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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

The American Journal of Tropical Medicine and Hygiene

A Sustainable Treatment Protocol for Organophosphate Poisoning in Rural Kenya for Facilities without Intensive Care Units and Where Transfer Is Not Possible

Jerome Koleski, Sommer Aldulaimi, Jonathan Nthusi

ABSTRACT. Organophosphate poisoning is a common method of attempting suicide in developing countries, particularly in rural areas. The current WHO protocols emphasize intubation and transfer to a facility with intensive care. Both recommendations are beyond the resources of many rural hospitals in developing countries and their poor patients. Because organophosphate poisoning is a commonly seen condition in Kenya and because intubation is beyond the equipment and training of many rural hospitals, a protocol involvi …

02.09.2026journal-article

Cancer Research Communications

The role of germline transposable element insertions in pediatric cancer predisposition

Corinne E. Sexton, Kayla V. Hamilton, Chong Chu, David T. Ting, Judy E. Garber, Peter J. Park, Junne Kamihara

Abstract At least 15% of children with cancer have a pathogenic germline variant in a cancer predisposition gene. Studies of germline cancer predisposition, however, have focused primarily on single nucleotide and copy number variants, leaving other classes such as transposable elements (TEs) largely unexplored. Although rare pathogenic TE insertions have been implicated in inherited cancer, their contribution to pediatric cancer predisposition remains unknown, partly because these repetitive sequences often requir …

02.09.2026journal-article

Problems of Gathering Treatment and Transportation of Oil and Oil Products

FEATURES OF GEOPHYSICAL METHODS FOR STUDYING HYDRAULIC FRACTURE PARAMETERS IN VERTICAL AND DIRECTIONAL WELLS

R.R. Murtazin

The paper presents a comprehensive systematic analysis of modern geophysical methods for evaluating hydraulic fracture parameters in vertical and deviated wells. The main existing approaches are reviewed, including well testing, microseismic monitoring, and a suite of production geophysics techniques: cross-dipole broadband acoustic logging (BAL), thermometry, radioactive tracers, and non-radioactive tagged (NRT) proppant technology. A comparative analysis of the information content and reliability of each method i …

02.09.2026journal-article

Cancer Epidemiology, Biomarkers & Prevention

Racial/Ethnic Disparities in Risk of Second Primary Malignancies among Diffuse Large B-Cell Lymphoma Survivors

Pragati Gole Advani, Han Yu, Kayla Catalfamo, Pallawi Torka

Abstract Background: Previous studies have shown an increased risk of second primary malignancies (SPM) among diffuse large B-cell lymphoma (DLBCL) survivors; however, this has not been comprehensively examined by race/ethnicity. Methods: From 17 US population–based Surveillance, Epidemiology, and End Results (SEER) program cancer registry areas, we identified 68,358 ≥ 12-month DLBCL survivors diagnosed between 2000 and 2022. Standardized incidence ratios (SIR) and accompanying 95% confidence intervals (CI) quantif …

02.09.2026journal-article

Pathogens

Surgical Treatment of Tuberculous Pleural Empyema in Children and Adolescents: A Retrospective Cohort Study

Dmitry B. Giller, Alexandr D. Chuishchev, Inga I. Enilenis, Vadim V. Koroev, Oleg S. Kesaev, Galina V. Shcherbakova, Patimat G. Gadzhieva, Ludmila P. Severova, Nadezhda I. Klevno, Alexey V. Kazakov, Olga P. Frolova, Olga V. Butylchenko, Alexandr N. Ilyukhin, Valeriya A. Basangova, Evelina Y. Morozova, Ivan I. Martel

Background: While non-specific pleural empyema in children can be successfully managed with conservative drainage and thoracentesis in 80–84% of cases, tuberculous pleural empyema (TB empyema) exhibits high resistance and frequently requires extensive thoracic surgery. The choice of surgical scope depends directly on disease stage and secondary complications. Methods: We conducted a retrospective cohort study of 85 pediatric patients (aged 4 to 17 years) with confirmed TB empyema treated between 1984 and 2022, and …

