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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Pediatrics

Clinical utility of renal and urinary tract point-of-care ultrasound in the neonatal intensive care unit: insights from a case series

Gayatri Morajkar, Sujata Deshpande, Sachin Verma, Vivek Goyal, Jayanta Hazarika, Prasoon Bansal, Yogen Singh, Pradeep Suryawanshi

Background Clinical decision-making in acutely ill neonates often depends on the timely identification of the underlying pathology. Bedside point-of-care ultrasound (POCUS), performed by the treating clinician, allows immediate correlation of imaging findings with evolving clinical status. However, its role in evaluating renal and urinary tract abnormalities in neonates remains relatively underexplored and is not yet widely integrated into routine practice. Methods This multicenter case series included data from fo …

03.09.2026journal-article

Journal of Palliative Medicine

Liminal Personhood and Continuity of Moral Identity in Clinical Care

Harvey Max Chochinov, Marianne Sofronas, Joseph J. Fins

Capacity-based frameworks of personhood risk marginalizing individuals whose agency, cognition, or consciousness are diminished by illness, brain injury, or proximity to death. This article introduces the concept of liminal personhood , which describes the persistence of moral and relational identity even as conventional markers of personhood fade. Drawing on ethical, philosophical, and neuroethical scholarship, the paper argues that failing to recognize enduring personhood can fracture patient identity and erode c …

03.09.2026journal-article

Frontiers in Pharmacology

Pharmaco-multiomics in major depressive disorder: a narrative review and proposed translational framework for difficult-to-treat and treatment-resistant depression

Bernhard T. Baune

Background Antidepressant prescribing in major depressive disorder (MDD) remains dominated by sequential trial and error, particularly when illness becomes difficult to treat (DTD) or meets conventional treatment-resistant depression (TRD) criteria. Objective This narrative review evaluates pharmacogenomics (PGx), therapeutic drug monitoring (TDM), metabolomics/lipidomics, immune-inflammatory markers, proteomics, transcriptomics, epigenomics, microbiomics, and multi-omics machine learning according to their capacit …

03.09.2026journal-article

Diabetic Medicine

A novel deep intronic EIF2AK3 variant disrupts splicing and causes Wolcott–Rallison syndrome

Alaa Al Assi, Georgia Bonfield, James Russ‐Silsby, Suhel Ahmed, Thomas W. Laver, Kadri Karaer, Bayram Özhan, Ayca Altincik, Kashyap A. Patel, Jayne A. L. Houghton, Sarah E. Flanagan, Matthew B. Johnson, Elisa De Franco

Abstract Aim Deep intronic variants can disrupt splicing and cause monogenic disease but are missed by routine genetic testing. This study assessed the contribution of deep intronic variants to Wolcott–Rallison syndrome (WRS), a recessive disorder characterized by early‐onset diabetes and progressive multisystem disease caused by loss‐of‐function EIF2AK3 variants. Methods We investigated a cohort of 116 individuals referred to the Exeter Genomics Laboratory for genetic testing who had diabetes diagnosed at ≤2 years …

03.09.2026journal-article

Indian Journal of Nuclear Medicine

18 F FDG PET/CT in a Rare Case of CIC::NUTM1 Sarcoma

Yamini Dharmashaktu, Sameer Rastogi, Adarsh Barwad, Ritwik Nitin Wakankar, Shamim A Shamim

Capicua transcriptional repressor ( CIC )-rearranged sarcomas are exceedingly rare and highly aggressive malignancies affecting young individuals predominantly, and CIC::NUTM1 is thought to be a molecular variant of CIC-rearranged sarcoma. It has a poor prognosis and a rapid progression. Here, we present a case of a 3-year-old male with CIC::NUTM1 sarcoma of the pelvis who presented with complaints of constipation associated with severe pain for which 18 F fluorodeoxyglucose positron emission tomography/computed to …

