Therapie & Reha: neue Gesundheitspublikationen – Seite 177

13.08.2026journal-article

Blood Cancer Discovery

Sequenced, Not Stirred: Positioning CAR T and Bispecific Antibody Therapy in Multiple Myeloma

Rahul Banerjee

Summary: In this issue of Blood Cancer Discovery, Merz and colleagues study more than 600 recipients of chimeric antigen receptor T-cell (CAR T) and/or bispecific antibody therapy in multiple myeloma with an emphasis on patients who received both modalities sequentially. They find a clear progression-free survival advantage when CAR T therapy was used first; importantly, because outcomes with both modalities were similar when following progression after the converse modality, this advantage was driven by CAR T ther …

13.08.2026journal-article

Revista Ibero-Americana de Humanidades, Ciências e Educação

CANCELAMENTO VIRTUAL: UMA VIA (IN)ADEQUADA DE COMBATE AO DISCURSO DE ÓDIO

Nayanna Priscilla Silva Bezerra Guerra, Cleide Alves de Souza, José Welhinjton Cavalcante Rodrigues

Este artigo trata sobre a problemática da adoção do cancelamento virtual como ferramenta de combate ao discurso de ódio. Para atingir os objetivos deste trabalho, foi adotada como metodologia a pesquisa bibliográfica, utilizando-se de artigos científicos, dissertação e livros que tratam acerca da eugenia, discurso de ódio e cancelamento virtual, cuja análise dos trabalhos se deu por meio de uma abordagem qualitativa, de modo a oferecer esclarecimentos relativos aos alvos propostos. As reflexões proporcionadas por e …

13.08.2026journal-article

Journal of Education and Research in Nursing

Assessment of Post-Earthquake Trauma and Coping Strategies for Earthquake-Related Stress Among Midwifery Students

Beril Nisa Yaşar, Sibel İçke

Background: Earthquakes are major sources of psychological stress that can adversely affect university students' personal and professional lives. Aim: This study aimed to assess post-earthquake trauma levels and coping strategies among midwifery students. Methods: This cross-sectional study included 251 midwifery students enrolled at a state university (participation rate: 71.71%). Data were collected online using the Introductory Information Form, the Scale that Determines the Level of Trauma After the Earthquake, …

13.08.2026journal-article

Jurnal Kegawatdaruratan Medis Indonesia

Comparison of Animated Videos and E-Pocket Books Regarding Occupational Health and Safety Knowledge Among Anesthesia Nursing Students

Nurul Fadila Sofyan, Ratih Kusuma Dewi, Niken Anggraini Sri Saputri

Background: Occupational Safety and Health (OSH) is a crucial aspect of anesthesiology practice. Anesthesia students need to understand OSH principles early, given their exposure to physical, chemical, biological, and ergonomic hazards in the workplace. The high number of workplace accidents in Indonesia (462,241 cases in 2024) highlights the need for effective learning media. Animated videos and e-pocket books are important because they provide engaging, flexible, and repeatable learning experiences that can impro …

13.08.2026journal-article

BMC Sports Science, Medicine and Rehabilitation

How many athletes are enough? Small-sample instability of reliability indices and the minimum sample size for a trustworthy minimal detectable change in two-trial sport field tests: a Monte Carlo study

İrfan Marangoz

Abstract Background Test-retest reliability of sport and rehabilitation field tests is usually reported from very small samples, yet how unstable the resulting indices are, and how many participants are needed, is rarely quantified. We used Monte Carlo simulation to evaluate relative (intraclass correlation coefficient, ICC) and absolute (minimal detectable change, MDC₉₅) reliability statistics under sport-realistic small-sample conditions. Methods Two-trial data were simulated for a counter-movement-jump-like meas …