02.09.2026journal-article

Scientific Reports

Supportive care needs among patients with breast and cervical cancer at a tertiary cancer treatment center in ethiopia: a cross-sectional study

Bedilu Deribe Derese, Eva Johanna Kantelhardt, Thomas Frese, Betty Ferrell, Muluken Gizaw, Sefonias Getachew, Abigiya Wondimagegnehu, Adamu Addissie, Eric Sven Kroeber, Lesley Taylor, Susanne Unverzagt

Abstract The rising incidence of cancer diagnoses alongside improving survival rates in low- and middle-income countries (LMICs) has substantially increased the demand for comprehensive supportive care. This study aimed to assess the supportive care needs of patients diagnosed with breast or cervical cancer at Hawassa University Comprehensive Specialized Hospital Cancer Treatment Center, Ethiopia. A hospital-based cross-sectional study was conducted among 349 patients with breast or cervical cancer between December …

02.09.2026journal-article

Problems of Gathering Treatment and Transportation of Oil and Oil Products

INNOVATIVE TECHNOLOGY FOR MAIN PIPELINE OVERHAUL BY INSULATION COATING REPLACEMENT

V.A. Ivanov, A.V. Aksenov, V.A. Rybin, Ya.M. Kurbanov, E.L. Chizhevskaya, N.A. Borisov, T.G. Ponomareva

Main pipelines are one of the principal methods for hydrocarbon raw materials transportation over long distances. The majority of these pipelines are laid underground. This, in turn, has a number of advantages and disadvantages. For example, when performing certain technological operations aimed at maintaining the operability of an underground pipeline, additional time is required for excavation work, specifically, uncovering the pipeline from the backfill soil that is trapping it. Maintaining the required reliabil …

02.09.2026journal-article

Insights into Imaging

Delphi consensus of specialist radiologists on imaging criteria for gadolinium contrast use and whole-body MRI in prostate cancer

Eric Nduka Onwuharine, Alexander James Clark, Matthew Dimmock, Jonathan Hill

Abstract Objective To achieve expert consensus on structured prostate MRI criteria for gadolinium-based contrast agent (GBCA) administration and whole-body MRI (WB-MRI) escalation in the diagnostic evaluation and staging of prostate cancer (PCa). Materials and methods A three-round modified online Delphi survey was conducted among UK specialist prostate radiologists. Participants rated predefined clinical and MRI criteria using structured Likert agreement scales and provided free-text comments to refine decision-ma …

02.09.2026journal-article

Cancer Imaging

The 3‑mm peritumoral margin provides optimal prognostic information in soft tissue sarcoma radiomics: a retrospective multi‑sequence MRI study

Yu Zhang, Tingting Cui, Yifeng Zhu, Lijun Wei, Huayong Cai

Abstract Background To construct an integrated prognostic model combining intra‑ and peritumoral radiomics with MRI features for predicting progression‑free survival (PFS) in soft tissue sarcomas (STS). Methods This retrospective study included 305 patients with trunk or extremity STS. Radiomic features were extracted from intratumoral and peritumoral regions at expansion distances of 3 mm, 5 mm, and 10 mm on both contrast‑enhanced T1‑weighted (CE‑T1WI) and fat‑suppressed T2‑weighted (FS‑T2WI) sequences. Features w …

02.09.2026journal-article

Molecular Cancer Therapeutics

Suppressing phosphatidylserine externalization overcomes cancer immune evasion and enhances immunotherapy

Johann S. Bergholz, Grace Trombley, Gwendolyn Cusing, Zhaoqi Li, Margaret E. Torrence, Geneva J. Sganga, Jennifer G. Casey, Shangtao Liu, Ashley H. Choi, Samuel R. Meier, Tenzing Khendu, Yi Yu, Teng Teng, Binzhang Shen, Hannah Stowe, Salam Shaaban, Jannik N. Andersen, Serge Gueroussov

