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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

BMC Geriatrics

Challenges and solutions to family engagement in the medication management of older adults during transitions of care: a qualitative exploratory study

Caitlin Deery, Kerry Hwang, Grace Marconi, Maneesh Prasad, Kelly Ottosen, Stephanie Garratt, Pauline Wong, Elizabeth Manias

Abstract Background The presence of multimorbidity and polypharmacy in older adults (aged 65 years and older) increases their susceptibility to medication harm, particularly during transitions of care. Family members are a source of continuity throughout transitions of care, but their medication competence remains largely underutilized. We sought to explore family members’ perspectives regarding the challenges and possible solutions for improving their engagement in the medication management of older adults during …

03.09.2026journal-article

The Economic and Labour Relations Review

When work hurts: The health consequences of job stress and part-time work among a longitudinal sample of older European workers

Sabela Siaba, Berta Rivera, Luis Currais

Abstract In the context of population ageing and extended working lives, understanding how employment quality affects older workers’ health is of growing policy relevance. Although previous research has linked working conditions to health, significant gaps remain in panel designs, unobserved heterogeneity, measurement validity, and sample representativeness. Using longitudinal microdata from the Survey of Health, Ageing, and Retirement in Europe (SHARE), we estimate individual fixed-effects models over a 12-year pe …

03.09.2026journal-article

Frontiers in Immunology

HIV associated immune aging among people living with HIV: implications for long-term antiretroviral therapy and potential HIV cure interventions in sub-Saharan Africa

Praiscillia Kia, Edward Kankaka, Patricia Kankundiye, Marcel Tongo, Rose Nabatanzi, Tokameh Mahmoudi, Damalie Nakanjako

Background Clinical and biological consequences of accelerated immune aging are substantial, with growing evidence of increased risk of non-communicable diseases (NCD) among people living with HIV (PLHIV). However, there is limited understanding of reliable biomarkers of immune aging, singly or in combination, that can be used for monitoring HIV treatment in large longitudinal cohorts in sub-Saharan Africa (SSA). This review describes candidate biomarkers of immune aging during HIV treatment and their potential cli …

03.09.2026journal-article

Frontiers in Neurology

Robot-assisted gait training in people with subacute and chronic stroke: a randomized controlled trial

Michaela Stampfer-Kountchev, Sarah Mildner, Isabella Hotz, Janice Habig, Markus Pröglhöf, Johanna Panzl, Christian Brenneis, Barbara Seebacher

Introduction The effectiveness of robot-assisted gait training (RAGT) after stroke remains uncertain, particularly regarding its role across different recovery stages. This single-blind, randomized, parallel-group trial examined whether a 4-week inpatient program of end-effector-based RAGT plus conventional physiotherapy (RAGT+CPT) improved walking ability and basic activities of daily living (ADL) more than conventional physiotherapy alone (CPT), and whether effects differed by stroke phase. Methods One hundred pe …

03.09.2026journal-article

Frontiers in Aging

Peripheral adaptive immune remodeling associated with severe hearing loss in older adults: a single-center flow-cytometry study with mouse cochlear transcriptomic context

Qunhui Zhang, Wei Liu, Meijun Shao, Jinyu Wang, Qianyi Zhong, Linlan Jiang

Objective To investigate the association between severe hearing loss and systemic immune aging in older adults using participant-level clinical immunophenotyping, and to explore potential inflammatory pathways and cellular contexts using public mouse cochlear transcriptomic data. Methods We analyzed a single-center cohort of 76 older adults, classified into normal hearing (NH), mild-to-moderate hearing loss (MMHL), or severe-to-profound hearing loss (SPHL) groups. Age- and sex-adjusted models were used to assess im …

03.09.2026journal-article

Journal of Experimental Political Science

Shared Discrimination’s Effect on Solidarity between People of Color Is Uniform Across Major Racial, Political, and Social Differences

Kasheena Rogbeer, Emily Ortiz, Efrén Pérez

Abstract Solidarity between people of color (PoC) is key to understanding multiracial coalition-building in the United States. However, limited statistical power has constrained research on whether shared discrimination’s effect on solidarity is reliably moderated by differences in race, political orientation, and social background, which structure the internal diversity of racially stigmatized subgroups within the mega-category, PoC. We report a preregistered meta-analysis of eight published experiments ( N = 5,81 …

03.09.2026journal-article

Frontiers in Medicine

Development and validation of a nomogram prediction model for perioperative delirium in older patients with osteoporotic fractures based on LASSO regression and multiple parameters

