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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

Journal of Cancer Research and Clinical Oncology

Knowledge and attitude towards breast and cervical cancer screening among women caregivers of cancer patients: a cross-sectional study from a tertiary cancer centre in India

Mahak Gupta, Akshay Dinesan, Lahari Udyawar, Ashmitha Prasad, Arathi P Rao, Umesh Velu, Ankita Mehta, Jayashree N P, Sharada Mailankody, Shirley Lewis

Abstract Purpose Female informal caregivers, who provide critical support to cancer patients, may face substantial caregiver burden that may adversely affect their participation in preventive healthcare. We aimed to evaluate their knowledge and attitudes toward breast and cervical cancer screening and its correlation with caregiver burden. Methods A cross-sectional study was conducted at a tertiary cancer centre using a structured questionnaire, which assessed demographics, caregiving burden (using the Zarit Burden …

02.09.2026journal-article

IECCMEXICO

Patient-Centered Facial and Orofacial Reconstruction After Cutaneous Cancer Resection: Integrating Function, Aesthetics, and Quality of Life

Sandro José Nava Daza, Erick Fernando Flores García, Luis Felipe Espinal Pérez, Oscar Emmanuel Garcia Moreno, Slendy Dayanna Gil Ayala, Diego Clemente Moreno, Gustavo Adrián Pineda Yañez, Cristian Raziel Pacheco Hernandez, Ashley Jesús García Cortes

Facial and orofacial reconstruction following cutaneous oncologic resection represents a complex clinical challenge in which tumor control must be integrated with preservation of function, restoration of facial appearance, and maintenance of quality of life. This study analyzed contemporary reconstructive strategies used after facial skin cancer excision, with emphasis on the relationship between defect characteristics, anatomical location, surgical technique, functional recovery, aesthetic integration, postoperati …

02.09.2026journal-article

Frontiers in Immunology

Gift of nature: non-human-derived exosomes showing application prospects in periodontitis treatment

Hongbo Fei, Zhuoran Wang, Yujiao Li, Hongchen Sun, Xiuping Meng, Hongbing Lin

Periodontitis, a chronic inflammatory disorder, results in tooth loss and adversely affects oral and systemic health. Current therapies fail to effectively regenerate bone loss caused by inflammation. Human stem cell-derived exosomes have emerged as important mediators of tissue regeneration and inflammation modulation in periodontitis, yet their clinical use faces ethical and technical challenges. Non-human-derived exosomes present a viable alternative, leveraging their ability to enhance tissue repair, reduce inf …

02.09.2026journal-article

Dysphagia

The Relationship between Swallowing Muscle Mass and Tongue Muscle Strength and Endurance in Head and Neck Cancer Patients

Javier Hurtado-Oliva, Lucy Núñez-Miranda, Guus van der Valk, Jeroen Vister, Anouk van der Hoorn, Inge Wegner, Gyorgy B. Halmos

Abstract Sarcopenic dysphagia is a significant concern in head and neck cancer (HNC) patients and contributes to malnutrition, aspiration pneumonia and poor clinical outcomes. Although tongue strength (TS) and swallowing muscle mass (SwMM) are central components of swallowing physiology, their relationship in HNC patients remains unclear. This study investigated the association between SwMM and TS and tongue endurance in HNC patients. This prospective cross-sectional study was conducted at the University Medical Ce …

02.09.2026journal-article

Journal of Pressure Vessel Technology

Controlling Mechanism of Local Rapid Cooling Heat Treatment to Reduce Internal Cladding Residual Stress of Pressure Vessels

Yun Luo, Yanbin Liu, Yao Zhang, Wenbin Gu, Wenchun Jiang, Qian Zhang

Abstract Due to different material parameters between the cladding layer and the base metal, significant tensile residual stresses still remain within the internal cladding layer after traditional heat treatment, seriously affecting the service safety of pressure vessels. Local rapid cooling heat treatment is an effective method to reduce the tensile residual stress in the cladding layer until a compressive stress state is achieved. In this paper, the influence of local rapid cooling heat treatment process paramete …

