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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

Journal of Sustainable Mining

Microwave thermal pre-treatment to improve nickel extraction from lateritic ore

Johana Borda, Daniel Sosa, Robinson Torres

Two heat treatment processes for a nickeliferous laterite sample are presented, one by the conventional muffle route and the other by microwave. The heating was carried out in order to improve the dissolution of nickel in an acid medium. The study describes the changes observed in the mineral for the increase in temperature as a consequence of radiation in the microwave and in the muffle. The changes in the mineral crystalline phases were analyzed by X-ray diffraction. The leaching media consisted of a 1 M sulfuric …

02.09.2026journal-article

Journal of Adolescent and Young Adult Oncology

Ho‘oulu Me Ke Ikaika: A Community-Support Group that Improves Long-Term Emotional and Social Health of Adolescent and Young Adult Survivors of Childhood Cancer

Maile Enos, Kiyomi Goto, Joyce Wong, Patricia W. Nishimoto, Erin O. Bantum, Ian Pagano, Dianne Fochtman, Paulette M. Yamada

Purpose: Survivors of childhood cancer have unique needs, requiring tailored psychosocial support. To ascertain the effectiveness of a community-based survivorship group’s services on changes in emotional and social self-efficacy, perceived purpose and meaning in life, loneliness, and post-traumatic growth from pre- to postretreat among minority adolescent and young adult (AYA) survivors over a 2-year period. Methods: Two annual residential retreats were attended by 15 and 13 AYA survivors, respectively. Experienti …

02.09.2026journal-article

IECCMEXICO

Cancer Care Inequities: Social Determinants, Diagnostic Delays, and Health-System Strategies for Equitable Access

Andrés Omar Triviño Pinto, Lisset Georgett Saldaña Cortés, José Arnulfo Pérez Carrillo, Blas David Santana Perez, Aldo Bolivar Zavala Segovia, María Fernanda Carbajal Hernández, Jorge Angel Velasco Espinal, Alexa Fernanda Uriostegui Navarro

Inequities in access to cancer diagnosis and treatment remain a major challenge for contemporary health systems, particularly among populations affected by socioeconomic disadvantage, financial vulnerability, geographic isolation, limited health literacy, and fragmented healthcare pathways. This study analyzed the interaction between social determinants of health and structural characteristics of healthcare systems that influence timely access to oncology services. A documentary, integrative, descriptive, and analy …

02.09.2026journal-article

Cancers

Long-Term Outcomes and Paired Immune and Genomic Exploratory Analyses After Neoadjuvant Dose-Dense MVAC in Muscle-Invasive Bladder Cancer: A Single-Centre Case Series

Daan De Maeseneer, Alexander Decruyenaere, Joni Van der Meulen, Siebe Loontiens, Toon Rosseel, Pieter-Jan Volders, Sofie Verbeke, Valerie Fonteyne, Charles Van Praet, Camille Berquin, Sylvie Rottey

Background/Objectives: Cisplatin-based neoadjuvant chemotherapy (NAC) followed by radical cystectomy has been the standard of care for muscle-invasive bladder cancer (MIBC) for two decades, yet a substantial proportion of patients derive no benefit. As antibody–drug conjugates and immune checkpoint inhibitors reshape perioperative treatment, it is unclear which patients retain meaningful benefit from platinum. We describe long-term outcomes and exploratory paired immune and genomic analyses in a single-centre cohor …

02.09.2026journal-article

Konya Journal of Engineering Sciences

FIBONACCINET: A BIOLOGICALLY-INSPIRED DEEP LEARNING ARCHITECTURE FOR ACCURATE AND EXPLAINABLE BRAIN TUMOR CLASSIFICATION FROM MRI

Şafak Kılıç

Brain tumor classification using magnetic resonance imaging (MRI) remains a critical yet challenging task in medical image analysis. In this study, we propose a novel convolutional neural network (CNN) architecture, termed FibonacciNet, which is inspired by the recursive and hierarchical nature of the Fibonacci sequence. The architecture integrates progressive contextual blocks (PCBs), attention mechanisms (CBAM), and multi-scale feature fusion to improve classification accuracy and computational efficiency. Furthe …

