03.09.2026journal-article
Frontiers in Cardiovascular Medicine
Ziad Zalaquett, Stuart Waymack, Patrick Collier
Background Anthracyclines are highly effective chemotherapeutic agents but are limited by cumulative, dose-dependent cardiotoxicity, leading to strict lifetime exposure thresholds. L-Annamycin is a next-generation liposomal anthracycline designed to preserve antitumor efficacy while reducing cardiotoxicity. Methods We performed a pooled analysis of cardiac safety data from five sponsor- and investigator-initiated clinical trials evaluating L-Annamycin in acute myelogenous leukemia (AML) and metastatic soft tissue s …
03.09.2026journal-article
Frontiers in Medicine
Xiaoyan Chen, Masoud Mohammadnezhad, Yuhua Zhou, Yubing Qin
This case report evaluated the effectiveness of individualised cut-to-fit dressings, guided by moist wound healing principles, in managing multiple refractory wounds in an elderly patient with bullous pemphigoid. A multidisciplinary team collaborated with a wound specialist nurse who tailored and combined dressings according to wound exudate levels, pressure exposure, and skin tension, while reinforcing comprehensive assessment, medication management, skin protection, and health education. During hospitalisation, p …
03.09.2026journal-article
Frontiers in Oral Health
Rojin Adabdokht, Manuel Lagravere Vich, Thanandon Imaromkul, Kridsada Tosakparalerd, Victor de Miranda Ladewig, Wenji Cai, Chitian Ji, Hollis Lai
Introduction Artificial intelligence (AI)-based tooth segmentation has the potential to improve the efficiency and consistency of digital clinical workflows; however, the generalizability of commercially available algorithms on clinical datasets and their interpretability remain limited. Methods This study proposed a two-level evaluation method. It evaluated the performance of a black-box commercial algorithm using an expert-annotated clinical reference dataset of 126 intraoral scans representing diverse clinical p …
03.09.2026journal-article
Frontiers in Education
Jiao Li, Juan Yang, Sheng Zheng
Background The bridge-in, objective, preassessment, participatory learning, postassessment, summary (BOPPPS) instructional model and flipped classroom pedagogy are increasingly recognized as effective active learning strategies in medical education. However, their combined application in gastroenterology residency training has not been systematically evaluated. This study investigated the impact of the BOPPPS + flipped classroom model on clinical practice competency, clinical thinking, self-directed learning, and t …
03.09.2026journal-article
Frontiers in Medicine
Falah Mohammed Almarzooqi, Saif Al-Shamsi, Syed Fahad Javaid, Afaf Alblooshi, Faten AlRadini
Background Work-related distress may present in primary care through nonspecific physical, psychological, or functional complaints. This study assessed professional quality of life in a United Arab Emirates medical-school workforce through primary-care and occupational-health perspectives. Methods A cross-sectional electronic survey was conducted among employees of the College of Medicine and Health Sciences, United Arab Emirates University, between October 2025 and February 2026. The sampling frame comprised 373 e …
03.09.2026journal-article
Journal of Digestive Diseases
Carolina González‐Abós, Ignacio Gil, Àngels Ginés, Guillem Soy, Oriol Sendino, Iván Archilla, Fabio Ausania
ABSTRACT Objectives Incidental diagnosis of pancreatic neuroendocrine tumors (PNETs) is increasing. Its surgical indication depends on the risk of progression, whereas histological features can be assessed by endoscopic ultrasound‐guided fine‐needle biopsy (EUS‐FNB). However, its systematic use remains a matter of debate. We aimed to analyze the impact of EUS‐FNB on therapeutic management in patients with radiologically suspected PNETs. Methods In this retrospective observational single‐center study, all patients w …
03.09.2026journal-article
Frontiers in Neurology
Aishah Ibrahim Albakr, Ziyad Masoud Alqahtani, Abdulmonem Mohammed AlSharidah, Adel Abdalla Zeidan, Ahmed Abdulrahman Al Ibrahim, Mohammed Abdulmonem Al Zaher, Khurshid Khan
Background Stroke is a significant cause of morbidity and mortality, with profound medical and economic consequences. Accurate diagnosis and minimizing delays in acute stroke management has become a global priority. Mobile stroke units (MSUs) have the potential to effectively shorten key time intervals. Objective We conducted this review aiming to investigate the benefits of MSU implementation on functional, safety and time metrics outcomes in acute stroke care. Moreover, we assessed whether the presence of an onbo …
03.09.2026journal-article
International Journal of Legal Medicine
L. Küppers, S. Ritz, L. M. König
Abstract Background While thermal injuries caused by heat are well-recognized in cases of child maltreatment, injuries resulting from cold exposure (hypothermia and local cold injury) appear to be rare in this context. Although hypothermia and cold injuries related to child abuse and neglect pose a significant threat to affected children, systematic data on this topic are currently lacking. The goal of this article was to better understand the frequency, forms and contexts of child maltreatment involving cold expos …