Ni Hua, Hongmei Yuan, Yanhong Wei, Zhenqi Wei, Yanping Feng, Yong Liu, Tongguang Xu, Suliang Zhao, Li Zhang, Xiaohong He

Background Perioperative delirium (POD) is a severe postoperative complication in older patients with osteoporotic fractures. This study aimed to establish a nomogram prediction model incorporating multisystem stress, inflammation and frailty-related biomarkers for risk prediction. Methods This retrospective cohort study included 176 older patients (≥65 years) with osteoporotic fractures. Potential predictors, including the rate-pressure product (RPP), systemic inflammation response index (SIRI) and prognostic nutr …

03.09.2026journal-article

Frontiers in Endocrinology

Joint trajectories of loneliness and depressive symptoms and risk of incident osteoporosis among middle-aged and older adults: a prospective cohort study

Dongnan Chen, Lincheng Duan, Xiaoxue Huang, Jingyu Li, Dan Wu

Background Loneliness, depressive symptoms, and osteoporosis are major public health concerns in ageing populations worldwide. Although the interplay between mental and physical health is well recognized, evidence remains limited regarding whether long-term joint patterns of loneliness and depressive symptoms are prospectively associated with incident osteoporosis. This study aimed to investigate the prospective associations between joint trajectories of loneliness and depressive symptoms and incident osteoporosis …

03.09.2026journal-article

Frontiers in Public Health

Fitness for work and the aging workforce: medical assessment as a de facto mechanism of retirement in the United Kingdom after the abolition of the default retirement age

Alida Langlois

Background Fitness for work is the judgement that a person is medically able to perform a role safely. This review considers the concept to have been shaped for a younger workforce expected to leave employment at a fixed retirement age. As populations have aged and mandatory retirement ages have been abolished, it is the instrument that remains available for questions it was not designed to answer. Methods This review traces the origins of the concept and examines what fitness for work means when applied to an agin …

03.09.2026journal-article

European Review of Aging and Physical Activity

Predictive value of physical activity and walking time for dual cognitive-physical decline: a multinational cohort study using temporal deep learning and explainable AI

Zhenhao Lin, Haonan Liu, Young-Je Sim, Dong Li, Zhonghua Sun, Jingbo Zhang, Yuwen ShangGuan, Litao Yan

Abstract Objective To develop an interpretable deep-learning framework to identify risk factors for dual cognitive-physical decline in older adults and evaluate the impact of physical activity (PA) on functional trajectories. Methods Using HRS ( n = 11,574) for discovery and ELSA ( n = 3,810) for external validation, we employed a Temporal Attention Network (TAN) to screen 15 core variables. Six conventional machine-learning algorithms and TAN were compared, with SHAP used to interpret the best-performing model. PA …

03.09.2026journal-article

Frontiers in Endocrinology

Endocrine regulation of uromodulin in aging

Kerim Mutig, Prim B. Singh, Svetlana Lebedeva

Uromodulin (Umod) is the most abundant urinary protein produced by the thick ascending limb (TAL) and distal convoluted tubule (DCT) of the kidney. Its physiological functions range from the protection against urinary tract infections (UTIs) and prevention of urinary stones to the modulation of ion transport along the distal nephron. Apart from the apical release into urine, Umod is delivered to the renal interstitium and serum via basolateral secretion to fulfil immunoregulatory tasks. Mutations and polymorphisms …

03.09.2026journal-article

Current Journal of Applied Science and Technology

Integration of Battery Aging into the Energy Management of Hybrid Vehicles

Yahouza Chaibou Chapi, Noma Talibi Soumaïla, Attoumane Kosso Mamadou Moustapha, Insa Issoufou Moussa, Issaka Ango Mahaman Noura, Boureima Seibou

Hybrid electric vehicles use coordinated thermal and electrical power sources to reduce fuel consumption, but battery ageing progressively limits the electrical contribution to propulsion. This study integrates battery ageing into the energy management of a parallel hybrid electric vehicle controlled by an equivalent consumption minimisation strategy (ECMS). The strategy prioritises the battery as the principal power source and updates the equivalence factor using battery state-of-charge feedback. Battery ageing is …

03.09.2026journal-article

Frontiers in Aging Neuroscience

Sex hormones in the nucleus incertus: a novel perspective on sex/gender differences in memory and mood dysfunction in Alzheimer’s disease

