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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

International Journal of Sports Physical Therapy

Calcific Patellar Tendinopathy. A Case Report Integrating Diagnostic Ultrasound Throughout a Multi-Modal Treatment Approach

Ian Young, Adam Salzman, James Dunning, Joshua Prall, Sam Fischer, Brittany Forbes, James Escaloni

Background Calcific tendinopathy can be difficult to diagnose and manage from a traditional, non-invasive physical therapy perspective. However, there is preliminary evidence supporting the use of diagnostic ultrasound and dry needling interventions to evaluate and treat the pain and disability associated with this chronic condition. The purpose of this case report was to describe the integration of diagnostic ultrasound in the successful evaluation and multi-modal treatment of a patient with calcific patellar tend …

02.09.2026journal-article

Frontiers in Oncology

Migrastatics: an overview of the current scenario and future cancer treatments

Irene Olivas-Cano, M. Angeles Juanes

Metastasis is the main cause of cancer-related death worldwide. Thus, significant efforts have been directed towards inhibiting metastasis to avoid regrowth or relapse after cytostatic and/or cytotoxic cancer treatments. Drugs targeting cell-invasiveness are known as migrastatics and primarily target the cytoskeleton to impair cell motility and/or invasive mechanisms. However, the cytoskeleton is essential to perform many fundamental processes, including cell division. Consequently, migrastatics often prompt high t …

02.09.2026journal-article

Pharmaceutics

Extracellular Vesicle–Lipid Hybrid Systems for RNA Delivery in Cancer: Structural Classification, Functional Delivery, and Translational Challenges

Lu Lu, Yige Qiu, Jiayu Wu, Wei Dou, Jing Yang, Bo Zhang

RNA therapeutics offer considerable potential for cancer treatment. Their therapeutic application, however, remains limited by rapid degradation, inefficient cellular uptake, and restricted intracellular release. Extracellular vesicles (EVs) are cell-derived membrane vesicles that have been exploited as promising vehicles for drug delivery due to their high biocompatibility and low immunogenicity, whereas liposomes and lipid nanoparticles provide tunable lipid composition and efficient loading of exogenous nucleic …

02.09.2026journal-article

ACS Photonics

Ultrasensitive Whispering-Gallery Extracellular Vesicle Biosensor for Early Gastric Cancer Detection

Chenjie Xu, Bing Duan, Mingyuan Liu, Xiangji Li, Yixuan Zhao, Tao Yang, Yisu Yang, Haosu Zhan, Qi-Tao Cao, Jin-hui Chen, Li Min, Daquan Yang

Abstract Extracellular vesicles (EVs) have emerged as superior tools compared with plasma tumor biomarkers for gastric cancer detection. However, clinical practice of EV detection for early stage gastric cancer (EGC) discrimination remains limited, primarily hindered by the low sensitivity of current detection technologies and the intrinsic complexity of EVs. Here, we propose a label-free microfluidic microsensor for the ultrasensitive and rapid detection of EVs in mixed environments. An estimated detection limit o …

02.09.2026journal-article

Proceedings of the National Academy of Sciences

Targeting CTGF + cancer-associated fibroblasts disrupts tumor–stroma crosstalk in pancreatic ductal adenocarcinoma

Yiwen Shen, Qingyan Sun, Yunzhe Wang, Sichao Tian, Yuzhu Li, Dong Lu, Shiqun Wang, Jinmei Jin, Hao Zhang, Hongzhuan Chen, Zhao Zhang, Jiangjiang Qin, Weidong Zhang, Xin Luan

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a heavily fibrotic tumor microenvironment (TME), primarily driven by cancer-associated fibroblasts (CAFs). Due to the high heterogeneity and diverse biological behaviors of CAFs, the current strategies targeting CAFs have limited benefits in clinic. This study identifies a subset of CAFs marked by high expression of connective tissue growth factor (CTGF), which enhances tumor cell migration and correlates with advanced PDAC stages. By combining in silico s …

