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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

Journal of Sport Rehabilitation

Foot and Ankle Characteristics in 225 Runners With and Without a History of Running-Related Injury: A Case-Control Study

Guillaume Abran, Aude Aguilaniu, Nadia Dardenne, Stephen Bornheim, François Delvaux, Jean-Louis Croisier, Cédric Schwartz

Context : A previous study has shown that strengthening the foot muscles could decrease the risk of running-related injuries by 2.4 times in endurance runners. However, it remains unclear whether runners with stronger foot muscle have less risk of running-related injuries. The aim of this study was to compare foot–ankle characteristics between runners with and without a history of running-related injury. Design : Retrospective case–control study. Methods : This study enrolled 225 runners in this retrospective study …

01.09.2026journal-article

Bulletin of Faculty of Physical Therapy

Effects of shaping-enhanced mirror therapy on motor function in healthy adults: a case-control study

Sergen Öztürk, Özlem Doğan, Alime Nur Kara, Burcu Ersoz Huseyinsinoglu

Abstract While mirror therapy (MT) has shown efficacy in treating various conditions, its practice remains inconsistent due to the lack of a standardized protocol. This study aimed to assess the impact of integrating shaping activities into MT on motor learning, motor dexterity and reaction time of the non-dominant hand in healthy individuals. This case-control study included 30 healthy adults in the MT group (MTG) and 30 age- and gender-matched controls. MTG underwent shaping activities combined with MT twice a we …

01.09.2026journal-article

Frontiers in Immunology

Tertiary lymphoid structures in chronic rhinosinusitis with nasal polyps: spatial organization, pathological functions, and implications for surgical strategy and biologic therapy

Yu-Shan Lin, Guan-Jiang Huang, Biao-Qing Lu, Qi-Ping Luo, Zhi-Jun Fan, Xue-Sen Yang, Chao-Qing Long

Chronic rhinosinusitis with nasal polyps (CRSwNP) presents three persistent clinical enigmas that conventional immunological frameworks have failed to resolve. These include the paradox of locally elevated specific IgE in the absence of systemic sensitization, a high polyp recurrence rate exceeding 60% following technically complete functional endoscopic sinus surgery (FESS), and disease rebound observed in the majority of patients within 6 to 12 months after discontinuation of dupilumab. Converging lines of eviden …

01.09.2026journal-article

Applied Biosciences

Can Plant-Derived Anti-Inflammatory Compounds “Replace” Indomethacin in NSAID Therapy? Advances in Drug Delivery Systems of Indomethacin and Off-Label Medical Applications

Petya Georgieva, Petya Peneva, Yana Gvozdeva

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for the management of inflammatory disorders, pain, and fever due to their significant anti-inflammatory and antipyretic properties. However, their long-term use is often associated with multiple adverse effects, including gastric erosion, hemorrhage, and perforation, as well as cardiovascular, hepatic, and renal complications. Indomethacin is a potent NSAID commonly used in the treatment of pain and rheumatoid arthritis. Its poor water solubility, Biop …

01.09.2026journal-article

Therapeutic Advances in Medical Oncology

A phase II study of DFP-14323, a non-specific immunomodulator, in combination with low-dose afatinib as first-line therapy for common EGFR mutation-positive NSCLC

Hiroshige Yoshioka, Masahide Mori, Nobuyuki Katakami, Toshihide Yokoyama, Hiroyasu Kaneda, Hirotaka Matsumoto, Motohiro Tamiya, Kouji Yamamoto, Cheng-long Huang

Background Aminopeptidase N (CD13) has been reported to be a prognostic factor in non-small cell lung cancer (NSCLC). DFP-14323 (INN: ubenimex) is a CD13 inhibitor and a low-toxicity, non-specific immunomodulator approved in Japan for the maintenance treatment of adult acute non-lymphocytic leukemia. Objectives This study explored the potential immunomodulatory synergy of DFP-14323 with EGFR-TKIs in patients with advanced NSCLC. Design A prospective, multicenter, open-label, single-arm phase II study. Methods Stage …

01.09.2026journal-article

European Journal of Translational Myology

Mapping the literature about brain-computer interface in rehabilitation: a graph-theory-based PCA framework for semantic space analysis

Daniele Coraci, Gianluca Regazzo, Stefano Masiero

Brain-Computer Interfaces (BCIs) are increasingly used in neurorehabilitation, but the rapid expansion of scientific literature complicates the identification of clinically relevant studies. This study investigated whether expert-defined relevance within BCI rehabilitation literature emerges as a structural property of semantic networks through the integration of graph theory and Principal Component Analysis (PCA). A Lexical Network Analysis Based on Graph Theory (LENGTH) was applied to randomized controlled trials …

