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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
13.08.2026journal-article

Advanced Healthcare Materials

Overcoming Photodynamic Therapy Resistance: GSH‐Responsive AIE Photosensitizer‐Hydroxycamptothecin Nanoliposomes for Extrahepatic Cholangiocarcinoma

Yong Qu, Tao Peng, Yating Zhang, Juanmei Cao, Birong Wang, Chuxing Chai, Zhiyuan Gao, Yiting Xu, Yifan Jin, Yuqing Wang, Zhuoxia Li, Xu Liu, Tianqi Zhao, Yufan Chen, Weimin Lv, Di Lu, Changzheng Huang, Dan Ding, Jinxiang Zhang, Min Li

ABSTRACT Photodynamic therapy (PDT) has been shown to improve survival and quality of life in patients with unresectable extrahepatic cholangiocarcinoma. However, its therapeutic efficacy is frequently limited by the survival of residual tumor cells that can re‐enter the proliferative cycle. Our previous studies showed that residual cholangiocarcinoma cells can re‐enter the proliferative cycle following PDT accompanied by hypoxia‐induced activation of the HIF‐1α survival pathway and intracellular antioxidant progra …

1 Zitationen
13.08.2026journal-article

Obstetrics & Gynecology

Cost-Effectiveness Analysis of Menopausal Hormone Therapy

Elizabeth Gill, Wu Zeng, Katerina Shvartsman, Jill Brown

OBJECTIVE: To evaluate the cost effectiveness of menopausal hormone therapy (MHT) based on the risk–benefit profiles of current MHT formulations. METHODS: We used a Markov model to examine the cost effectiveness of MHT for hypothetical 50-year-old women with vasomotor symptoms compared with transdermal estradiol (E2) alone for patients without a uterus and transdermal E2 in combination with micronized progesterone for patients with a uterus, assuming 5 years of use. Using a health system perspective, we expressed t …

13.08.2026journal-article

Diseases of Aquatic Organisms

Blood analytes in California sea lion Zalophus californianus pups: reference intervals and malnutrition effects, from admission to rehabilitation

Faye E. Giebink, Alissa C. Deming, Justin R. Perrault, Malena Berndt, Sharon R. Melin, Nicole I. Stacy

Blood analyte data are limited for California sea lion Zalophus californianus pups despite frequent admission to rehabilitation facilities. The objectives of this study were to establish blood analyte reference intervals for rehabilitated California sea lion pups (n = 58) deemed clinically normal for release and for free-ranging California sea lion pups (n = 37) during routine health assessment on San Miguel Island, California, USA; to compare manual white blood cell (WBC) differentials to an in-house hematology an …

13.08.2026journal-article

Current Oncology

Durable Hematologic Response in Therapy-Related Myelodysplastic Syndrome During Nivolumab Treatment for Metastatic Melanoma: A Case Report

Fathima Nashfa M. Hamza, Fatima Eltayeb, Mohammed Al Katari, Mohammed F. K. Ibrahim

Immunotherapy is the standard first-line palliative treatment for metastatic melanoma; however, its role in myelodysplastic syndrome (MDS) remains uncertain. We report a case in which nivolumab, administered for metastatic melanoma, was associated with a marked improvement in concurrent treatment-related MDS. A 67-year-old man with a history of oligosecretory multiple myeloma developed transfusion-dependent MDS following autologous stem cell transplantation, requiring twice-weekly blood transfusions. He subsequentl …

13.08.2026journal-article

HIV Infection and Immunosuppressive Disorders

Features of the course of HIV infection and the structure of comorbid diseases in women of childbearing age during antiretroviral therapy

E. B. Yastrebova, V. Ya. Rosenberg, I. E. Nebozhin, Ya. V. Romanova

The aim : to analyze the characteristics of HIV infection and the structure of comorbid diseases in women of childbearing age. Materials and methods . A total of 100 women of childbearing age were studied at the Republican Clinical Infectious Diseases Hospital. The average age was 42.5±0.6 years (range: 35 to 52 years). The duration of HIV infection was 15.6±1.2 years (range: 2 to 26 years). Transmission routes: sexual (63%) and parenteral (37%), HCV infection (42%) (90% treated). Marital status: married (62%), coh …

13.08.2026journal-article

Signal Transduction and Targeted Therapy

Translational insights and clinical challenges of targeting cancer stem cells

Mehreen Ahmed, Amr Al-Haidari, Shruti Agarwal, Jianmin Sun, Emma U. Hammarlund, Lars Rönnstrand, Kenneth J. Pienta, Özge Tatli, Julhash U. Kazi

