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Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

JAIDS Journal of Acquired Immune Deficiency Syndromes

Incidence and Risk Factors for Non-AIDS Comorbidities After COVID-19 in People Living With HIV in Atlanta, Georgia

Cecilia Castellano, Caitlin A. Moran, Minh T. Nguyen, Vijay Ramesh, Cecile D. Lahiri

Background: Coronavirus disease 2019 (COVID-19) infection rates disproportionately affect persons with underlying health conditions. People living with HIV (PLWH) acquire COVID at a higher rate than those without HIV and may be at risk for developing incident comorbidities after acute infection. Risk factors for, and incidence of, post-COVID non-AIDS comorbidities (NACM) in PLWH remain unknown. Setting: We assessed incidence of and risk factors for post-COVID NACM among PLWH using data from the Emory Center for AID …

01.09.2026journal-article

Journal of Applied Physiology

Reliability and validity of surface electromyography to identify contractile muscle fatigue during cycling in people with COPD

Simone Pancera, Paulien Mellaerts, Daniel Langer, Mathieu Brancaleone, Mykyta Chunikhin, Luc Janssens, Bart Vanrumste, Wim Janssens, Stephanie Everaerts, Heleen Demeyer, Thierry Troosters

This study provides novel evidence that exercise-induced changes in the amplitude of the vastus lateralis surface electromyography signal during a standardized constant-work-rate cycling test can represent a reliable and valid biomarker of quadriceps contractile muscle fatigue in individuals with moderate-to-severe COPD.

01.09.2026journal-article

Frontiers in Medicine

Evaluating the effectiveness of the geriatrician-designed “Older Patient Care and Seek Course” for family physicians

Esra Ates Bulut, Zeynep Kemik, Feride Gozen, Ali Ekrem Aydın, Ersin Akpinar, Derya Kaya, Ahmet Turan Isık

Background The population is aging and many primary care providers report gaps in managing complex geriatric conditions. This study aims to evaluate the effectiveness of a six-hour training program delivered by geriatricians in improving family physicians' knowledge and understanding of geriatric syndromes. Methods The study included 22 participants who attended an “Older Patient Care and Seek Course” held during an international family physicians congress. The course consisted of six hours of in-person, interactiv …

01.09.2026journal-article

Emergencias

Impact of overnight boarding in the emergency department on in-hospital mortality and length of stay among older patients

Agustín Fernández-Cisnal, Òscar Miró, Carla Boixeda, Christian Luis Di Paolo, Carolina Rangel, Luisa F Villate Robles, Laura Fernández Gutiérrez, Ernest Bragulat

Objetivo. Evaluar la asociación entre pernoctar en urgencias tras decidirse el ingreso y la mortalidad intrahospitalaria y la duración total del episodio en pacientes mayores ingresados desde urgencias en un hospital de Boston (EE.UU.) poco saturado. Método. Estudio de cohortes retrospectivo (MIMIC-IV, 2011-2019) en pacientes de 65 o más años ingresados desde urgencias con orden de ingreso documentada, excluidos los cuidados intensivos. Se definió pernoctación como permanecer en urgencias hasta las 08:00 y control …

01.09.2026journal-article

Frontiers in Immunology

Lymphatic vascular aging and age-related bone loss: current status and future perspectives

Maryam Chudhary, Shuting Zhang, Pavel Docshin, Jing Liu, Tamara Aripova, Jiaying Zhou, Jinghao Li, Anna Malashicheva, Ju Liu

Age-related bone loss is a major contributor to osteoporosis and fragility fractures in older adults. Skeletal aging is accompanied by reduced bone mineral density, impaired bone microarchitecture, chronic low-grade inflammation, and immune dysregulation. Lymphatic vascular aging refers to age-related structural and functional decline of lymphatic vessels. This decline impairs immune surveillance and inflammatory mediator clearance, thereby disrupting tissue homeostasis. Age-related lymphatic dysfunction impairs dr …

02.09.2026journal-article

Journal of International Medical Research

Context-dependent roles of osteopontin in aging-related neurological disorders

Dong Huang, Zhen Zhang, Xili Gong

Osteopontin (encoded by secreted phosphoprotein 1) is a multifunctional matricellular phosphoglycoprotein that has emerged as an important mediator in the aging nervous system. During aging, osteopontin interacts with microglial priming, vascular remodeling, myelin repair, and innate immune responses and is consistently implicated in major late-life neurological disorders. However, its biological effects are highly context dependent. Depending on its cellular source, proteolytic processing, receptor interactions, a …

01.09.2026journal-article

Annals of Clinical and Analytical Medicine

Can LUC differentiate complicated appendicitis in the geriatric age group?

