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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Journal of Palliative Care

Respecting Spinal Cord Injury Patient Autonomy in the Context of Terminal Extubation

Rainy B.S. Wortelboer, Lauren Hall, Fareea Khaliq

Terminal extubation, or palliative or compassionate extubation, is a legally and ethically accepted practice in the United States where mechanical ventilation is withdrawn when ongoing life-sustaining treatment no longer aligns with a patient's stated goals of care. Nearly 42% of intensive care unit deaths involve withdrawal of such measures. Despite its legal acceptance, terminal extubation remains a nuanced decision, particularly in patients with spinal cord injury (SCI). Approximately 18,000 new traumatic SCIs o …

03.09.2026journal-article

Oxford Open Digital Health

Leveraging Digital Pathology to Enhance Breast Cancer Diagnosis in Low-Resource Settings: A Cross-Sectional Study of Major Histopathology Laboratories in Uganda

Agnes Rwashana Semwanga, James Serubugo, Vincent Micheal Kiberu, Hawa Nalwoga, Evelyn Kigozi Kahiigi, Nazarius Mbona Tumwesigye, Sam Kalungi

ABSTRACT Background Breast cancer remains a leading cause of morbidity and mortality among Ugandan women, particularly in rural areas where pathology infrastructure and specialist access are limited. This study aimed to improve diagnostic efficiency and accuracy by digitizing breast cancer slides and implementing a web-based histopathology system to support remote diagnostics. Methods A total of 100 glass slides from core breast biopsy samples were digitized using an Aperio AT2 slide scanner. A web-based Breast His …

03.09.2026journal-article

Journal of Addiction Medicine

Outpatient Direct Initiation of Injectable Buprenorphine From Methadone: A Case Series

Daniel Liauw, Ram Sundaresh, Dinah Applewhite, Jessica R. Gray, Laura Kehoe, Evangeline Kennedy, Susan Regan, Sarah Wakeman

Objectives: Published protocols for directly initiating injectable buprenorphine from full opioid agonists (“direct-to-inject” or DTI) have largely described patients with active or recent fentanyl use. Among patients with opioid use disorder (OUD) in remission, transitioning from methadone to buprenorphine with sublingual buprenorphine can be challenging. Published experience utilizing DTI buprenorphine from methadone is limited. Methods: In this retrospective cohort study, we identified 15 patients across an acad …

03.09.2026journal-article

European Journal of Clinical Microbiology & Infectious Diseases

Comparative efficacy of oral antibiotics against intracellular populations of uropathogenic Escherichia coli and bladder cell inflammatory response

Michelle Kalu, Peter Jorth, Annie Wong-Beringer

Abstract Predisposing risks to recurrent urinary tract infections caused by uropathogenic Escherichia coli (UPEC) include the formation of intracellular bacterial communities (IBCs) as a reservoir for persistence within bladder epithelial cells and sustained elevation of proinflammatory mediators that interfere with wound healing. Here we investigated the efficacy of oral agents (nitrofurantoin, doxycycline, and gepotidacin) in intracellular bacterial clearance and proinflammatory signaling in bladder epithelial ce …

03.09.2026journal-article

Frontiers in Medicine

Impact of antibody-mediated rejection detected on one-year protocol biopsies on long-term kidney allograft survival

Galina Severova, Vlatko Karanfilovski, Lada Trajceska, Irena Rambabova-Bushljetik, Pavlina Dzekova-Vidimliski, Igor G. Nikolov, Nikola Gjorgjievski, Gordana Petrushevska, Slavica Kostadinova-Kunovska, Goce Spasovski, Ninoslav Ivanovski

Introduction Kidney transplantation undoubtedly remains the best way of treatment for end-stage chronic kidney disease. Enormous success has been achieved in improving short-term graft survival, but long-term graft survival has presented a great challenge, especially from an immunological perspective. This study aimed to evaluate the impact of antibody-mediated rejection (ABMR) detected on one-year protocol graft biopsies in kidney transplant recipients with stable graft function on 10-year death-censored graft sur …

03.09.2026journal-article

Frontiers in Surgery

Artificial intelligence in gangrenous cholecystitis: advances in risk factor identification and preoperative prediction—a scoping review

Ping Wang, Xingyu Chen, Tianjiao Hao, Jisong Chen

Background Gangrenous cholecystitis (GC) is a severe pathological subtype of acute cholecystitis, yet its preoperative diagnostic rate remains below 10%. Conventional scoring systems based on logistic regression demonstrate limited predictive performance. Artificial intelligence (AI) approaches may offer improved risk stratification, but the evidence base remains limited. Methods A scoping review was conducted across PubMed, Web of Science, Embase, and CNKI databases for publications from January 2020 to June 2026. …