13.08.2026journal-article

Jurnal Informatika dan Teknik Elektro Terapan

IMPLEMENTASI DEEP LEARNING HYBRID RESNET50V2-BIGRU PADA APLIKASI WEB VISUAL SPEECH RECOGNITION BAGI KOMUNITAS TULI

Salma Nurfauziah

Visual Speech Recognition (VSR) merupakan teknologi komunikasi krusial bagi komunitas Tuli, terutama di lingkungan bising di mana sistem berbasis audio gagal berfungsi. Pengembangan VSR untuk bahasa Indonesia menghadapi tantangan kelangkaan dataset audio-visual dan tingginya ambiguitas kata homofon. Selain itu, tingginya beban komputasi data video seringkali menghambat implementasi pada platform web. Oleh karena itu, penelitian ini bertujuan mengembangkan sistem VSR bahasa Indonesia yang efisien menggunakan arsitek …

13.08.2026journal-article

Current Oncology

Overcoming Trial Exclusion: A Multicenter Analysis of Hemodialysis Multiple Myeloma Patients Who Underwent BCMA-Directed CAR-T Therapy

Eli Zolotov, Reema Mody, Kimberley Doucette, Aimee Chappell, Chantal Accolatse-Mati, Harsh Parmar, James Di Palma-Grisi, Noa Biran, Pooja Phull, Joseph Franz, David S. Siegel, David H. Vesole

Multiple myeloma (MM) patients with end-stage renal disease (ESRD) requiring hemodialysis (HD), who are disproportionately Black, have been excluded from all pivotal trials of BCMA-directed chimeric antigen receptor T-cell (CAR-T) therapy, leaving a critical evidence gap in a population. We conducted a multicenter retrospective analysis of all MM patients who received CAR-T therapy while on HD at two U.S. centers between June 2021 and December 2025. Of 284 CAR-T recipients, 8 (2.8%) were HD-dependent. Median age wa …

13.08.2026journal-article

Haematologica

Irradiated CD19 chimeric antigen receptor YTS cells retain antitumor activity and offer a scalable alternative to autologous CAR-T therapy

Hanan Jaber, Anas Abu Khalaf, Lola Weiss, Itay Cohen, Natali Bannoura, Tamara Osaili, Ortal Maximov, Abigael Eva Chaouat, Mark Kournos, Adi Tabib, Dror Mevorach, Yarden Engel, Michael Berger, Ofer Mandelboim, Shlomo Elias

Chimeric antigen receptor (CAR) T cell therapies have revolutionized treatment of hematologic malignancies such as lymphoma and multiple myeloma. However, their success is limited by high manufacturing costs, reliance on autologous T cells, variable product quality, and life-threatening toxicities like cytokine release syndrome. In contrast, natural killer (NK) cells offer a safer, more flexible alternative, but their clinical translation remains constrained by complex expansion protocols and high production costs. …

13.08.2026journal-article

Healthcare

Pulmonary emphysema: from molecular mechanisms to personalized therapy

I. Lapteva, A. Laptev, I. Orlova

This article presents a modern definition of pulmonary emphysema, diagnostic and modern methods of differentiated and surgical treatment. The role of rehabilitation and preventive measures in preventing the development of a disability in patients with pulmonary emphysema is discussed.

13.08.2026journal-article

Alimentary Pharmacology & Therapeutics

Review Article: Immune Effector Cell‐Mediated Enterocolitis Following CAR ‐T Cell Therapy—Clinical Features, Pathophysiology and Management

John A. Damianos, Yi Lin, Zongming Eric Chen, Kenneth J. C. Lim, Navreet M. Chowla

ABSTRACT Background Chimeric antigen receptor T‐cell (CAR‐T) therapy has revolutionised the treatment of hematologic malignancies, and its use is expanding rapidly into numerous other disease states including autoimmune diseases. However, CAR‐T therapy is associated with a spectrum of immune‐related toxicities. In addition to the already well characterized cytokine release syndrome and immune effector cell‐associated neurotoxicity syndrome, it has become apparent that rarely, CAR‐T can cause gastrointestinal mucosa …

13.08.2026journal-article

International Journal of Innovative Science and Research Technology

Targeting Cellular Senescence for Cancer Therapy

Awateef Fatima, Saba Yousuf

Cellular senescence is a permanent state of growth arrest that develops when cells encounter various forms of physiological or pathological stress. Although senescence initially functions as a protective mechanism by preventing the proliferation of damaged cells, persistent senescent cells can alter the surrounding tissue environment through the release of bioactive molecules collectively known as the senescence-associated secretory phenotype (SASP). These secretions may promote chronic inflammation, tumor progress …

