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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

Current Oncology

Identifying Distinct Quality-of-Life Profiles in Prostate Cancer Patients: A Latent Profile Approach

Linan Cheng

Background: Prostate cancer substantially affects patients’ quality of life (QoL). However, whether distinct QoL profiles exist among patients remains unclear. Objective: This study aimed to identify latent QoL profiles among patients with prostate cancer and explore factors associated with profile membership. Methods: A cross-sectional study included 200 patients with prostate cancer recruited from a tertiary hospital in China between May and December 2024. QoL was assessed using the Functional Assessment of Cance …

02.09.2026journal-article

Journal of Surgical Oncology

Morbidity and Mortality of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in Patients Aged 70 Years and Older: A Two‐Center 10‐Year Experience

Ali Ediz Kıvanç, Mehmet Oduncu, Pırıltı Özcan, Özgül Düzgün, Neşet Köksal

ABSTRACT Background and Objectives Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is established for peritoneal surface malignancies, but its use in older patients is debated. We assessed CRS‐HIPEC morbidity and mortality in patients aged ≥ 70 years using a cohort of younger patients as a comparator. Methods We retrospectively reviewed consecutive patients aged ≥ 70 and < 70 undergoing CRS‐HIPEC for peritoneal carcinomatosis at two centers (2017−2026). Peritoneal carcinomatosis i …

02.09.2026journal-article

Biomolecules

Post-Exposure JNJ-26366821 Treatment Attenuates Systemic Inflammation and Limits Cardiotoxic Risk

Nabarun Chakraborty, Gregory P. Holmes-Hampton, Lily S. Neff, Vidya P. Kumar, Swapna Kannan, Amrita Cheema, Chandan Guha, Sanchita P. Ghosh, Rasha Hammamieh

Introduction: Thrombopoietin mimetics (TPOm) are known to increase blood cell counts, thereby ameliorating various diseases, including cardiomyopathy—a leading cause of mortality because of delayed radiotoxic effects. Previous preclinical studies demonstrated significant survival enhancement following lethal radiation exposure with a single dose of JNJ-26366821 in two mouse strains, CD2F1 and C57BL/6. Materials and Methods: In this study, a single dose of JNJ-26366821 (1.0 mg/kg) or saline was administered 24 h pos …

02.09.2026journal-article

Annals of Surgery

Multidisciplinary Rehabilitation Following Upper Gastrointestinal Cancer Surgery (RESTORE II)

Linda M. O’Neill, Emily Smyth, Neil Kearney, Grainne Sheill, Louise Brennan, Sophie Grehan, Sanela Begic, Fiona Murphy, Ciara Tansey, Niamh Flanagan, Mikel Egaña, Ricardo Segurado, Marie Galligan, Jinbo Zhao, Ciaran M. Fairman, Claire M. Timon, Suzanne L. Doyle, Deirdre Connolly, Jacintha O’Sullivan, John V. Reynolds, Juliette Hussey, Emer M. Guinan

Objective: RESTORE II compared in an RCT the impact of a 12-week multidisciplinary rehabilitation program versus standard care (SC) on cardiorespiratory fitness and physical function in patients postupper gastrointestinal (UGI) oncologic surgery. Summary of Background Data: The value of multidisciplinary cancer rehabilitation in UGI cancer survivorship is unclear, with limited high-quality data. Methods: Disease-free patients, ≥3 months post-UGI cancer resection were randomized to SC or RESTORE (physiotherapy-led a …

02.09.2026journal-article

Healthcare

Turkish Cross-Cultural Adaptation of the BRIEF-MPI in Older Adults with Cancer: Convergent and Discriminative Validity Compared with the G8 and Clinical Frailty Scale

Sercan On, Haydar Cagatay Yuksel, Semih Sergen Semerci, Ecem Ozdemir, Mustafa Kagan Ozdel, Fatma Ozge Kayhan Kocak

Background: Older adults with cancer represent a heterogeneous population with varying levels of frailty and multidimensional vulnerability. Rapid screening tools are needed to identify patients who may benefit from comprehensive geriatric assessment (CGA). This study aimed to translate and culturally adapt the Brief Multidimensional Prognostic Index (BRIEF-MPI) into Turkish and evaluate its performance in older adults with cancer. Methods: This cross-sectional methodological study included 177 patients aged ≥65 ye …

02.09.2026journal-article

Zeitschrift für Naturforschung C

Investigating the phytochemical composition of Curcuma longa , Azadirachta indica , and Asparagus racemosus using network pharmacology and molecular docking approaches for ovarian cancer therapy

Seneha Santoshi, Aastha Tanwar, Riddhi Bahri, Navya Aggrawal, Deepak Ganjewala, Hina Bansal

