eigner, Melissa Atallah, Yuval Shafran, Gilad Amiel, Azik Hoffman

Trimodality therapy (TMT) is an established bladder-preserving option for selected patients with muscle-invasive bladder cancer, but non-muscle-invasive recurrence remains a clinically relevant challenge. The role of intravesical bacillus Calmette–Guérin (BCG) after prior bladder-directed chemoradiation is uncertain because the available evidence is limited to small retrospective cohorts and indirect studies in previously irradiated bladders. This mini-review examines the efficacy and tolerability of BCG after TMT, …

01.09.2026journal-article

American Journal of Veterinary Research

Survival outcomes in canine nasal tumors treated with megavoltage radiation therapy with or without toceranib phosphate: a retrospective study of 279 cases

Rui Mizuno, Takashi Mori

Abstract Objective To evaluate whether adjunctive toceranib phosphate improves survival time in dogs with nasal tumors treated with megavoltage radiation therapy using a simplified 2-tier, CT-based staging system. Methods The medical records of 279 client-owned dogs with nasal tumors that underwent CT and megavoltage radiation therapy from 2015 through 2024 were retrospectively reviewed. Dogs were classified as stage I (no cribriform plate destruction) or stage II (cribriform plate destruction present). Survival ti …

01.09.2026journal-article

Journal of the Egyptian Women's Dermatologic Society

Evaluation of the efficacy and safety of photodynamic therapy using liquid crystal-loaded methylene blue and intense pulsed light in treatment of vitiligo

Manal M. Abdel-Monem, Amany M. Abdel-Latif, Gamal M. El Maghraby, Esraa E. Elhawary

Background Depigmented macules and patches characterize vitiligo, an acquired autoimmune skin condition that has several lines of treatment. A new treatment for vitiligo, photodynamic therapy (PDT), has mixed results. Objective To evaluate the efficacy and safety of PDT using liquid crystal-loaded methylene blue and intense pulsed light in the treatment of vitiligo. Patients and methods This prospective, randomized study was conducted in 40 patients with multiple vitiligo lesions. For each patient, three vitiligo l …

02.09.2026journal-article

Journal of Investigative Medicine High Impact Case Reports

Cracking the Catatonia: Plasma Exchange as Salvage Therapy in Refractory Neuropsychiatric Lupus

Kuruvilla Rohan, Bilal Hiba

Neuropsychiatric systemic lupus erythematosus (NPSLE) is an uncommon but severe manifestation of systemic lupus with limited evidence to guide management when standard therapies fail. We report the case of a 19-year-old woman with new-onset SLE with myositis and nephritis overlap, positive for anti-Smith, anti-dsDNA, anti-PL7, and anti-Mi-2 antibodies with hypocomplementemia. Despite treatment with hydroxychloroquine and corticosteroids, she developed progressive weakness, catatonia and psychosis. MRI demonstrated …

01.09.2026journal-article

International Journal of Sports Physical Therapy

Isokinetic Quadriceps and Hamstring Peak Torque in Athletes Aged 10-50+: Preoperative Uninvolved Limb Reference Values for ACL Reconstruction

John D Kipp, Amy L Bednarek, Marc A Sherry, Michael W Keefe, Elizabeth S Chumanov

Background Current recommendations for quadriceps and hamstring peak torque normalized to body mass after anterior cruciate ligament reconstruction are derived from athletes in the second and third decades of life. There is a paucity of literature exploring the relationship between sex, age, and peak torque normalized to body mass. Purpose The purpose of this study was to examine the relationship between age and isokinetic quadriceps and hamstring peak torque normalized to body mass, as well as the hamstrings-to-qu …

01.09.2026journal-article

The European Research Journal

Evaluation of Ozone Therapy Effectiveness by the Red Cell Distribution Width/Albumin Ratio

Meryem Betos Koçak, Mehmet Akif Nas, Ideal Beraa Yılmaz Kartal

Objective: Ozone is an inorganic gas utilized for medical purposes. Ozone therapy has gained increasing popularity in recent years and is employed in the treatment of chronic diseases associated with inflammation. The red cell distribution width/albumin ratio (RAR) has recently emerged as an inflammatory marker. The aim of this study was to evaluate the efficacy of ozone therapy in patients with spinal pain and to investigate the effect of ozone therapy on inflammation through changes in the RAR value. Methods: Thi …

01.09.2026journal-article

Artefactum - revista de estudos interdisciplinares

FROM BIOMECHANICS TO NOCIPLASTICITY: RESTRUCTURING CLINICAL REASONING IN THE REHABILITATION OF TRAUMATIC CERVICAL SPINAL CORD INJURY

Rogério da Silva Rocha

Traumatic cervical spinal cord injury is one of the most severe neurological conditions in modern clinical practice, resulting in profound motor, sensory, autonomic, respiratory, functional, and psychosocial impairments. Advances in neuroscience have significantly transformed the understanding of chronic pain, neuroplasticity, and functional recovery following central nervous system injuries. Consequently, contemporary physical therapy has evolved beyond a purely biomechanical perspective, incorporating concepts re …

01.09.2026journal-article

Scientific Reports

Sorafenib/piroxicam therapy with biomarker-defined survival benefit in canine muscle-invasive urothelial carcinoma