03.09.2026journal-article

Frontiers in Medicine

A comparative study on mental health outcomes in patients with rheumatoid arthritis and knee osteoarthritis

Meng Jia, Shuang Wang, Chenxi Yu, Ping Li

Objective This study aimed to analyze the current status and differences in mental health levels between patients with rheumatoid arthritis (RA) and knee osteoarthritis (OA) to provide a reference for clinical nursing interventions. Methods Using convenience sampling, patients with knee osteoarthritis and rheumatoid arthritis who were hospitalized at a tertiary first-class hospital in Shandong Province from May to August 2025 were selected for a cross-sectional survey, and the differences in mental health levels be …

03.09.2026journal-article

Frontiers in Medicine

Syphilis causing elevation of anti-CCP: a case report of medical mimicry

Tara Subrahmanyan, Ashley Martinez, Justin Baik, Matthew Kelly

Introduction Infection with Treponema pallidum, or syphilis, is often called the “Great Imitator” because of its propensity for atypical presentations and non-specific symptoms. In addition, syphilis has been shown to create false-positive results for common tests, including Lyme disease, HIV, and multiple autoimmune conditions. One that has not been documented is anti-cyclic citrullinated peptide (anti-CCP). Anti-CCP is a highly specific test for Rheumatoid Arthritis. However, in this case, syphilis led to false-e …

03.09.2026journal-article

Frontiers in Neurology

Brain-computer interface for post-stroke upper-limb recovery: a systematic review integrating clinical efficacy with neuroplasticity evidence

Yu Wu, Feilong Zhu, Qiumeng Dong, Ming Zhang

Objective Over 20 systematic reviews have evaluated brain-computer interface (BCI) training for post-stroke upper-limb rehabilitation, but published syntheses have focused predominantly on clinical efficacy, and the neuroplasticity mechanisms remain comparatively underexplored. This review integrates pooled clinical efficacy with a structured synthesis of neuroplasticity evidence from the same trials. Methods PubMed, Embase, CINAHL via EBSCO, Web of Science, Scopus, and Cochrane CENTRAL were searched from inception …

03.09.2026journal-article

Frontiers in Psychiatry

Psychiatric comorbidities in hoarding disorder: a structured clinical interview study

Nami Nishida, Keitaro Murayama, Hirofumi Tomiyama, Kenta Kato, Kang Mingi, Kou Matsukuma, Makoto Kawahito, Kana Tsunoda, Takuro Kamio, Ayaka Shuto, Tomohiro Nakao

Objective Hoarding disorder (HD) is a psychiatric condition characterized by persistent difficulty in discarding possessions, leading to significant clutter and functional impairment. HD is often comorbid with other psychiatric disorders, but previous findings of these comorbidities are inconsistent due to limited structured assessments. This study investigates the psychiatric comorbidities in individuals with HD using structured, clinician-administered interviews. Methods Between 2016 and 2022, 68 individuals diag …

03.09.2026journal-article

Frontiers in Surgery

A transformer-based multi-modal fusion framework for laryngeal lesion classification using contact endoscopy

Yunjing Duan, Wei Li

Purpose This study introduces a novel multi-modal transformer-based framework that integrates clinical data, radiomic features, and deep learning representations for automated classification of laryngeal lesions from contact endoscopy images. Methods We retrospectively enrolled 300 patients with laryngeal lesions from three independent medical centers (Centers A, B, and C), acquiring 7,847 contact endoscopy images with narrow band imaging. Clinical variables (18 features), radiomic features extracted using PyRadiom …

03.09.2026journal-article

Current Opinion in Otolaryngology & Head & Neck Surgery

Contemporary management of tympanic membrane retraction

Johan Bastianpillai, Paraskevi Karamitsou, Ananth Vijendren

Purpose of review Tympanic membrane retraction is a common condition in otology. In most cases, it does not lead to significant complications. However, because there is a risk of progression to cholesteatoma, accurate diagnosis and appropriate management are crucial. In this review, we present the diagnostic strategy and the conservative or surgical management options available for patients with tympanic membrane retractions. Recent findings Diagnosis is primarily clinical and tympanic membrane retractions may be i …

03.09.2026journal-article

American Journal of Surgical Pathology

Expanding the Morphologic, Clinical, and Molecular Spectrum of Succinate Dehydrogenase A (SDHA)-Deficient Renal Cell Carcinoma

Shivani Kandukuri, Anandi Lobo, Harrison Tsai, Manju Aron, Shilpy Jha, Michelle S. Hirsch, Sambit Mohanty