13.08.2026journal-article

Child Language Teaching and Therapy

Supporting language development in preschools: Exploring teachers’ perceptions and SLT–teacher co-practice in SOLEM's classrooms

Edith Kouba Hreich, Christelle Maillart

This study investigated the SOLEM (Soutenir et Observer le Langage de l’Enfant en Maternelle; Supporting and observing children's language in preschool) intervention, a collaborative approach between preschool teachers and speech and language therapists designed to enhance language support in preschool classrooms. Fourteen teachers engaged in SOLEM's structured observation and support cycles, over 12–24 school months, receiving in-situ coaching from speech and language therapists. Using a convergent mixed-methods d …

13.08.2026journal-article

Open Forum Infectious Diseases

Fluoroquinolone-Free Prophylaxis and Impact on Bacterial Infections, Resistance, and Survival in Allo-HSCT: 5-Year Follow-up of the BATMO Protocol (Best Anti-microbical Therapy Trapianto di Midollo Osseo)

Daniele Avenoso, Mirko Farina, Simone Ferri, Lorenzo Masina, Liana Signorini, Silvia Lorenzotti, Evelyn Van Hauwermeiren, Biagio Francesco Canino, Silvia Corbellini, Francesca Caccuri, Gabriele Magliano, Enrico Morello, Vera Radici, Simona Bernardi, Federica Re, Alessandro Leoni, Arnaldo Caruso, Domenico Russo, Michele Malagola

Abstract Background Infectious complications and antimicrobial resistance (AMR) are leading causes of morbidity and non-relapse mortality (NRM) in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). The BATMO protocol, implemented in 2019, removed fluoroquinolone prophylaxis and introduced a personalized, stewardship-based antimicrobial approach. Methods We retrospectively analyzed 323 allo-HSCT recipients transplanted between 2016 and 2023 at a single center, comparing outcomes in p …

13.08.2026journal-article

Signo y seña

Entre falas e fios: Repertórios linguísticos, pertencimentos e identidades em uma comunidade de prática de rendeiras

Carla Regina Martins Paza

In this article, I aim to understand how linguistic repertoires are shared and restructured within the lacemaking group of Rio Vermelho, in Florianópolis, Santa Catarina (Brazil), revealing modes of learning, movements of identity and belonging, and the ideologies and power relations that permeate this practice. Drawing on the theoretical and methodological principles of the ethnography of speaking, I conducted participant observation, taking part in the group as both researcher and learner, as well as ethnographic …

13.08.2026journal-article

Frontiers in Oncology

Recent advancement in inflammatory biomarkers for cervical cancer diagnosis and therapy

Utkarsha Sahu, Sumeet Singh, Surbhi Jain, Mukesh Samant, Prashant Khare

Background Cervical cancer (CC) ranks as the fourth most prevalent malignancy among women. High-risk human papillomavirus (HPV) infection is a significant contributor to CC in economically disadvantaged nations. The incidence of CC may be significantly reduced by preventive measures, and early detection is strongly associated with improved survival rates. CC presents a substantial danger to women in low- and middle-income countries who often have severe and untreatable sicknesses due to limited resources. Results I …

13.08.2026journal-article

Student Journal of Occupational Therapy

Advancing occupational therapy practice: Evaluating a continuing education module to support the integration of 3D printing into clinical care.