Shingo Maeda, Shohei Yokota, Mao Komori, Yuko Goto-Koshino, James K. Chambers, Kazuyuki Uchida, Tomohiro Yonezawa, Yasuyuki Momoi

Abstract Molecular-targeted therapies require biomarker-driven evaluation to optimize precision oncology strategies; however, translational models integrating clinical outcomes with mechanistic biomarkers are limited. Canine urothelial carcinoma shares molecular features with human muscle-invasive bladder cancer, including activation of VEGFR signaling, providing a valuable comparative oncology platform. Sorafenib is a multi-kinase inhibitor targeting VEGFRs, PDGFRβ, BRAF, and related pathways, but its therapeutic …

01.09.2026journal-article

Dentistry Journal

Chimeric Antigen Receptor T-Cell Therapy Is Associated with Low Absolute Rates of Orofacial Adverse Events and Significantly Less When Compared to Hemopoietic Stem Cell Therapy

Stella O. Oyewole, Emma Butler, Sagun D. Goyal, Adepitan A. Owosho

Background/Objectives: Chimeric antigen receptor T-cell (CAR-T) therapy has been approved for the management of relapsed and refractory hematologic malignancies, transforming the oncologic landscape and producing durable remissions in patient populations with limited alternatives. The systemic adverse events of CAR-T are well characterized; however, the orofacial adverse events have not been well described. The objective of this study is to leverage a large, de-identified, real-world dataset to (1) estimate the pre …

01.09.2026journal-article

Jornadas de Automática

Nueva estrategia háptica para rehabilitación de miembros inferiores con CDPR

Enrique Riveiro Fernandez, Diego Silva-Muñiz, Uxía Pérez García, Julio Garrido Campos

This work presents a haptic control strategy for a cable-driven parallel robot designed to assist lower-limb rehabilitation. The proposed approach uses a harness as an input interface, estimating locomotor intention from the forces measured by four load cells attached to the corresponding suspension straps, together with body orientation obtained from an absolute encoder. Based on this information, the controller generates velocity commands in the horizontal plane and adjusts the vertical position of the end-effect …

01.09.2026journal-article

INTERNATIONAL JOURNAL OF CARE SCHOLARS

Adjunctive Relaxation Modalities (Deep Breathing and Murottal Therapy) For Pain and Hypertension Control in Non-ST-Elevation Myocardial Infarction (NSTEMI): A Case Study

Rita, Hanida Hani Mohd Mokhtar, Fitri Arofiati, Noor Hanita Zaini

Abstract Background: NSTEMI is an acute coronary syndrome characterized by elevated cardiac biomarkers without persistent ST-segment elevation. This syndrome carries a high risk of mortality in elderly patients with hypertension. This can increase the workload of the heart and trigger ischemia due to extreme blood pressure and an imbalance in oxygen supply and demand. Objective: To explore the application of evidence-based nursing interventions in the management of chest pain in patients with Non-ST-Elevation Myoca …

01.09.2026journal-article

The Egyptian Journal of Internal Medicine

Herpes zoster in inflammatory bowel disease: pathogenesis, therapy-related risks, and prevention strategies

Guiqin Wu, Ting Xiang, Wenxin Wang, Qing Zhou

Abstract Inflammatory bowel disease (IBD) is a chronic, immune-mediated condition characterized by inherent immune dysregulation, which is further compounded by immunosuppressive therapies. Patients with IBD face a 1.5- to 1.7-fold elevated risk of herpes zoster (HZ), often at a younger age, with immunosuppression as the primary driver. Beyond increasing clinical burden, HZ leads to debilitating complications such as postherpetic neuralgia, profoundly diminishing quality of life. While anti-tumor necrosis factor (T …

02.09.2026journal-article

Alzheimer's & Dementia

A world view: Considerations of sociocultural diversity in the study of subjective cognitive decline in Alzheimer's disease and related dementias

Mark A. Dubbelman, Tanisha G. Hill‐Jarrett, Silvia Chapman, Gustavo Alves Andrade dos Santos, Martina Azar, Ganesh M. Babulal, Tyler R. Bell, Mark A. Bernard, Carolina Boza‐Calvo, Anthony Q. Briggs, Omonigho Michael Bubu, Heather E. Cuevas, N. Maritza Dowling, Darlingtina K. Esiaka, Bernadette A. Fausto, Fabricio Ferreira de Oliveira, Carol E. Franz, Joyla A. Furlano, Christopher Gonzalez‐Corona, M. Aaron Guest, Veer Bala Gupta, Vivek K. Gupta, Daija Jackson, Jillian L. Joyce, Michael R. Kann, William S. Kremen, Athene Lee, Jairo E. Martinez, Arjun V. Masurkar, Maia A. McLin, Elisa de Paula França Resende, Zahra Rahemi, Brianca C. Renfro, Márlon Juliano Romero Aliberti, Shaina Shagalow, Andrea Slachevsky, Juliana N. De Souza Talarico, Jean François Trani, Carol Van Hulle, Leah Waltrip

Abstract Subjective cognitive decline (SCD) refers to cognitive concerns that may occur with or without objective impairment on standardized testing. Studies suggest that SCD may be an early clinical marker of Alzheimer's disease and related dementias, and that it can predict future objective cognitive decline and progression to dementia. However, the research that supports these conclusions is primarily based on samples with homogeneous socioeconomic and cultural backgrounds. The limited studies in samples with mo …