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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
13.08.2026journal-article

Cancers

Cardiac Conduction Disorders in Melanoma Patients Treated with CTLA-4-Containing Versus PD-1-Only Immune Checkpoint Inhibitor Therapy: A Propensity Score-Matched Real-World Analysis

Ali Awad, Joe Khodeir, Qusai AlQudah, Nur Saleh, Mariam Chalhoub, M. Chadi Alraies

Background: Immune checkpoint inhibitors (ICIs) have transformed the treatment of advanced melanoma, but the comparative cardiac safety of cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4)-containing regimens versus programmed cell death protein 1 (PD-1)-only regimens in real-world populations remains poorly characterized. We compared cardiac outcomes between melanoma patients exposed to CTLA-4 blockade (ipilimumab) and those treated with anti-PD-1 therapy alone (nivolumab or pembrolizumab) using a large multice …

13.08.2026journal-article

Frontiers in Oncology

Multi-omics integration in malignant pleural mesothelioma: from molecular evolution and immune ecosystems to precision therapy

Hongmei Li, Kunzhong Zhou, Ruiting Xu, Weifang Wang, Tingting Song, Yonghong Zhou, Jing Ren, Zhiyong Wang, Yiteng Liang, Yilin Chen, Saurav Poudel, Junxuan Yu, Rui Lin, Ke Yin, Shengjie Yang, Li Zhuang

Malignant pleural mesothelioma (MPM) exhibits substantial molecular and cell-state heterogeneity, together with marked spatial variation in its immune and stromal microenvironment. Histological classification and individual biomarkers alone cannot adequately explain its evolution or heterogeneous treatment responses. This review critically integrates genomic, epigenomic, transcriptomic, single-cell, and spatial omics evidence along a conceptual continuum encompassing tumor-intrinsic molecular evolution, microenviro …

13.08.2026journal-article

Blood

IDH2 clonal hematopoiesis and IKAROS loss cooperate in a B-ALL subtype after lenalidomide therapy for multiple myeloma

Johanna M. Horns, Thomas Beder, Axel Künstner, Malwine J. Barz, Sonja Bendig, Cecilia Bozzetti, Guranda Chitadze, Nikos Darzentas, Katharina Iben, Michaela Kotrova, José I. Martín-Subero, Mayukh Mondal, Martin Neumann, Raúl F. Pérez, Aeint-Steffen Ströh, Wiebke Weßels, Lennart Lenk, Lars Velten, Boris Böll, Krischan Braitsch, Veit Bücklein, Johannes Duell, Christoph Faul, Walter Fiedler, Maher Hanoun, Snjezana Janjetovic, Felix Klingler, Stefan Knop, Christoph Röllig, Stefan Schwartz, Bernd Spriewald, Björn Steffen, Klaus Wethmar, Hauke Busch, Nicola Gökbuget, Claudia D. Baldus, Lorenz Bastian, Monika Brüggemann

Abstract Lenalidomide, a maintenance treatment in multiple myeloma first-line therapy, increases the risk of secondary malignancies, including B-cell precursor acute lymphoblastic leukemia (B-ALL). We present a comprehensive molecular characterization of 57 patients with lenalidomide-associated B-ALL (LenB-ALL), revealing 3 mutational subgroups: (1) TP53mt (30%); (2) IDH2mt (p.R140Q) (23%); and (3) other, including NRAS/KRASmt. Remarkably, IDH2 R140Q mutations were highly enriched in LenB-ALL compared with those in …

3 Zitationen
13.08.2026journal-article

Oral

Effects of Periodontal Therapy on Psoriasis Severity: A Systematic Review of the Clinical Evidence

Giuseppe Trapanese, Leopoldo Mauriello, Luca Ramaglia, Alessandro E. di Lauro, Vincenzo Iorio-Siciliano, Elio Ramaglia, Andrea Blasi, Vitolante Pezzella

Background: Periodontitis and psoriasis are chronic inflammatory diseases that share common risk factors and immune-mediated pathogenic pathways, suggesting a potential bidirectional relationship. Periodontal inflammation contributes to systemic inflammatory burden, which may influence the severity of immune-mediated diseases, such as psoriasis. Objective: The aim of this systematic review is to evaluate the effects of periodontal therapy on psoriasis severity in patients affected by both conditions. Methods: This …

13.08.2026journal-article

Indian Journal of Plastic Surgery

Modified Negative Pressure Wound Therapy (NPWT) and Prophylactic Lymphovenous Anastomosis (LVA) in the Early Management of Open Degloving Injury

