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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Psychiatry

A critical appraisal of integrating family constellation therapy with pharmacological treatment for depression

Wenhao Zhong, Mei Rao, Qian Zhou, Zeying Leng, Bing Zhang, Zhijian Lin

Depression remains a leading cause of disability worldwide, driven by a complex interplay of biological, psychological, and social factors. While pharmacotherapy, particularly selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors, provides essential symptom control, its limitations—including delayed onset, variable response, and side effects—underscore the need for complementary approaches that address systemic and relational roots of the disorder. This narrative review synthesize …

03.09.2026journal-article

Frontiers in Medicine

Aerosolized antifungal therapy in pulmonary fungal disease: pharmacology, drug delivery and emerging clinical applications

Massimo Caracciolo, Sarah Antonella Caracciolo, Maria Francesca Stagno, Simona Pellicano, Antonino Ripepi, Nadia Pellicano, Clara Scopelliti, Angela Serranò, Antonino Loddo, Stefano La Scala

Pulmonary fungal diseases remain associated with substantial morbidity and mortality, particularly in immunocompromised individuals, transplant recipients, and critically ill patients. Although systemic antifungal therapy remains the cornerstone of treatment, its effectiveness may be limited by suboptimal penetration into selected pulmonary compartments, while systemic toxicity, drug–drug interactions, and prolonged treatment requirements may restrict therapeutic options. Aerosolized antifungal therapy provides a p …

03.09.2026journal-article

LABOR LAW IN RUSSIA AND ABROAD

Fragmentation of Occupational Safety Laws

Aleksey V. Menkenov

This article examines the problem of fragmentation in occupational safety and health (OSH) legislation. Three key manifestations of fragmentation are analyzed: (1) the regulatory disconnect between the protection of employees' physical and mental health; (2) the reliance on recommendatory norms instead of imperative regulation; and (3) excessive detailing of legal provisions. The analysis identifies structural deficiencies in the legal norms of Chapter X of the Russian Labor Code and associated subordinate legislat …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Hybrid cardiac rehabilitation in patients with durable left ventricular assist devices: the REHAB-ASSIST study

Ramón Garrido-González, Elisa Velasco Valdazo, Mónica Barbero Campos, Paloma Remior Pérez, Alba Martín Centellas, Cristina Daniela Mitroi, Francisco José Hernández-Pérez, Manuel Gómez Bueno, Clemencia de Rueda Panadero, Marta Jiménez-Blanco Bravo, Susana del Prado Díaz, Susana Villar García, Javier Segovia Cubero, José Luis Zamorano Gómez, Jesús Álvarez-García, Carmen De Pablo Zarzosa, Mercedes Rivas-Lasarte

Purpose Patients with durable left ventricular assist devices (LVADs) frequently remain functionally limited despite technological advances. Cardiac rehabilitation may improve functional status, yet access is limited, and hybrid models have not been evaluated. The REHAB-ASSIST study assessed the clinical outcomes, safety, and feasibility of a hybrid cardiac rehabilitation program in this population. Methods In this prospective multicenter proof-of-concept study, LVAD recipients underwent a 12-week hybrid cardiac re …

03.09.2026journal-article

Frontiers in Medicine

Neoadjuvant pembrolizumab-based therapy versus dual HER2 blockade in early breast cancer: comparable surgical complication rates in a real-world cohort

Kerstin Wimmer, Katharina Kantner, Ruth Exner, Rupert Bartsch, Zsuzsanna Bago-Horvath, Stefan Konrad, Florian Fitzal, Maximilian Marhold

Background Neoadjuvant systemic therapy (NST) has become a cornerstone in the management of aggressive early breast cancer (BC) subtypes, including triple-negative (eTNBC) and HER2-positive disease. Immune checkpoint inhibition with pembrolizumab represents an active immunotherapeutic approach, whereas dual HER2 blockade with trastuzumab and pertuzumab constitutes passive immunotherapy in early HER2-positive BC. Although both strategies demonstrate substantial antitumor efficacy, real-world data directly comparing …

03.09.2026journal-article

Frontiers in Immunology

Mammalian cell-derived extracellular vesicles remodel the immune-repair microenvironment in osteoarthritis: from pathological signal transmission to regenerative therapy

Lin Zhang, Xuxu Yang, Yang Yu, Lidan Yang

Osteoarthritis is a whole-joint disease involving articular cartilage, synovium, subchondral bone, fat pad, meniscus, blood vessels, and sensory nerves. Its core pathology is not simply passive wear of the cartilage matrix, but rather reciprocal driving forces among mechanical stress, low-grade inflammation, cellular senescence, immunometabolic reprogramming, and failure of endogenous repair. As lipid bilayer-enclosed intercellular information carriers, Extracellular vesicles (EVs) carry proteins, lipids, nucleic a …

