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European Health Evidence

The European alternative to PubMed

EUVIMED is the European alternative to PubMed: a central, multilingual research platform for medicine, nursing, life sciences and healthcare. It brings together international and European literature sources, study registries, open-access full texts, citations and retraction notices in one search. Unlike pure bibliographic databases, EUVIMED supports the entire research process – from discovery and appraisal with LIVIA and CLARA to traceable evidence synthesis. European in focus, transparent, interoperable and designed for science and healthcare.

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EUVIMED Themenbrowser · Therapie & Reha · Seite 181

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
12.08.2026journal-article

Diabetes, Obesity and Metabolism

Stage‐Adapted Disease‐Modifying Therapy in Type 1 Diabetes

Chenming Ye, Zhenning Jin, Shen S. Hu

ABSTRACT Aims To propose a stage‐adapted framework for disease‐modifying therapy in type 1 diabetes (T1D) that integrates immune plasticity and residual β‐cell function, and to examine how these evolving constraints may inform treatment selection, combination strategies, and trial endpoints. Materials and Methods This narrative review synthesizes mechanistic, observational, and interventional evidence across presymptomatic T1D, recent‐onset Stage 3 disease, and longer‐duration Stage 3 disease. Evidence relating to …

12.08.2026journal-article

Advanced Science

A pH‐Switchable Cerium Single‐Atom Enzyme for Peri‐Implantitis Therapy via JAK‐STAT Signaling Axis‐Mediated Macrophage Reprogramming

Xiaomin Xia, Haojie Wu, Xingyun Li, Lining Liu, Kaiqing Song, Jinpei Cui, Jie Liu, Jiaxuan Yin, Emtiaz Ahmed, Yusuke Yamauchi, Xue Li

ABSTRACT The development of high‐performance, environmentally adaptive enzyme‐mimicking catalysts for the treatment of peri‐implantitis (PI) is of great importance yet remains highly challenging. Herein, we report a high‐performance cerium single atom on B, N co‐doped carbon nanotubes enzyme (SAzyme), denoted as Ce‐BNC. Benefitting from its unique N/O‐coordinated electronic environment and reversible Ce 3+ /Ce 4+ redox cycle, Ce‐BNC exhibits an intrinsic pH‐switchable catalytic function, with acidic conditions favo …

12.08.2026journal-article

Current Opinion in Endocrinology, Diabetes & Obesity

Thyroxine withdrawal prior to radioiodine therapy in papillary thyroid carcinoma – current scenarios

Saumya Sunny, Julie Hephzibah

Purpose of review This review aims to compare the different methods of achieving adequate thyroid-stimulating hormone (TSH) stimulation prior to radioiodine (RAI) therapy in patients with differentiated thyroid carcinoma (DTC). It focuses on thyroid hormone withdrawal strategies and recombinant human TSH, examining their relative efficacy, safety, and impact on patient quality of life. Additionally, the review highlights recent guideline updates, and how these approaches influence postoperative risk stratification, …

12.08.2026journal-article

Frontiers in Endocrinology

Long-acting growth hormone therapy in paediatric growth hormone deficiency: reduced treatment burden and unproven motivation-related neuroendocrine effects

Rossella Gaudino, Franco Antoniazzi, Marco Zaffanello, Angelo Pietrobelli, Thomas Zoller, Ruggero Lanzafame, Giorgio Piacentini

Long-acting growth hormone (LAGH) formulations represent an important therapeutic advance in the management of growth hormone deficiency (GHD) because they reduce injection frequency and treatment burden and may improve adherence and patient-reported experience. Beyond these established advantages, we propose a hypothesis-generating framework in which motivation- and reward-related neuroendocrine pathways may interact with hypothalamic regulation of the growth hormone (GH) axis. This review summarises current knowl …

12.08.2026journal-article

Frontiers in Chemistry

Recent advances in photodynamic therapy systems based on pillar[n]arene host–guest chemistry

Fuqiang Zhao, Zhiying Zhu, Liang Li

Photodynamic therapy (PDT) is a minimally invasive and low-toxicity strategy for tumors and bacterial infections. However, conventional small-molecule photosensitizers have poor water solubility, severe aggregation-caused quenching and weak tumor targeting, restricting their clinical translation. Macrocyclic host-guest supramolecular assembly improves the performance of photosensitizers via reversible noncovalent recognition. Pillar[n]arenes feature symmetric electron-rich cavities, abundant modifiable sites and wi …