03.09.2026journal-article

Eastern Mediterranean Health Journal

Assessing the predictors of treatment-seeking and health care access barriers among transgender individuals in Pakistan

Athar Memon, Sameena Ourangzaib, Benjamin R. Bates, Shiraz Shaikh

Background: Transgender individuals in Pakistan face barriers to health care access, increasing the risk of serious disease transmission. Aim: To identify the predictors of treatment-seeking intention and health care access delays among transgender individuals in Karachi, Pakistan. Methods: Between December 2024 and April 2025 we interviewed 360 individuals, aged ≥18 years, who identified as transgender and had accessed health care within the past 12 months. We analysed the data using SPSS version 20 and conducted …

03.09.2026journal-article

World Journal of Traditional Chinese Medicine

Simultaneous Harvesting of PINK1, Parkin, and FUNDC1 Ligands from Herbal Medicines Using “Net Fishing” Strategy

Zhong-Yu Fu, Min Zhang, Fan Zhang, Cheng-Zhu Song, Yang-Yang Fu, Tao Wang, Xu-Dong He, Mei Zhang, Jie Yu, Xing-Xin Yang

Abstract Objective: Targeting mitophagy represents a promising therapeutic strategy for human diseases. This study aimed to develop an efficient approach to simultaneously identify natural ligands for PTEN-induced kinase 1 (PINK1), Parkin, and FUN14 domain containing 1 (FUNDC1) – core regulators of mitophagy – from complex herbal medicine (HM) extracts. Materials and Methods: We established a novel capture strategy where PINK1, Parkin, and FUNDC1 proteins were individually and physically adsorbed on the surface of …

03.09.2026journal-article

International Journal of Molecular Sciences

Myeloid-Derived Suppressor Cells (MDSCs) in Cardiovascular Risk of Obesity-Associated Diabetes

Rocío Flores-Campos, Lourdes Hontecillas-Prieto, Daniel J. García-Domínguez, Antonio Fernández-Suárez, Iker Egusquiza-Lasuen, Antonio Pérez, Josep Ribalta, Juan Pedro-Botet, Víctor Sánchez-Margalet, on behalf of the Immunology Group of the Spanish Society of Laboratory Medicine (SEMEDLAB), the Cardiovascular Disease Group of the Spanish Diabetes Society (SED)

The dysregulation of immune homeostasis and the persistence of chronic, low-grade inflammation represent core pathophysiological drivers governing the onset and progression of metabolic and cardiovascular disorders. Myeloid-derived suppressor cells (MDSCs) comprise a highly heterogeneous population of immature myeloid cells that are rapidly mobilized from the bone marrow in response to biological stressors, such as sustained tissue injury and chronic inflammatory signaling. Historically evaluated within oncology an …

03.09.2026journal-article

Pediatric Blood & Cancer

A Three‐Component Immune Framework Stratifies Treatment Response and Escalation in Pediatric Hemophagocytic Lymphohistiocytosis: A Prospective Single‐Center Cohort Study

Mai Anh Thi Nguyen, Truong Nhat Trinh, Duong Ngoc Mai, Phung Nguyen The Nguyen

ABSTRACT Background Pediatric hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome that can be classified into three principal etiologies (primary HLH [pHLH], Epstein–Barr‐virus‐driven HLH [EBV‐HLH], and secondary HLH [sHLH]) and is associated with disparate outcomes. Treatment escalation decisions remain largely empirical, guided by clinical presentation and conventional laboratory results rather than by an integrated biomarker framework. Procedure We prospectively enrolled 180 consecutive pedi …

03.09.2026journal-article

Frontiers in Medicine

AI-enabled language technologies for language-mediated learning and clinical communication in international undergraduate dental education: a scoping review