Sophia Wilkes, Rebecca Ozelie

Background: This study aimed to evaluate whether a continuing education module could improve occupational therapy practitioners’ perceived knowledge, awareness, confidence, and clinical utilization of 3D printing in occupational therapy practice, while also examining how access to resources may influence implementation. Methods: A 14-week cross-sectional pre–post design was used with occupational therapy practitioners participating in a one-hour educational session followed by a three-week trial of 3D printer acces …

13.08.2026journal-article

Advanced Electromagnetics

Applying TCN-Based Rhythmic Electroencephalogram Data to Assist in the Construction of Autism Intervention Pathways in Music Therapy

A. S. Zhang, W. Sun, B. Y. Song

This study addresses the challenge of personalizing music therapy pathways for autism spectrum disorder (ASD) by developing a rhythmic electroencephalogram (EEG) decoding framework based on Temporal Convolutional Networks (TCN). Considering EEG as a representative bioelectromagnetic signal, the proposed approach provides an effective means for extracting neural dynamics relevant to individualized intervention assessment. Pre- and post-intervention EEG data were collected from 55 children with ASD during a 12-week m …

13.08.2026journal-article

Case Reports in Oncology

Long-Term Continuation therapy with Nab-Paclitaxel and Bevacizumab ± Anti-PD-1 in Advanced NSCLC: Case Reports and Mechanistic Insights：case report

Xiaofen Pan, Xueying Li, Jiehao Liao, Suhua Chen, Bo Wang

Background. The role of nab-paclitaxel in non-small cell lung cancer (NSCLC) maintenance therapy remains underexplored, particularly in combination with anti-angiogenic agents and immunotherapy. We present two cases of advanced NSCLC achieving prolonged progression-free survival (PFS) with nab-paclitaxel-based regimens. Case presentation. Case 1 (ALK-positive) received nab-paclitaxel+ bevacizumab every 4 weeks for more than 48 months. Case 2 (driver-negative) received nab-paclitaxel + bevacizumab + toripalimab ever …

13.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

Physical activities predict life satisfaction Among manufacturing employees: Fatigue as a moderating factor

Mingnan Zhao, Hui He, Haoqi Jiang, Yan Zhang

Background High-intensity work and rising occupational stress in manufacturing highlight the need to examine protective factors like physical activity. Objective This study explored the impact of physical activity attitudes and behavior on work stress and life satisfaction among Chinese manufacturing employees. Methods A cluster-sampled cross-sectional survey recruited 1202 factory employees (mean age 26.76 ± 5.33 years; 482 females, 720 males) and collected data on physical activity levels, attitudes, work stress, …

13.08.2026journal-article

Blood

Haploidentical transplant, gene therapy, and standard care in sickle cell disease: a cost-effectiveness analysis

Karthik Chetlapalli, Satoko Ito, Ding Quan Ng, Manraj Sra, Daniel Wang, Harlan M. Krumholz, Lakshmanan Krishnamurti, Ankur Pandya, George Goshua

Abstract Nonmyeloablative-related haploidentical allogeneic stem cell transplantation (NMAC-HID allo-HSCT) has emerged as an additional treatment to achieve durable remission in sickle cell disease (SCD), a prevalent blood disorder characterized by painful vaso-occlusive crises and chronic anemia. The standard of care (SOC) for SCD includes hydroxyurea, pain management, and blood transfusion, but patients with SCD still lose several decades of life expectancy. Gene therapy (GT) for SCD is the other treatment for li …

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13.08.2026journal-article

HIV Infection and Immunosuppressive Disorders

Medical and social characteristics of HIV‑positive men with different timings of antiretroviral therapy initiation

Z. A. Khalukhoeva, V. V. Rassokhin, A. Yu. Kovelenov

The а im : To analyze clinical, laboratory, and socio-demographic characteristics of men with HIV infection at stage 4B depending on the timing of antiretroviral therapy (ART) initiation. Materials and methods . A retrospective study of 120 men with stage 4B HIV infection undergoing follow-up at the Leningrad Region AIDS Center was conducted in 2024–2025. Clinical, laboratory, and sociodemographic data from primary medical records were assessed and analyzed. Microsoft Excel 2010 and StatTech v. 4.1, the Kruskal–Wal …

13.08.2026journal-article

Journal of Back and Musculoskeletal Rehabilitation

Postural angles, musculoskeletal pain, and body awareness in school-aged adolescents: An exploratory cross-sectional study