01.09.2026journal-article

Journal Human Research in Rehabilitation

Paul, Marschark, & Mayberry: An Integrated Perspective for Reading Development of D/Deaf and Hard of Hearing Students

Peter V. Paul, Husnija Hasanbegovic

The development of grade-level or age-level reading proficiency continues to be a challenge for a number of d/Deaf and hard of hearing (d/Dhh) children and adolescents. There have also been ongoing research debates on recommending evidence-based or effective practices to facilitate the acquisition of reading skills. These debates are fueled, in part, by the major principles of three broad frameworks: Paul’s Qualitative Similarity Hypothesis, Marschark’s Cognitive “Qualitative Difference” Hypothesis, and Mayberry’s …

01.09.2026journal-article

Journal Human Research in Rehabilitation

Cyberbullying Experiences Among Students with Disabilities: An Empirical Investigation

Arsim Avdiu, Aferdita Ibrahimi

Cyberbullying represents a specific form of psychological violence that has intensified with the development of digital technology and the widespread use of social media. This study aims to analyze cyberbullying and its impact on students with disabilities in secondary education, considering them as a particularly vulnerable group. The research focuses on the forms in which cyberbullying manifests, the psychological, emotional, and social consequences it produces, as well as the factors contributing to its occurren …

01.09.2026journal-article

American Journal of Physical Medicine & Rehabilitation

Current Musculoskeletal Pain and Injury History in Former NCAA Division I Female Athletes

Irene Kalbian, Miguel Escalon, Katharine Holmes, Rebecca Maitin

Objective: To determine the prevalence of current musculoskeletal pain among former NCAA Division I female athletes and examine associations with prior injury history, anatomical distribution of symptoms, and functional outcomes. Design: Cross-sectional web-based survey of former NCAA Division I female athletes. Participants completed questionnaires regarding athletic history, prior injuries, current pain, osteoarthritis diagnosis, physical activity, and PROMIS Pain Interference outcomes. Results: A total of 428 fo …

01.09.2026journal-article

Journal of Medical Internet Research

Internet-Delivered Cognitive Behavioral Therapy for Fathers With Postnatal Depression: Randomized Controlled Trial of DadBooster

Charlene Holt, Jennifer Ericksen, Alan W Gemmill, Andre L Rodrigues, Jeannette Milgrom

Abstract Background Up to 1 in 10 fathers experience postnatal depression. Fathers are less likely to seek help and receive adequate treatment than depressed mothers. Digital treatments hold significant potential for engaging and supporting fathers, but no effective program exists. Objective The aim of the study is to evaluate the efficacy of an online cognitive behavioral therapy program, DadBooster, for treating postnatal depression in fathers. Methods A parallel, 2-group randomized controlled trial (N=50) was co …

01.09.2026journal-article

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH

Integrated Approach of Physiotherapy with Ayurveda in Management of Tethered Cord Syndrome: A Case Report

Shreya Mukund Kulkarni, Vijay Kage, Ramesh Killedar, Peeyoosha Gurudut, Aarti Welling

Tethered Cord Syndrome (TCS) is a rare neurological condition caused by pathological anchoring of the spinal cord, resulting in abnormal stretching and progressive neurological deficits. Although TCS is commonly diagnosed in childhood, adult-onset cases present diagnostic and therapeutic challenges due to delayed recognition and varied clinical manifestations. The present case report describes a 38-year-old male presenting with chronic low back pain, progressive lower limb weakness and bilateral lower limb tremors, …

01.09.2026journal-article

Tributaries journal for Studies and Researches In sports sciences

Differential Effects of Aquatic and Land-Based Rehabilitation Programs on Functional Mobility and Quality of Life in Women with Knee Osteoporosis

Amal Mohamed Ibrahim Babiker, Atega Al‑Amin, Rahma Ibrahim

This study aimed to compare the differential effects of aquatic and land‑based rehabilitation programs on functional mobility and quality of life in women with knee osteoporosis. Thirty women aged 45–60 years were randomly assigned to an aquatic training group (n = 15) or a land‑based training group (n = 15). Both groups completed an 8‑week supervised rehabilitation program. Functional outcomes were assessed using the Timed Up and Go Test (TUG), the Six‑Minute Walk Test (6MWT), range of motion (ROM), the Visual Ana …

01.09.2026journal-article

International Journal of Health Management Review

TREATMENT OF ROOT PERFORATION WITH INDICATION FOR EXTRACTION AND IMPLANT-SUPPORTED REHABILITATION

Giacomo Gobbo Trojan, Pamela Rufina Stefanello Wideck, Adria Myllene Pinto de Barros, Nicolly Menezes de Oliveira, Katiane Vieira Menezes Leite, Leonel Souza de Oliveira, Saymon Calixto Rodrigues, Thiago Andre Cruz da Costa

Root perforations occurring during endodontic instrumentation are primarily associated with iatrogenic errors, technical limitations, and a lack of awareness regarding anatomical variations. Proper treatment planning, combined with the use of supplementary diagnostic tests, is essential for enhancing treatment safety and predictability. In the event of complications or treatment failure, an individualized assessment of the tooth's prognosis becomes imperative. Although tooth preservation is the primary goal of endo …

01.09.2026journal-article

The Professional Medical Journal

Efficacy of melatonin as an adjunct to first-line therapy in epileptic patients.