Wenjuan Qiang, Xiaohong Deng, Tiezhou Hou, Le Qiang

Background International undergraduate dental students often learn and communicate in a language other than their first language, affecting terminology acquisition, clinical reasoning, patient explanations, informed consent, clinical communication, and patient safety. AI-enabled language technologies—including generative artificial intelligence (GenAI), large language models (LLMs), and neural machine translation (NMT)—may support these tasks, but their use in this population has not been systematically mapped. Met …

03.09.2026journal-article

Frontiers in Medicine

Fulminant group A streptococcal necrotizing fasciitis presenting as severe calf pain after pharyngitis in an adolescent: a case report

Lisa Roncoroni, Jan Kühle, Lampros Kousoulas, Katharina Müller-Peltzer, Dawid L. Staudacher

Background Invasive Group A Streptococcus (GAS) infection can rapidly progress to life-threatening conditions, including necrotizing fasciitis (NF) and streptococcal toxic shock syndrome (STSS). While typically associated with cutaneous breaches or underlying comorbidities, hematogenous seeding following primary pharyngeal infection is a rare but documented phenomenon. Early diagnosis is often complicated by subtle skin changes and the rarity of the disease. Case A previously healthy 17-year-old female presented wi …

03.09.2026journal-article

Wilderness & Environmental Medicine

Effects of Metal Climbing Gear and Lightning Safety Position During Simulated Lightning

Mathias Maurer, Wolfgang Lederer, Benjamin Treichl, Markus Isser, Sandra Bauchinger, Stephan Pack

Introduction When trapped in a climbing route during a thunderstorm, it is generally recommended that climbers should maintain a maximum distance from rock formations and water accumulations. It is common practice for climbers to untie themselves from the rope and deposit metal equipment a few meters away. Methods In an experimental study, the formation of upward leaders from metal gear attached to a climbing harness and the number of lightning strikes to rope, metal gear, and subject were evaluated. A lightning im …

03.09.2026journal-article

BMC Microbiology

First identification and characterization of a plasmid co-harbouring poxtA and cfr in a clinical linezolid-resistant Staphylococcus aureus isolate

Kang Xu, Kaixin Zhou, Linlin Xu, Qing Chen, Lianyan Xie, Feifei Gu, Aikuang Ma, Shuzhen Xiao, Jingyong Sun, Dongan Zhu

Abstract Background Linezolid remains an important treatment option for serious infections caused by Gram-positive pathogens; however, acquired oxazolidinone resistance genes carried by mobile genetic elements are an increasing clinical concern. In Staphylococcus aureus , cfr and poxtA have previously been reported together in the chromosomal mosaic transposon Tn 6349 , whereas complete plasmid-borne structures co-harbouring these genes remain poorly defined. Methods Isolate D2958 was identified by matrix-assisted …

03.09.2026journal-article

Journal of Intensive Care Medicine

Incidence and Risk Factors for Invasive Mechanical Ventilation Dependency in Japan: A Nationwide Retrospective Cohort Study

Hiroyuki Ohbe, Monique Daniels, Daisuke Kudo, Hiroki Matsui, Stef Groenewoud, Werner Brouwer, Hideo Yasunaga

Objectives To describe the incidence and risk factors for becoming dependent on invasive mechanical ventilation (IMV) in Japan. Design Retrospective cohort study using a nationwide inpatient database from April 1, 2014, to March 31, 2020. Setting More than 1500 acute care hospitals participating in the Diagnosis Procedure Combination Study Group Database, covering approximately 50% of all hospitalizations in acute care hospitals in Japan. Patients Adults (≥18 years), in whom IMV was initiated during hospitalization …

03.09.2026journal-article

Journal of Imaging Informatics in Medicine

A Clinically Grounded Review of Medical Image Classification: Quantitative Insights into CNNs, Vision Transformers, and Hybrid CNN-ViT Models