02.09.2026journal-article

JAMA Network Open

Dietary Fat Intake and Mortality Among Patients With Nonmetastatic Prostate Cancer

Yiwen Zhang, Megan R. Shanahan, Hannah E. Guard, Jiachen Ji, Maria Celia Fernandez, Nadia Boufaied, Jane B. Vaselkiv, Binkai Liu, Chaoran Ma, Rebecca E. Graff, Stacy Loeb, Caroline Himbert, Yuan Ma, Edward L. Giovannucci, David P. Labbé, Lorelei A. Mucci

Importance There are 3.5 million prostate cancer survivors in the US, with a need for evidence-based lifestyle recommendations that improve survivorship. Objective To assess whether consumption of specific dietary fats after diagnosis is associated with long-term survival among patients with nonmetastatic prostate cancer. Design, Setting, and Participants This study, nested in the Health Professionals Follow-Up Study, a cohort of male health professionals from across 50 US states ongoing since 1986, included partic …

1 Zitationen
02.09.2026journal-article

Biomedicines

Stem Cell-Derived Extracellular Vesicles for the Treatment of Osteoporosis: A Systematic Review of Preclinical Evidence

Yi Yang, Lifen Qiao, Yan Huang, Qin Xia, Hui Xie

Background: Osteoporosis is a prevalent skeletal disorder characterized by reduced bone mass and microarchitectural deterioration, resulting in an increased risk of fractures. Stem cell-derived extracellular vesicles (EVs) have emerged as a promising cell-free therapeutic strategy owing to their inherent advantages, including excellent biocompatibility, low immunogenicity, diverse biological activities, and engineering potential. Despite growing interest in this field, the existing preclinical evidence remains high …

02.09.2026journal-article

Experimental & Molecular Medicine

Histone deacetylases in cancer metabolic reprogramming

Yu Hyun Jeon, Hyeyeong Seo, Ji Woo Youn, Jung Yoo, Sang Wu Lee, Soo Yeon Oh, So Hee Kwon

Abstract Cancer cells undergo extensive metabolic reprogramming to sustain rapid proliferation and adapt to heterogeneous tumour microenvironments. These metabolic alterations are tightly linked to epigenetic regulation, which reshapes gene expression and cellular signalling mechanisms. Among epigenetic regulators, histone deacetylases (HDACs) have emerged as key modulators of cancer metabolic reprogramming. Along with their canonical roles in histone deacetylation, HDACs regulate non-histone substrates, including …

02.09.2026journal-article

Pharmaceuticals

Treatment-Emergent Epiretinal Membrane in Diabetic Macular Edema: A Real-World OCT-Based Comparative Pharmacotherapy Study Across Intravitreal Agents—The TRIDENT-DME Study

Debdulal Chakraborty, Tushar Kanti Sinha, Rupak Kanti Biswas, Aniruddha Maiti, Manab Jyoti Barman, Ranabir Bhattacharya, Subhendu Kumar Boral, Arnab Das

Purpose: To evaluate the incidence, predictors, and clinical impact of treatment-emergent epiretinal membrane (ERM) in diabetic macular edema (DME) treated with dexamethasone implant, aflibercept, ranibizumab, bevacizumab, or faricimab. Methods: In this multicenter, retrospective, nonrandomized study, 501 eyes with center-involving DME were assessed and 423 eyes without ERM on pretreatment OCT and with 24-month follow-up were included. Eyes were classified by the intravitreal agent selected by the treating physicia …

02.09.2026journal-article

American Journal of Surgical Pathology

International Society of Urological Pathology Multidisciplinary Expert Consultation Conference on Evaluation of Treatment Effects in Prostate and Bladder Cancer

