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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

American Journal of Physiology-Cell Physiology

Dysregulated iron metabolism in remodeling of aging asthmatic human airways

Maunick Lefin Koloko Ngassie, Yamillie Ortiz, Preetham Ravi, Daniel A. Pfeffer-Kleemann, Samantha K. Hamrick, Michael A. Thompson, Yun Hua Fang, Christina M. Pabelick, Y. S. Prakash

Iron is an essential element for cellular homeostasis and functionality. Increased iron in the lung is associated with aging and asthma in the elderly (AIE). Using human airway smooth muscle cells from young versus elderly versus AIE patients, we found that dysregulated iron metabolism (more than iron accumulation), resulting in activation of antioxidant systems and increased susceptibility to ferroptosis, occurs in AIE, contributing to cell hyperplasia and matrix remodeling of aging and AIE.

04.09.2026journal-article

Home Healthcare Now

Effect of Neighborhood Disadvantage on Home Health Quality Received by Older Adults

Tracey L. Collins, Courtney Zaic

More than 3 million Medicare beneficiaries use home healthcare annually. The prevalence of neighborhood disadvantage for community-living older adults is 15.8%. Medicare's Home Health Value-Based Purchasing (HHVBP) model quality measures for home health were initiated in 2016. There is little data on the quality of care received in home health by vulnerable beneficiaries living in disadvantaged neighborhoods. The purpose of this literature review was to analyze the quality of home healthcare (HHC), as determined by …

01.09.2026journal-article

The Review of Higher Education

“Finding Other People Whose Minds Work Similarly to Mine:” Supporting Autistic College Student Success

Bradley E. Cox, Brett Ranon Nachman, Julie Lounds Taylor, Nicholas Gelbar, Kristen Gillespie-Lynch, Emily Raclaw, Karly Ball Isaacson, Yilun Jiang

Abstract: The number of autistic college students has rapidly increased over the past decade. Using a convergent, mixed-methods design, we analyzed data from 930 surveys completed by autistic undergraduates attending roughly 400 U.S. institutions in Fall 2022 and Fall 2023 to identify factors students themselves believe most affect their postsecondary success. Guided by a novel IPACE framework (Identity, Psychology, Academics, Community, Employment) and Astin’s Inputs–Environments–Outputs model, students rated 23 i …

01.09.2026journal-article

Journal of South Asian Languages and Linguistics

The Lhokpu of southwestern Bhutan: the people and their language

George van Driem

Abstract The Lhokpu people are a language community indigenous to the hills of southwestern Bhutan. Historically, the Lhokpu homeland extended further into the mountains of western Bhutan as well as out into the jungles on the plains of the Western Duars, where their ancestors used to hunt wild hnar ‘elephants’ and hnaisa ‘bear’. The Lhokpu language represents a distinct linguistic subgroup unto itself within the Trans-Himalayan language family, world’s second most populous language family in terms of numbers of sp …

01.09.2026journal-article

Disinfection affairs

Evaluation of the safety of pediculicidal agent in the context of mass involvement of people with head pediculosis

M.V. Matrosenko

Presentation at the scientific-practical conference with international participation «Perspectives of disinfectology. Disinfection measures in emergency situations and in the territories of natural foci of infectious diseases» (September 22-23, 2026, Moscow)

01.09.2026journal-article

Social Sciences

Associations of Smartphone Ownership with Health-Related Quality of Life and Social Connectedness Among Older Japanese Adults: A Quantile Regression Analysis

Takashi Kawano, Goro Moriki

Loneliness and social isolation in later life are important public health concerns, and information and communication technology (ICT) may support everyday functioning and social participation among older adults. However, mean-based analyses may obscure variation in associations across outcome distributions. Using quantile regression, we examined the associations of smartphone ownership with health-related quality of life (SF-36v2: PCS, MCS, and RCS) and social connectedness (LSNS-6) among 919 community-dwelling se …

01.09.2026journal-article

European Journal of Education

Alternative Educational Provision and Care Experienced Young People: An Administrative Data Study in Wales

Nell Warner, Phil Smith, Anna Rawlings

ABSTRACT Care experienced young people are at higher risk of poor educational outcomes than other young people, but little is known about the relationship between care experience and attendance at a pupil referral unit (PRU), the most common type of alternative educational provision in Wales. This study explored how the type of care experience that a young person has is related to the likelihood of them attending a PRU or other alternative provision. Education data covering the population of Wales was used to creat …