03.09.2026journal-article

International Journal of STD & AIDS

Anti–IL-17 therapy in people living with HIV who have cutaneous psoriasis: A four-patient case series

Melike Merve Güçlü, Fatma Aslı Hapa, Fatma Elif Yıldırım

Aim To describe the clinical, immunological, virological and safety outcomes observed during anti–IL-17 therapy in patients living with HIV who had cutaneous psoriasis. Method Four patients living with HIV who had cutaneous psoriasis and were treated with anti–IL-17 agents were included in this case series. Psoriasis Area Severity Index (PASI) scores, CD4 cell counts, HIV RNA levels, treatment duration and adverse events were obtained from medical records. Results Three patients received secukinumab and one receive …

03.09.2026journal-article

Infection Control & Hospital Epidemiology

Limited English proficiency is a risk for CLABSI in pediatric hematopoietic cell transplant or cellular therapy recipients

Afreen Abraham, Craig Gilliam, Jose Amadeo Ferrolino, Kelly Wills, Lauren Reeves, Ronald Dallas, Gabriela Maron, Hana Hakim

Abstract Objectives: Pediatric patients undergoing hematopoietic transplant or cellular therapy (TCT) are at increased risk of developing central line-associated bloodstream infections (CLABSI). The role of language barriers in CLABSI risk has not been well-explored in this population. This study aimed to evaluate the risk for CLABSI in pediatric TCT patients with limited English proficiency (LEP). Design and patients: A retrospective cohort study of patients hospitalized in the TCT unit in a single pediatric oncol …

03.09.2026journal-article

Monaldi Archives for Chest Disease

Prescribing patterns of antimicrobial therapy in respiratory tract infections at a tertiary care teaching hospital: a prospective study

Mandati Santhosh Reddy, Vaishnavi Jotiba Gurav, Jyoti A Hanamgond, Anasuya Vannur, Alika V Martins, Pradnya Rajmane

Respiratory tract infections (RTIs) are among the most common causes of hospital admissions and antibiotic use worldwide, and inappropriate antimicrobial prescribing in such cases significantly contributes to the growing problem of antimicrobial resistance, particularly in tertiary care settings. This prospective observational study was conducted in the Departments of General Medicine and Respiratory Medicine at a tertiary care teaching hospital from March to May 2026 and included 113 adult inpatients (≥18 years) d …

03.09.2026journal-article

Frontiers in Psychiatry

Speech features as potential objective assessment indicators in schizophrenia patients with violence-related symptoms

Junjie Wang, Xindi Ling, Shujian Wang, Wen Li, Qinting Zhang, Weixiong Cai, Ningning Li, Haozhe Li

Introduction Schizophrenia is a chronic mental disorder characterized by impairments that can significantly disrupt daily functioning, particularly in speech and language. Speech features serve as valuable indicators of mental disorders. This study aimed to identify potential speech features that reflect the clinical symptoms, particularly violence-related symptoms in patients with schizophrenia. Methods The present study enrolled 25 schizophrenia patients with violent behaviors, 25 schizophrenia patients without v …

03.09.2026journal-article

Frontiers in Immunology

HIV associated immune aging among people living with HIV: implications for long-term antiretroviral therapy and potential HIV cure interventions in sub-Saharan Africa

Praiscillia Kia, Edward Kankaka, Patricia Kankundiye, Marcel Tongo, Rose Nabatanzi, Tokameh Mahmoudi, Damalie Nakanjako

Background Clinical and biological consequences of accelerated immune aging are substantial, with growing evidence of increased risk of non-communicable diseases (NCD) among people living with HIV (PLHIV). However, there is limited understanding of reliable biomarkers of immune aging, singly or in combination, that can be used for monitoring HIV treatment in large longitudinal cohorts in sub-Saharan Africa (SSA). This review describes candidate biomarkers of immune aging during HIV treatment and their potential cli …

03.09.2026journal-article

Frontiers in Cellular and Infection Microbiology

Absolute quantification by mouthwash testing screens severe periodontitis and tracks species-specific microbial response to periodontal therapy

Je-Hyun Eom, Mu-Yeol Cho, Ji-Won Kim, Yunwoo Kim, Jeehyun No, Jiyoung Hwang, Seokwon Kim, Dahye Lee, Hanseung Baek, Bae-Kyung Kim, Young-Youn Kim, Soo-Bok Her, Dong-Yub Ko, Inseong Hwang, Hye-Sung Kim