Oğuz Uğur Aydın, Nermin Damla Okay, Rezzan Ermanoğlu, Eda Uysal Aydın

Aim Appendicitis in the geriatric age group accounts for 5%-10% of all acute appendicitis. In this study, we aimed to find out the diagnostic value of LUC, which is investigated as a new inflammatory parameter in acute complicated appendicitis in patients over 65 years of age, and whether WBC, neutrophil, lymphocyte, monocyte, platelet count, NLR, lymphocyte-to-monocyte ratio (LMR), CRP, DNI, and procalcitonin can differentiate complicated appendicitis in the geriatric age group. Methods Between January 2020 and De …

03.09.2026journal-article

International Journal of Geriatric Psychiatry

Association Between Geriatric Depression and Musculoskeletal Disorders Among Older Nigerian Adults: A Multicenter Cross‐Sectional Study

Uchenna Cosmas Ugwu, Cordelia Chinonyerem Ugwu, Chuka Mackson Jones, Happiness Chidinma Emelike, Agatha Nneka Obayi, Christian Chukwuka Eze

ABSTRACT Background/Objectives Older adults with musculoskeletal disorders (MSDs) are at increased risk of psychological distress and reduced quality of life, yet evidence on depressive symptoms among older Nigerians with MSDs remains limited. This study aimed to examine the prevalence and predictors of clinically significant depressive symptoms among older adults with musculoskeletal disorders (MSDs) in southeastern Nigeria, exploring both clinical and sociodemographic correlates. Methods A multicenter cross‐secti …

01.09.2026journal-article

International Journal of Molecular Sciences

Low-Sample Input miRNA Profiling in Extracellular Vesicles-Enriched Plasma Fractions from Older Adults With/out Cognitive Impairment

Arianna Consiglio, Ylenia Antonacci, Claudia Lograno, Claudia Chiapparino, Katia Pinto, Apollonia Tullo, Maria Liguori

The RNA cargo of extracellular vesicles (EVs) has been investigated to search for circulating biomarkers possibly associated with a given disease. In this direction, vesicular small RNAs like microRNAs (miRNAs) showed great potential e.g., in monitoring neurodegenerative diseases and their clinical signs. In this exploratory cross-sectional study, we looked for miRNAs possibly associated with age-related cognitive impairment. Using a high processivity and sensitive OpenArray technology, we analyzed the expression o …

01.09.2026journal-article

Archives of Pathology & Laboratory Medicine

Reassessing Ferritin Levels in Healthy Older Adults: Updated Reference Ranges and Associated Health Outcomes

Sultana Monira Hussain, John K. Olynyk, Hans G. Schneider, Paul Lacaze, Chenglong Yu, Lawrence J. Beilin, Andrew M. Tonkin, Daniel Clayton-Chubb, Cammie Tran, David Clark, Amanda J. Rickard, Robyn L. Woods, Rowan G. Walker, John J. McNeil

Context.— Ferritin is used as a biomarker for iron storage, but levels vary significantly among individuals. Objective.— To define a ferritin reference range in older adults and explore its associations with health outcomes. Design.— A post hoc analysis included 5247 men and 6075 women aged 70 years or older from the Aspirin in Reducing Events in the Elderly trial. At enrollment, participants had no diagnosed cardiovascular disease (CVD), dementia, physical disability, or life-threatening illness. Longitudinal data …

01.09.2026journal-article

INTERNATIONAL JOURNAL OF CARE SCHOLARS

A Scoping Review to Refine A Framework for Self-Consumption of Herbal and Dietary Supplement among the Older Adults

Amal Abid Razali, Nur Ain Mahat, Nur Kamilia Karim, Airin Umairah Basri

Background: Older adults in Malaysia increasingly use herbal and dietary supplements (HDS), often alongside conventional medicine, despite the potential risks of adverse herb-drug interactions and low disclosure rates to healthcare professionals. Current safety frameworks lack specific stakeholder role definitions and clinical integration protocols. This scoping review aimed to map and synthesise evidence regarding the roles of stakeholders, including the elderly, caregivers, healthcare providers, and regulatory bo …

01.09.2026journal-article

PLOS One

Retinal neurovascular and mitochondrial function signatures related to cognition improvement following yoga exercise in older adults

Mariam Moarefi, Kylie Martinez, Giovana Rosa Gameiro, Andrew Hoover, Brooke Fitzgerald, Collin Rich, Joseph Signorile, Natalie C. Ebner, Jianhua Wang, Hong Jiang

