Medizin: neue Gesundheitspublikationen – Seite 24

03.09.2026journal-article

Frontiers in Surgery

A transformer-based multi-modal fusion framework for laryngeal lesion classification using contact endoscopy

Yunjing Duan, Wei Li

Purpose This study introduces a novel multi-modal transformer-based framework that integrates clinical data, radiomic features, and deep learning representations for automated classification of laryngeal lesions from contact endoscopy images. Methods We retrospectively enrolled 300 patients with laryngeal lesions from three independent medical centers (Centers A, B, and C), acquiring 7,847 contact endoscopy images with narrow band imaging. Clinical variables (18 features), radiomic features extracted using PyRadiom …

03.09.2026journal-article

Frontiers in Neurology

Brain-computer interface for post-stroke upper-limb recovery: a systematic review integrating clinical efficacy with neuroplasticity evidence

Yu Wu, Feilong Zhu, Qiumeng Dong, Ming Zhang

Objective Over 20 systematic reviews have evaluated brain-computer interface (BCI) training for post-stroke upper-limb rehabilitation, but published syntheses have focused predominantly on clinical efficacy, and the neuroplasticity mechanisms remain comparatively underexplored. This review integrates pooled clinical efficacy with a structured synthesis of neuroplasticity evidence from the same trials. Methods PubMed, Embase, CINAHL via EBSCO, Web of Science, Scopus, and Cochrane CENTRAL were searched from inception …

03.09.2026journal-article

European Journal of Clinical Microbiology & Infectious Diseases

Comparative efficacy of oral antibiotics against intracellular populations of uropathogenic Escherichia coli and bladder cell inflammatory response

Michelle Kalu, Peter Jorth, Annie Wong-Beringer

Abstract Predisposing risks to recurrent urinary tract infections caused by uropathogenic Escherichia coli (UPEC) include the formation of intracellular bacterial communities (IBCs) as a reservoir for persistence within bladder epithelial cells and sustained elevation of proinflammatory mediators that interfere with wound healing. Here we investigated the efficacy of oral agents (nitrofurantoin, doxycycline, and gepotidacin) in intracellular bacterial clearance and proinflammatory signaling in bladder epithelial ce …

03.09.2026journal-article

Lupus

Clinical characteristics of patients with primary antiphospholipid syndrome and “single” antiphospholipid antibody: Retrospective results from the APS ACTION clinical database and repository (“registry”)

Silvia Grazietta Foddai, Irene Cecchi, Massimo Radin, Laura Bertolaccini, Danieli de Andrade, Maria Tektonidou, Vittorio Pengo, Chary Lopez-Pedrera, Diana Paredes-Ruiz, Howard Michael Belmont, Paul R. Fortin, Denis Wahl, Ware Branch, Maria Gerosa, Guilherme de Jesus, Zhouli Zhang, Tatsuya Atsumi, Maria Efthymiou, Laura Andreoli, Esther Rodriguez, Michelle Petri, Ricard Cervera, Bahar Artim-Esen, Rosana Quintana, Jason S. Knight, Rohan Willis, Reyhan Kose Cobanoglu, Hannah Cohen, Doruk Erkan, Savino Sciascia

Objective While triple antiphospholipid antibody (aPL) positivity is associated with a higher risk of thrombosis, the clinical significance of single aPL positivity remains unclear. This study aimed to assess the prevalence, clinical characteristics, and cardiovascular disease (CVD) risk profile of persistently single aPL-positive primary antiphospholipid syndrome (PAPS) patients. Methods We conducted a retrospective analysis for APS patients from the APS ACTION registry with confirmed persistent single aPL positiv …

03.09.2026journal-article

South Asian Journal of Cancer

AsiaPacific Geriatric Oncology Society (AGOS; virtual tumour board no 9) real world consensus for management of endometrial cancer with multiple co-morbidities and polypharmacy in the older patient

Purvish M Parikh, Nikhil Ghadyalpatil, Dharshitha Varigonda, TVSVGK Tilak, Bipinesh Sansar, Karishma De, Mosale Venkatesha Chandrakant, VenkataSampath Vankamamidi, Steve Paul Manjaly, Athika Shaik, Madhusudhan Perumandla

The AsiaPacific Geriatric Oncology Society (AGOS) conducts a monthly virtual tumour board. One of the cases discussed was a 70-year-old female with Stage IIIA endometrial cancer, multiple co-morbidities and polypharmacy. A group of experts discussed the challenges in the real world with specific reference to improving Timed Up and Go (TUG) score, managing the effect of co-morbidities, preventing risk due to drug-drug interactions and evaluating the risk of delaying anti-cancer therapy in an attempt to improve patie …