Abstract Given that ovarian cancer is a major health concern for women worldwide, we explored the potential of Indian medicinal plants, namely Curcuma longa (Turmeric), Azadirachta indica (Neem), and Asparagus racemosus (Shatavari) via a combined approach of network pharmacology and molecular docking. Initially, bioactive phytochemicals of these plants were sourced from the IMPPAT and SwissTargetPrediction databases, resulting in the identification of 202 compounds along with 1,124 corresponding protein targets. Th …

02.09.2026journal-article

Annals of Surgical Oncology

A Spleen-Preserving Approach Using Partial Splenectomy for Pancreatic Tail Lesions: A Video Case Report

Jonathan Ben Daniel, Krishna Kotecha, Anubhav Mittal, Jaswinder Samra

Abstract Background This video demonstrates a robotic distal pancreatectomy with partial splenectomy for a pseudopapillary neoplasm located at the splenic hilum. Total splenectomy during distal pancreatectomy carries a lifelong risk of overwhelming post-splenectomy infection. Although splenic preservation is preferred, tumors adjacent to the splenic hilum often preclude standard vessel-sparing techniques. Methods A 38-year-old woman presented with an incidentally discovered asymptomatic 4-cm pancreatic tail mass du …

02.09.2026journal-article

Frontiers in Immunology

Tumor-associated macrophages in gastric cancer peritoneal metastasis: orchestrating immune evasion, niche remodeling, and therapeutic resistance

Min Chen, Yuyang Li, Huinan Wang, Xuyang Li, Qian Shen, Lei Yang

Peritoneal metastasis is the most devastating form of progression of gastric cancer, characterized by strong immune suppressive properties and resistance to treatment. Tumor-associated macrophages (TAMs) are the main population of immune cells in the peritoneal cavity and participate in nearly every step of this process. In this Review, we focus on the two major origins of peritoneal macrophages (embryonic-derived GATA6+ resident cells and monocyte-derived CCR2+ cells), and we describe how gastric cancer cells expl …

02.09.2026journal-article

Nutrients

Early Nutritional–Immune Biomarker Trajectories Following Gastrectomy for Gastric Cancer: A Prospective Longitudinal Cohort Study

Catalin Dumitru Cosma, Vlad Olimpiu Butiurca, Dragos Molnar, Cosmin Nicolescu, Calin Molnar, Marian Botoncea

Background: Nutritional deterioration is a common consequence of gastrectomy for gastric cancer and may persist despite standardized perioperative care. However, prospective longitudinal evidence describing the early course of postoperative nutritional recovery remains limited. This study aimed to characterize nutritional recovery trajectories following curative gastrectomy and to evaluate the influence of the extent of gastric resection on postoperative recovery. Methods: A prospective cohort of 239 consecutive pa …

02.09.2026journal-article

Problems of Gathering Treatment and Transportation of Oil and Oil Products

DEVICES FOR CLEANING WATER SURFACES FROM OIL POLLUTION

V.D. Katin, A.N. Lutsenko, M.A. Potetyurin

The problem of environmental pollution from oil and its byproducts has become particularly acute in recent decades. Despite technological advances and stricter safety measures, the transportation and storage of these substances remain high-risk. Regular accidents cause serious damage not only to the economy but, more importantly, to the fragile natural balance. When oil spills into water, the consequences are always dire: fish and microorganisms die, birds lose their ability to fly, natural oxygen exchange is disru …

02.09.2026journal-article

Clinical Cancer Research

Phase I Trial of IL13Rα2-Targeted CAR T-cell Therapy for Recurrent Malignant Glioma: Clinical Results and Pharmacokinetics

Kiwan Kim, Seong-Won Song, Yeongha Jeon, Soyoung Choi, Jiyoun Choi, Sungmin Jun, Ju-Hwang Park, Song-Jae Lee, Nayoung Han, Yun-Sik Dho, Sang-Hoon Shin, Heon Yoo, Kyu-Chang Wang, Ho-Shin Gwak

Abstract Purpose: This single-center, open-label, phase I trial evaluated the safety and tolerability of chimeric antigen receptor (CAR) T cells targeting interleukin 13 receptor α2 (IL13Rα2) in patients with malignant gliomas. Patients and Methods: Adults with World Health Organization grade 3 to 4 gliomas, recurrent after standard treatment and expressing IL13Rα2 (confirmed by immunohistochemistry), received a single intravenous infusion of autologous CAR T cells. Primary objectives were to measure the maximum to …

02.09.2026journal-article

Pure and Applied Chemistry

Development of functional materials for the microplastics removal and treatment in surface water

Fio Febrian, Henny Purwaningsih, Mohammad Khotib

Abstract Microplastics (MPs) are persistent emerging contaminants increasingly detected in aquatic environments and pose potential risks to ecosystems and human health. Conventional single-stage removal technologies may be limited by their treatment efficiency and operational costs. This study aimed to develop a sustainable integrated approach for MP removal by combining aluminum chlorohydrate (ACH) coagulation, polyacrylamide (PAM) flocculation, and column adsorption using phosphoric acid (H 3 PO 4 )-activated bio …