12.08.2026journal-article

Journal of Midwifery & Women's Health

Differentiating Inflammatory Breast Cancer From Lactational Mastitis: A Diagnostic Challenge

Irena Zakarija‐Grković

Abstract Inflammatory breast cancer (IBC) is a rare but aggressive form of cancer; hence, early diagnosis is essential. Although predominantly occurring in older women, it can occur during pregnancy and lactation, making the diagnosis especially challenging. IBC is characterized by erythema and edema of the breast skin, with or without an underlying palpable mass. In pregnant and postpartum women, it can be easily confused with lactational mastitis. Awareness of the history and clinical signs of IBC, and how it dif …

12.08.2026journal-article

Current Cancer Drug Targets

Targeting Metal-Dependent Cell Death in Cancer: From Molecular Circuitry to Biomarker-Guided Precision Combination Therapy

Xuyang Huang, Xinyue Zhang, Wei Chen, Qi Zhu

Abstract: Cuproptosis and ferroptosis are increasingly recognised not merely as parallel metal-dependent regulated cell death programmes, but as dynamic state variables of tumour metabolism, redox buffering and immune contexture. In this review, we synthesise the field beyond a descriptive pathway summary. We first integrate the core circuitry that governs death susceptibility, including copper trafficking, mitochondrial protein lipoylation and oxidative phosphorylation, iron handling, polyunsaturated-lipid remodel …

12.08.2026journal-article

American Journal of Occupational Therapy

Toward Scalable Driver Readiness Screenings for Autistic Teens: Clinical Measures Correlated With Real-World Evaluations

Chelsea Ward McIntosh, Miriam Monahan, Laura Bennett, Allison E. Curry, Emma B. Sartin

Importance There are no standardized pathways to guide autistic adolescents through the learning-to-drive process, beginning with deciding whether they are ready to pursue driving. Objective To examine whether commonly used clinical assessments correlate with driver readiness determinations. Design Cross-sectional, nonexperimental study using a single in-person visit comprised of a clinical assessment and on-road passenger activities. Setting A primary care clinic in an urban city. Participants Twenty-one autistic …

12.08.2026journal-article

Signal Transduction and Targeted Therapy

From probe to prodrug: immunoproteasome activity as a trigger for disease-selective therapeutics

Cody A. Loy, Yijun Gu, Samuel C. Kim, Mariam V. Mohagheghi, Noah B. Trask, Marina Suarez-Pizarro, Lisa E. Wagar, Claudia A. Benavente, Darci J. Trader

Abstract Developing novel strategies that can exploit a cell's endogenous machinery to selectively release toxic compounds in diseased cells, while leaving healthy cells unaffected, is a challenging task to accomplish. An established approach involves antigen recognition on tumor cells, enabling targeted delivery of prodrugs in which a cytotoxic compound is appended to an antibody by a cleavable linker. However, this strategy depends on the presence of highly expressed surface markers for which antibodies can be de …

12.08.2026journal-article

Cancer Biome and Targeted Therapy

Targeting immune checkpoint B7-H6 in cancer immunotherapy

Ziyi Yang, Qi Zhao

Natural killer (NK) cells are central mediators of antitumor immunity and possess the unique ability to recognize and eliminate malignant cells independently of major histocompatibility complex (MHC) restriction. Compared with T-cell-based approaches, NK-cell immunotherapies generally exhibit a more favorable safety profile, highlighting their growing therapeutic potential in oncology. Among the ligands that regulate NK-cell activity, B7-H6 has emerged as a particularly attractive target because of its highly restr …

12.08.2026journal-article

Journal of Clinical Medicine

Psilocybin-Assisted Therapy in Psychiatry: A Narrative Clinical Review of Mechanisms, Therapeutic Applications, and Emerging Evidence (2025–2026)

Teodora Anghel, Adriana Cojocaru, Lavinia Hogea, Iuliana Costea, Amalia Marinca, Raluca Dumache, Laura Nussbaum, Iuliana-Anamaria Trăilă