02.09.2026journal-article

Frontiers in Oncology

Human papilloma virus as causal in breast cancer

James S. Lawson, Wendy K. Glenn

The aim of this review is to consider the role of high-risk human papillomaviruses (HPVs) in breast cancer. HPVs have established causal roles in cancers of the cervix, anus, penis, vagina, vulva, and oropharyngeal cancers. High-risk HPVs have been consistently detected in breast cancers in 23 countries. HPVs have been identified in 32.7% of breast cancers as compared to 7.6% of benign and normal breast controls. HPV-positive benign breast lesions can progress to HPV-positive malignancies, suggesting an early role …

02.09.2026journal-article

Medicine Advances

Nutritional Treatment After Discharge of Older Patients at Nutritional Risk: A Study Protocol for a Feasibility Study

Martine Kjærsgaard Nielsen, Tina Munk, Anne Marie Beck, Jacob Rosenberg, Jesper Ryg

ABSTRACT Background Malnutrition is prevalent among older hospitalized patients, increasing the risk of complications, extended hospital stays, and reduced quality of life. Upon discharge, a nutritional gap frequently arises, leading to insufficient intake for optimal recovery. Ensuring nutritional treatment in research settings after hospital discharge has demonstrated improvements in readmission rates, muscle strength, quality of life, and nutritional status. This study aims to evaluate the feasibility and effect …

02.09.2026journal-article

ANZ Journal of Surgery

Prioritising Psychological Prehabilitation Interventions for Cancer Surgery: An International Delphi Study

Nicholas Hirst, Jesse Gates, Haryana M. Dhillon, Ilona Juraskova, Kate Alexander, Jack Reeves, Zirong Bai, Michael J. Solomon, Kate McBride, Leani Souza Máximo Pereira, Ana Paula Drummond Lage, Daniel Steffens, Global (P)rehabilitation Initiative

ABSTRACT Background Preoperative mental wellbeing is an important determinant of postoperative recovery, yet psychological care is frequently overlooked within multidisciplinary prehabilitation programmes. When included, psychological interventions are fragmented and inconsistently delivered. This study aimed to establish international multidisciplinary consensus on preferred psychological prehabilitation interventions for patients undergoing urogenital, thoracic or gastrointestinal cancer surgery, and to describe …

02.09.2026journal-article

The Journal of Infectious Diseases

Functional T Cell Responses Are Associated With Prolonged HIV Control After Treatment Interruption

Anders B Andersen, Anna K Juhl, Jesper D Gunst, Thomas A Rasmussen, Martin Tolstrup, Ole S Søgaard

Abstract Background CD8+ T cell responses are thought to be critical for spontaneous control of human immunodeficiency virus (HIV) but findings supporting their role in post-intervention control have been mixed. We hypothesized that HIV-specific T cell proliferation, interferon-γ (IFN-γ) and granzyme B response prior to analytical treatment interruption (ATI) were associated with time to viral rebound. Methods We pooled data from six different HIV cure trials including people living with HIV receiving antiretrovira …

02.09.2026journal-article

Blood Cancer Discovery

Therapy-persistent leukemia is selectively vulnerable to SLC23A1 restoration via targeting KHSRP

Qingyu Luo, Karley S. Whalen, Xiaowei Wu, Amanda L. Fortune, Jacqueline S. Garcia, Kate Marinchev, Lin Zhang, Weiye Qian, Evangeline G. Raulston, Yabing Nan, Christopher A.G. Booth, Kezhi Yan, David E. Root, John G. Doench, Andrew A. Lane

Abstract Acute myeloid leukemia (AML) is prone to relapse driven by therapy-persistent residual cells. To discover specific vulnerabilities in this population, we performed genome-wide CRISPR interference screens in leukemia cells treated with multiple agents. KHSRP was the top hit, whose depletion sensitized AML cells to therapy and substantially prolonged survival in treated AML-bearing mice. Analysis of in vivo residual disease after venetoclax/azacitidine treatment identified downregulation of the vitamin C and …