Background Non-invasive molecular tools that can both screen for severe periodontitis and quantify treatment-associated pathogen changes remain an unmet need. We evaluated a non-invasive multiplex quantitative polymerase chain reaction (qPCR) mouthwash panel providing absolute colony-forming-unit (CFU) quantification of five periodontal pathogens ( Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, Prevotella intermedia, Fusobacterium nucleatum ), and asked whether a single test can both screen fo …

03.09.2026journal-article

F1000Research

Effect of Passive Versus Active Aquatic Therapy Over Conventional Physiotherapy in Patients With Chronic Low Back Pain: A Randomized Crossover Trial — Study Protocol

Ammar Mohamed, Watson Arulsingh, Praveen Kumar Kandakurti, Ramprasad Muthukrishnan

Background Chronic low back pain (CLBP) is a highly prevalent musculoskeletal disorder worldwide, often associated with long-term disability and reduced quality of life. 1,2 Conventional physiotherapy continues to be the cornerstone of management; however, alternative approaches such as aquatic therapy have gained increasing attention in recent years due to their surging therapeutic benefits. 3,4 Within aquatic rehabilitation, various methods including passive aquatic therapy (Watsu) and active aquatic therapy are …

03.09.2026journal-article

Revista Portuguesa de Doenças Infecciosas (RPDI)

Protocolo de utilização de soluções de bloqueio com antibiótico em cateter venoso central

Luisa Graça, Betânia Abreu Faria, Joana Laranjinha, Charlene Viana, Catarina Silva, Marcelo Costa, Sandra Teixeira, Susana Ribeiro, Diana Gaspar, Joana Alves, Ana Cláudia Carvalho

Introdução: Perante uma infeção associada a cateter venoso central, a remoção do cateter é a opção privilegiada para o controlo do foco. Quando tal não é possível, o uso de soluções de bloqueio de altas concentrações de antibiótico (ou lock) associa-se a uma melhor resposta do que a antibioterapia sistémica isoladamente. A eficácia desta técnica está dependente do agente de infeção e das soluções utilizadas. Objetivos: Uniformizar a prescrição e aplicação da solução de bloqueio com antibiótico e, assim, maximizar a …

03.09.2026journal-article

Journal of NeuroEngineering and Rehabilitation

Potential modulation of cortical oscillations by temporal interference stimulation in the primary somatosensory cortex

Koshi Iimuro, Naofumi Otsuru, Yusuke Akazawa, Ilkka Laakso, Hitomi Ikarashi, Sota Inoue, Kazuaki Nagasaka, Ryoki Sasaki, Hiroshi Shirozu, Hideaki Onishi, Akimasa Hirata

Abstract Background Temporal interference stimulation (TIS) is a promising non-invasive technique for reaching deep brain regions that are difficult to modulate with conventional transcranial electrical stimulation. A critical question is whether TIS can reliably induce neural modulation at its envelope frequency in humans. Objective As an initial step toward applications targeting deeper structures, we investigated whether TIS can modulate cortical oscillations at the envelope frequency within the primary somatose …

03.09.2026journal-article

Pediatric Blood & Cancer

Safety and Effectiveness of a High‐Dose, Tailored Tissue Plasminogen Activator Therapy Protocol: A Joint Pediatric Hematology and Cardiac ICU Quality Improvement Initiative Analysis

Eran Shostak, Oded Gilad, Yael Feinstein, Sigal Nakav, Ofer Schiller, Joanne Yacobovich

ABSTRACT Background Pediatric thromboembolism is increasingly encountered in critical care. Systemic thrombolysis with tissue plasminogen activator (tPA) facilitates vessel or valve patency, yet pediatric‐specific protocols remain undefined, and safety concerns persist. Objective To evaluate the efficacy and safety of a tailored, prolonged systemic tPA protocol for vessel thrombosis and mechanical valve obstruction in infants and children, and to characterize D‐dimer kinetics by indication. Methods This retrospecti …

03.09.2026journal-article

Frontiers in Immunology

Predictive value of serum HBcrAg in antiviral therapy for chronic hepatitis B

Shiyu Wang, Hongxiao Hao, Wen Deng, Lu Zhang, Weihua Cao, Ziyu Zhang, Xinxin Li, Yaqin Zhang, Xin Wei, Linmei Yao, Zixuan Gao, Shuojie Wang, Minghui Li

Chronic hepatitis B (CHB) remains a significant global public health challenge. The goals of its antiviral therapy are gradually shifting from long-term viral suppression toward achieving safer treatment discontinuation, more accurate risk stratification, and deeper functional cure. Traditional serological markers, such as HBV DNA and HBsAg, remain clinically important in CHB. However, their ability to reflect residual viral activity and long-term outcomes is limited after long-term nucleos(t)ide analog (NA) therap …