Simay Ersahin, Mehmet H. Unersoy, Gulsen Ozsahin, Aydan A. Kose

Abstract Degloving injuries disrupt perforating vessels and lymphatics, making early viability assessment difficult and predisposing patients to hematoma, seroma, persistent cavities, and posttraumatic lymphedema. We report a 19-year-old male with a 180-degree open thigh degloving injury managed with quilting sutures and a modified negative pressure wound therapy technique using perforated Nelaton catheters to enhance drainage and dead-space collapse. On postoperative day 22, prophylactic lymphovenous anastomosis ( …

13.08.2026journal-article

Journal of NeuroEngineering and Rehabilitation

Ipsilateral inhibitory rTMS restores interhemispheric motor cortex balance and reduces phantom limb pain: an exploratory longitudinal nTMS mapping study

Ghaith Altawalbeh, Eugen Ursu, Filippo Emanuele Colella, Maria Goldberg, Raimunde Liang, Axel Schröder, Sebastian Ille, Sandro M. Krieg, Melissa Zavaglia, Amartya Ganguly, Chiara Negwer, Bernhard Meyer, Arthur Wagner

Abstract Background Phantom limb pain (PLP) is a debilitating condition associated with maladaptive neuroplastic changes following limb amputation. The prevailing neuromodulatory approach targets the deafferented contralateral motor cortex, yet interhemispheric imbalance is increasingly recognized as a central pathophysiological feature of PLP. We investigated whether inhibitory repetitive transcranial magnetic stimulation (rTMS) applied to the ipsilateral (unaffected) hemisphere could reduce PLP and induce measura …

13.08.2026journal-article

Advanced Electromagnetics

Collaborative Analysis of Multi-School Midwifery Teaching Data Driven by Federated Learning

Y. Wang, J. Wang

Midwifery teaching data from multiple universities are often dispersed across institutions, forming data silos that hinder cross-university teaching analysis and optimization while increasing privacy risks under centralized processing. To address this problem, this paper constructs a cross-university collaborative analysis framework based on federated learning. The framework first uniformly encodes and standardizes midwifery teaching data features across universities to ensure cross-institutional data comparability …

13.08.2026journal-article

INTERNATIONAL JOURNAL OF ENGINEERING AND MODERN TECHNOLOGY

Integrating Nature and Healing Landscapes in an NDLEA Rehabilitation Center, Port Harcourt

Oluwaferanmi Adepetu

Substance abuse was identified as a major public health challenge in Nigeria, with increasing drug use creating a greater demand for rehabilitation facilities that support both treatment and long-term recovery. Although existing rehabilitation centres primarily emphasized security and supervision, evidence from healthcare architecture indicated that the physical environment could significantly influence patients' psychological well-being and recovery outcomes. This study therefore explored the integration of nature …

13.08.2026journal-article

OTJR: Occupational Therapy Journal of Research

Flow and Technology Acceptance in Extended Reality Leisure Participation During Mental Health Occupational Therapy

Chia-Hui Hung, Shiu-Yuan Yang, Hsiang-Ju Chang, Yu-Ju Chen, Han-Si Shih, Shih-Chen Fan

This convergent mixed-methods study examined extended reality (XR)-supported leisure participation among 12 long-term psychiatric inpatients completing an 8-week virtual reality and augmented reality program within occupational therapy. Flow experience and technology acceptance were assessed quantitatively alongside qualitative thematic analysis of weekly semi-structured interviews. Flow experience increased significantly ( p < .05, r = .82), while technology acceptance remained stable. Perceived usefulness signifi …

13.08.2026journal-article

Multiple Sclerosis Journal

Gynecologic complications of disease-modifying therapy in women with multiple sclerosis

Alexandra Balshi, John P Dempsey, Yanli Zhang-James, Riley Bove

Background/Objectives: The long-term implications of multiple sclerosis (MS) disease-modifying therapies (DMTs) on gynecologic health remain understudied. We leverage a multicenter database to evaluate whether DMTs are associated with such complications. Methods: We propensity-score 1:1 matched women with MS on (1) any versus no or (2) moderate- to high- (vs low-) immunosuppressive DMT by age, marital status, race, ethnicity, tobacco use, body mass index, human papilloma virus (HPV) vaccination, and gynecologic exa …

13.08.2026journal-article

JAMA

Focal Therapy for Prostate Cancer

Andrea Cosenza, David-Dan Nguyen, Zhiyu Qian, Rui Bernardino, Adam Olson, Alexander P. Cole, Benjamin J. Davies, Giorgio Gandaglia, Bruce L. Jacobs, Quoc-Dien Trinh

This retrospective study uses data from the National Cancer Database to examine patterns and temporal trends in use of focal therapy for prostate cancer in US cancer centers; characterize inappropriate use in low-, high-, or very–high-risk disease; and describe intermediate-risk use.