Abstract Cancer stem cells (CSCs) are tumor cell subsets with self-renewal, multilineage differentiation, and tumor-initiating capacity that sustain cancer initiation, progression, metastasis, and relapse. Targeting CSCs therefore represents a promising route to improve the durability of cancer treatment. However, translation of this approach into routine care has been slow because of the biological complexity and clinical constraints. This review discusses current concepts of CSC origin and plasticity, the criteri …

13.08.2026journal-article

PLOS One

L-Phenylalanine restriction enhances L-boronophenylalanine uptake and improves boron neutron capture therapy efficacy in tumor cell lines

Yuki Tamari, Rie Saba, Takushi Takata, Hiroyuki Kimura, Mao Takita, Kenta Yashiro, Minoru Suzuki, Hideya Yamazaki, Kei Yamada

Boron neutron capture therapy (BNCT) relies on the selective uptake of boron-10 compounds by tumor cells. L-boronophenylalanine (BPA) serves as a key carrier, and enhancing its accumulation is critical for improving BNCT efficacy. In this study, we examined how L-phenylalanine (Phe) restriction affects BPA uptake and related cellular responses in the tumor cell lines SAS, U87-MG, PANC-1, and A375, as well as in the immortalized keratinocyte line HaCaT. Quantitative analysis using inductively coupled plasma atomic e …

13.08.2026journal-article

American Journal of Physical Medicine & Rehabilitation

Contemporary Phase I Cardiac Rehabilitation

Lena Cook, Bijay Mukesh Jeswani, Dale M. Needham, Paul Ricard, Stephanie L. Hiser

Patients in cardiac intensive care units (ICUs) often require mechanical circulatory support (MCS) devices. Phase I cardiac rehabilitation for patients requiring a single MCS device appears safe and feasible. However, the simultaneous use of multiple MCS devices is relatively new and rehabilitation practices have had less evaluation in these circumstances. This case report describes phase I cardiac rehabilitation delivery in a 73-year-old man with cardiogenic shock supported with simultaneous femoral-femoral, veno- …

13.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

The influence of the physical work environment on presenteeism: A theoretical exploration

Christian Bassaw, Mehdi Ghiai, Debajyoti Pati

Background Presenteeism, defined as attending work despite reduced functional capacity, has been widely studied in occupational health and organizational research. However, the role of the physical work environment remains underexplored and inconsistently integrated into dominant conceptual models. Objective This integrative review examines the role of the physical work environment in presenteeism in knowledge-intensive workplaces, while considering organizational structures and health-related resources, and synthe …

13.08.2026journal-article

Biophotonics Discovery

Extracorporeal near-infrared–activated antimicrobial photodynamic therapy for pneumonia using an ICG–polymer formulation

Isabelle Almeida de Lima, Michelle Barreto Requena, Vadila Giovana Guerra, Cristina Kurachi, Natalia Mayumi Inada

SignificancePneumonia remains a global health challenge, exacerbated by antimicrobial resistance, which limits the effectiveness of conventional treatments. Antimicrobial photodynamic therapy (aPDT) has emerged as a promising alternative for lower respiratory infections; however, its in vivo performance is hindered by lung surfactant, which traps photosensitizers and reduces their ability to reach bacterial targets.AimTo address this limitation, recent studies demonstrated that combining indocyanine green (ICG) wit …

13.08.2026journal-article

Advanced Electromagnetics

Positive Effects of Solution-Focused Short-Term Therapy Combined with Routine Nursing Care on the Psychological State and Quality of Life of Patients with Geriatric Syndromes

W. J. Ye, Q. Li, Q. Wang, Z. L. Liu

Patients with geriatric syndromes often show limited improvement in psychological state and quality of life after routine care alone. This study applies a structured solution-focused brief therapy intervention combined with routine nursing care, guiding patients to focus on personal strengths and achievable goals through six standardized sessions. The intervention is implemented by uniformly trained nursing staff according to an operating manual, ensuring procedural consistency and scalability. At the 4-week follow …

13.08.2026journal-article

Annali Italiani di Chirurgia

Effect of PDCA Cycle-Based Orthopedic Rehabilitation Nursing on Perioperative Pain and Functional Recovery in Patients With Femoral Fractures

Zhiyong Cui, Xin Song, Huipeng Zhou, Peng Zhao, Yanda Li, Yanyang Guo

AIM: To investigate the effects of orthopedic rehabilitation nursing based on the Plan–Do–Check–Act (PDCA) cycle model on perioperative pain and postoperative functional recovery in patients undergoing surgical treatment for femoral fractures.METHODS: This retrospective single-center study included 120 patients who underwent surgical treatment for femoral fractures at The 964th Hospital of Chinese People’s Liberation Army Joint Logistics Support Force between May 2023 and May 2025. Based on the nursing intervention …