Succinate dehydrogenase (SDH)-deficient renal cell carcinoma (RCC) is defined by mutations in SDH subunits (A, B, C, or D) and is associated with hereditary paraganglioma-pheochromocytoma syndrome and gastrointestinal stromal tumors (GISTs) in some patients. This multi-institutional study analyzed 5 SDHA-deficient RCCs using morphology, immunohistochemistry (IHC), and next-generation sequencing (NGS). Patients had a median age of 40 years with male predominance (4:1). Initially, tumors were diagnosed as SDHA-defici …

03.09.2026journal-article

Journal of Integrative and Complementary Medicine

Bounded Integration: The Regulation of Traditional and Complementary Medicine in Türkiye

Ayşe Polat

Introduction: This study examines Türkiye’s recent policies on traditional and complementary medicine (T&CM), focusing on how centralized governance has expanded and regulated T&CM while maintaining it within biomedical standards. It analyzes how the state-led integration proceeds through control, standardization, and oversight, generating both formal incorporation and persistent frictions. Methods: The study is based primarily on qualitative content analysis of official Ministry of Health materials, including laws …

03.09.2026journal-article

Frontiers in Surgery

Giant adrenal pseudocyst with unclear preoperative origin: a case report and literature review

Shouyi Long, Bin Xiong, Zhen Long, Bo Li, Xiujun Yuan, Shulian Chen

Introduction Adrenal cysts are relatively rare, and most are nonfunctional and lack specific clinical manifestations, often being discovered incidentally during imaging examinations. For giant adrenal cysts with a maximum diameter exceeding 10 cm, especially when accompanied by degenerative changes such as hemorrhage, fibrosis, and calcification, compression of adjacent organs and obscuration of anatomical planes may increase the difficulty of determining the origin preoperatively, and they may even be misdiagnosed …

03.09.2026journal-article

Measurement Science and Technology

Hybrid loss-driven source-free domain adaptation with post-hoc explainability for bearing fault diagnosis

Chenghao Yan, Dongsheng Liu, Tong Wu, Renjie Sun, Yahui Chen, Wenjun Huang, Zhongqiu Liu

Abstract While conventional fault diagnosis excels in steady-state scenarios, reliable detection under variable operating conditions remains a critical challenge in modern industrial drive systems. Although domain adaptation techniques address cross-domain distribution shifts, their deployment is often hindered by data privacy concerns and the impracticality of labeling massive target data in real-world factories. Furthermore, standard methods typically require concurrent access to source and target data, which vio …

03.09.2026journal-article

Journal of Hospital Medicine

Reducing inpatient falls with a mobility‐first, multidisciplinary intervention at a VA Medical Center

Ryan Duffy, Padideh Imenikashani, Tymeeka Davis, Steven Fairbanks, Folake Ogunmola, Laura Previll, Brian Schneider

Abstract Inpatient falls are a common and preventable source of harm among hospitalized patients. At a Veterans Health Affairs medical center, we implemented a mobility‐first, multidisciplinary intervention using sequential Plan‐Do‐Study‐Act cycles, including redesigned activity orders to “mobilize unless contraindicated,” physical therapist‐led education, and interdisciplinary fall huddles with rapid feedback. Over 18 months, total falls decreased by 34%, from 7.6 to 5.0 per 1000 bed‐days, and injurious falls decr …

03.09.2026journal-article

Journal of Hospital Medicine

National trends in pathogen‐specific diagnoses and outcomes among hospitalizations for infectious diarrhea

David Wong Arias, Spencer R. Goble, Mauricio Torrealba

Abstract Background The diagnostic evaluation of infectious diarrhea has evolved with increasing adoption of multiplex gastrointestinal nucleic acid amplification tests and changing diagnostic strategies for Clostridioides difficile . Objectives We aimed to assess changes in inpatient pathogen‐specific documentation rates and clinical outcomes on a national level. Methods We performed a retrospective cross‐sectional study using the National Inpatient Sample from 2016 to 2023. Adult hospitalizations with a primary d …

03.09.2026journal-article

Journal of Medicine and Health Research

Psychiatric Morbidity among Fresher Medical Students in a Nigerian Tertiary Institution: A Mixed-Methods Study

Adeoye Oyewole, Adedotun Oyewole, Samson Ojedokun, Chukwunonso Ndulue

Background: The transition into medical school represents a major developmental, academic, and psychosocial challenge for young adults. These challenges may be particularly significant among freshers. The study aimed to determine the prevalence and predictors of psychiatric morbidity among freshers in the medical school of a public university in Nigeria. Methods: A convergent mixed-methods design was used for the study. The quantitative component involved a cross-sectional survey of first-year medical students usin …