02.09.2026journal-article

Journal of Adolescent and Young Adult Oncology

Caring for Young Adults with Breast Cancer: Providers’ Perspectives on Burnout in a Complex Care Landscape

Caroline Lommer, Lila Schroeder, Caroline Amato, Katie Kenny, Lindsey Sova, Ann Scheck McAlearney, Tari A. King, Ashley P. Davenport, Sara P. Myers

Purpose: While challenges faced by young adults (YAs) aged 18–39 years with breast cancer are well-documented, health care providers’ experiences caring for YAs are underinvestigated. Given high burnout rates among oncologists, this study explores providers’ perspectives about how complex care of YAs may impact emotional well-being. Participants and Methods: A multidisciplinary cohort of breast oncology practitioners from a single Comprehensive Cancer Center were recruited to complete (1) semistructured interviews, …

02.09.2026journal-article

Journal of Clinical Medicine

Beyond Binary ICU Admission: Duration-Sensitive Evaluation and Patient-Level Reclassification of Textbook Outcome After Colorectal Cancer Surgery

Adem Ozcan, Gizem Gunes, Ali Bal, Abdulkadir Unsal

Background/Objectives: Textbook outcome (TO) is an all-or-none composite in which a common, practice-sensitive component may exert disproportionate influence on patient classification. We evaluated the classification impact of binary postoperative intensive care unit (ICU) admission and the additional information retained by actual ICU duration after colorectal cancer surgery. Methods: This retrospective single-center cohort included 241 patients undergoing colorectal cancer resection between 2020 and 2026. Compreh …

02.09.2026journal-article

Journal of Clinical Medicine

Considerations in Using Artificial Intelligence to Simulate Orthodontic Treatment for Implant-Prosthetic Purposes

Amelia Smaranda Roșianu, Sanda Mihaela Popescu, Daniel Adrian Târtea, Stelian Mihai Sever Petrescu, Răzvan Mercuț, Marina Olimpia Amărăscu, Mihaela Ionescu, Ionuț Cristian Reşceanu, Alin Gabriel Ionescu

Background/Objectives: Orthodontic treatment planning software with artificial intelligence has been introduced into practice in recent years. They allow the simulation of the results of orthodontic treatment in several scenarios. The aim of the study was to compare the results of a simulated preimplantation orthodontic treatment plan in cases of oral rehabilitation between two software, with three different setups and their evaluation by an orthodontist. Methods: The in silico study included 10 cases of digital mo …

02.09.2026journal-article

Journal of the Egyptian National Cancer Institute

Use of indocyanine green fluorescence versus patent blue V dye for sentinel lymph node biopsy in early breast cancer, a randomized controlled trial

Muhammad Nida, Ashraf Abdelmoghny, Ahmed G. Osman, Mohammad A. Abd-erRazik, Dina M. Hanafy

Abstract Background Sentinel lymph node biopsy (SLNB) is standard for axillary staging in early breast cancer. While the combination of radioisotope and blue dye (e.g., patent blue V, PBV) remains the standard, it has limitations including logistics, variable identification rate (IR), and allergic potential. Indocyanine green (ICG) fluorescence is a promising alternative, but high-quality comparative evidence is needed. Methods This was a single-center, prospective, randomized controlled trial. Forty patients with …

02.09.2026journal-article

Bioinformatics

Identifying expanding TCR clonotypes with a longitudinal Bayesian mixture model and their associations with cancer patient prognosis, metastasis-directed therapy, and VJ gene enrichment

David Swanson, Alexander Sherry, Cara Haymaker, Alexandre Reuben, Chad Tang

Abstract Motivation Examination of T cell receptor (TCR) clonality has become a way of understanding immunologic response to cancer and its interventions in recent years. An aspect of these analyses is determining which receptors expand or contract statistically significantly as a function of an exogenous perturbation such as therapeutic intervention. Results We characterize the commonly used Fisher’s exact test approach for such analyses and propose an alternative formulation that does not necessitate pairwise, wi …

02.09.2026journal-article

Frontiers in Endocrinology

Hashimoto’s thyroiditis both promotes and protects against papillary thyroid cancer

Xin Lin, Zhi Chen, Dandan Song, Jie Shen

The growing body of evidence suggests a complicated association between papillary thyroid cancer (PTC) and Hashimoto’s thyroiditis (HT). Although HT is a major risk factor for PTC development, it is also associated with improved patient outcomes. However, the molecular mechanisms between these two diseases remain unclear. This narrative review summarizes clinical evidence that connects HT with PTC and examines how these two conditions interact. It explores the involvement of CD4 + T-cell subsets, regulatory T cells …