Background/Objectives: Psilocybin-assisted therapy has progressed from early proof-of-concept work to a substantially expanded evidence base, with four pivotal studies published in 2025–2026 that were not incorporated into earlier reviews. This review synthesizes the pharmacological and neurobiological foundations of psilocybin and appraises clinical evidence across major depressive disorder (MDD), treatment-resistant depression (TRD), post-traumatic stress disorder (PTSD), cancer-related distress, and substance us …

12.08.2026journal-article

Frontiers in Cardiovascular Medicine

Patent foramen ovale closure versus medical therapy for prevention of recurrent ischemic events in patients with cryptogenic stroke or transient ischemic attack and documented patent foramen ovale: a systematic review and network meta-analysis of randomized controlled trials and observational studies

Yuanpeng Deng, Di An, Xiaoman Xiong, Zhengmei Zhou, Xingde Liu, Yi Xiang

Background This network meta-analysis (NMA) aimed to compare the efficacy and safety of patent foramen ovale (PFO) closure and medical therapy categories, including antiplatelet therapy, anticoagulation, and mixed medical therapy. Methods We systematically searched PubMed, Embase, the Cochrane Library, and Web of Science from inception to June 22, 2026. Eligible randomized controlled trials and observational studies comparing PFO closure with medical therapy in adult patients with cryptogenic ischemic stroke or tra …

12.08.2026journal-article

Molecules

Development and Validation of a Method to Determine CYP4V2 Enzyme Activity in rAAV-hCYP4V2 Gene Therapy Products Using a Bioluminescent Substrate Assay

Yiran Li, Wenhong Fan, Shuting Hou, Yue Ding, Xiuqing Jia, Xi Zhu, Yuemeng Yuan, Yufei Zhang, Yanrong Cao, Xi Qin, Chenggang Liang, Lan Wang

Bietti crystalline dystrophy like retinal degeneration (BCD) is an inherited retinal degenerative disease caused by defects in the CYP4V2 gene. Recombinant AAV-based gene replacement therapy holds promise for this disease, yet reliable enzymatic activity assays for product potency evaluation remain urgently needed. This study established and validated a method for determining the enzymatic activity of CYP4V2 based on the bioluminescent substrate Luciferin-MultiCYP.HEK293-AAVR cells were seeded at 1 × 104 cells/well …

12.08.2026journal-article

South Florida Journal of Environmental and Animal Science

Adjunctive antioxidant therapy in the bidirectional relationship between periodontitis and type 2 diabetes mellitus: a narrative review emphasizing glycemic interaction and metabolic improvement

Suzana Carolina Ramos Silva, Paulo Vinicius de Oliveira Bastos, Pedro Augusto Dias Lima, Rafael Rudimar Holler Peres, Kelly Barbosa Leal Castro, Paula Regina de Souza Inácio, Daniel Domingues S. Junior, Dayane Rosevics Saran Chagas

Periodontitis and type 2 diabetes mellitus (T2DM) are linked by a well-established bidirectional relationship, mediated by hyperglycemia-driven oxidative stress, advanced glycation end-products (AGEs), and chronic low-grade inflammation. Because oxidative stress sits at the mechanistic crossroads of both diseases, adjunctive antioxidant therapies have emerged as a rational strategy to interrupt this cycle. To review current evidence on antioxidant adjuncts to non-surgical periodontal therapy (NSPT) in patients with …

12.08.2026journal-article

HAND

The Associations Between Social Determinants of Health and Therapy Attendance With Early Recovery After Operative Distal Radius Fractures

Eric X. Jiang, Elle M. MacAlpine, Moneer M. Abouljoud, Kelly M. Tomasevich, Abigail G. Carey-Ewend, Casey Uffelmann, Ryan P. Calfee

Background: The purpose of this study was to: (1) examine the demographic and socioeconomic factors associations with lack of formal hand therapy after operatively treated distal radius fractures (DRFs); and (2) determine whether formal postoperative therapy was associated with differences in patient-reported function, range of motion (ROM), and incidence of complications after operatively treated DRFs. Methods: This study analyzed adult patients (>18 years) with operatively treated DRFs at a tertiary center betwee …