03.09.2026journal-article

Journal of Imaging Informatics in Medicine

Long-PVSUNet: A Longitudinal Deep Learning Framework for Count-Oriented Perivascular Space Segmentation in Brain MRI

Shizuka Hayashi, Lei Fan, Jiyang Jiang, Yang Song, Dadong Wang, Henry Brodaty, Perminder S. Sachdev, Wei Wen

Abstract Enlarged perivascular spaces (ePVS) are small, sparse MRI-visible markers of cerebral small vessel disease and brain ageing. Their size, low contrast, and severe foreground–background imbalance make automated segmentation challenging. Existing methods are mainly cross-sectional and do not model temporal consistency, limiting their utility for tracking longitudinal change. We developed Long-PVSUNet, a two-timepoint framework for count-oriented ePVS segmentation on paired baseline/follow-up T1-weighted and F …

03.09.2026journal-article

European Heart Journal: Acute Cardiovascular Care

Electrocardiographic Principles for the Diagnosis of Occlusion Myocardial Infarction

Hans C Helseth, Pedro Mansur, Mazen El-Baba, Jesse T T McLaren, José Nunes de Alencar, Stephen W Smith

Abstract The ECG is the only rapid, noninvasive diagnostic test that can identify coronary occlusion warranting reperfusion therapy at the bedside. The diagnostic paradigm of STEMI/NSTEMI is based on millimeter ST Elevation (STE) criteria as stated in the 4th Universal Definition of MI. It has identified candidates for emergent reperfusion for decades, but is limited by the low sensitivity and specificity of STE for acute coronary occlusion. A paradigm shift to Occlusion MI/Non-Occlusion MI (OMI/NOMI) has been prop …

03.09.2026journal-article

South Asian Journal of Cancer

AsiaPacific Geriatric Oncology Society (AGOS; virtual tumour board no 9) real world consensus for management of endometrial cancer with multiple co-morbidities and polypharmacy in the older patient

Purvish M Parikh, Nikhil Ghadyalpatil, Dharshitha Varigonda, TVSVGK Tilak, Bipinesh Sansar, Karishma De, Mosale Venkatesha Chandrakant, VenkataSampath Vankamamidi, Steve Paul Manjaly, Athika Shaik, Madhusudhan Perumandla

The AsiaPacific Geriatric Oncology Society (AGOS) conducts a monthly virtual tumour board. One of the cases discussed was a 70-year-old female with Stage IIIA endometrial cancer, multiple co-morbidities and polypharmacy. A group of experts discussed the challenges in the real world with specific reference to improving Timed Up and Go (TUG) score, managing the effect of co-morbidities, preventing risk due to drug-drug interactions and evaluating the risk of delaying anti-cancer therapy in an attempt to improve patie …

03.09.2026journal-article

Lupus

Clinical characteristics of patients with primary antiphospholipid syndrome and “single” antiphospholipid antibody: Retrospective results from the APS ACTION clinical database and repository (“registry”)

Silvia Grazietta Foddai, Irene Cecchi, Massimo Radin, Laura Bertolaccini, Danieli de Andrade, Maria Tektonidou, Vittorio Pengo, Chary Lopez-Pedrera, Diana Paredes-Ruiz, Howard Michael Belmont, Paul R. Fortin, Denis Wahl, Ware Branch, Maria Gerosa, Guilherme de Jesus, Zhouli Zhang, Tatsuya Atsumi, Maria Efthymiou, Laura Andreoli, Esther Rodriguez, Michelle Petri, Ricard Cervera, Bahar Artim-Esen, Rosana Quintana, Jason S. Knight, Rohan Willis, Reyhan Kose Cobanoglu, Hannah Cohen, Doruk Erkan, Savino Sciascia

Objective While triple antiphospholipid antibody (aPL) positivity is associated with a higher risk of thrombosis, the clinical significance of single aPL positivity remains unclear. This study aimed to assess the prevalence, clinical characteristics, and cardiovascular disease (CVD) risk profile of persistently single aPL-positive primary antiphospholipid syndrome (PAPS) patients. Methods We conducted a retrospective analysis for APS patients from the APS ACTION registry with confirmed persistent single aPL positiv …

03.09.2026journal-article

Journal of Intensive Care Medicine

Maternal Sepsis for the Intensivist: Recognition, ICU Triage, and Pregnancy-Adapted Management

Felicia Chen

Sepsis in pregnancy and the puerperium is a leading, and often preventable, cause of maternal critical illness. This narrative review summarizes pregnancy-adapted physiology, epidemiology, clinical recognition, intensive care unit triage, and management, with particular emphasis on decision-making around ICU admission and the practical delivery of organ support for intensivists who do not routinely manage obstetric patients.