Feyza Altındal Karabulut, Nihal Büker

Background Adolescence is a critical developmental period during which habitual postural patterns and musculoskeletal behaviors are established. Altered sagittal alignment in this stage has been linked to discomfort, reduced body awareness, and later functional limitations. Understanding these relationships may support early musculoskeletal risk identification. Objective To examine the associations between sagittal postural angles, multisite musculoskeletal pain, and body awareness in school-aged adolescents. Metho …

13.08.2026journal-article

Rehabilitation Counseling Bulletin

An Application of Rehabilitation Counseling Theory for Understanding Coping Among People With Alopecia Areata

Garrett E Huck, Yongsu Song, Kylee Kohlhoff, Emma Montero, Annika Covington, Shaina Baxter

Theories of rehabilitation counseling have enriched our understanding of individual responses to chronic disease and disability for nearly a century. Nevertheless, despite its prevalence and profound psychosocial impact, alopecia areata (AA) remains underrecognized in rehabilitation and health literature. This research aims to investigate the role of different coping styles on relationship-related and subjective quality-of-life outcomes among individuals with AA, considering Livneh’s conceptualization of psychosoci …

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Aktuelle Forschung nach Fachgebiet

Sequenced, Not Stirred: Positioning CAR T and Bispecific Antibody Therapy in Multiple Myeloma

CANCELAMENTO VIRTUAL: UMA VIA (IN)ADEQUADA DE COMBATE AO DISCURSO DE ÓDIO

Assessment of Post-Earthquake Trauma and Coping Strategies for Earthquake-Related Stress Among Midwifery Students

Comparison of Animated Videos and E-Pocket Books Regarding Occupational Health and Safety Knowledge Among Anesthesia Nursing Students

How many athletes are enough? Small-sample instability of reliability indices and the minimum sample size for a trustworthy minimal detectable change in two-trial sport field tests: a Monte Carlo study

IMPLEMENTASI DEEP LEARNING HYBRID RESNET50V2-BIGRU PADA APLIKASI WEB VISUAL SPEECH RECOGNITION BAGI KOMUNITAS TULI

Overcoming Trial Exclusion: A Multicenter Analysis of Hemodialysis Multiple Myeloma Patients Who Underwent BCMA-Directed CAR-T Therapy

Irradiated CD19 chimeric antigen receptor YTS cells retain antitumor activity and offer a scalable alternative to autologous CAR-T therapy

Pulmonary emphysema: from molecular mechanisms to personalized therapy

Review Article: Immune Effector Cell‐Mediated Enterocolitis Following CAR ‐T Cell Therapy—Clinical Features, Pathophysiology and Management

Targeting Cellular Senescence for Cancer Therapy

Supporting language development in preschools: Exploring teachers’ perceptions and SLT–teacher co-practice in SOLEM's classrooms

Fluoroquinolone-Free Prophylaxis and Impact on Bacterial Infections, Resistance, and Survival in Allo-HSCT: 5-Year Follow-up of the BATMO Protocol (Best Anti-microbical Therapy Trapianto di Midollo Osseo)

Entre falas e fios: Repertórios linguísticos, pertencimentos e identidades em uma comunidade de prática de rendeiras

Recent advancement in inflammatory biomarkers for cervical cancer diagnosis and therapy

Advancing occupational therapy practice: Evaluating a continuing education module to support the integration of 3D printing into clinical care.

Applying TCN-Based Rhythmic Electroencephalogram Data to Assist in the Construction of Autism Intervention Pathways in Music Therapy

Long-Term Continuation therapy with Nab-Paclitaxel and Bevacizumab ± Anti-PD-1 in Advanced NSCLC: Case Reports and Mechanistic Insights：case report

Physical activities predict life satisfaction Among manufacturing employees: Fatigue as a moderating factor

Haploidentical transplant, gene therapy, and standard care in sickle cell disease: a cost-effectiveness analysis

Medical and social characteristics of HIV‑positive men with different timings of antiretroviral therapy initiation

Postural angles, musculoskeletal pain, and body awareness in school-aged adolescents: An exploratory cross-sectional study

An Application of Rehabilitation Counseling Theory for Understanding Coping Among People With Alopecia Areata