12.08.2026journal-article

BMC Health Services Research

Strengthening the patient perspective in quality development: a mixed-methods observational study on suitability of the PROMIS GH-10 in Swiss inpatient rehabilitation

Marie Utsch, Gavin Brupbacher, Gaia Garuffi, Anke Scheel-Sailer, Stephan Tobler, Manuela Marquardt

Abstract Objective Healthcare systems increasingly use patient-reported outcome measures (PROMs) to complement traditional clinical and performance-based outcomes by capturing health outcomes from the patient perspective and supporting quality improvement and patient-centred care. In Switzerland, the National competence centre for quality measurements in hospitals and clinics ANQ performs the external quality development program. We conducted a nationwide pilot study in inpatient rehabilitation using the generic PR …

12.08.2026journal-article

PeerJ

Dimethyl fumarate therapy in a Western diet pregnancy model: a pilot study in guinea pigs

Daniella Hasan, Michelle Kutzler, Kristin M. Patton, Massimo Bionaz

Background Maternal Western diet (WD) consumption during pregnancy is linked to adverse gestational and offspring metabolic outcomes. Dimethyl fumarate (DMF), a Nrf2 activator with antioxidant and anti-inflammatory properties, is a proposed therapeutic candidate, but its safety and efficacy during pregnancy remain unexplored. This pilot study aimed to establish a guinea pig model of gestational WD consumption and evaluate the feasibility of DMF treatment on maternal, placental, and fetal outcomes. Methods Pregnant …

12.08.2026journal-article

Journal of Cardiovascular Pharmacology

Machine Learning Models Integrating CYP2C19 Genotypes for Long-Term Risk Prediction and Personalized Antiplatelet Therapy Selection in Myocardial Infarction

Alexander Kirdeev, Konstantin Burkin, Anton Vorobev, Elena Zbirovskaya, Galina Lifshits, Konstantin Nikolaev, Elena Zelenskaya, Maxim Donnikov, Irina Astrakhantseva, Ludmila Kovalenko, Irina Urvantseva, Maria Poptsova

Machine learning (ML) models integrating genetic and clinical data show promise for personalizing antiplatelet therapy after myocardial infarction (MI). This study aimed to develop an ML model using clinical features and CYP2C19 genotype to predict long-term major adverse cardiac events (MACEs) and guide P2Y12 inhibitor selection. In a prospective observational study of 218 MI patients undergoing percutaneous coronary intervention, with up to 9-year follow-up for MACEs, we trained and evaluated multiple models inco …

12.08.2026journal-article

Current Gene Therapy

Targeting FUNDC1 Enhances Radiosensitivity of Esophageal Squamous Cell Carcinoma by Suppressing Mitochondrial Function

Weinan Yao, Dong Guo, Xueyuan Zhang, Xingyu Du, Wenbin Shen, Shuchai Zhu

Introduction: As one of the most important treatments of Esophageal Squamous Cell Carcinoma (ESCC), the therapeutic effect of radiotherapy is still limited. FUN14 DomainContaining 1 (FUNDC1), a key regulator of mitophagy, has been implicated in tumor progression in several malignancies. However, its role in ESCC remains unclear. This study investigated the role of FUNDC1 in mitochondrial morphology, mitophagy, and radiosensitivity in ESCC cells. Materials and Methods: We evaluated FUNDC1 expression in ESCC using bi …

12.08.2026journal-article

Genetics and Molecular Research

MOLECULAR MECHANISMS OF RASAYANA THERAPY FOR HEALTHY AGEING: A SYSTEMATIC REVIEW OF GENOMIC AND EPIGENOMIC EVIDENCE

Dr Chhaya Trimbakrao Munde, Dr. Pradnya S., Dr. Shilpa B. Kavatge, Dr. Jyoti Vinod Dombe, Dr. Yogita Abhijeet Jamdade, Dr. Ketki Wagh

Healthy ageing has become a global health priority owing to the increasing burden of age-related disorders and the need for interventions that preserve physiological and cognitive function. Rasayana therapy, a rejuvenative branch of Ayurveda, has gained scientific interest for its potential to modulate molecular mechanisms associated with ageing. To systematically synthesize the available genomic, transcriptomic, epigenomic, proteomic, metabolomic, and microRNA evidence describing the molecular mechanisms through w …