02.09.2026journal-article

Cancers

Bronchoscopic Ablation and Intratumoral Therapies for Lung Cancer: Expanding Local Treatment Beyond Surgical Resection

Trevor Parton, Mayowa Oturko, Audra J. Schwalk, Aitua C. Salami, Laura Frye

Advances in navigational bronchoscopy, robotic platforms, and intraprocedural imaging have transformed bronchoscopy from a diagnostic modality into a potential therapeutic platform for localized treatment of lung cancer. These developments are particularly relevant for patients who are medically inoperable, have limited pulmonary reserve, or require lung-sparing treatment strategies. This narrative review summarizes current evidence regarding bronchoscopic ablative technologies and intratumoral therapies for lung c …

02.09.2026journal-article

Antimicrobial Agents and Chemotherapy

Adaptive immunity shapes baseline physiology of M. tuberculosis in high-dose versus low-dose infection BALB/c mouse drug treatment models

Jo Hendrix, Reem Al Mubarak, Karen Rossmassler, Holly Nielsen, Elizabeth Wynn, Camile Moore, Isabelle L. Jones, Martin I. Voskuil, Brendan K. Podell, Gregory T. Robertson, Chuangqi Wang, Nicholas D. Walter

ABSTRACT Preclinical tuberculosis (TB) drug evaluation relies heavily on mouse infection models. Drug efficacy varies depending on inoculum and the timing of treatment initiation. These differences reflect, in part, physiological adaptations of Mycobacterium tuberculosis ( Mtb ) to host immune pressure. We used novel molecular markers of pathogen health (RS ratio and SEARCH-TB) to contrast Mtb phenotypes in the BALB/c high dose aerosol (HDA) subacute TB and low dose aerosol (LDA) chronic TB infection models, focusi …

02.09.2026journal-article

Polski Przegląd Otorynolaryngologiczny

Use of Alsarhan Maneuver for the treatment of Subjective benign positional paroxysmal vertigo

Haider Alsarhan, Ioana Alexandra Voda, Avinash Bijlani

Introduction:Benign positional paroxysmal vertigo is the most common cause of vertigo worldwide; a subclinical or subjective variant of that disease is defined as the presence of subjective vertigo without corresponding nystagmus; it accounts for 11.5% of all cases of Benign positional paroxysmal vertigo.Materials and methods:A prospective study of 32 patients presented with subjective Benign positional paroxysmal vertigo and had performed Alsarhan ( Rapid Bilateral Sitting Up) maneuver and followed up for a period …

02.09.2026journal-article

Pediatric Blood & Cancer

Pain in Children and Adolescents With Low‐Flow Vascular Malformation and Its Relation to Thrombosis

Nihal Hussien Aly, Mohamed Mostafa Al Taweel, Bothina Mohsen Gouda Ghonim, Amr Abdel‐Hamid Zaki Abouzeid, Shaimaa Abdelsattar Mohammad, Iman Ahmed Ragab

ABSTRACT Background Patients with vascular malformations (VMs) experience a wide spectrum of symptoms including pain, physical impairment, bleeding, thrombosis and psychosocial problems. The occurrence of pain in these patients might be caused by thrombosis or phleboliths (due to venous stasis), ischemia, or neuropathy. We aimed to assess the frequency of pain in patients with low‐flow VM and to study its association with laboratory markers and radiological evidence of thrombosis. Patients and Methods A cross‐secti …

02.09.2026journal-article

Journal of Fungi

A Review of the Therapeutic Challenges and Novel Treatment Options in Mitigating Invasive Mycosis Associated with Aspergillus, Candida, Cryptococcus, and Pneumocystis

Elaine Meade, Mark Slattery, Mary Garvey

Globally, invasive fungal diseases are increasing in incidence and are associated with high rates of mortality. A lack of effective diagnostic protocols, antifungal resistance and poor antifungal stewardship contribute to negative outcomes. Aspergillus, Candida, Cryptococcus, and Pneumocystis are the most common pathogens associated with fatal fungal diseases. These species are responsible for 90% of reported invasive fungal deaths globally. Fungal species employ a diverse and effective array of virulence factors t …