Michelle R. Downes, Sara E. Wobker, Steven C. Smith, Markus Eckstein, Mahmut Akgul, Dilek E. Baydar, Fadi Brimo, Eva Compérat, Arndt Hartmann, Ashish M. Kamat, Anandi Lobo, Maria R. Raspollini, Ankur R. Sangoi, Shahrokh F. Shariat, Toyonori Tsuzuki, Bas W. G. van Rhijn, Sean R. Williamson, Geert J. L. H. van Leenders, Liang Cheng, Antonio Lopez-Beltran, the Members of ISUP GU Cancer Treatment Effects Consensus Panel

Treatment effects in the urinary bladder are variable and range from localized post-transurethral resection changes to widespread systemic therapy effects. The International Society of Urological Pathology (ISUP) organized a consensus meeting in Vienna, Austria, in September 2025, focused on the evaluation of treatment effects in both the prostate and bladder. Working Group 2 was assigned the topic of the urinary bladder, and a group of pathologists and clinicians was convened. They worked cooperatively to develop …

02.09.2026journal-article

Analytical Chemistry

Precise Mutation Detection in Low-Abundance Tumor-Derived Extracellular Vesicles via Microfluidic Immunomagnetic Reversible Affinity Capture

Xing Xu, Shanshan Liang, Hengkai Chen, Tianchen Lan, Xinyan Peng, Yupeng Chen, Guanlong Wei, Canjie Liao, Ao Li, Zhiwei Liu, Rui Su, Jinfu Zhuang, Chaoyong Yang

Abstract Molecular diagnostic technologies based on liquid biopsy are increasingly vital for clinical tumor molecular profiling. Compared to highly fragmented and easily degradable cell-free DNA (cfDNA), extracellular vesicles (EVs) offer distinct advantages by protecting nucleic acids from degradation. Enrichment of tumor-derived EVs using specific surface markers significantly enhances the relative abundance of mutant nucleic acids, establishing a foundation for highly sensitive mutation detection. To fully lever …

02.09.2026journal-article

Bioresources and Bioprocessing

Unveiling the mechanism of metabolites derived from gut microbiota in the treatment of acute kidney injury via network pharmacology and bioinformatics

Weiguo Yao, Jinlin Huo, Kun liu, Pengyu Tao

Abstract Background Acute kidney injury (AKI) affects a considerable proportion of patients that represents a major challenge for clinical treatment. Gut microbiota metabolites have been reported to attenuate acute kidney injury (AKI), yet their underlying mechanisms remain largely elusive. The present study aimed to explore the protective mechanisms of these metabolites against AKI using. Methods The targets of metabolites and AKI were obtained from public databases. The PPI network is utilized to identify the cor …

02.09.2026journal-article

Cancer Research

Varying Cancer Drug Doses to Balance Tumor Control and Resistance Evolution

Amy E. Pomeroy, Adam C. Palmer

The effectiveness of any cancer therapy depends on its dose and its treatment schedule. A potential third dimension of regimen design is whether intentional fluctuations in administered dose might improve treatment outcomes. In this issue, West and colleagues demonstrate that dose fluctuations can alter both tumor drug response and the evolution of drug resistance, in ways related to the shapes of dose–response functions. In mouse xenograft models of ALK-fusion non–small cell lung cancer treated with the ALK inhibi …

02.09.2026journal-article

Acta Oncologica

Tolerability and adherence to adjuvant abemaciclib in hormone receptor-positive, HER2-negative, node-positive high-risk early breast cancer: a real-world study

Carl Rosander, Karolina Larsson, Per Karlsson

Background and purpose: Abemaciclib in addition to adjuvant endocrine therapy for hormone receptor positive (HR+) breast cancer improves disease free survival (IDFS) and overall survival (OS). However, treatment-related adverse events may lead to early discontinuation. Sahlgrenska University Hospital implemented a gradual increase in initial dosing, with the intention to improve tolerability and adherence.Patient/material and methods: This retrospective observational study described adherence, tolerability and heal …

02.09.2026journal-article

Cancers

Benefit–Hematotoxicity Stratification in Patients with Triple-Negative Breast Cancer Receiving Platinum-Based Neoadjuvant Therapy: A Multitask Deep Learning Study