03.09.2026journal-article

Journal of Intensive Care Medicine

Maternal Sepsis for the Intensivist: Recognition, ICU Triage, and Pregnancy-Adapted Management

Felicia Chen

Sepsis in pregnancy and the puerperium is a leading, and often preventable, cause of maternal critical illness. This narrative review summarizes pregnancy-adapted physiology, epidemiology, clinical recognition, intensive care unit triage, and management, with particular emphasis on decision-making around ICU admission and the practical delivery of organ support for intensivists who do not routinely manage obstetric patients.

03.09.2026journal-article

ANZ Journal of Surgery

Negative Pressure Wound Therapy Does Not Reduce Wound Complications Following Simple Mastectomy: A Retrospective Cohort Study

Robert Torode, David Walsh, Jonathan Fong

ABSTRACT Background Negative pressure wound therapy (NPWT) reduces wound complications following oncoplastic breast surgery, yet there is limited evidence supporting its use in mastectomy without reconstruction. This study evaluated the effect of NPWT on post‐mastectomy wound complications in a rural Australian centre. Methods A single centre retrospective cohort study assessed simple mastectomy outcomes between 2020 and 2025. Wounds were grouped by post‐operative dressing type (NPWT vs. no NPWT). The primary outco …

03.09.2026journal-article

Journal of Public Health and Preventive Medicine

Research Progress on the Impacts of Social Isolation and Loneliness on the Health of the Elderly

Elisa M. Carter, Ryan D. Simmons, Megan L. Henderson, Julia A. Bennett

Social isolation and loneliness have emerged as critical public health concerns affecting older adults worldwide. Despite being distinct concepts—social isolation referring to the objective lack of social connections and loneliness representing the subjective distress of feeling alone—both conditions are associated with profound adverse effects on physical and mental health. This narrative review synthesizes current research on the conceptual definitions, measurement tools, health impacts, intervention strategies, …

03.09.2026journal-article

Frontiers in Medicine

Facial discoid lupus erythematosus complicated by a Candida tropicalis fungal granuloma in a patient with rhupus syndrome: a case report of successful treatment with oral itraconazole

Lingling Dong, Ting Zhang, Tong Hua, Yan Wang, Zhenhua Nie, Qingkang Lyu, Zuotao Zhao

Discoid lupus erythematosus (DLE) is a chronic cutaneous subtype of lupus erythematosus characterized by inflammatory lesions that are highly susceptible to secondary infection, particularly in immunocompromised individuals. Cutaneous fungal granulomas caused by Candida tropicalis and superimposed on pre-existing DLE lesions are exceedingly rare and pose substantial diagnostic challenges. We report the case of a 48-year-old female patient with a 2-year history of rheumatoid arthritis (RA), who presented with facial …

03.09.2026journal-article

International Journal of Science, Strategic Management and Technology

White Spot Lesions Following Orthodontic Treatment: Contemporary Management

Y.Muni Akash

White spot lesions (WSLs) often develop after fixed orthodontic treatment. They appear as milky white spots on teeth due to enamel demineralization. These lesions are a common aesthetic concern, affecting 45.8% to 97% of orthodontic patients [1]. Today, dentistry focuses on non-invasive remineralization therapies to treat WSLs and prevent their progression.

03.09.2026journal-article

Frontiers in Oncology

Deep learning model using contrast-enhanced CT imaging features and clinical variables to predict surgical risk after hepatic resection for hepatocellular carcinoma

Kimika Kato, Yasuhito Mitsuyama, Hiroji Shinkawa, Takuma Okada, Atsushi Sugimoto, Ryota Tanaka, Sadaaki Nishimura, Jun Tauchi, Masahiko Kinoshita, Genki Watanabe, Kohei Nishio, Takeaki Ishizawa

Background Accurate preoperative risk assessment is crucial for patients undergoing hepatic resection for hepatocellular carcinoma (HCC). Conventional prediction methods are limited by the inability to capture complex relationships among multiple factors, and existing deep learning (DL) approaches focus on individual surgical outcomes. In this study, we developed and evaluated a DL model that integrates preoperative contrast-enhanced computed tomography (CT) imaging features and clinical variables to predict intrao …

03.09.2026journal-article

Journal of Dance Medicine & Science

Dance as Rehabilitation in Parkinson’s Disease: A Scoping Review of Motor, Non-Motor, and Cognitive Outcomes