02.09.2026journal-article

Current Oncology

Beyond Tumor Diameter: Exploratory Cohort-Derived Calcitonin Secretory Categories and Invasive Pathology in Medullary Thyroid Carcinoma

Adem Ozcan, Gizem Gunes, Ali Bal, Abdulkadir Unsal, Furkan Savas, Mustafa Omer Yazicioglu

Background: Serum calcitonin is commonly interpreted as a marker of tumor burden in medullary thyroid carcinoma (MTC), but patients with comparable tumor diameters may show markedly different calcitonin levels. This exploratory study aimed to derive cohort-specific, tumor diameter–adjusted calcitonin secretory categories and examine their relationship with invasive pathological features. Methods: This retrospective single-center study included 70 unique patients with histopathologically confirmed MTC. Seventeen pat …

02.09.2026journal-article

Journal of Cancer Research and Clinical Oncology

Knowledge and attitude towards breast and cervical cancer screening among women caregivers of cancer patients: a cross-sectional study from a tertiary cancer centre in India

Mahak Gupta, Akshay Dinesan, Lahari Udyawar, Ashmitha Prasad, Arathi P Rao, Umesh Velu, Ankita Mehta, Jayashree N P, Sharada Mailankody, Shirley Lewis

Abstract Purpose Female informal caregivers, who provide critical support to cancer patients, may face substantial caregiver burden that may adversely affect their participation in preventive healthcare. We aimed to evaluate their knowledge and attitudes toward breast and cervical cancer screening and its correlation with caregiver burden. Methods A cross-sectional study was conducted at a tertiary cancer centre using a structured questionnaire, which assessed demographics, caregiving burden (using the Zarit Burden …

02.09.2026journal-article

IECCMEXICO

Patient-Centered Facial and Orofacial Reconstruction After Cutaneous Cancer Resection: Integrating Function, Aesthetics, and Quality of Life

Sandro José Nava Daza, Erick Fernando Flores García, Luis Felipe Espinal Pérez, Oscar Emmanuel Garcia Moreno, Slendy Dayanna Gil Ayala, Diego Clemente Moreno, Gustavo Adrián Pineda Yañez, Cristian Raziel Pacheco Hernandez, Ashley Jesús García Cortes

Facial and orofacial reconstruction following cutaneous oncologic resection represents a complex clinical challenge in which tumor control must be integrated with preservation of function, restoration of facial appearance, and maintenance of quality of life. This study analyzed contemporary reconstructive strategies used after facial skin cancer excision, with emphasis on the relationship between defect characteristics, anatomical location, surgical technique, functional recovery, aesthetic integration, postoperati …

02.09.2026journal-article

Frontiers in Immunology

Gift of nature: non-human-derived exosomes showing application prospects in periodontitis treatment

Hongbo Fei, Zhuoran Wang, Yujiao Li, Hongchen Sun, Xiuping Meng, Hongbing Lin

Periodontitis, a chronic inflammatory disorder, results in tooth loss and adversely affects oral and systemic health. Current therapies fail to effectively regenerate bone loss caused by inflammation. Human stem cell-derived exosomes have emerged as important mediators of tissue regeneration and inflammation modulation in periodontitis, yet their clinical use faces ethical and technical challenges. Non-human-derived exosomes present a viable alternative, leveraging their ability to enhance tissue repair, reduce inf …

02.09.2026journal-article

Dysphagia

The Relationship between Swallowing Muscle Mass and Tongue Muscle Strength and Endurance in Head and Neck Cancer Patients

Javier Hurtado-Oliva, Lucy Núñez-Miranda, Guus van der Valk, Jeroen Vister, Anouk van der Hoorn, Inge Wegner, Gyorgy B. Halmos

Abstract Sarcopenic dysphagia is a significant concern in head and neck cancer (HNC) patients and contributes to malnutrition, aspiration pneumonia and poor clinical outcomes. Although tongue strength (TS) and swallowing muscle mass (SwMM) are central components of swallowing physiology, their relationship in HNC patients remains unclear. This study investigated the association between SwMM and TS and tongue endurance in HNC patients. This prospective cross-sectional study was conducted at the University Medical Ce …

02.09.2026journal-article

Journal of Pressure Vessel Technology

Controlling Mechanism of Local Rapid Cooling Heat Treatment to Reduce Internal Cladding Residual Stress of Pressure Vessels

Yun Luo, Yanbin Liu, Yao Zhang, Wenbin Gu, Wenchun Jiang, Qian Zhang

Abstract Due to different material parameters between the cladding layer and the base metal, significant tensile residual stresses still remain within the internal cladding layer after traditional heat treatment, seriously affecting the service safety of pressure vessels. Local rapid cooling heat treatment is an effective method to reduce the tensile residual stress in the cladding layer until a compressive stress state is achieved. In this paper, the influence of local rapid cooling heat treatment process paramete …