03.09.2026journal-article
Frontiers in Surgery
Linsheng Zhu, Tingchong Zhang
Introduction Pneumatosis cystoides intestinalis (PCI) in children is a disorder characterized by gas-filled cystic lesions located in the submucosa and subserosa of any segment of the gastrointestinal tract, with pneumoperitoneum occurring in partial cases. This disease is well recognized as an early imaging sign of necrotizing enterocolitis secondary to intestinal ischemia in preterm neonates, yet PCI is rare in older children. Unlike pneumatosis intestinalis associated with life-threatening conditions such as neo …
03.09.2026journal-article
Frontiers in Surgery
Xing Du, Hongyi Dong, Diangang Liu
Background Reflux risk after sleeve gastrectomy is closely linked to gastroesophageal junction anatomy, but the relative influence of preoperative Hill grade vs. hiatal hernia size on the decision to add concurrent Dor fundoplication remains unclear. Identifying the dominant driver may improve patient selection for an adjunctive anti-reflux procedure. Objective To compare the relative contributions of Hill grade and hiatal hernia size to the decision for Dor fundoplication during sleeve gastrectomy, and to evaluate …
03.09.2026journal-article
Frontiers in Cardiovascular Medicine
Jingyi Tian, Xinru Gan, Dan Yin, Huichao Sun, Ping Xiang, Mi Li
Background Transcatheter closure has been widely used for the treatment of ventricular septal defect (VSD) in children. However, post-procedural hemolysis remains a clinically relevant complication, and its underlying mechanisms and risk factors have not been systematically investigated. Methods In this single-center retrospective cohort study, children who underwent transcatheter VSD closure at the Children's Hospital of Chongqing Medical University between June 2015 and June 2024 were included. Perioperative clin …
03.09.2026journal-article
Ege Tıp Dergisi
Deniz Alçı, Sevda Yıldız Saray
Aim: This study aimed to compare treatment continuation and follow-up discontinuation in adult psychiatric outpatients and to evaluate the clinical variables associated with discontinuation.Materials and Methods: In this retrospective, single-center, observational study, patients aged 18 years and older who were evaluated and started on treatment at the Psychiatry Outpatient Clinic of Balıkesir University Faculty of Medicine Hospital between January 1, 2024 and December 31, 2024 were reviewed. One hundred patients …
03.09.2026journal-article
Clinical Oral Investigations
Roberta Borg-Bartolo, Maurus Jaeggi, Martin Schimmel, Hendrik Meyer-Lueckel
Abstract Objectives This systematic review analysed the oral health status, chewing function, and quality of life among individuals aged ≥ 65 years in Switzerland using studies published from 1970 onwards. Materials and methods The electronic databases Embase, MEDLINE via PubMed, Swiss data repositories, and manual searches were screened. Risk of bias was assessed using the Joanna Briggs Institute tools. Meta-analyses were performed using the random-effects models with 95% confidence intervals to assess the prevale …
03.09.2026journal-article
Ege Tıp Dergisi
Berra Bilgin, Mustafa Eren Yüncü, Erman Güler, Ali Karadag, Necmettin Tanrıöver
Aim: The temporo–parieto–occipital junction (TPOJ) represents a critical convergence zone of the dorsal and ventral language pathways. Preservation of these tracts is essential during surgery for lesions involving this region. The aim of this study is to define the microsurgical anatomy of the dorsal and ventral language pathways at the TPOJ using the fiber dissection technique and to propose a surgical strategy based on the principles of fiber separation.Materials and Methods: Three formalin-fixed adult human cada …
03.09.2026journal-article
Frontiers in Medicine
Jyh-Woei Lin
Human cloning involves creating a genetically identical copy of a human cell, tissue, or embryo. That is, human reproductive cloning, producing a genetic copy of an existing person, has never been successfully done and remains globally banned or restricted. While there is no scientific evidence of successful human reproductive cloning, biotechnology combines cloning methods with genetic engineering to drive advancements in medical research and disease treatment. With the development of genetic engineering and cloni …
03.09.2026journal-article
Frontiers in Medicine
Zhulin Zhang, Yun Lan
Purpose To evaluate the diagnostic value of the FT4/FT3 ratio combined with other laboratory markers in distinguishing malignant from benign thyroid nodules. Methods This retrospective study analyzed 359 patients with thyroid nodules (142 benign, 217 malignant) based on histopathological results. Clinical and laboratory data, including FT3, FT4, FT4/FT3 ratio, thyroglobulin (TG), parathyroid hormone (PTH), and TSH, were collected. Statistical analyses included ROC curves and multivariate logistic regression. Result …