1 Zitationen
13.08.2026journal-article

Jurnal Informatika dan Teknik Elektro Terapan

IMPLEMENTASI SPEECH EMOTION RECOGNITION UNTUK KLASIFIKASI TINGKAT STRES DARI VOICE NOTE BERBASIS HYBRID CNN-LSTM

Muhamad Fakhri Khairil Imam

Kesehatan mental menjadi isu penting seiring meningkatnya tekanan psikologis akibat gaya hidup digital, namun deteksi stres masih mengandalkan instrumen self-report yang bersifat terjadwal dan subjektif. Penelitian ini mengembangkan sistem Speech Emotion Recognition (SER) berbasis voice note berbahasa Indonesia untuk mengklasifikasikan tingkat stres menggunakan pendekatan hybrid CNN-LSTM (akustik) dan Zero-Shot Classification IndoBERT (linguistik) dengan metodologi CRISP-DM. Model dilatih menggunakan dataset gabung …

13.08.2026journal-article

Journal of VitreoRetinal Diseases

Incidence and Recovery of 15-Letter Loss of Visual Acuity in Patients With Neovascular Age-Related Macular Degeneration on Antivascular Endothelial Growth Factor Therapy

Calvin X. Taylor, Hayden Reed, Katherine E. Talcott, Rishi P. Singh

Purpose: To describe how 15-letter loss of visual acuity (VA) in patients with neovascular age-related macular degeneration (nAMD) results in transient fluctuations in vision. In addition, to compare recoverability of letter loss in patients treated with antivascular endothelial growth factor (anti-VEGF) with untreated patients. Methods: Patients with previously untreated nAMD in the Comparisons of AMD Treatments Trials were assigned to transient and nontransient groups based on recovery of baseline best-corrected …

13.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

Occupational strain and post-retirement rehabilitation among older factory workers

Hema Shangkari Poobalan, Viswanathan Annamalai, Briget Yi Jack Chin, Dina Adam, Pradeep Balakrishnan, Vikram Mohan, Ai Yean Phan

Background Long-term factory work involves repetitive, physically demanding tasks that contribute to musculoskeletal degeneration in later life, particularly affecting the knee and cervical spine among ageing workers. Qualitative evidence on how retired industrial workers perceive occupational strain, arthritis progression and post-retirement rehabilitation remains limited. Objective To explore the lived experiences of retired factory workers with knee and neck arthritis, focusing on perceived occupational causatio …

13.08.2026journal-article

Turkish Journal of Medical Sciences

Repurposing diclofenac for combination therapy: targeting the Warburg effect to enhance breast cancer treatment ​

GONCA TUNA, ELİF ERTÜRK, AYŞEN SAĞNAK, FERDA ARI

Background/aim: Diclofenac (Diclo), a widely used nonsteroidal antiinflammatory drug, has emerged as a potential candidate for drug repurposing in oncology, with reported anticancer effects extending beyond cyclooxygenase (COX) inhibition, including modulation of tumor metabolism. This study investigated the antiproliferative and glycolysis-associated effects of Diclo in MCF-7 breast cancer cells, alone and in combination with docetaxel (Doc) or 5-fluorouracil (5-FU). Materials and methods: Cell viability was asses …

13.08.2026journal-article

International Journal of Nursing and Midwifery Science (IJNMS)

CADRE SATISFACTION IN USING THE SI CETING APPLICATION AS AN INFORMATION AND EDUCATION MEDIA FOR STUNTING PREVENTION IN LEMINGGIR VILLAGE, MOJOSARI DISTRICT, MOJOKERTO REGENCY

Elies Meilinawati S. Budihartini

Cadres play an important role in delivering health education to prevent stunting. The use of digital educational media is expected to improve access to accurate information and support cadres in carrying out health promotion activities. This study aimed to determine cadres' satisfaction with the use of the SI CETING application as an information and education media for stunting prevention. This study employed a descriptive quantitative design. The research was conducted among cadres in a rural area. A total of 31 r …

13.08.2026journal-article

Trials

Remote STrOke Rehabilitation (ReSTORe): study protocol for a randomised controlled trial

Stuart Ennis, Lucy Eggleston, Nicole De Valliere, Harbinder Sandhu, Julie Bruce, Ranjit Lall, Anower Hossain, Mariam Ratna, Jason Madan, Mandana Zanganeh, Yufei Jiang, Jo Parsons, Yin-Ling Lin, Frances Ford, Marcus Davies, Rebecca Palmer, Ali Ali, Gordon McGregor