02.09.2026journal-article

Healthcare

Economic Factors Associated with AI Adoption in Oncology: Cost-Effectiveness Perceptions, Reimbursement Readiness, and Return-on-Investment Confidence Among Romanian Healthcare Professionals

Dragoș-Ciprian Negoiță, Livia Stanga, Horia Silviu Branea, Ciprian Ilie Roșca, Adrian Cosmin Ilie, Ovidiu Rosca

Background and Objectives: Artificial intelligence (AI) tools promise efficiency gains in oncology, yet adoption depends on economic factors that remain under-characterized in Eastern European health systems. We quantified AI economic literacy, cost-effectiveness perceptions, reimbursement readiness, and return-on-investment (ROI) confidence among Romanian oncology professionals; we described candidate economic adoption profiles and examined whether sector was associated with the strength of the indirect associatio …

02.09.2026journal-article

Scientific Reports

Subsite-specific prediction of lymphatic spread in head-and-neck cancer using a mixture of hidden Markov models

Yoel Pérez Haas, Roman Ludwig, Julian Brönnimann, Esmée L. Looman, Noemi Bührer, Panagiotis Balermpas, Tineke E. H. van Zoe-Meijer, Johannes A. Langendijk, Jan Unkelbach

Abstract Head-and-neck squamous cell carcinomas (HNSCC) metastasize to neck lymph nodes. Radiation treatments include the elective irradiation of lymph node levels (LNLs) at risk of harboring occult (clinically undetected) metastases. We present a statistical model for personalized estimation of ipsilateral occult metastases risk given an individual patient’s clinical LNL involvement, T-stage, and tumor subsite. Each LNL is described by a binary random variable: healthy/metastatic. Lymphatic cancer progression is d …

02.09.2026journal-article

Konya Journal of Engineering Sciences

BRAIN TUMOR SEGMENTATION USING U-NET-BASED DEEP LEARNING MODELS

Merve Kayar, Emine Okumuş, Rıdvan Saraçoğlu

When examining segmentation methods developed for brain tumor detection, a significant gap exists in the comparative performance analysis of standard and hybrid U-Net models. This study systematically evaluates four Convolutional Neural Network (CNN) models to address this gap, particularly regarding the practical effectiveness of integrating complex, pre-trained encoders: Classic U-Net, U-Net+VGG-16, U-Net+ResNet50, and U-Net++. The BraTS 2019 dataset was used for training and testing the models (with 5-fold cross …

02.09.2026journal-article

Skin Health and Disease

Dermatology residency education in the treatment of testosterone-induced acne and androgenic alopecia in trans men: a cross-sectional survey of academic dermatologists in the USA

Thinh Q Nguyen, Zachary Neubauer, Angela Zaladonis, Sherry Yang

This cross-sectional survey study explores the experience, comfort and knowledge of dermatology residents and attendings in managing testosterone-induced acne (TiAV) and androgenic alopecia (TiAGA) in trans men. While most respondents reported some level of comfort treating these conditions, objective knowledge scores were modest and revealed gaps across both conditions, particularly TiAGA. Our findings suggest that current LGBTQIA+-focused education may be perceived as adequate but may not translate into knowledge …

02.09.2026journal-article

Indian Journal of Surgical Oncology

Patient-Reported Body Image, Pain, and Satisfaction After Breast-Conserving Surgery, Mastectomy, and Mastectomy With Reconstruction: A Cross-Sectional Cohort Study

Noam Weiner, Eran Sharon, Tal Kind, Helit Nakar, Tomer Mimouni, Yehonatan Noyman, Lior Har-Shai, Assi Levi

Abstract Background Surgical treatment for breast cancer may affect long-term body image, pain, and satisfaction, yet the relative contribution of surgical approach and patient-level factors remains uncertain. We evaluated patient-reported outcomes after breast-conserving surgery, mastectomy without reconstruction, and mastectomy with reconstruction. Methods In this cross-sectional cohort study, 230 women treated between 2015 and 2021 at a single Israeli tertiary center completed an investigator-developed Hebrew te …