03.09.2026journal-article

Frontiers in Immunology

Mapping the research landscape of antibody therapy for Ebola virus disease: a bibliometric analysis

Zengwei Kou, Yunsheng Liu, Wujie Qian, Sihan Zhang, Shulei Lou, Da Shao

Background Antibody-based therapies have become a cornerstone of Ebola virus disease (EVD) treatment and prevention, particularly following the successful clinical development of monoclonal antibody therapeutics against Zaire ebolavirus. However, despite substantial advances, the global research landscape, collaboration patterns, and evolving thematic trends of Ebola antibody therapy have not been systematically characterized. The ongoing 2026 Bundibugyo ebolavirus outbreak, for which no licensed vaccines or therap …

03.09.2026journal-article

Frontiers in Psychiatry

Psychosocial recovery and nutritional rehabilitation in residential treatment for anorexia nervosa: an exploratory longitudinal multi-frequency bioelectrical impedance analysis study

Francesco Monaco, Annarita Vignapiano, Stefania Landi, Rossella Bonifacio, Daniela Falchetta, Emanuela Ferrara, Ernesta Panarello, Bruno Attianese, Annaluce Caputo, Luca Steardo, Gennaro Sosto, Giulio Corrivetti

Background Nutritional rehabilitation is widely considered a prerequisite for recovery in anorexia nervosa (AN), given the profound effects of malnutrition on cognitive, emotional, and behavioral functioning. However, whether psychiatric improvement during residential treatment is directly coupled with the degree of nutritional restoration remains insufficiently understood. This study investigated longitudinal changes in body composition and psychosocial outcomes during residential psychiatric rehabilitation for AN …

03.09.2026journal-article

Frontiers in Public Health

Knowledge, attitudes, and practice regarding rehabilitation among postoperative patients with spinal degenerative diseases: a cross-sectional study

Mingming Liu, Xiaoye Guo, Yutong Bi, Doudou Chen, Qiao Chen, Jinqing Zhang, Ying Han, Bing Han

Background This study aimed to investigate postoperative patients’ knowledge, attitudes, and practice (KAP) regarding spinal degenerative diseases and rehabilitation training. Methods This single-center cross-sectional study was conducted from July 1, 2025, to September 30, 2025, at Beijing Jishuitan Hospital, Capital Medical University. The questionnaire was developed through two rounds of Delphi consultation with seven experts, pilot-tested in 35 patients, and evaluated using confirmatory factor analysis (CFA). R …

03.09.2026journal-article

LABOR LAW IN RUSSIA AND ABROAD

Occupational Safety and Technological Development: Legal Aspects

Yulia S. Sergeenko

The author of the article explores the issues of occupational safety and technological development. The analysis of the International Labour Organization Conventions, legal acts of the Russian Federation devoted to occupational safety is carried out. Legal aspects are highlighted in the topic under consideration.

03.09.2026journal-article

Pilot and Feasibility Studies

FASTINA – protocol for a randomised feasibility trial of time-restricted eating to improve response to multiple myeloma therapy

Anna Franziska Hamm, Jan Vorwerk, Mona Maria Merz, Martin Smollich, Christina Schwitlick, Kay Horn, Inke Regina König, Theo Leitner, Lorenz Oelschläger, Helal Ahmed, Felix Sommer, Nikolas von Bubnoff, Cyrus Khandanpour

Abstract Multiple myeloma (MM) is an incurable plasma cell malignancy with relapses and diminishing response durations. Preclinical studies suggest that time-restricted eating (TRE)-related metabolic changes may enhance chemosensitivity by exploiting cancer cell vulnerabilities to nutrient deprivation. Clinical data in solid tumours remain limited and heterogeneous, mainly supporting feasibility and possible toxicity reduction rather than definitive efficacy. While efficacy has been explored in breast cancer patien …

03.09.2026journal-article

Frontiers in Medicine

Impact of antiplatelet therapy on erectile dysfunction following percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction

Joongwon Choi, Chung Un Lee, Hyun Woong Park, Jung Hoon Kim, Yong Seong Lee, Jong-Hwa Ahn, Jin Sin Koh, Min Gyu Kang, Weon Kim, Udaya S. Tantry, Paul A. Gurbel, Jin-Yong Hwang, Young-Hoon Jeong

Background: Acute myocardial infarction (AMI) is strongly associated with erectile dysfunction (ED). This study evaluated the association between P2Y 12 receptor inhibitor type and ED, and factors associated with moderate-to-severe ED in high-risk patients with AMI. Methods The HEALING-AMI trial randomized patients with naïve ST-segment elevation myocardial infarction (STEMI) to dual antiplatelet therapy (DAPT) with either ticagrelor or clopidogrel. This substudy included 59 male patients who completed 6 months of …