13.08.2026journal-article

International Journal of Surgery Case Reports

Controlled hypotension therapy with isosorbide dinitrate for postoperative bleeding of transurethral resection of the prostate

Zihao Li, Hongliang Li, Zhenzhuo Chen, Li Wang, Tie Chong, Dong Zhang

Introduction: Postoperative bleeding is a well-known complication of transurethral resection of the prostate (TURP). This study aims to evaluate the efficacy and safety of controlled hypotension using isosorbide dinitrate (ISDN) as a treatment for refractory postoperative bleeding after TURP when conventional non-surgical treatments have failed. Methods: A retrospective analysis was conducted of eight patients who experienced postoperative bleeding following TURP and did not respond to standard non-surgical interve …

13.08.2026journal-article

OTJR: Occupational Therapy Journal of Research

Structural Relationships Among Positive Occupations, Psychological Distress, Life Functioning, and Well-Being in Community Mental Health

Takuya Noguchi, Makoto Kyougoku

This cross-sectional study examined associations among positive occupations, psychological distress, life functioning, subjective well-being, and perceived interpersonal difficulties among 276 adults with mental illness receiving community-based mental health services, including psychiatric day hospitals, in Japan. Positive occupations were defined as occupational experiences characterized by personally meaningful engagement, a sense of involvement, opportunities for achievement, and supportive social interaction. …

13.08.2026journal-article

Advanced Electromagnetics

Learning Behavioral Characteristics and Teaching Intervention Strategies of Midwifery Students in Higher Vocational Colleges Using K-means Clustering Algorithm

Y. Sun, N. Han, C. Liu, Y. Q. Bi, L. C. Meng, G. H. Gao

To address the difficulty of integrating multi-source heterogeneous learning behavior data and the broadness of conventional teaching intervention strategies, this paper proposes a data-driven analysis framework based on K-means clustering for higher vocational midwifery education. The study collects multidimensional behavioral data from online learning logs, smart classroom interaction records, and practical training assessments, and constructs a 12-dimensional feature system covering cognitive input, behavioral a …

13.08.2026journal-article

MedScien

Research on Conservative Rehabilitation and Prevention Strategies for Patellar Dislocation Among College Students

Linglang Chen

In recent years, with the extensive popularization of campus sports activities, the number of reported knee injuries such as patellar dislocation has kept rising among college students. Although most such injuries can reset spontaneously, insufficient attention has resulted in a persistently high recurrence rate after the first dislocation, and female students face a notably higher onset risk than male students. A review of existing domestic and overseas literature shows that current research mainly focuses on surg …

13.08.2026journal-article

Philology. Theory & Practice

Changes in the morphological structure of Walter White’s speech as a marker of the film character’s transformation in the television series “Breaking Bad”

Tatiana Igorevna Utkina, Elizaveta Sergeevna Kuznetsova

The study aims to identify the correlation between changes in the morphological structure of speech and the stages of Walter White’s identity transformation in the television series “Breaking Bad”. Using a corpus of the character’s utterances (50,290 tokens divided into three periods – the emergence, ascendancy, and dominance and downfall of Heisenberg), the study analyzes the frequency of personal pronouns (“I”, “you”, “we”, “me”, “us”) and proto-agentive / emotive verb constructions. The scientific novelty of the …

13.08.2026journal-article

Jurnal Informatika dan Teknik Elektro Terapan

PERANCANGAN ANNOUNCEMENT SYSTEM BERBASIS WEB DENGAN FITUR TEXT TO SPEECH UNTUK AKSESIBILITAS INFORMASI PRAKIRAAN CUACA PERAIRAN SELATAN JAWA

Rosyid -

Kawasan pesisir selatan Jawa memiliki potensi bahaya gelombang tinggi dan angin kencang, sementara akses publik terhadap informasi prakiraan cuaca perairan dari BMKG masih terbatas. Penelitian ini bertujuan merancang dan mengimplementasikan STMKG-OcA (Ocean Announcer), sebuah sistem pengumuman cuaca perairan berbasis web yang mengambil data prakiraan cuaca dari data terbuka BMKG dan menyampaikannya kepada masyarakat di kawasan pesisir dalam bentuk pengumuman suara menggunakan teknologi text-to-speech berbahasa Indo …

13.08.2026journal-article

LATAM Revista Latinoamericana de Ciencias Sociales y Humanidades

Efectividad de la terapia dialéctico-conductual en reducción de conductas autolesivas en personas con trastorno límite de la personalidad y muestras clínicas mixtas