Camila de Ávila, Ayanabha Chakraborti, Andrew L. Gundlach, Lisa Y. Maeng

About 60% of the individuals living with Alzheimer’s disease (AD) in the United States are women. Increasing evidence points to a role for sex hormones, especially estrogen, in making women more vulnerable to AD than men. Several brainstem signaling pathways, as well as multiple neuropeptide modulators and their receptors, are implicated in AD pathology and therapeutic possibilities. However, there is limited research evaluating how the modulatory effects of sex hormones on mood and cognition interact with these br …

03.09.2026journal-article

Frontiers in Public Health

Factors associated with social support among older inpatients with schizophrenia: a cross-sectional study from a tertiary psychiatric hospital in Guangzhou, China

Jinrong Li, Junrong Ye, Jiao Chen, Dingjie Liu, Xueyu Zheng, Yulin Li, Na Ma, Yuhan Zhang, Yanheng Wei, Tian Zhou, Jianxiong Guo, Aixiang Xiao

Background Older inpatients with schizophrenia have lower social support levels that may affect clinical outcomes, yet the associated factors in this population remain underexplored. Objective To explore the factors associated with social support in older inpatients with schizophrenia. Methods A cross-sectional study was conducted among 204 inpatients with schizophrenia recruited from a tertiary psychiatric hospital in Guangzhou, China, between February 2023 and December 2024. Social support and its three dimension …

03.09.2026journal-article

Frontiers in Oncology

Lattice SFRT in a geriatric patient with an initially inoperable leg bulky sarcoma: case report and literature review

Francesco Di Siervi, Bruno Curcio, Renato Cuocolo, Silvio Maffei, Carolina Mainardi, Immacolata A.M. Pilotti, Davide Di Gennaro

Background Management of inoperable bulky soft tissue sarcomas mostly in geriatric patients presents a significant clinical challenge due to high and hypoxia-induced radioresistance, proximity to dose-limiting Organs at Risk (OARs), and the need to minimize systemic toxicity. Spatially Fractionated Radiation Therapy (SFRT), specifically 3D Lattice Radiation Therapy (LRT), offers a novel approach to safely escalate dose within the tumor volume. Case presentation 85-year-old female presenting a massive (20.7 x 9.8 cm …

03.09.2026journal-article

Frontiers in Health Services

Development of targeted strategies to enhance linkage and retention in HIV care among people living with HIV/AIDS in Mpumalanga province

Thuso Charity Mafhungo, Mygirl Lowane, Linda Skaal

Background Despite significant progress in HIV services, significant patient loss occurs at every stage of the HIV care continuum. While efforts made by the NDoH aim to combat the HIV epidemic and achieve the 95-95-95 targets, these targets cannot be reached unless PLHIV are effectively linked to and retained in care. This study aims to develop targeted strategies to improve linkage to and retention in HIV care among PLHIV in the Msukaligwa Sub-district, Mpumalanga Province. Methods A convergent parallel mixed-meth …

03.09.2026journal-article

Diabetes Technology & Therapeutics

Optimizing Continuous Glucose Monitoring for Older Adults with Diabetes: From Clinical Evidence to a Practical Implementation Pathway

Tong Yang, Jinghao Cai, Jiaying Ni, Jingyi Lu, Jian Zhou

Older adults represent a growing proportion of people with diabetes and often experience hypoglycemia, glycemic variability (GV), multimorbidity, frailty, and treatment-related vulnerabilities that are not fully captured by glycated hemoglobin A1c (HbA1c) alone. Continuous glucose monitoring (CGM) provides time-resolved glucose profiles, trend information, alerts, and remote data sharing, making it well suited to safety-focused geriatric diabetes care. In this narrative review, we synthesize evidence on CGM feature …

03.09.2026journal-article

Frontiers in Neurology

Pharmacological management in frontotemporal dementia and patient outcomes: a retrospective cohort study using the TriNetX platform

Lorenza Pabst Botton, Fernando Jacob Lazzaretti, Carlos Lokschin, Tharick A. Pascoal, Jaderson Costa da Costa, Bruce L. Miller, Lucas P. Schilling, Cristiano S. Aguzzoli

Symptomatic treatment remains the cornerstone of therapeutic management in frontotemporal dementia (FTD), as disease-modifying therapies are currently unavailable. However, several medications originally developed for other neuropsychiatric conditions may represent potentially harmful medications (PHMs) in FTD. This study aimed to describe prescribing patterns following an FTD diagnosis and to evaluate the association between PHM exposure and hospital-based acute care (HBAC) utilization. We conducted a retrospectiv …