Abstract Immune checkpoint blockade (ICB) has transformed cancer therapy, yet many tumors remain refractory to treatment due to diverse immune evasion mechanisms. To uncover novel drivers of ICB resistance, we performed an in vivo CRISPR-Cas9 screen in mice with increasing levels of immune pressure. This screen identified phosphatidylserine (PS) externalization as a potent mediator of immune escape. Tumors with elevated surface PS exposure prevented reinvigoration of CD8+ T cells upon PD-1 blockade, which was assoc …

02.09.2026journal-article

Scientific Reports

Latent profile analysis of benefit finding in maintenance hemodialysis patients and its association with treatment adherence

Xianghao Chen, Wenli Cai, Xiaodan Lin, Haidan Xie, Jialian Huang, Huifeng Song, Xiaozhou Zhou

Abstract Maintenance hemodialysis (MHD) patients experience prominent negative emotions, and dialysis outcomes/prognosis rely heavily on treatment adherence. Few studies have explored the relationship between latent Benefit Finding (BF) categories and adherence. This study aims to identify BF’s latent characteristics in MHD patients and analyze their link to adherence for targeted interventions. From Oct. 2024 to Mar. 2025, 250 MHD patients were convenience-sampled from 2 tertiary hospitals in Guangzhou. Measuremen …

02.09.2026journal-article

British Journal of Pharmacology

Extracellular vesicles in pharmacology: Innovations in drug delivery and therapeutic applications in cancer

Evangelia Pantazaka, Georgios Sivvas, Evangelia Papadimitriou, Constantinos M. Mikelis

Extracellular vesicles (EVs) are a diverse population of membrane nanoparticles secreted by nearly all cell types, playing a key role in intercellular communication by transferring bioactive macromolecular cargo. In cancer, EVs shape both the local tumour microenvironment and distant premetastatic niches. They are essential regulators of tumour initiation, progression, immune modulation, angiogenesis and metastatic dissemination. Due to their abundance in biofluids, EVs have attracted attention as diagnostic and pr …

02.09.2026journal-article

Cancer Science

Musashi‐1 Drives Radioresistance and Stemness in Head and Neck Squamous Cell Carcinoma via a Radioresistant FaDu Model

Na‐Eun Kang, Chan‐Woong Jung, Yun‐Ju Kim, Sung‐Gil Chi, Jeong‐Yub Kim, Myung‐Jin Park

ABSTRACT Head and neck squamous cell carcinoma (HNSCC) is frequently managed with radiotherapy, but the emergence of radioresistant cancer cells with cancer stem cell (CSC) properties remains a major clinical obstacle. Here, we established a radioresistant FaDu cell line (F‐IRR) by repeated fractionated irradiation to investigate the molecular basis of radiation resistance in HNSCC. Irradiated colony‐forming assays confirmed the radioresistant phenotype of F‐IRR cells. Although F‐IRR cells proliferated more slowly …

02.09.2026journal-article

Cancers

Expression of HER2 Ultralow in Endometrial Carcinoma, High-Grade Serous Ovarian Cancer and Their Metastases

C. Backhaus, A. Gabriel, V. Guyon, D. Weiß, M. Werner, P. Bronsert, P. Groß, I. Juhasz-Böss, K. Kurowski

Background/Objectives: HER2-directed antibody–drug conjugates have expanded the clinical relevance of low-level HER2 expression. However, the prevalence and clinical significance of HER2-ultralow expression in gynecologic malignancies remain insufficiently defined. This study characterized the full spectrum of HER2 expression in endometrial carcinoma (EC) and high-grade serous ovarian carcinoma (HGSOC), including matched metastatic lesions. Methods: HER2 expression was assessed by immunohistochemistry in tissue mic …