Hao Sun, Xinglu Zhou, Jian Liang, Yujie Shi, Bao Deng, Ziqi Guo, Tong Su, Binbin Guo, Lei Zhong

Objectives: Platinum-based neoadjuvant therapy can improve pathological response in triple-negative breast cancer (TNBC), but severe hematotoxicity may compromise treatment delivery. This study developed and validated a multitask learning framework to jointly predict pathological complete response (pCR) and severe hematotoxicity and to support benefit–hematotoxicity stratification. Methods: This multicenter retrospective study included 2060 consecutive patients with TNBC receiving platinum-based neoadjuvant therapy …

02.09.2026journal-article

Artefactum - revista de estudos interdisciplinares

COMPATIBILITY OF RICE HUSK AS A CARRIER MEDIUM FOR BACILLUS SP. IN AN ACTIVATED SLUDGE PROTOTYPE FOR DOMESTIC SEWAGE TREATMENT

Carlos Eduardo Saraiva Mauer

Sanitation in Brazil still shows significant gaps in coverage and operational efficiency, which encourages the search for inputs capable of enhancing the performance of wastewater treatment plants. Among these inputs are granular bioremediators, whose formulation relies on food-grade cereals – mainly wheat bran – as the carrier medium for microorganisms, accounting for roughly 70% of the product cost. This article assesses the compatibility of rice husk, an abundant and low-cost agro-industrial residue, as a carrie …

02.09.2026journal-article

Academy for Practical Oncology

Comparative analysis of clinical and functional results of one-stage and two-stage breast reconstruction after mastectomy in patients with large mammary glands

S. V. Kozlov, O. I. Kaganov, M. V. Tkachev, A. V. Bukin

BACKGROUND : The advancement and refinement of surgical treatment approaches for breast carcinoma facilitate the preservation of a high quality of life in patients following reconstructive procedures, particularly in cases of substantial breast volume and pronounced ptosis. AIM : To compare the immediate and long-term outcomes and quality of life in patients undergoing two-stage versus one-stage reconstruction after skin-sparing mastectomy in breasts exceeding 150 mL in volume. METHODS : A retrospective analysis of …

02.09.2026journal-article

Frontiers in Medicine

Real-world effectiveness and safety of tenofovir amibufenamide in treatment-naïve chronic hepatitis B: a 48-week retrospective cohort study

Jiarui Zheng, Yuxuan Song, Bo Feng, Yandi Xie

Objectives Tenofovir amibufenamide (TMF) is a newly recommended first-line nucleos(t)ide analogues for chronic hepatitis B (CHB) in China. However, real-world evidence on its safety and effectiveness are limited. This study aimed to evaluate the short-term virological efficacy, biochemical response, as well as safety profile of TMF over 48 weeks in a real-world cohort of CHB individuals. Methods In this single-center retrospective cohort study, 129 treatment-naïve CHB patients were administered TMF at 25 mg daily. …

02.09.2026journal-article

International Orthopaedics

Historical contributions and future horizons of Japanese orthopaedic oncology: from surgical innovation to nationwide collaborations

Akira Kawai, Keisuke Horiuchi, Koji Hiraoka, Toshifumi Ozaki, Kazuhiro Tanaka, Hirotaka Kawano

Abstract Purpose Bone and soft tissue sarcomas are rare, heterogeneous malignancies presenting major diagnostic and therapeutic challenges. Over the past century, Japanese orthopaedic surgeons have occupied a unique position as both primary surgeons and comprehensive oncologists. On the occasion of the Centennial of the Japanese Orthopaedic Association (JOA), this review synthesizes the key historical milestones and future prospects of Japanese orthopaedic oncology. Methods A narrative synthesis was structured acro …

02.09.2026journal-article

The American Journal of Tropical Medicine and Hygiene

A Sustainable Treatment Protocol for Organophosphate Poisoning in Rural Kenya for Facilities without Intensive Care Units and Where Transfer Is Not Possible