02.09.2026journal-article

Pediatric Blood & Cancer

Global Efforts to Reduce Paediatric Cancer Care Disparities in Radiotherapy: A Decade Change

Raymond B. Mailhot Vega, Daniel J. Indelicato, Jeanette Parkes, Natia Esiashvili, Josué Hernández Benítez, Miriam Mikhail‐Lette, Olivera Cirajc Bjelac, Daniel Berger, Eva Ciurana, Yavuz Anacak, Lisbeth Cordero‐Mendez

ABSTRACT Background We present an update on the status, needs and challenges faced by paediatric imaging and radiotherapy (RT) programmes globally after a previous survey conducted by the International Atomic Energy Agency (IAEA) 10 years prior. Methods We developed and distributed a 121‐question survey to radiation oncologists, medical physicists and radiologists from participating Member States (MSs). It included questions on radiation oncology, imaging, nutrition, human capacity to support these services, qualit …

02.09.2026journal-article

The American Surgeon™

Late Recurrence Matters: Delayed Hepatic Metastasis After Rectal Neuroendocrine Tumor

Jeremy N. Burt, Arnold M. Conforti

Rectal neuroendocrine tumors (NETs) are rare, typically indolent neoplasms arising from enterochromaffin cells that may recur locally or distantly after long disease-free intervals. We report a case of robotic partial hepatectomy for delayed hepatic metastasis from a rectal NET. Methods: A 68-year-old woman was referred for evaluation of a liver lesion suspicious for metastatic rectal NET. Ten years earlier, a 4 mm rectal NET had been identified on screening colonoscopy and treated with endoscopic mucosal resection …

02.09.2026journal-article

Acta Poloniae Pharmaceutica - Drug Research

Multidrug-Resistant Acinetobacter baumannii: an Overview of Therapeutic Options and Treatment Regimens

Paweł Sacha, Mateusz Modzelewski, Łukasz Korczak, Elżbieta Tryniszewska

Acinetobacter baumannii, a Gram-negative coccobacillus, is an opportunistic pathogen originating from the natural environment (soil, water, and plants). This bacterium is common in the human skin microbiota and is capable of colonizing diverse environments (e.g., hospital environments). A. baumannii is a bacterium naturally resistant to multiple antibiotic classes. In recent years, due to its ability to acquire resistance genes from other bacteria, it has become a critical threat, particularly in intensive care uni …

02.09.2026journal-article

Journal of Clinical Medicine

Male Breast Cancer: An Analysis of Clinicopathological Features, Treatment Patterns, and Survival Outcomes over 10 Years from a Tertiary Center

Hüseyin Tepetam, Cemal Ugur Dursun, Mustafa Mert Hanilce, Solen Nasifoglu, Nursena Ciflik, Duygu Gedik, Sermin Kokten, Sule Karabulut Gul

Background/Objectives: Male breast cancer (MBC) is a rare malignancy accounting for less than 1% of all breast cancers, and current treatment recommendations are largely extrapolated from studies in women. We aimed to evaluate the clinicopathological characteristics, treatment patterns, survival outcomes, and prognostic factors of male breast cancer patients treated at a tertiary referral center. Methods: We retrospectively reviewed 45 patients with histopathologically confirmed MBC treated between January 2015 and …

02.09.2026journal-article

Journal of Clinical Medicine

Spermatocytic Tumor Arising in a Cryptorchid Testis: A Case Report and Narrative Review

Laurențiu Augustus Barbu, Stelian-Stefaniță Mogoantă, Liliana Cercelaru, Marius Cristian Marinaș, Nicolae-Dragoș Mărgăritescu, Mihai Popescu, Valentina Căluianu, Gabriel Florin Răzvan Mogoș, Liviu Vasile, Tiberiu Stefăniță Țenea Cojan