02.09.2026journal-article

Diagnostics

Predictors of Sentinel Lymph Node Metastasis and External Validation of the MSKCC Nomogram in Breast Cancer: A Retrospective Single-Center Cohort Study

Darko Zdravković, Barbara Loboda, Simona Petricevic, Milan Gojgic, Natasa Colakovic, Dragana Bjelica, Igor Nađ, Vladimir Milosavljević, Svetlana Opric, Aleksandar Jovanović, Višnja Stojanović, Ljiljana Marković-Denić, Vladimir Nikolić

Background/Objectives: Predicting sentinel lymph node (SLN) involvement in breast cancer can reduce unnecessary axillary lymph node dissections (ALND) and facilitate clinical decision-making. This study aimed to: (i) identify independent predictors for SLN metastasis, and (ii) assess the predictive performance of the MSKCC nomogram for SLN positivity in early-stage breast cancer patients. Methods: A retrospective cohort study spanning a six-year period was conducted at a tertiary care oncology department in Belgrad …

02.09.2026journal-article

PLOS Mental Health

Alcohol and substance-induced disorder treatment cases in mental health and addiction treatment facilities from 2013 to 2022: A descriptive study

Orrin D. Ware

Substance use disorders may arise when individuals use substances to cope with adverse mental health symptoms. Conversely, mental health symptoms can develop because of substance use, a category of conditions called substance-induced disorders. This study used two United States-based datasets, the Mental Health Client-Level Data and the Treatment Episode Data Set Admissions, to summarize the number of cases with “alcohol-induced disorders” and “substance-induced disorders” from both mental health and substance use …

02.09.2026journal-article

Molecular Cancer Therapeutics

Molecular Design and Preclinical Evaluation of GenSci143, a Novel B7-H3–Directed and PSMA-Directed Bispecific Antibody–Drug Conjugate, for the Treatment of Prostate Cancer

Yao Xu, Fu Li, Zhiyu Cui, Hongmei Xie, Liang Xu, Yihui Lin, Tete Li, Nan Li, Dechen Cao, Weiming He, Wenqiang Zhai, Xiaozhen Wang, Shu Zhang, Haizhou Zhang, Fanglong Yang, Siqin Wang, Lei Jin, John L. Xu

Abstract Antibody–drug conjugate (ADC) has rapidly transformed the treatment landscape for solid tumors; however, owing to heterogeneity in target antigen expression, suboptimal efficacy and emergence of acquired resistance present significant challenges to the development of curative ADCs for cancers. In this study, we report the preclinical evaluation of GenSci143, a novel B7-H3 × PSMA-directed bispecific ADC, designed to overcome tumor antigen heterogeneity–associated drug resistance for the treatment of metasta …

02.09.2026journal-article

Frontiers in Oncology

Dietary supplements in integrative oncology

Lise Alschuler

Dietary supplement use is highly prevalent among adults and particularly common among individuals with cancer. Despite this prevalence, oncology providers have ambivalence about endorsing dietary supplements due to important questions regarding safety, interactions, and quality assurance. In the United States and globally, the dietary supplement market has expanded substantially under a regulatory framework established by the Dietary Supplement Health and Education Act (DSHEA), yet the absence of premarket approval …

02.09.2026journal-article

Academy for Practical Oncology

Experience with the use of trastuzumab deruxtecan in real-world clinical practice: data from Clinical Oncology Dispensary no. 1 (Krasnodar) and Federal Scientific Clinical Center of the fMBA of Russia

M. Yu. Mostovoy, S. V. Sharov, E. V. Lymar, A. G. Onishchenko, J. A. Bat, A. S. Melnikova, G. G. Lisachenko, A. G. Kedrova, T. A. Greyan

This article presents a systematic review of international and domestic experience with the use of trastuzumab deruxtecan in patients with HER2-positive and HER2-low metastatic breast cancer. Based on an analysis of key registration studies (DESTINY-Breast01, -03, -04), and confirmatory clinical trials (DESTINY-Breast02, -12) and real-world clinical practice data from the Clinical Oncology Dispensary No. 1 (Krasnodar) (n = 22) and Federal Scientific Clinical Center of the Federal Medical and Biological Agency of Ru …