Simran Rooprai, Nicholas Ramcharran, Caitlin van den Hoorn, Jenna Smith-Turchyn, Nicole D. Anderson, Joseph FX DeSouza

Introduction: Dance is a multimodal experience, integrating movement and music, with cognitive and psychosocial effects, potentially providing a non-pharmacological care approach for persons with Parkinson’s disease (PwPD). While numerous studies have investigated motor outcomes following dance interventions, less is known about the degree to which cognitive and non-motor outcomes are explored. The objective of this scoping review was to explore the scope and characteristics of dance-based interventions for PD, foc …

03.09.2026journal-article

Current Opinion in Otolaryngology & Head & Neck Surgery

Tympanomastoidectomy canal wall reconstruction with mastoid obliteration

Adam S. Vesole, Ravi N. Samy

Purpose of review To describe the various techniques in performing a tympanomastoidectomy canal wall reconstruction with mastoid obliteration for surgical management of chronic otitis media and cholesteatoma, and to assess the outcomes and complications compared to the more traditional canal wall up and canal wall down surgical techniques. Additionally, the purpose of this review is to highlight the versatility and novelty of this approach in addressing other middle ear pathologies such as glomus tympanicum. Recent …

03.09.2026journal-article

Global Spine Journal

Characteristics of Patients Achieving Clinically Meaningful Improvement in Neuropathic Pain After Surgery for Degenerative Cervical Myelopathy

Narihito Nagoshi, Junichi Yamane, Toshiki Okubo, Hitoshi Kono, Kentaro Fukuda, Takeshi Fujii, Yosuke Horiuchi, Yasuhiro Kamata, Norihiro Isogai, Takahito Iga, Kazuki Takeda, Masahiro Ozaki, Satoshi Suzuki, Morio Matsumoto, Masaya Nakamura, Kota Watanabe

Study Design Retrospective analysis of a prospectively maintained multicenter cohort. Objectives To identify clinical characteristics associated with clinically meaningful improvement in neuropathic pain and to evaluate its relationship with postoperative functional outcomes in patients with degenerative cervical myelopathy (DCM). Methods Among 816 patients with complete Neuropathic Pain Symptom Inventory (NPSI) data, 597 with baseline total NPSI scores ≥7 were included in the primary analysis because they were eli …

03.09.2026journal-article

European Journal of Trauma and Emergency Surgery

Repeated scoring with the adult appendicitis score improves the sensitivity and the specificity of appendicitis diagnosis in patients with early equivocal signs of appendicitis: a secondary analysis

Kirsi S. Lastunen, Ari K. Leppäniemi, Panu J. Mentula

Abstract Purpose The utilization of computed tomography in the early stage of acute appendicitis may result in overdiagnosis and unnecessarily expose patients to ionising radiation. The Adult Appendicitis Score (AAS) can be used to select patients for imaging. Observation and re-scoring in the DIAMOND trial reduced the need for imaging. Now, we wanted to determine if the change in AAS (∆AAS) can serve as a diagnostic tool to select patients for imaging even more precisely. Methods Eighty-eight patients with early e …

03.09.2026journal-article

Journal of Clinical Medicine

Long-Term Effects of Right Ventricular Pressure and Volume Overload: A Comparative Analysis in an Ovine Model

Hamida Al Hussein, Hussam Al Hussein, Simina-Elena Ghiragosian-Rusu, Simona Gurzu, Rita Szodorai, Carmen Sircuta, Marius Stefan Marusteri, Bogdan Cordos, David Emanuel Anitei, Andrei Atudorei, Sergiu Crisan, Dan Simionescu, Klara Brinzaniuc

Background/Objectives: Pressure overload (PO) and volume overload (VO) represent important mechanisms underlying right ventricular (RV) failure; however, long-term comparative data regarding their distinct pathophysiological consequences remain limited. This study aimed to compare the long-term effects of PO versus VO in a large animal model. Methods: Juvenile sheep were randomly assigned to either a PO group (n = 7) or a VO group (n = 8). PO was induced by pulmonary artery banding, whereas VO was induced by pulmon …

03.09.2026journal-article

Annals of Human Resource Management Research

Healthcare Human Resource Development: Organizational Support and Work Engagement among Clinical Clerkship Students