03.09.2026journal-article

Frontiers in Rehabilitation Sciences

Functional recovery and mortality after intensive inpatient rehabilitation for severe acquired brain injury in older adults: a retrospective cohort study

Valeria Pingue, Chiara Pavese, Jasmine Invernizzi Descalzi, Loretta Fiorina, Vittorio Gabba, Gianluca Bellaviti, Antonio Nardone

Background Severe acquired brain injury (sABI) is a major cause of mortality and long-term disability. Although its prevalence is increasing among older adults (≥65 years), evidence on independent determinant of rehabilitation outcomes in this population remains limited. This study aimed to identify early factors associated with poor functional outcomes and mortality in younger and older patients undergoing intensive inpatient rehabilitation following severe acquired brain injury (sABI). Methods In this single-cent …

03.09.2026journal-article

Frontiers in Surgery

Distal radius fractures reduction and immobilization using a novel device in older adults in emergency department

Dongdong Jiang, Junwei Yan, Xiao Wang, Bin Liang, Zhaowei Yin

Background The purpose of this study was to introduce a new device for the reduction and immobilization of distal radius fractures. Methods We retrospectively reviewed 40 patients aged 65 years or older who had been treated for displaced distal radius fractures between January 1 and December 31, 2023. Patients were grouped according to the treatment documented in their medical records: conventional manual closed reduction and cast immobilization ( n = 20) or device-assisted reduction and cast immobilization ( n = 2 …

03.09.2026journal-article

Frontiers in Aging Neuroscience

Engram cell vulnerability in neurodegeneration: from mechanistic insights to therapeutic horizons

Qingyu Bai, Yan Yan, Chao Zeng, Xue Li, Guihua Zeng, Aleena Saidova, Hui Li, Hong Qing

Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD) share progressive memory impairment, yet their upstream pathologies differ. This review synthesizes evidence across these disorders to frame memory decline through engram ensembles and proposes an excitability-vulnerability tradeoff, in which the physiological requirements for engram function, including elevated excitability, synaptic plasticity, and coordinated network activity, also increase sensit …

03.09.2026journal-article

Frontiers in Aging Neuroscience

Ferroptosis–neuroinflammation interplay: mechanistic pathways and therapeutic opportunities in central nervous system disorders

Khuzin Dinislam, Valeriy A. Kataev, Mohammad Rehan Ajmal, Ayman S. Amer, Pratibha Prasad, Azna Zuberi

Oxidative stress, iron dyshomeostasis, and chronic neuroinflammation are the principal mechanisms involved in the progression of central nervous system (CNS) disorders, which are a significant source of death and chronic disability worldwide. This review focuses on understanding the mechanistic relationship between ferroptosis and neuroinflammation in central nervous system (CNS) disorders, which involves the molecular mechanisms, their role in the pathogenesis of the disease, and therapeutic opportunities availabl …

03.09.2026journal-article

Frontiers in Medicine

Clinical Frailty Scale and 12-month adverse health outcomes among community-dwelling older adults in Vietnam: a prospective cohort study

Ha Bich Thi Trinh, Kien Gia To, Tan Van Nguyen

Background Frailty is an important predictor of adverse health outcomes in older adults, but evidence from community settings in Vietnam remains limited. This study examined the association between frailty and adverse health outcomes among community-dwelling older adults. Methods In this prospective cohort study, 1,208 community-dwelling older adults were assessed using the Clinical Frailty Scale (CFS) and followed for 12 months. The primary outcome was a composite of all-cause mortality, falls, and hospitalization …

02.09.2026journal-article

Journal of Alzheimer’s Disease

Memory, social cognition, and beyond: Neuropsychological markers differentiating Alzheimer's disease and frontotemporal dementia

Jana Marie Freitag, Franz Felix Konen, Johannes Heck, Kirsten Jahn, Stefanie Groba, Martin Klietz, Thomas Skripuletz, Florian Wegner, Martin Schulze Westhoff, Sebastian Schröder

Background Distinguishing Alzheimer's disease (AD) from frontotemporal dementia (FTD) remains a major clinical challenge, particularly in early disease stages due to overlapping symptoms. Although neuropsychological assessment is central to diagnosis, brief cognitive screening instruments often emphasize episodic memory, whereas comprehensive neuropsychological assessment encompasses multiple cognitive domains. Nevertheless, social cognition and other relevant functions may remain underrepresented in routine clinic …