01.09.2026journal-article

Journal of Petroleum Technology

Framework Enables Evaluation of Aging Offshore Platforms for CCS

Chris Carpenter

_ This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper SPE 225805, “Evaluating Aging Offshore Platforms for Next CCS: Path to Sustainable Decommissioning,” by Nur D.B. Alias, Bak S. Wong, and Ahmad R.A. Rahman, Petronas, et al. The paper has not been peer-reviewed. _ A series of structural-integrity evaluations were conducted to assess an aging offshore complex for the largest carbon capture, utilization, and storage (CCUS) project in southeast Asia. These evaluations were co …

01.09.2026journal-article

Innovation in Aging

Community-based solutions: A principles-to-practice framework to support individuals living with dementia and their care partners

Allie Peckham, Monika Roerig, Sage Sadow, Frances Morton-Chang, Laura Schmid, Clare Schuchardt, Molly Budhiraja, Sara Allin

Abstract Background and Objectives Alzheimer’s disease and related dementias represent a global public health concern, with persistent gaps in supports for individuals living with dementia and their unpaid care partners. This study synthesized promising community-based innovations that address these gaps and contribute to positive outcomes. Research Design and Methods A rapid literature review was conducted to develop a framework for guiding the design and evaluation of community innovations for individuals living …

01.09.2026journal-article

JMIR Formative Research

Examining Increased Ritalin and Adderall Use Among Low-Income People Who Use Drugs: Mixed Methods Study

Ian David Aronson, Robert Quiles, Anthony Cramer, Chunki Fong, Alex S Bennett

Abstract Background Popular discourse often frames prescription stimulants Ritalin and Adderall as drugs for teens and emerging adults with greater financial resources (eg, students or young professionals), while illicit stimulants such as crack or methamphetamine are often considered drugs for older adults with lower incomes. Crack and methamphetamine are also frequently used in combination with opioids to offset the sedating effects of adulterants such as fentanyl and xylazine in the unregulated drug supply. This …

01.09.2026journal-article

Diabetes & Metabolism Journal

Hypothalamic Inflammaging: A Central Driver of Type 2 Diabetes Mellitus and Metabolic Disease in Aging

Sang Hee Lyoo, Ki Hun Kim, Ki Woo Kim

Aging is a major risk factor for type 2 diabetes mellitus (T2DM) and is accompanied by chronic, low-grade inflammation known as inflammaging. Emerging evidence indicates that the hypothalamus, a central regulator of energy and glucose homeostasis, undergoes age-associated inflammatory remodeling that contributes to metabolic dysfunction. In particular, glial cells, including microglia, astrocytes, tanycytes, and neural stem cells, acquire senescence-associated phenotypes characterized by impaired homeostatic functi …

01.09.2026journal-article

Hispania

Epigenetics of Racial Trauma and Disability: Exploring the Transgenerational Effects of Racism on the Spanish Roma People

Ana León-Távora

Abstract: In 2025, the Spanish government marked the 600th anniversary of the Roma people's arrival in the Iberian Peninsula by declaring it the "Year of the Roma People." Despite this symbolic recognition, the Spanish Roma continue to be marginalized and excluded from dominant national narratives, a condition that is exacerbated for Roma individuals with disabilities. This article argues that racial trauma itself operates as a disabling force, shaped by centuries of structural antigitanismo (anti-Roma racism) and …

01.09.2026journal-article

Frontiers in Public Health

Knowledge, attitudes, and practices regarding cataract and diabetic retinopathy among middle-aged population and older adults in a rural area at eastern China

Junmei Pan, Yiqing Zhang, Ran Wu, Yan Cui, Hongling Yang

Background Cataract and diabetic retinopathy (DR) are the leading causes of visual impairment and blindness among middle-aged and older adults. This study aimed to investigate the knowledge, attitudes, and practices (KAP) of cataract and DR among middle-aged and older adults residing in a rural region of Eastern China. Methods This cross-sectional study was carried out from March to September 2024, targeting middle-aged and older adults aged 40 to 80 years residing in the rural region of Huanggang town, Shanxian co …

01.09.2026journal-article

Gerodontology

Ageism and Self‐Reported Attitudes Toward Older Adults Following a Multidisciplinary Educational Program Among Health Students: Implications for Geriatric Dentistry Education