Purpose To investigate the associations between retinal neurovascular and mitochondrial function signatures and cognitive performances following a 24-week yoga intervention in healthy older adults. Methods Thirty healthy older adults (mean age 72 ± 6 years; 25 females) participated in three 60-minute sessions per week of either YogaCue or Hatha yoga over 24 weeks. Retinal structure and vessel density were measured using optical coherence tomography angiography (OCTA), while retinal blood flow (RBF) was assessed usi …

01.09.2026journal-article

The Egyptian Journal of Internal Medicine

Use of analgesics in older individuals with special emphasis on organ failures: pitfalls and caveats

Asli Bahar Ucar, Mehmet Unaldi, Neslihan Kaytuoglu, Busra Erdem, Bilgen Ozkaya, Sezin Bozkurt, Pinar Vargun, Sennaz Sahin, Mehmet Can Girgin, Talha Ciftci, Ozgur Karcioglu

Abstract Pain in older adults is highly prevalent and persistently undertreated, and its management becomes substantially more hazardous when renal, hepatic, or respiratory failure co-exists. Age-related pharmacokinetic changes — reduced hepatic blood flow and cytochrome P450 activity, declining glomerular filtration, and altered body composition — are compounded by pharmacodynamic changes, including heightened central nervous system sensitivity and reduced homeostatic reserve. This narrative review synthesises con …

01.09.2026journal-article

PLOS Biology

Impaired midfrontal‑motor theta phase synchronization characterizes maladaptive motivational behavior in people with obsessive‑compulsive disorder

Yu Pang, Dongsheng Zhou, Ziwen Peng, Wanting Liu, Ruojie Huang, Carol A. Seger, Qi Chen

Obsessive‑compulsive disorder (OCD) is characterized by an insight‑action dissociation, in which people with OCD recognize that their behavior is irrational but still struggle to inhibit habitual responses. This dissociation may be related to abnormally strong motivational biases, reflected in excessive tendencies to approach reward and avoid punishment. We employed a motivational Go/NoGo learning task, combined with computational modeling and electroencephalography (EEG), to investigate how 36 people with OCD and …

01.09.2026journal-article

Alzheimer Disease & Associated Disorders

Speech-in-Noise Hearing Impairment and Incident Dementia

Cong Peng, Guoqing Gong, Zhetian Chen, Jingwei Wu, Dan Liu, Bin Chen

Objective: Hearing impairment is considered an important modifiable risk factor for dementia, but whether its association with incident dementia is consistent across inherited susceptibility profiles remains unclear. Methods: This prospective cohort study included 80,287 UK Biobank participants aged 40 to 69 years at baseline with valid Digit Triplet Test measurements, genetic data, linked follow-up data, and complete prespecified covariates. Hearing function was quantified using the better-ear speech reception thr …

01.09.2026journal-article

Inquiry@Queen's Undergraduate Research Conference Proceedings

Building Extracellular Vesicle-Based Aging Clocks

Charlotte Schankula

Chronological age refers to years an individual has been alive, whereas biological age reflects health and is influenced by genetics, lifestyle, and environment. Biological age can better predict health status. First-generation biological clocks relied on DNA methylation, whereas second-generation clocks incorporate methylation and biomarkers. For example, the DNAmFitAge (AgeAccelFit) clock considers blood-based biomarkers, DNA methylation, and fitness measures such as walking speed, lung function, and grip strengt …

03.09.2026journal-article

Ageing International

Primitive Reflexes Predict Cognitive Functioning and Psychological Resilience in Older Adults: Physical Activity Mediates the Relationship

Erzsébet Stephens-Sarlós, Eliza E. Tóth, Zoltán Alföldi, Angéla Somogyi, Ferenc Ihász, Attila Szabo

Abstract While physical activity (PA) is associated with cognitive benefits (COG) and psychological resilience (RES) in older adults, the reemergence of primitive reflexes (PRs) has been linked to cognitive dysfunction in this population. The antagonistic action of PA and PRs on COG and RES has not been studied despite the former’s capacity in preventing or delaying mental impairment in later years. Therefore, we examined the relationships between these measures in 115 healthy older adults over 60 (M age =75.9 year …

01.09.2026journal-article

Sage Open Aging

Nicotinic Acetylcholine Receptor Modulation Distinguishes Clinical Benefits of Galantamine in Alzheimer’s Disease

Pavel V. Svintozelskiy, Andrew J. Wahlert, Carson Harrod, Denis G. Kay, Kurt P. Grady, George T. Grossberg