Hamza Hussaini, Shahana Bano, Eyad Elyan, Carlos Francisco Moreno-Garcia

Abstract Medical image classification has advanced substantially with convolutional neural networks (CNNs), Vision Transformers (ViTs), and hybrid CNN–ViT architectures, yet clinical translation remains limited by dataset dependency, inconsistent evaluation practices, and insufficient external validation. This review provides a clinically grounded comparative synthesis of these model families across diverse medical imaging modalities. A structured literature review was conducted across PubMed, IEEE Xplore, Scopus, …

03.09.2026journal-article

Transplantologiya. The Russian Journal of Transplantation

A rare complication in a patient undergoing continuous ambulatory peritoneal dialysis

A. G. Yankovoy, V. A. Stepanov

Introduction. Continuous ambulatory peritoneal dialysis (PD) is one of the methods of treating patients in the structure of renal replacement therapy (RRT). The most common complications directly related to the peritoneal catheter usually occur during the first weeks and range from catheter dysfunction to dialysis peritonitis. Delayed intestinal perforation with a peritoneal catheter upon termination of peritoneal dialysis (PD) is extremely rare. Objective. The article describes a rare clinical case and successful …

03.09.2026journal-article

Journal of Clinical Medicine

Structural Deficit-Guided Reconstruction of an Extended Lower Eyelid–Bicanthal Defect

Zheng-Cai Wang, Zi-Chun Gu, Ying Hu, Jia-Qin Cai, Hua Li

Background/Objectives: Extended lower eyelid defects involving both lamellae and canthal supports require restoration of lining, support, vascularized coverage, and horizontal stability. We describe a two-stage reconstruction guided by structural deficits and available autologous tissues. Methods: A 63-year-old man underwent staged excision with frozen-section margin control for conventional-type basal cell carcinoma involving almost the entire right lower eyelid. A lengthened septal chondromucosal graft restored p …

03.09.2026journal-article

Microbial Drug Resistance

Using an Online Registry of Carbapenemase-Producing Gram-Negative Organisms to Report the Clinical Profile, Outcomes, and Phenotypic and Genotypic Resistances in Two Tertiary Level Hospitals in the Philippines (ORiGiN Study)

Cybele Lara R. Abad, Adrian Ronald A. Espino, Veil Maria T. Castro, Andrei Dominique Montero, Mark B. Carascal, Shanaia Esthelle Joy Daguit, Eariel Francisco, Lawrence S. Macalalad, Kim L. Cochon, Danice Faith Alombro, Benjo P. Ato, Jayson Lumasag, Ralph Bryan B. Hernandez, Anna Flor G. Malundo, Christel V. Gutierrez, Justin Allister Ong, Heather Gutierrez, Karl Abalajon, Marc Agnew M. Cajucom

Background: This study describes the clinical profiles, phenotypic and genotypic resistance mechanisms, and outcomes of patients with carbapenem-resistant infections (CRIs) using a registry. Methods: Hospitalized adults with CRIs in two tertiary institutions were included in this prospective study from January 1, 2023, to December 31, 2025. Results: A total of 411 patients were included. Half were male (207/411, 50.4%), with median age 59 (range 19–98) years. Hypertension (251, 65.5%), diabetes mellitus (150, 39.2% …

03.09.2026journal-article

Plastic & Reconstructive Surgery

Balancing the Breast: Transsternal Cable Grafts as a Libra in Mastopexy for Long Term Symmetry and Projection

Ulaş Bali, Berrak Karatan, Aziz Parspanci

Recurrent ptosis, loss of upper pole fullness, and postoperative asymmetry remain persistent challenges in mastopexy surgery. Most conventional techniques primarily rely on a vertical support vector, which may be insufficient to resist long-term gravitational descent and asymmetric settling. To address these limitations, we describe a modified mastopexy technique using transsternal dermal cable grafts to provide additional horizontal vector support and improve breast stability. The technique was performed in 75 wom …

03.09.2026journal-article

Frontiers in Medicine

Case Report: Secondary syphilis with pulmonary involvement mimicking eosinophilic granulomatosis with polyangiitis — targeted next-generation sequencing as an adjunct in resolving an atypical non-exanthematous presentation