02.09.2026journal-article

British Journal of Cancer

SLFN11 enhances cisplatin sensitivity in pediatric cancer via activation of stress-response and suppression of survival pathways

Ayesha Jabeen, Dina Awartani, Shimaa Sherif, Eiman I. Ahmed, Rania Alanany, Ayman Saleh, Wouter R. L. Hendrickx, Christophe M. Raynaud

Abstract Background Paediatric cancers pose treatment challenges due to biological heterogeneity and variable chemotherapy responses. SLFN11, a DNA/RNA helicase-like protein known to sensitise adult tumours to DNA-damaging agents, remains underexplored in paediatric malignancies. Methods We examined SLFN11 in Wilms tumour, osteosarcoma, and medulloblastoma using bioinformatics, epigenetic profiling and functional assays. Public datasets (TARGET, ICGC) were analysed to assess SLFN11 expression in relation to surviva …

02.09.2026journal-article

Medical Sciences

Precision Diagnostics in Prostate Cancer: Integrating Biomarkers, Imaging, Genomics, and Artificial Intelligence in Contemporary United States Practice

Moustafa Kardjadj

Prostate cancer is the most commonly diagnosed non-cutaneous malignancy among men in the United States and remains a leading cause of cancer-related mortality. Its marked biological, molecular, and histopathological heterogeneity creates a central diagnostic challenge: identifying clinically significant disease while limiting unnecessary biopsy and overdiagnosis of tumors unlikely to affect survival or quality of life. Although prostate-specific antigen (PSA) remains the foundation of early detection, its limited c …

02.09.2026journal-article

Frontiers in Oncology

State of high-grade glioma care in Africa: insights from a scoping review of the available published literature

Djiby Jean Marcel Okamon, Mèhomè Wilfried Dossou, Wilfried Yao Abo, Albéric Fabrice Bocco, Thierry Alihonou, Hugues Yao Christian Dokponou, Nourou Dine Adeniran Bankole

Background High-grade gliomas (HGGs), WHO grade 3–4 diffuse gliomas, are aggressive primary brain tumors. Evidence on their management and outcomes in Africa remains limited, unevenly distributed, and lacking population-based incidence data. This review mapped published literature on HGG epidemiology, clinical presentation, diagnosis, treatment, and outcomes across represented African countries. Methods This review followed the Arksey and O’Malley framework, refined by Levac et al. and the Joanna Briggs Institute, …

02.09.2026journal-article

Medicina

Beyond Device Safety: Organisational Burden and Quality of Life in Oncology Outpatients with PICCs. A Descriptive Exploratory Study

Laura Iacorossi, Francesca Gambalunga, Simona Molinaro, Paolo Basili, Irene Terrenato, Fabrizio Petrone, Giovanna Artioli, Orejeta Diamanti, Tatiana Bolgeo, Nicolò Panattoni, Federica Dellafiore

Background and Objectives: Cancer care is increasingly delivered through outpatient pathways, thereby progressively transferring part of the organisational and practical workload of care to patients and informal caregivers. Although peripherally inserted central catheters (PICCs) are widely used in oncology for safe vascular access, comparatively less attention has been devoted to the organisational and logistical burden of PICC management and to the related involvement of informal caregivers in ambulatory settings …

02.09.2026journal-article

World Journal of Surgery

Extended D3 Mesenterectomy in Small Bowel Cancer Treatment: Feasibility and Importance for Staging. First Results of a Prospective Clinical Trial

Erik Kjæstad, Espen Thiis‐Evensen, Bjørn Edwin, Arne Olav Bakka, Anne Helene Lilleaas, Yngve Thorsen, Johannes Kurt Schultz

ABSTRACT Background There is no consensus on surgical techniques in small bowel cancer, particularly regarding the extent of lymph node dissection and strategic choices according to tumor localization and histological type. Clearance of central lymph node metastases can be challenging, especially when small intestinal neuroendocrine tumor (siNET) metastases give rise to fibrosis and desmoplasia around the cranial parts of the superior mesenteric vessels. The aim of this study was to assess the feasibility and stagi …