Gunawan Eko Nurtjahjono, Hefry Johan Ferdhianzah

Purpose: This study examined work engagement among clinical clerkship students from a healthcare human resource development perspective. Specifically, it analyzes how perceived organizational support and the clinical learning environment influence work engagement during pediatric clinical education and evaluates whether the clinical learning environment functions as a moderating condition in this relationship. Methodology: A quantitative cross-sectional survey involving 251 clinical clerkship students at Rumah Saki …

03.09.2026journal-article

Journal of Clinical Investigation

Enhancing Gemcitabine Uptake by Promoting Dimerization of the ENT1 Transporter Improves Sarcoma Patient Response Rate

Aditya Ganju, Shyam Rao, Mark A. Dickson, Robert A. Lefkowitz, Chris Thompson, Jin Cheng, Katia Manova, Adriana Haimovitz-Friedman, Gary Schwartz, Zhigang Zhang, Zvi Fuks, William D. Tap, Richard Kolesnick

Transport of nucleoside chemotherapeutic drugs into tumor cells is primarily accomplished through Equilibrative Nucleoside Transporter 1 (ENT1), considered to be constitutively-active, redistributing drugs across lipid bilayers via facilitated diffusion. Here we discover that ENT1 is not constitutively-active but rather requires activation of acid sphingomyelinase (ASMase) by gemcitabine, generating ceramide-rich platforms (CRPs) on external plasma membranes of endothelial and tumor cells into which ENT1 inserts, d …

03.09.2026journal-article

Clinical Spine Surgery

Assessing Global Upper Extremity Function Before and After Decompressive Surgery in Patients With Degenerative Cervical Myelopathy (DCM)

Angie Zhang Lung, John Hong, Vicky Chan, Maya N. Hatch, Jay J. Han, Yu-Po Lee, Nitin N. Bhatia, Michael Oh

Study Design: A total of 20 patients with degenerative cervical myelopathy (DCM) and a plan for surgical decompression were recruited in this pilot study to assess a new outcome measure. Patients were evaluated preoperatively and 3 months, 6 months, and 1 year postoperatively using a 3-dimensional motion-tracking application (reachable workspace) to calculate an upper extremity (UE) relative surface area (RSA) and standard measurements [modified Japanese Orthopedic Association (mJOA), 12-Item Short Form Health Surv …

03.09.2026journal-article

Journal of Clinical Pathology

Anaplastic lymphoma kinase immunohistochemical positivity in high-grade pulmonary neuroendocrine carcinoma: an actionable signal or merely a shadow?

Ullas Batra, Sabeena Choudhary, Ritwika Choudhury, Alka Yadav, Mansi Sharma, Abhinav Dewan, Sunil Pasricha, Anurag Mehta, Priyanka Venkataraman

Aims Anaplastic lymphoma kinase (ALK) rearrangements are actionable drivers in non-small cell lung carcinoma (NSCLC), but the biological significance of ALK-immunohistochemistry (IHC) positivity in high-grade pulmonary neuroendocrine carcinoma (NEC) remains unclear. This study evaluated the diagnostic and therapeutic implications of discordant ALK IHC and genomic findings and the role of multimodal molecular testing in resolving them. Methods We retrospectively analysed eight South Asian patients (Indian and Nepali …

03.09.2026journal-article

Military Medicine

Military Medical Training for Role 1 and Role 2 Combat Casualty Care Skills: A Narrative Review

Jennifer L Patton, Kiffin R Smallegan, Emily R Latimer, Anna R Prendergast, Gary J Jimenez Pena, Angela K Phillips

Abstract Introduction Military medics are often tasked to train other medics. While there is ample content of what to train, there exists a lack of trainer education or emphasis on how to train others effectively. Current military medical training is highly variable, often relying on anecdotal methods, with limited evaluation of training effectiveness. Although the importance of readiness training is well recognized, little attention has been devoted to identifying evidence-based approaches for training military me …

03.09.2026journal-article

Ege Tıp Dergisi

Can preoperative thrombocytopenia be a risk indicator for emergency surgery due to liver transplant complications?