Alzheimer’s disease (AD) is the leading cause of dementia and represents a public health challenge in aging populations. Acetylcholinesterase inhibitors (AChEIs) remain first-line symptomatic therapy for mild to moderate AD, with real-world effectiveness largely influenced by tolerability, adherence, and treatment persistence. Galantamine and its inactive prodrug benzgalantamine are differentiated within the class by a dual mechanism that combines reversible acetylcholinesterase inhibition with positive allosteric …

01.09.2026journal-article

Frontiers in Cardiovascular Medicine

LVEF-based phenotyping in very old adults hospitalised for heart failure: cardiological discrimination, shared geriatric burden, and treatment gaps

Rémi Esser, Sophie Balesdent, Jennifer Corny, Marine Larbaneix, Alejandro Mondragon, Marlène Esteban, Christine Farges, Marc Harboun, Sophie Nisse Durgeat, Vincenzo Palermo, Olivier Maurou

Methods We conducted a retrospective observational cohort study in a cardiogeriatric unit to compare cardiological, geriatric, biological, and therapeutic profiles across LVEF phenotypes in very old adults hospitalised for heart failure (HF). All patients with HF and classifiable LVEF were included and categorised according to 2021 European Society of Cardiology (ESC) criteria as heart failure with reduced ejection fraction (HFrEF, ≤40%), heart failure with mildly reduced ejection fraction (HFmrEF, 41%–49%), and he …

01.09.2026journal-article

BMJ Open

Nurse-led care model to overcome migration-related language barriers in people with cancer ( IntVeM ): study protocol for a controlled before-and-after study, process and economic evaluation

Carolin Höckelmann, Johannes Bösche, Richard Dano, Stefanie Federhen, Annika Dangendorf, Wiebke Müller, Anne Adams, Kübra Annac, Yüce Yilmaz-Aslan, Patrick Brzoska, Minh Hai Vu, Sascha Köpke

Introduction In 2024, 30.4% of the German population had a migration background. People with migration-related language barriers face numerous challenges within the healthcare system, which can negatively impact their health outcomes. While language barriers affect healthcare in general, oncology represents a complex field in which effective communication is crucial. For people with cancer in particular, difficulties in understanding information, treatment options, and the healthcare system itself may hinder access …

01.09.2026journal-article

Australasian Journal on Ageing

Staff Perspectives on Interventions for Confabulation in Brain Injury and Dementia

Rebecca Sharp, Victoria Burney, Douglas Elliffe

ABSTRACT Objective Providing inaccurate narratives of events (confabulation) is a commonly reported difficulty for people with brain injuries and dementia. We aimed to capture staff perceptions on the frequency and cause of confabulation, as well as interventions they find acceptable and effective. Methods We surveyed staff in dementia and brain injury services using convenience sampling. We developed a bespoke survey capturing staff views on confabulation prevalence, context, causes, the acceptability and effectiv …

01.09.2026journal-article

Healthcare

Prevalence and Influencing Factors of Motoric Cognitive Risk Syndrome Among Older Adults in Long-Term Care Facilities

Xinxin He, Yangyang Jiang, Langli Gao, Juan Lv, Ying Li

Background/Objectives: To investigate the prevalence of the Motoric Cognitive Risk (MCR) Syndrome among older adults in long-term care facilities and its associated risk factors. Methods: From January to December 2024, older adults were recruited from five long-term care facilities in Southwest China via convenience sampling. All participants underwent a series of standardized assessments, including a self-designed demographic questionnaire, the 15-item Geriatric Depression Scale (GDS-15), the Timed Up and Go (TUG) …

01.09.2026journal-article

Lecture Notes in Education Psychology and Public Media

The Theoretical Origin of Adhering to People-Centeredness in Ideological and Political Education in the New Era —An Investigation Based on Marxist Classic Texts

Shuyuan Hao

The people-centeredness advocated by ideological and political education has profound Marxist theoretical origins, and its core essence is consistent with Marx and Engels' theories on human beings. Adhering to people-centeredness in ideological and political education in the new era represents the dialectical unity of logical starting point and logical destination: taking "free and conscious human beings" as the logical starting point, it requires ideological and political education to respect human subjectivity, c …

01.09.2026journal-article

Sports

Physical Fitness Index for Older Adults in a Chinese Retirement Community

Jiahao Li, Zhifan Ye, Jiali Lu, Huizhi Yang, Huiping Yan, Yifan Lu

Background: Physical fitness is important for health and independence in older adults, but existing systems do not always provide a continuous multidomain score. Objective: To develop and preliminarily evaluate a Physical Fitness Index (PFI) for older adults in a Chinese retirement community. Methods: A total of 561 participants aged 65–89 years completed assessments of body composition, strength, endurance, balance, mobility, and flexibility. Scores were normalized within sex and 5-year age groups and combined usi …