Background: Spermatocytic tumor (ST) is a rare non-GCNIS-derived testicular germ cell neoplasm that predominantly affects older men and generally follows an indolent course. Its occurrence in a cryptorchid testis is exceptionally uncommon. Methods: A narrative literature review was conducted using the PubMed database, including studies published up to August 2026. The search used combinations of the terms “spermatocytic tumor”, “spermatocytic seminoma”, “cryptorchidism”, “undescended testis”, “immunohistochemistry” …

02.09.2026journal-article

Cancers

Impact of Post-Primary Treatment Hormone Replacement Therapy on Survival in Women with Cervical Cancer

Hee Joong Lee, Banghyun Lee

Background/Objectives: The effects of hormone replacement therapy (HRT) after primary treatment on survival outcomes in women with cervical cancer (CC) remain unclear. This nationwide cohort study evaluated the association between post-primary treatment HRT and overall survival (OS) in women with CC. Methods: We identified 15,261 women aged ≤60 years with CC who received primary treatment using the Korean Health Insurance Review and Assessment Service database. HRT users were defined as women who received HRT presc …

02.09.2026journal-article

Surgical and Radiologic Anatomy

Preoperative CT-based 3D analysis of middle colic vein anatomy for complete mesocolic excision in right-sided colon cancer: a retrospective cohort study from a prospective clinical trial

Vladimir Zivanovic, Dejan Ignjatovic, Javier Armando Luzon, Bojan Vladimir Stimec

Abstract Purpose Complete mesocolic excision requires central mesenteric dissection near the middle colic vein (MCV) confluence, where anatomic variability may increase operative risk. However, MCV multiplicity, confluence patterns, and relationships to the middle colic artery (MCA) are not sufficiently defined. Methods We performed a retrospective secondary analysis of 300 consecutive three-dimensional vascular reconstructions from a prospectively maintained database of patients undergoing surgery for right-sided …

02.09.2026journal-article

JAMA Surgery

An Exosomal Signature for Preoperative Detection of Occult Liver Metastasis in Pancreatic Cancer

Takayuki Noma, Jingyang Yin, Junfeng Zhang, Caiming Xu, Mitsuro Kanda, Song Cheol Kim, Yuji Morine, Mitsuo Shimada, Vincent Chung, Ali H. Zaidi, Daniel Von Hoff, Huaizhi Wang, Ajay Goel

Importance Early liver metastasis (early-LiM) after pancreatectomy represents an aggressive biological phenotype of pancreatic ductal adenocarcinoma (PDAC) and is associated with markedly poor survival. Reliable preoperative biomarkers to identify occult hepatic micrometastasis remain lacking. Objective To develop and externally validate a circulating exosomal microRNA (exo-miRNA)–based machine learning model for preoperative detection of occult early-LiM in PDAC. Design, Setting, and Participants This multicenter …

02.09.2026journal-article

CRO (Clinical & Refractive Optometry) Journal

Teprotumumab Treatment for Thyroid Eye Disease in a Patient with Pre-Existing Hearing Loss: Worth the Risk?

Wyatt Hyke, Cheryl Polinsky, Lisa Schifanella

Thyroid eye disease (TED) can lead to reduced vision from corneal scarring or optic nerve compression. Other manifestations of thyroid eye disease that can be troubling for TED patients include proptosis, extraocular muscle restrictions and diplopia, soft tissue swelling, dry eye, and conjunctival injection over the extraocular muscle insertions. Intravenous teprotumumab was approved by the Food and Drug Administration (FDA) in 2020 for the treatment of active TED. Teprotumumab can cause potentially permanent sever …

02.09.2026journal-article

Animals

Clinical Findings, Treatment and Long-Term Outcome in 37 Cats with Non-Associative Immune-Mediated Hemolytic Anemia: A Retrospective Observational Study of Two Treatment Cohorts