Emrah Şahin, Ender Anılır, Abuzer Dirican, Bülent Ünal

Aim: This study aimed to investigate the effect of preoperative thrombocytopenia and other risk factors on the need for emergency surgery due to complications following living donor liver transplantation (LDLT), and to evaluate the impact of emergency surgery on patient survival.Materials and Methods: The data of 270 patients who underwent LDLT for end-stage liver disease between July 2021 and October 2023 were analyzed retrospectively. Patients were divided into two groups: those requiring postoperative emergency …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

A refined phenomenological model of viscoelastic clot formation and lysis in trauma-induced coagulopathy

Guanyun Liu, Amanda E. Shick, Maya Shamash, Caroline M. Cook, Mario L. Molina, Mitchell J. Cohen, Amor A. Menezes

Background Hyperfibrinolysis is strongly associated with early post-injury mortality, but the condition is preventable with timely detection and targeted interventions. Unfortunately, current hyperfibrinolysis diagnostic assays such as thromboelastography (TEG) are time-consuming, making them infeasible for use in real-time treatment strategies to guide adjustable, precise, and personalized interventions. Computational models offer a fast alternative to current practice for ascertaining patient hemostatic state fro …

03.09.2026journal-article

Clinical Chemistry and Laboratory Medicine (CCLM)

Validation of synthetic M-protein materials for external quality assessment: homogeneity, commutability, and stability

Moniek M. Bioch, Theo Rispens, Corrie M. de Kat Angelino, Anke J. ten Haaken-Meijer, Miranda van Berkel, Marc H.M. Thelen, Joannes F.M. Jacobs

Abstract Objectives Accurate quantification of M-proteins is important for clinical management of monoclonal gammopathies. Reliable assessment of trueness on M-protein quantification in External Quality Assessment (EQA) schemes is difficult due to the lack of reference methods and materials for target value assignment. We propose a strategy to produce targeted synthetic M-protein EQA materials by spiking known amounts of human(ised) therapeutic monoclonal antibodies (t-mAb) into null serum. This paper validates hom …

Was ist neu im Gesundheitswesen?

Aktuelle Forschung nach Fachgebiet

A transformer-based multi-modal fusion framework for laryngeal lesion classification using contact endoscopy

Brain-computer interface for post-stroke upper-limb recovery: a systematic review integrating clinical efficacy with neuroplasticity evidence

Comparative efficacy of oral antibiotics against intracellular populations of uropathogenic Escherichia coli and bladder cell inflammatory response

Clinical characteristics of patients with primary antiphospholipid syndrome and “single” antiphospholipid antibody: Retrospective results from the APS ACTION clinical database and repository (“registry”)

AsiaPacific Geriatric Oncology Society (AGOS; virtual tumour board no 9) real world consensus for management of endometrial cancer with multiple co-morbidities and polypharmacy in the older patient

Maternal Sepsis for the Intensivist: Recognition, ICU Triage, and Pregnancy-Adapted Management

Negative Pressure Wound Therapy Does Not Reduce Wound Complications Following Simple Mastectomy: A Retrospective Cohort Study

Research Progress on the Impacts of Social Isolation and Loneliness on the Health of the Elderly

Facial discoid lupus erythematosus complicated by a Candida tropicalis fungal granuloma in a patient with rhupus syndrome: a case report of successful treatment with oral itraconazole

White Spot Lesions Following Orthodontic Treatment: Contemporary Management

Deep learning model using contrast-enhanced CT imaging features and clinical variables to predict surgical risk after hepatic resection for hepatocellular carcinoma

Dance as Rehabilitation in Parkinson’s Disease: A Scoping Review of Motor, Non-Motor, and Cognitive Outcomes

Tympanomastoidectomy canal wall reconstruction with mastoid obliteration

Characteristics of Patients Achieving Clinically Meaningful Improvement in Neuropathic Pain After Surgery for Degenerative Cervical Myelopathy

Repeated scoring with the adult appendicitis score improves the sensitivity and the specificity of appendicitis diagnosis in patients with early equivocal signs of appendicitis: a secondary analysis

Long-Term Effects of Right Ventricular Pressure and Volume Overload: A Comparative Analysis in an Ovine Model

Healthcare Human Resource Development: Organizational Support and Work Engagement among Clinical Clerkship Students

Enhancing Gemcitabine Uptake by Promoting Dimerization of the ENT1 Transporter Improves Sarcoma Patient Response Rate

Assessing Global Upper Extremity Function Before and After Decompressive Surgery in Patients With Degenerative Cervical Myelopathy (DCM)

Anaplastic lymphoma kinase immunohistochemical positivity in high-grade pulmonary neuroendocrine carcinoma: an actionable signal or merely a shadow?

Military Medical Training for Role 1 and Role 2 Combat Casualty Care Skills: A Narrative Review

Can preoperative thrombocytopenia be a risk indicator for emergency surgery due to liver transplant complications?

A refined phenomenological model of viscoelastic clot formation and lysis in trauma-induced coagulopathy

Validation of synthetic M-protein materials for external quality assessment: homogeneity, commutability, and stability