A. Braud, V. Bloch, P. Maillot, S. Prissette

ABSTRACT Background Preparing future dental professionals to care for an ageing population requires more than knowledge acquisition. While educational interventions may improve attitudes toward older adults, underlying forms of ageism may persist and influence clinical practice. Objective To assess self‐reported attitudes and ageism among healthcare students, including dental students, following participation in a multidisciplinary training program focused on older adult care, and to explore the implications for ge …

01.09.2026journal-article

Frontiers in Aging Neuroscience

Advances in the treatment of age-related hearing loss: from molecular mechanisms to targeted interventions

Le Mao, Sijie Ma, Kun Zhu, Chao Feng, Xinyu Chen, Fangli Yang, Maoli Duan, Xiaowan Chen

Age-related hearing loss (ARHL) is the most common sensory disorder in older adults. Current hearing interventions, including hearing aids and cochlear implants, face limitations in accessibility and adherence. Therefore, efforts have been devoted to elucidating the molecular mechanisms underlying cochlear aging and identifying effective therapeutic targets for ARHL. This review summarizes several molecular mechanisms implicated in cochlear aging and ARHL, including autophagy dysregulation, oxidative stress, stereo …

01.09.2026journal-article

International Journal of Geriatric Psychiatry

Household Energy Infrastructure, Cooking Fuel Use, and Mental Health Among Older Adults in Rural China

You‐hua Wang, Rui Liu, Ming‐yang Chen, Zi‐xuan Xiong, Yue Li

ABSTRACT Objectives To compare the associations of household energy infrastructure and primary cooking fuel use with mental health among older adults in rural China. Methods This cross‐sectional analysis included 4975 rural adults aged 60 years or older from 3291 households in the 2018 China Health and Retirement Longitudinal Study. Mental health was operationalized as depressive symptoms measured using the 10‐item Center for Epidemiologic Studies Depression Scale (CESD‐10); the continuous score was primary and CES …

01.09.2026journal-article

Sustainability Science

Specialized and generalized non-material Nature’s Contributions to People: insights from tourists at Mount Kilimanjaro, Tanzania

M. Eugenia Degano, Katrin Böhning-Gaese, Neema Robert Kinabo, Lisa Lehnen, Berta Martín-López, Matthias Schleuning, Thomas Mueller, Ugo Arbieu

Abstract Nature contributes to our quality of life through a wide range of non-material Nature’s Contributions to People (NCP), including aesthetic enjoyment, restorative experiences and recreational opportunities. However, quantifying and managing the supply of non-material NCP requires a mechanistic understanding of how they are associated with the entities of nature that support them across different ecological contexts. We characterized such associations using network path theory, which allowed us to distinguis …

01.09.2026journal-article

Annual Review of Genetics

Stemness as a Systems-Level State: From Ancestral Plasticity to Systemic Control in Regeneration, Aging, and Cancer

Jagriti Arora, Sakshi Tiwari, Dasaradhi Palakodeti, Tina Mukherjee

Multicellularity necessitated the evolution of cellular diversity and specialization, yet across organisms, the retention of cellular plasticity within defined physiological contexts is a recurring principle. Here, we examine early-diverging metazoans to reevaluate the evolutionary logic of stemness. Rather than viewing stem cells as exceptional, we argue that cellular plasticity represents a deeply conserved attribute of early life. The ability of cells to remain responsive, multipotent, and regenerative under eco …

02.09.2026journal-article

European Journal of Clinical Investigation

The Triglyceride‐Glucose (TyG) Index and Incident Diabetes and Cardiovascular Events in People Living With HIV‐1 Infection. A 14‐Year Observational Cohort Study

Daniele Pastori, Gianluca Gazzaniga, Tommaso Brogi, Marco Rivano Capparuccia, Caterina Fimiani, Claudio Mastroianni, Ivano Mezzaroma

ABSTRACT Background People living with HIV (PWH) are at increased risk for metabolic and cardiovascular diseases. However, there is no structured prevention strategy for these subjects. The triglyceride‐glucose (TyG) index has shown predictive value for Type 2 diabetes mellitus (T2DM) and cardiovascular events (CVEs) in the general population, but its utility in PWH remains unclear. Methods We conducted a retrospective study including 477 PWH without baseline T2DM. TyG index was calculated as follows: ln[fasting tr …