12.08.2026journal-article

Frontiers in Genetics

SEPTIN9 R106W in a Chinese family with hereditary neuralgic amyotrophy: phenotypic heterogeneity and rehabilitation in a pediatric case

Jing Chen, Shuang Chen, Xin-yi Zhu, Wei Su, Wen-Han Zhang, Dan Gao, Zhi-sheng Liu, Jing-jing Li, Hong-min Zhu

Introduction Hereditary neuralgic amyotrophy (HNA) is a rare autosomal dominant recurrent focal neuropathy characterized by acute episodes of severe neuropathic pain followed by muscle weakness and atrophy, most commonly affecting the brachial plexus. Pathogenic variants in SEPTIN9 with c.316C>T (p. Arg106Trp; NM_001113491.2) missense mutation corresponding to c.262C>T (p. Arg88Trp; NM_006640.4) constituting a recurrent hotspot that accounts for approximately 55% of HNA families in which a pathogenic SEPTIN9 varian …

12.08.2026journal-article

Alzheimer's Research & Therapy

Live brain biopsy during CSF shunt surgery for precision diagnostics and multi-omic research

Heikki E. M. Lukkarinen, Antti J. Luikku, Antonios G. Dougalis, Anssi Pelkonen, Mireia Gomez-Budia, Polina Abushik, Nataliia Novosolova, Henna Jäntti, Antti-Pekka Elomaa, Aku Kaipainen, Nikolai Klimko, Paula Walle, Henna-Kaisa M. Jyrkkänen, Nils Danner, Katri Piilonen, Nora E. Firtser, Arto Immonen, Juha E. Jääskeläinen, Ross W. Paterson, Kristopher T. Kahle, Per Kristian Eide, Evan Macosko, Beth Stevens, Valtteri Julkunen, Eino Solje, Mari Takalo, Sini-Pauliina Juopperi, Susanna Kemppainen, Henna Martiskainen, Anssi Lipponen, Mikko Hiltunen, Tuomas Rauramaa, Tarja Malm, Ville Leinonen

Abstract Diagnostic testing and neurosurgical management involving CSF shunting in patients with idiopathic normal pressure hydrocephalus (iNPH) offers a unique, ethically sustainable opportunity to study the aging human brain. The common co-occurrence of neurodegenerative pathologies such as amyloid-β plaques and neurofibrillary tau tangles (NFT) provides a valuable window for research into the Alzheimer’s disease-related mechanisms. Interindividual variability among iNPH patients enables investigation and validat …

12.08.2026journal-article

Smart Molecules

Photostabilized halocyanine for near‐infrared excited bimodal photothermal synergism and tumor‐targeted therapy

Zongjin Qu, Yurong Guo, Cuixia Yao, Can Wang, Zhen Wang, Jiali Li, Zhao Wang, Yingying Jing, Yen Leng Pak, Xing Gao, Shusheng Zhang

Abstract In this work, we replaced hydrogen with halogen atoms in the BC7 molecule to enhance the parent molecule's photostability and improve the photothermal therapy (PTT) and photodynamic therapy (PDT) effects. We further improve and enhance the properties of BC7 while maintaining its optical properties, tumor targeting, and optical therapeutic effects. Nuclear magnetic resonance (NMR) spectroscopy of the four synthesized compounds confirms the success of the target products. We briefly screen BC7‐Cl, BC7‐Br, an …

12.08.2026journal-article

Cancers

Computational Pathology Reveals Extracellular-Matrix Imaging Biomarkers of Therapy Response in Preclinical Breast Cancer

Stelios Lamprou, Styliana Georgiou, Triantafyllos Stylianopoulos, Chrysovalantis Voutouri

Background/Objectives: Histological biomarkers of therapy response remain incompletely defined in preclinical breast cancer models. We evaluated whether quantitative immunofluorescence imaging and multimodal machine learning (ML) could identify image-derived tissue biomarkers associated with response in a 4T1 murine breast cancer therapy-response setting. Methods: We analysed 1696 immunofluorescence images across nine immunofluorescence staining panels: aPDL1, alpha-smooth muscle actin-CD31, alpha-smooth muscle act …