Jerome Koleski, Sommer Aldulaimi, Jonathan Nthusi

ABSTRACT. Organophosphate poisoning is a common method of attempting suicide in developing countries, particularly in rural areas. The current WHO protocols emphasize intubation and transfer to a facility with intensive care. Both recommendations are beyond the resources of many rural hospitals in developing countries and their poor patients. Because organophosphate poisoning is a commonly seen condition in Kenya and because intubation is beyond the equipment and training of many rural hospitals, a protocol involvi …

02.09.2026journal-article

Cancer Research Communications

The role of germline transposable element insertions in pediatric cancer predisposition

Corinne E. Sexton, Kayla V. Hamilton, Chong Chu, David T. Ting, Judy E. Garber, Peter J. Park, Junne Kamihara

Abstract At least 15% of children with cancer have a pathogenic germline variant in a cancer predisposition gene. Studies of germline cancer predisposition, however, have focused primarily on single nucleotide and copy number variants, leaving other classes such as transposable elements (TEs) largely unexplored. Although rare pathogenic TE insertions have been implicated in inherited cancer, their contribution to pediatric cancer predisposition remains unknown, partly because these repetitive sequences often requir …

02.09.2026journal-article

Problems of Gathering Treatment and Transportation of Oil and Oil Products

FEATURES OF GEOPHYSICAL METHODS FOR STUDYING HYDRAULIC FRACTURE PARAMETERS IN VERTICAL AND DIRECTIONAL WELLS

R.R. Murtazin

The paper presents a comprehensive systematic analysis of modern geophysical methods for evaluating hydraulic fracture parameters in vertical and deviated wells. The main existing approaches are reviewed, including well testing, microseismic monitoring, and a suite of production geophysics techniques: cross-dipole broadband acoustic logging (BAL), thermometry, radioactive tracers, and non-radioactive tagged (NRT) proppant technology. A comparative analysis of the information content and reliability of each method i …

02.09.2026journal-article

Cancer Epidemiology, Biomarkers & Prevention

Racial/Ethnic Disparities in Risk of Second Primary Malignancies among Diffuse Large B-Cell Lymphoma Survivors

Pragati Gole Advani, Han Yu, Kayla Catalfamo, Pallawi Torka

Abstract Background: Previous studies have shown an increased risk of second primary malignancies (SPM) among diffuse large B-cell lymphoma (DLBCL) survivors; however, this has not been comprehensively examined by race/ethnicity. Methods: From 17 US population–based Surveillance, Epidemiology, and End Results (SEER) program cancer registry areas, we identified 68,358 ≥ 12-month DLBCL survivors diagnosed between 2000 and 2022. Standardized incidence ratios (SIR) and accompanying 95% confidence intervals (CI) quantif …

02.09.2026journal-article

Pathogens

Surgical Treatment of Tuberculous Pleural Empyema in Children and Adolescents: A Retrospective Cohort Study

Dmitry B. Giller, Alexandr D. Chuishchev, Inga I. Enilenis, Vadim V. Koroev, Oleg S. Kesaev, Galina V. Shcherbakova, Patimat G. Gadzhieva, Ludmila P. Severova, Nadezhda I. Klevno, Alexey V. Kazakov, Olga P. Frolova, Olga V. Butylchenko, Alexandr N. Ilyukhin, Valeriya A. Basangova, Evelina Y. Morozova, Ivan I. Martel

Background: While non-specific pleural empyema in children can be successfully managed with conservative drainage and thoracentesis in 80–84% of cases, tuberculous pleural empyema (TB empyema) exhibits high resistance and frequently requires extensive thoracic surgery. The choice of surgical scope depends directly on disease stage and secondary complications. Methods: We conducted a retrospective cohort study of 85 pediatric patients (aged 4 to 17 years) with confirmed TB empyema treated between 1984 and 2022, and …