03.09.2026journal-article
Frontiers in Medicine
Muge Qi, Xianrong Yang
Background Ocular anatomy is difficult to teach due to complex three-dimensional relationships. Traditional two-dimensional methods limit comprehension, while virtual simulation is often unavailable in underdeveloped regions. The “Hand as Foot” teaching method uses hand gestures to simulate anatomical structures and has been effective in other disciplines. This study introduces this method into ocular anatomy teaching to address three core obstacles: layered wall structure, dynamic circulation/lens accommodation, a …
03.09.2026journal-article
Frontiers in Medicine
Jili Hu, Yuchen Duan, Qingqing Zhou, Denggao Zheng, Yu Li, Chi Qin, Hongxing Kan, Fan Xu
Introduction The Confucian principle of “teaching students in accordance with their aptitude” remains challenging to implement at scale in Traditional Chinese Medicine (TCM) education. We developed an Intelligent TCM Tutoring System integrating a large language model (LLM) with a domain-specific knowledge graph (KG) derived from the Golden Mirror of Medicine and evaluated its system performance and short-term educational outcomes. Methods System outputs were rated by five TCM teachers. In a three-group pedagogical …
03.09.2026journal-article
Frontiers in Medicine
Fengsheng Yin, Liang Wang, Lingli Tang, Long Yang
Background Durable hybrid zone 2 thoracic endovascular aortic repair depends on adequate healthy sealing length, appropriate oversizing, and close endograft apposition. Severe arch tortuosity can compromise these requirements even when completion angiography is satisfactory. Case presentation A 46-year-old woman with a primary non-post-surgical distal arch and proximal descending thoracic aneurysm underwent left carotid-subclavian bypass, left subclavian artery origin occlusion, and zone 2 thoracic endovascular aor …
03.09.2026journal-article
Frontiers in Medicine
Aichun Liu, Yina Wang, Yu Yan, Shuying Zheng, Bao Dong, Meishun Cai, Xin Li, Chunying Shao, Li Zuo
Background Type I cryoglobulinemia consists of a single monoclonal immunoglobulin and can induce small-vessel vasculitis with renal involvement. Cryoglobulinemic glomerulonephritis is a rare manifestation, pathologically characterized by membranoproliferative glomerulonephritis (MPGN). In this report, we present a case of type I cryoglobulinemic renal injury characterized by crystalline cryoglobulinemic glomerulonephritis type I. Our objective is to provide a detailed insight into the presentation, underlying disea …
03.09.2026journal-article
Indian Journal of Nuclear Medicine
Priyanka Yadav, Jaya Shukla
Selective Internal Radiation Therapy (SIRT) is a locoregional treatment for primary and secondary liver neoplasms that spares the surrounding parenchyma while selectively delivering a high radiation dose to the tumour tissue. It functions by injecting radioactive microspheres into the hepatic artery supplying the tumour. SIRT has emerged as a valuable locoregional treatment for liver cancers, including unresectable hepatocellular carcinoma (HCC) and some liver-dominant metastases, such as neuroendocrine tumours and …
03.09.2026journal-article
Frontiers in Child and Adolescent Psychiatry
Nabila Amin Ali, Shillah Mwaniga Mwavua, Obadia Yator, Joseph Kathono, Anja C. Huizink, Manasi Kumar
Introduction Adolescents in low- and middle-income countries experience high rates of common mental disorders (CMDs) but have limited access to adolescent-friendly, evidence-based care. While Interpersonal Psychotherapy for Adolescents (IPT-A) is effective, brief group IPT-A delivered through task-shifted, stepped-care has not been rigorously evaluated in Kenyan primary care. Methods We conducted a pilot randomized controlled trial to examine the acceptability, feasibility, and preliminary effectiveness of the Ushi …
03.09.2026journal-article
Frontiers in Immunology
Fabio Suarez-Trujillo, Theodore S. Steiner, Javier P. Gisbert, María Chaparro
Background Inflammatory bowel disease (IBD) is a chronic immune-mediated disorder characterized by dysregulated mucosal immunity. Despite major advances in therapies, a high proportion of patients do not achieve or sustain remission. Cellular immunotherapies have emerged as a mechanistically distinct therapeutic strategy with potential relevance for refractory disease. In the present paper, the authors aim to evaluate the rationale and current evidence supporting chimeric antigen receptor (CAR)-engineered immune ce …
03.09.2026journal-article
Frontiers in Cardiovascular Medicine
Mei Liang, Wen Jia Wang, Peng Yu Wang, Qing Gu
Objective Transseptal puncture (TSP) is a critical step in left atrial appendage occlusion (LAAO) but presents certain technical challenges. Conventional puncture needles, due to their inherent rigidity, often cause unpredictable needle tip “bouncing” or upward migration at the moment of septal puncture, resulting in a high or suboptimal puncture site, which subsequently compromises the coaxial alignment between the sheath and the left atrial appendage (LAA). This study aims to evaluate the safety and feasibility o …