Shunjun Tang, Tiehan Zhang, Aiyi Hao, Bin Su, Bin Liu

Background The global resurgence of syphilis poses growing challenges for clinical diagnosis, particularly when atypical presentations without classic mucocutaneous lesions mimic systemic autoimmune diseases. Pulmonary involvement in secondary syphilis is rare and frequently misdiagnosed, leading to inappropriate immunosuppressive therapy. Case presentation A 24-year-old male presented with one month of inflammatory back pain and two weeks of cough, purulent sputum, and intermittent low-grade fever. He initially de …

03.09.2026journal-article

Frontiers in Medicine

Development and validation of a nomogram prediction model for perioperative delirium in older patients with osteoporotic fractures based on LASSO regression and multiple parameters

Ni Hua, Hongmei Yuan, Yanhong Wei, Zhenqi Wei, Yanping Feng, Yong Liu, Tongguang Xu, Suliang Zhao, Li Zhang, Xiaohong He

Background Perioperative delirium (POD) is a severe postoperative complication in older patients with osteoporotic fractures. This study aimed to establish a nomogram prediction model incorporating multisystem stress, inflammation and frailty-related biomarkers for risk prediction. Methods This retrospective cohort study included 176 older patients (≥65 years) with osteoporotic fractures. Potential predictors, including the rate-pressure product (RPP), systemic inflammation response index (SIRI) and prognostic nutr …

03.09.2026journal-article

Ege Tıp Dergisi

Evaluating GPT-4.1 Mini and GPT-5 in Postmastectomy Lymphedema Patient Education: A Comparative Study of Usefulness and Reliability

Benil Nesli Ata, Ece Cinar, Sibel Eyigör

Aim: To compare the reliability and usefulness of GPT-4.1 mini and GPT-5 in postmastectomy lymphedema patient education.Materials and Methods: Twenty patient-centered questions were developed from reputable sources. Responses from both models were independently rated by three blinded physiatrists using 7-point Likert scales for reliability and usefulness.Results: GPT-5 demonstrated higher usefulness and reliability scores compared to GPT-4.1 mini (p = 0.005 and p = 0.021, respectively).Conclusions: Both models prod …

03.09.2026journal-article

Frontiers in Psychiatry

Pre-treatment serum extracellular vesicle-enriched microbiome profiles and SSRI treatment response in obsessive-compulsive disorder: a prospective naturalistic cohort study

Jee In Kang, Chun Il Park, June-Ho Seo, Chil-sung Kang, Yoon-Keun Kim, Se Joo Kim

Objective The microbiome is emerging as an important component of brain–body communication and may influence treatment outcomes in psychiatric disorders. This naturalistic cohort study prospectively evaluated whether baseline microbiome abundance and composition of circulating bacterial extracellular vesicles (EVs) are associated with subsequent response to selective serotonin reuptake inhibitors (SSRIs) in patients with obsessive-compulsive disorder (OCD). Methods Thirty-two drug-naïve or medication-free patients …

03.09.2026journal-article

Frontiers in Immunology

Overall survival with immune checkpoint inhibitors across treatment settings and clinical and PD-L1-defined subgroups in advanced esophageal squamous cell carcinoma: a systematic review and meta-analysis of randomized trials

Bing Wang, Xiaoyu Han, Zengli Shen

Introduction To quantify overall-survival effects of immune-checkpoint-inhibitor (ICI)-containing regimens by treatment line and to evaluate whether clinical characteristics or PD-L1 definitions modify relative treatment benefit in advanced esophageal squamous cell carcinoma (ESCC). Methods PubMed, Embase, the Cochrane Central Register of Controlled Trials, and Web of Science were searched from inception through 1 August 2026. Two reviewers independently screened records, assessed full texts, extracted data, and ev …