Lisa-Maria Kulmer, Pavlos G. Doulidis, Iwan A. Burgener, Nicole Luckschander-Zeller

Background: Non-associative immune-mediated hemolytic anemia (IMHA) is uncommon in cats and carries substantial mortality. Glucocorticoids are first-line treatment, and cyclosporin A (CsA) is frequently added, but data on the clinical course and long-term outcome are limited. We describe clinical findings, treatment, adverse events and outcome in cats with non-associative IMHA. Methods: In this retrospective observational single-center study (October 2014–October 2024), 37 cats diagnosed by the 2019 ACVIM consensus …

02.09.2026journal-article

Water Science & Technology

Antimicrobial resistance control in wastewater treatment plants: from removal efficiency to resistance-risk reduction

Timoth Mkilima

ABSTRACT Flow diagram showing AMR-related constituents moving from municipal, hospital-influenced, and industrial or pha rmaceutical wastewater through primary treatment, biological treatment, solids separation, and disinfection or advanced polishi ng. Outputs include treated effluent, reclaimed water, sludge or biosolids, and residual streams. These connect to receiving wat ers, irrigation or reuse, land application or further handling, and return-to-treatment or separate management pathways. Resista nce-risk endp …

02.09.2026journal-article

Scientific Reports

Extensively drug-resistant ESBL-producing enterobacterales and coexisting antimicrobial resistance genes are associated with mortality in critically ill patients with cancer

Samah Mohammed Refay, Noha Gaber Sayed, Waleed M. El Kazzaz

Abstract ESBL-producing bacteria are a problem in patients with cancer. The emergence of XDR phenotypes with ESBLs increases mortality. We aimed to evaluate ESBL-producing bacteria, the prevalence of MDR and XDR phenotypes, ESBL genes, and mortality predictors in patients with cancer in the ICU. Different clinical cultures were collected from patients in oncology ICUs. We used the VITEK2 system to identify isolates and assess antibiotic sensitivity, and the combination disk method to detect ESBL phenotypes. β-lacta …

02.09.2026journal-article

Problems of Gathering Treatment and Transportation of Oil and Oil Products

STABILIZATION OF MULTIPHASE HYDROCARBON FLOW IN OIL AND GAS GATHERING PIPELINES IN FIELDS WITH COMPLEX TOPOGRAPHY

E.F. Khamatdinov, G.E. Korobkov

Integrated oil and gas gathering and transportation systems have become widely used in the development of remote fields. These areas are often characterized by significant logistical and infrastructural constraints. When organizing joint collection of oil and gas via field gathering pipelines at oil and gas, as well as oil and gas condensate fields, certain factors may arise that adversely affect the stable transportation of multiphase hydrocarbon flows to wellstream treatment facilities.This creates tasks whose so …

02.09.2026journal-article

Nature Cell Biology

Multi-stromal organoid co-culture modelling reveals epithelial–fibroblast heterogeneity in pancreatic cancer and pancreatitis

Wenlong Li, Muntadher Jihad, Eloise G. Lloyd, Marta Zaccaria, Gianluca Mucciolo, Gideon Nsubuga, Alwin Koonan-Lonappan, Joaquín Araos Henríquez, Priscilla S. W. Cheng, Sneha Harish, Sally Mills, Paul M. Johnson, Weike Luo, Alejandro Alonso Montero, Rebecca Brais, Alex Deamer, Ania M. Piskorz, Julia Jones, Jodi L. Miller, Bristi Basu, Paul D. W. Kirk, Mireia Vallespinos, Giulia Biffi

Abstract Interactions between epithelial cells and fibroblasts influence disease progression and treatment response in pancreatic ductal adenocarcinoma (PDAC). While the diversity of fibroblasts in PDAC is increasingly recognized, it remains unclear how these cells differ from fibroblasts found in pancreatic inflammation. Chronic pancreatitis is a stroma-rich inflammatory disease and a risk factor for PDAC, making it a useful setting to study how epithelial cells and fibroblasts change during disease. Here we compa …