Safiullah, Sadia Riaz

Objective: To determine the efficacy of melatonin as an adjunct to first-line antiepileptic therapy in reducing seizure severity, seizure frequency, and electroencephalographic (EEG) abnormalities in pediatric patients with generalized epilepsy. Study Design: Quasi-experimental Comparative study. Setting: Department of Pediatrics, Pakistan Institute of Medical Sciences (PIMS), Islamabad. Period: July 2025 to Dec 2025. Methods: A total of 60 children aged 2–12 years with generalized epilepsy and suboptimal seizure c …

01.09.2026journal-article

Angewandte Chemie International Edition

Sono‐Triggered In Situ Vaccine via a Chlorin‐Based Small Molecule Sensitizer for Systemic Cancer Therapy

Jinrong Li, Kun Shao, Lin Cheng, Guanyi Zhang, Jianlong Su, Yiming Liu, Yang Wang, Chengdong Wang, Zhihao Wu, Xu Wang, Yuxuan Zhang, Bohua Yan, Lei Wang, Guangzhe Li

ABSTRACT Unimolecule‐mediated sonodynamic therapy (SDT) offers a promising approach to combat tumors systemically by enabling synergistic sono‐triggered cytotoxicity and in situ vaccine‐like effects within tumors. Although chlorin‐based sensitizers have achieved clinical success in phototherapy, their translation to SDT has been impeded by inadequate ultrasound (US)‐triggered reactive oxygen species (ROS) generation, leading to suboptimal immunogenic cell death (ICD) and compromised antitumor immunity. To address t …

01.09.2026journal-article

Journal of Iranian Medical Council

Knowledge and Attitudes Toward Electroconvulsive Therapy Among Companions of Psychiatric Patients: A Cross-Sectional Study from Northern Iran, Rasht

Ali Pourramzani, Zahra Fallah, Maryam Nasseri Alavi, Zahra Atrkarroushan, Nazanin Rahmanian

Background: Electroconvulsive Therapy (ECT) is a highly effective treatment for psychiatric disorders, particularly in emergency cases, pregnancy, and when pharmacological treatments are contraindicated. However, misconceptions and negative attitudes among patients’ companions can hinder its acceptance and adherence. This study aimed to evaluate the knowledge and attitudes of companions of ECT recipients at Shafa Hospital in 2024. Methods: A cross-sectional descriptive study was conducted among companions of psychi …

01.09.2026journal-article

American Journal of Physical Medicine & Rehabilitation

Understanding Discordant Board Outcomes

Sherilyn W. Driscoll, Mikaela M. Raddatz, Susan Apkon, Gerard E. Francisco, Christopher Garrison, Carolyn L. Kinney, Vu Q.C. Nguyen, David W. Pruitt

It is unexpected when initial certification examinees pass the American Board of Physical Medicine and Rehabilitation (ABPMR) Part I Examination with a top score and subsequently fail the Part II Examination. This study aims to determine individual and residency program factors associated with this outcome. A retrospective, observational review of ABPMR data between 1999 and 2025 identified 161 individuals (1.6% of all examinees) who passed Part I with top quartile performance but subsequently failed one or more at …

01.09.2026journal-article

Journal of Sport Rehabilitation

One-Week Reliability of the Multimodal Exertional Test for Concussion in Healthy Athletes

Kyla L. Pyndiura, Alex P. Di Battista, Doug Richards, Nick Reed, David W. Lawrence, Michael G. Hutchison

Context (Aim) : To estimate the test–retest reliability of performance metrics, heart rates, and symptoms collected during the Multimodal Exertional Test (MET) in healthy interuniversity athletes. Study : Test–retest reliability. Methods : Twenty-five participants (n = 14 males, n = 11 females) completed the MET twice, 1 week apart. Participants’ performance metrics and symptom severity scores were obtained following each task, and average and maximum heart rates were collected prior to the MET and during each stag …

01.09.2026journal-article

Arteriosclerosis, Thrombosis, and Vascular Biology

Vascular Health and Gender-Affirming Hormone Therapy: The Immune System in Motion