Abstract Background At least one third of long-term stroke survivors living at home experience ongoing (≥6 months) mild to moderate disability including fatigue, low functional capacity, muscle weakness, anxiety, and depression. Health-related quality of life (HRQoL) and societal participation are affected, particularly after routine contact with health professionals ends. Outpatient centre-based exercise rehabilitation programmes can improve physical and mental health, but these services are rarely provided in the …

13.08.2026journal-article

Frontiers in Medicine

Biomarker-driven immunotherapy and adoptive cell therapy in recurrent pancreatic ductal adenocarcinoma

Tao He, Guoan Li, Fuzhen Qi

Recurrent pancreatic ductal adenocarcinoma (PDAC) includes circulating tumor DNA (ctDNA)-defined molecular residual disease (MRD), isolated or oligometastatic relapse, disseminated measurable recurrence, and heavily pretreated refractory disease. These states differ in tumor burden, treatment urgency, tissue accessibility, and immune competence and should not be treated as one population. Immune checkpoint blockade has minimal activity in unselected PDAC, and randomized trials have not shown consistent benefit from …

13.08.2026journal-article

Journal of Endovascular Therapy

Transradial Access Versus Transfemoral Access in Angioplasty and Stenting for Peripheral Arterial Diseases: A Meta-Analysis of Comparative Studies and Systematic Review

Wenxin Yang, Zhaoxi Peng, Hongji Pu, Yan Fu, Yijun Liu, Peng Qiu, Xinwu Lu, Kaichuang Ye

Purpose: To compare the efficacy and safety of transradial (TR) versus transfemoral (TF) access in peripheral arterial angioplasty and stenting, providing evidence to guide clinical decision-making in endovascular interventions. Methods: A systematic review and meta-analysis were conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Randomized controlled trials (RCTs) and cohort studies comparing TR and TF approaches in patients with peripheral artery disease (P …

13.08.2026journal-article

Designs

Design of a New 3-UPU/S Parallel Ankle Rehabilitation Mechanism

Assia Abdi, Ridha Kelaiaia, Brahmia Allaoua, Adlen Kerboua, Ameur Latreche

Ankle injuries may lead to severe complications, including chronic instability and reduced mobility. Rehabilitation therefore plays a critical role in restoring normal ankle function and preventing long-term impairment. However, conventional manual physiotherapy presents several limitations, such as limited availability of therapists, variability in treatment, and reduced accessibility for home-based rehabilitation. Consequently, significant research efforts have been devoted to the development of robotic and mecha …

13.08.2026journal-article

RESEARCH JOURNAL OF PURE SCIENCE AND TECHNOLOGY

Spatial–Temporal Assessment of Indoor Air Quality and Occupational Risk-Control Practices in an Oil and Gas Facility in Delta State, Nigeria

Yusuf Saibu

This study evaluated the space- and time-varying Indoor Air Quality (IAQ) and Occupational Risk control Practices (ORCP) in Administrative Workspaces (AW) of an operating Oil and Gas Facility (OGF) in Delta State, Nigeria. A workplace-based observational cross-sectional design was used, with morning and evening measurements conducted in the reception area and three administrative offices, yielding 8 workspace-period observations. PM₂.₅, PM₁₀, CO₂, CO, SO₂, NO₂, TVOC, and relative humidity and temperature were measu …

13.08.2026journal-article

Anatomical Sciences Education

Re‐humanizing anatomy? Learning through human body donors in physiotherapy education

Robert Parish, Chris Carter, John Stephens, Debs Patten

Abstract Anatomical knowledge underpins clinical skills and professional identity in physiotherapy. However, dedicated teaching has declined in recent years. Body donor‐based learning, though common in medical education, is rarely used in physiotherapy. Its integration may enhance learning through embodied, haptic experiences, and greater physical and emotional engagement with anatomical structures. A qualitative methodology grounded in phenomenology and hermeneutics was employed, using Interpretative Phenomenologi …

13.08.2026journal-article

Advanced Electromagnetics

Application of Conformer Architecture in Clinical Speech Input and Intelligent Medical Record Generation

X. K. Zou, L. Wang, J. Sun, S. Y. Guo, N. Li

Accurate clinical speech recognition remains challenging because rapid pronunciation, domain-specific terminology, and background noise often degrade automatic speech recognition and subsequent medical record generation. This study proposes a multi-stage intelligent documentation framework that integrates a 12-layer Conformer architecture, BERT-BiLSTM-CRF semantic modeling, and BART-based structured text generation. The Conformer encoder captures both local acoustic characteristics and long-range contextual depende …