02.09.2026journal-article

Cancers

Spiritual Well-Being, Religiosity, Psychological Distress and Quality of Life in Adults with Cancer: A Cross-Sectional Study in a Romanian Oncology and Palliative Care Centre

Dana Sonia Nagy, Alexandru Catalin Motofelea, Sorin Saftescu, Vlad-Norin Vornicu, Razvan Gheorghe Diaconescu, Dan Ionel Orbulescu, Catalin Alexandru Pirvu, Serban Mircea Negru

Background: Spiritual wellbeing is increasingly recognised as a key area of complex oncology and palliative care, but evidence from Eastern Europe is still limited. Understanding how spiritual well-being and religiosity are related to psychological distress and quality of life can inform holistic support interventions in cancer patients. Objective: To describe spiritual well-being, religiosity, anxiety, depression, and quality of life in a Romanian cancer cohort, and to examine associations between spiritual well-b …

02.09.2026journal-article

PLOS Neglected Tropical Diseases

Understanding the association between immune-modulating helminths and HPV or cervical cancer: A scoping review

Allison Frank, Margarita Correa-Mendez, Alicia A. Livinski, Kalina Duncan, Eva H. Clark, Patti E. Gravitt

Background Cervical cancer disproportionately affects people living in low- and middle-income countries (LMICs). While access to effective preventive interventions explains some of the disparity, biological causes cannot be ruled out as important contributors to the observed disparities in cervical cancer outcomes. Since chronic infection with helminths which cause immune dysregulation and suppress anti-viral responses is common in LMICs, we sought to review the available epidemiologic evidence evaluating associati …

02.09.2026journal-article

PLOS One

Core components of physical activity interventions in the prevention and management of breast cancer-related lymphoedema (BCRL): A scoping review

Laura Henry, Julie S. Wilson, Jason J. Wilson, Esther R. Beck

Background Breast cancer-related lymphoedema, a chronic and debilitating swelling condition, can occur as a sequela of breast cancer treatment. Physical activity is a key recommendation of cancer survivorship guidelines. However, uncertainties that remain around physical activity and breast cancer-related lymphoedema management, have potentially contributed to low physical activity levels in this population. Aim The aim of this scoping review was to explore the core components of physical activity interventions to …

02.09.2026journal-article

Rehabilitation Oncology

Parental Awareness of Preventive Health Practices and Health-Related Quality of Life in Children with Cancer

Müberra Tanriverdi, Güleser Güney Yilmaz, İrem Nur Usluer, Hafize Reyhan Çalikuşu, Fatma Betül Çakir

Background: This study aimed to examine parents’ awareness of health promotion and preventive care in childhood cancer and to investigate whether children’s HR-QoL (Health-Related Quality of Life) differs according to parental awareness items. Methods: This prospective cross-sectional study included 76 parents of children aged 0 to 18 years diagnosed with cancer and followed at a pediatric hematology/oncology clinic. Parents completed a Demographic Information Form, the Barratt Measure of Social Status, the Pediatr …

02.09.2026journal-article

Current Issues in Molecular Biology

A Systematic Machine Learning Framework for Evaluating and Ranking Omics Layers in Cancer Drug Response Prediction

Sara Amjad, M. M. Sufyan Beg, Mohd. Azhar Aziz

This study introduces a top-down framework for evaluating the utility of multi-omics features to predict the response of 309 drugs in cancer cell lines. This was done by taking a multi-omics approach where data from proteomic, transcriptomic, genomic, metabolomic, and miRNA were integrated with drug sensitivity (area under the curve, AUC) data. We performed modular dimensionality reduction using t-SNE (t-distributed Stochastic Neighbor Embedding), followed by K-Means clustering to stratify cell lines into data-driv …