02.09.2026journal-article

ACS Nano

A Metabolic Nanoplatform Potentiates Triple-Negative Breast Cancer Radiosensitivity via Disrupting Carbonic Anhydrase IX/Pentose Phosphate Pathway Crosstalk

Zhili Ma, Bin Zhao, Yun Wang, Shuaishuai Ding, Yuhua Cao, Lijuan Zeng, Yunping Hu, Xiu-Wu Bian, Xiao Zhang, Gan Tian, Chuan Xu

Abstract Radiotherapy resistance in tumors driven by metabolic adaptations within acidic microenvironments involves the upregulation of both carbonic anhydrase IX (CA IX) and the pentose phosphate pathway (PPP) as well as the functional crosstalk between them. To overcome this, we developed a polyvinylpyrrolidone (PVP)-modified gadolinium acetazolamide (PGA) nanoradiosensitizer. PGA simultaneously inhibits CA IX to trigger intracellular acidification and tumor cell acidosis, suppresses PPP through regulation of glu …

02.09.2026journal-article

Annals of Surgery

Transcriptome Dynamics From Primary Gastric Cancer to Peritoneal Metastases: Translational Insights for Surgical Oncology

Maria Bencivenga, Michele Simbolo, Stefano Gobbo, Alessandra Franceschi, Angela Sandri, Alberto Verlato, Federica Filippini, Erica Secchettin, Fabrizio Tedone, Cristina Migliore, Claudio Luchini, Jan Ewald, Rita Teresa Lawlor, Alessia Nottegar, Giovanni de Manzoni

Background and Aims: Peritoneal metastases (PMs) represent the most frequent, clinically challenging dissemination pattern in advanced gastric cancer, especially poorly cohesive (PCGC) subtype, and are associated with poor prognosis. We aimed to characterize the transcriptomic landscape of primary gastric tumors (PGTs) and matched PMs to identify differential molecular programs, tumor-microenvironment (TME) features, and potential biomarkers. Methods: We analyzed 55 FFPE samples from 23 treatment-naïve patients wit …

02.09.2026journal-article

Breast Cancer Research

Ambient air pollution and subtype-specific breast cancer risk by race and rurality: findings from a population-based study

Leah Moubadder, Lindsay J. Collin, Maret L. Maliniak, Lauren E. Barber, Kevin C. Ward, Michael R. Kramer, Ashley Naimi, Howard Chang, Alexandra W. White, Lauren E. McCullough

Abstract Background Air pollution is the leading environmental risk factor in the U.S. for premature morbidity and mortality and disproportionately impacts marginalized populations. Although the causal link between air pollution and lung cancer is well established, its impact on breast cancer is less understood. Therefore, in this study, we examined the association between traffic-related air pollution (NO 2 ) and particulate matter (PM 2.5 ) with the development of breast cancer-specific subtypes among non-Hispani …

02.09.2026journal-article

Oral Diseases

Intratumoral Administration of Recombinant Murine Interleukin‐12 Prevents Tumor Progression and Bone Invasion

Shun Kasahara, Miki Kashiwagi, Toshihiro Inubushi, Akinari Sugauchi, Wu Deyong, Kyoko Kurioka, Kazuaki Miyagawa, Takuma Matsuda, Soju Seki, Mikihiko Kogo, Susumu Tanaka, Toshihiro Uchihashi

ABSTRACT Objective Oral squamous cell carcinoma (OSCC) frequently invades the mandibular bone, leading to metastasis and poor prognosis. This study aimed to evaluate the therapeutic effects of locally administered interleukin‐12 (IL‐12) using an immunocompetent mouse model mimicking the clinical features of mandibular bone invasion. Methods The effects of IL‐12 on tumor growth and bone resorption were evaluated using subcutaneous and bone invasion models of OSCC in both immunocompetent and athymic mice. Bone resorp …