01.09.2026journal-article

Journal of Digestive Diseases

Association Between Proton‐Pump Inhibitors and Muscle Strength in Older Adults: A Population‐Based Analysis

Jaakko Ollila, Konsta Teppo, Kimmo Salminen, Adriana Lääti, Jenni Vire, Matti Viitanen, Ville Langén

ABSTRACT Objective We aimed to assess the association of proton‐pump inhibitor (PPI) use with muscle strength in older adults. Methods All 1940‐born residents of Turku, Finland were surveyed during 2016 and 2017 as part of the New Turku Older Adults Study. Associations between PPI use, regardless of dosing pattern, and physical function were analyzed using Welch's t ‐test, chi‐square test, and linear and logistic regression models. Models were initially run as crude, then adjusted for age, sex, and body mass index …

01.09.2026journal-article

Cancer Diagnosis & Prognosis

Real-world Outcomes of First-line Platinum-based Chemotherapy in Patients Aged 80 Years or Older With Metastatic Urothelial Carcinoma

AKINORI MINATO, KAZUMASA JOJIMA, YUTO TSUBONUMA, YUI MIZUSHIMA, YOSHIHIRO SUGITA, TAKUO MATSUKAWA, IKKO TOMISAKI, EIJI KASHIWAGI

Background/Aim: As populations age, more patients aged ≥80 years with metastatic urothelial carcinoma (mUC) require systemic therapy. However, the efficacy and safety of first-line platinum-based chemotherapy (PBC) in octogenarians remain unclear. This study aimed to describe clinical outcomes in patients aged ≥80 years with mUC eligible for PBC. Patients and Methods: We retrospectively analyzed 30 patients with mUC who received first-line PBC between 2005 and 2022. Patient characteristics, tumour response, treatme …

01.09.2026journal-article

American Journal of Physiology-Cell Physiology

Combination therapy of RAS inhibition and glucagon-like peptide-1 receptor agonist improves a marker of kidney fibrosis in people with type 2 diabetes

Alexandra L. Møller, Stefanie Thöni, Felix Keller, Samir Sharifli, Federica Genovese, Morten Karsdal, Daniel G. K. Rasmussen, Gert Mayer

Urinary C3M is a dynamic biomarker of ECM turnover with pharmacodynamic relevance in kidney disease. Previous studies in diabetic and nondiabetic kidney disease have shown that therapeutic interventions can increase urinary C3M levels. Here, compared with RASi monotherapy, GLP-1 RA-based combination therapy with RASi was associated with a more favorable longitudinal urinary C3M trajectory and an altered association between urinary C3M and kidney function in type 2 diabetes.

01.09.2026journal-article

Healthcare

An Integrated Prevention, Treatment, and Rehabilitation Program for Toileting-Related Falls in Older Adults and People with Disabilities: The Protocol for a Multicenter Prospective Single-Arm Implementation Study

Zexuan Lv, Yin Lu, Hongyu Zhang, Rentang Li, Chengsong Mi, Kefeng Li, Fan Gao, Qiang Hu, Yi Wang, Qing Yuan

Background/Objectives: Toileting-related falls may arise from interacting urinary symptoms, impaired mobility and balance, cognitive or psychological factors, environmental hazards, and caregiver limitations that are often managed separately. This study aims to evaluate the implementation, safety, and 6-month clinical outcomes of an integrated multidisciplinary prevention, treatment, and rehabilitation pathway for older adults and people with disabilities at risk of toileting-related falls. Methods: This multicente …

03.09.2026journal-article

Alzheimer's & Dementia

Neurobiological mechanisms of 40‐Hz stimulation in Alzheimer's disease: evidence, heterogeneity, and constraints

Lin Qi, Weiye Wang, Reema Abdullah, Yilei Zhao, Zhibin Wang, Yi Tang, Benyan Luo, Guoping Peng

Abstract Early disruption of gamma oscillations is increasingly recognized as a contributor to neurodegeneration and cognitive decline in Alzheimer's disease (AD), positioning 40‐Hz stimulation as a promising neuromodulatory strategy. However, its neurophysiological and cognitive effects remain highly variable across studies, underscoring the need for a more integrated mechanistic framework. This review synthesizes current evidence on the neurobiological mechanisms engaged by 40‐Hz stimulation in AD, including circ …