Jeimison D. Santos, Jefferson Elias-Oliveira, Ualter G. Cipriano, Pedro Vargas-Pinilla, Daniela Carlos, Vania L.D. Bonato, Rita C. Tostes

Given that fluctuations in sex hormone levels greatly influence cardiovascular homeostasis, this review addresses how gender-affirming hormone therapy impacts vascular function and the immune system, and how these effects may contribute to altered cardiovascular performance in transgender individuals. Gender-affirming hormone therapy alters leukocyte activation and cytokine secretion, that may impact vascular responsiveness, with distinct effects in feminizing and masculinizing regimens. Moreover, gender-affirming …

01.09.2026journal-article

Jurnal Ilmiah Telsinas Elektro, Sipil dan Teknik Informasi

Occupational Health and Safety Risk Management in Toll Road Construction

Misbah Misbah, Leli Honesti, Fajar Nugroho, Meli Muchlian, Nur Hamiza Adenan, Yessy Yusnita

Construction projects carry substantial risk of work accidents. This study aims to (1) identify hazards in project activities, (2) assess and rank the associated risks, and (3) determine appropriate risk controls, using Hazard Identification, Risk Assessment, and Determining Control (HIRADC) combined with Job Safety Analysis (JSA), with Toll Road X as the case study. Of the hazards identified, none were classified as large risk; 10 were classified as medium risk and 12 as small risk. The six highest-risk findings, …

02.09.2026journal-article

Growth and Change

AI‐Related Hiring Expansion and Within‐City Occupational Demand Reallocation in China: Evidence From Listed‐Firm Job Postings

Zhaoming Sun, Yawen Zhai, Xianghui Tian

ABSTRACT AI‐related hiring demand is unevenly distributed across urban labor markets. Using online job‐posting data from Chinese listed firms between 2016 and 2024, this study constructs a city–occupation–year panel and examines whether expanding AI‐related hiring demand is associated with differences in the structure of occupational hiring demand within cities. The results show that: (1) higher city‐level AI‐related hiring demand is significantly associated with greater relative hiring demand for occupations that …

02.09.2026journal-article

The Oncologist

85 Phase 3 LITESPARK-033 (NCT07227402) Study of Belzutifan Plus Zanzalintinib Versus Cabozantinib for Recurrent Clear Cell Renal Cell Carcinoma During or After Adjuvant Anti–PD-(L)1 Therapy

Toni K Choueiri, Thomas Powles, Martin H Voss, Marc-Oliver Grimm, Kelly N Fitzgerald, Brian Simmons, Jerry Cornell, Joseph E Burgents, Priyanka Chablani, Cristina Suarez

Abstract Background Adjuvant pembrolizumab is the standard of care for patients with renal cell carcinoma (RCC) at increased risk for recurrence after nephrectomy. However, treatment options are needed following adjuvant anti–PD-(L)1 therapy because none of the currently available treatments for advanced RCC were evaluated in this setting. Belzutifan, a potent and selective hypoxia-inducible factor 2α inhibitor, is approved for advanced RCC following a PD-(L)1 inhibitor and vascular endothelial growth factor tyrosi …

01.09.2026journal-article

Jornadas de Automática

Evolución del diseño mecánico de un robot de rehabilitación en entorno acuático

Fco. Javier Miñano, Daniel Diaz-Diaz, Javier Chinchilla-Pastor, Yolanda Vales, Andrea Blanco-Ivorra, Nicolas García-Aracil

Neurological disorders, such as stroke, multiple sclerosis, or severe neuropathies, drastically impact patient autonomy and quality of life. Although rehabilitation technologies have demonstrated great potential, their application remains limited in patients with severe impairments, particularly those presenting high levels of spasticity. In this context, aquatic therapy stands out for its capacity to reduce such spasticity through the physical properties of water, which facilitate movement and promote muscle relax …

01.09.2026journal-article

JAIDS Journal of Acquired Immune Deficiency Syndromes

Comparing Self-Reports, Pill Counts, and Electronic Devices in Assessing Antiretroviral Therapy Adherence and its Association With Viral Suppression in Adolescents Living With HIV

Samuel Kizito, Fred M. Ssewamala, Josephine Nabayinda, Proscovia Nabunya, Ozge Sensoy Bahar, Phionah Namatovu, Torsten B. Neilands

Background: We compared the performance of self-reports, pill counts, and electronic adherence measures in monitoring antiretroviral therapy (ART) adherence and association with viral suppression among adolescents living with HIV (ALHIV). Setting: This study was conducted among 39 study clinics in the Greater Masaka region in Southern Uganda. Methods: We used baseline data from 702 ALHIV aged 10–16 years receiving ART. Self-report was assessed using a three-item tool and pill counts were unannounced, while Wisepill …