Paúl Fernando Calle Cadme, Odalia Llerena Companioni

El presente estudio tuvo como objetivo analizar la efectividad de la terapia dialéctico-conductual (DBT) en la reducción de conductas autolesivas en adolescentes y adultos, tanto en personas con trastorno límite de la personalidad como en muestras clínicas mixtas. Se realizó una revisión sistemática siguiendo los lineamientos PRISMA, mediante la búsqueda en las bases de datos Scopus y Web of Science durante los últimos diez años, incluyendo estudios en español e inglés. Se seleccionaron 25 estudios empíricos que cu …

13.08.2026journal-article

Revista Ibero-Americana de Humanidades, Ciências e Educação

INTERNAÇÃO HOSPITALAR PROLONGADA E AGRAVOS À SAÚDE MENTAL: CONTRIBUIÇÕES DA TERAPIA COGNITIVO-COMPORTAMENTAL

Maria de Fátima Costa Silva, Nycolly Farias Neres, Paula Oliveira Silva, Silvia Helena Modenesi Pucci

A internação hospitalar prolongada pode ter desencadeado impactos psicológicos, emocionais e cognitivos, associados à ruptura da rotina, à perda de autonomia e ao enfrentamento do adoecimento. Nesse contexto, a Terapia Cognitivo-Comportamental (TCC) foi analisada como uma abordagem com potencial contribuição para o manejo dos agravos à saúde mental em pacientes hospitalizados. O presente estudo teve como objetivo discutir as contribuições da Terapia Cognitivo-Comportamental para o manejo dos agravos à saúde mental …

13.08.2026journal-article

Cancers

Cardiac Conduction Disorders in Melanoma Patients Treated with CTLA-4-Containing Versus PD-1-Only Immune Checkpoint Inhibitor Therapy: A Propensity Score-Matched Real-World Analysis

Ali Awad, Joe Khodeir, Qusai AlQudah, Nur Saleh, Mariam Chalhoub, M. Chadi Alraies

Background: Immune checkpoint inhibitors (ICIs) have transformed the treatment of advanced melanoma, but the comparative cardiac safety of cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4)-containing regimens versus programmed cell death protein 1 (PD-1)-only regimens in real-world populations remains poorly characterized. We compared cardiac outcomes between melanoma patients exposed to CTLA-4 blockade (ipilimumab) and those treated with anti-PD-1 therapy alone (nivolumab or pembrolizumab) using a large multice …

13.08.2026journal-article

Frontiers in Oncology

Multi-omics integration in malignant pleural mesothelioma: from molecular evolution and immune ecosystems to precision therapy

Hongmei Li, Kunzhong Zhou, Ruiting Xu, Weifang Wang, Tingting Song, Yonghong Zhou, Jing Ren, Zhiyong Wang, Yiteng Liang, Yilin Chen, Saurav Poudel, Junxuan Yu, Rui Lin, Ke Yin, Shengjie Yang, Li Zhuang

Malignant pleural mesothelioma (MPM) exhibits substantial molecular and cell-state heterogeneity, together with marked spatial variation in its immune and stromal microenvironment. Histological classification and individual biomarkers alone cannot adequately explain its evolution or heterogeneous treatment responses. This review critically integrates genomic, epigenomic, transcriptomic, single-cell, and spatial omics evidence along a conceptual continuum encompassing tumor-intrinsic molecular evolution, microenviro …

13.08.2026journal-article

Blood

IDH2 clonal hematopoiesis and IKAROS loss cooperate in a B-ALL subtype after lenalidomide therapy for multiple myeloma

Johanna M. Horns, Thomas Beder, Axel Künstner, Malwine J. Barz, Sonja Bendig, Cecilia Bozzetti, Guranda Chitadze, Nikos Darzentas, Katharina Iben, Michaela Kotrova, José I. Martín-Subero, Mayukh Mondal, Martin Neumann, Raúl F. Pérez, Aeint-Steffen Ströh, Wiebke Weßels, Lennart Lenk, Lars Velten, Boris Böll, Krischan Braitsch, Veit Bücklein, Johannes Duell, Christoph Faul, Walter Fiedler, Maher Hanoun, Snjezana Janjetovic, Felix Klingler, Stefan Knop, Christoph Röllig, Stefan Schwartz, Bernd Spriewald, Björn Steffen, Klaus Wethmar, Hauke Busch, Nicola Gökbuget, Claudia D. Baldus, Lorenz Bastian, Monika Brüggemann

Abstract Lenalidomide, a maintenance treatment in multiple myeloma first-line therapy, increases the risk of secondary malignancies, including B-cell precursor acute lymphoblastic leukemia (B-ALL). We present a comprehensive molecular characterization of 57 patients with lenalidomide-associated B-ALL (LenB-ALL), revealing 3 mutational subgroups: (1) TP53mt (30%); (2) IDH2mt (p.R140Q) (23%); and (3) other, including NRAS/KRASmt. Remarkably, IDH2 R140Q mutations were highly enriched in LenB-ALL compared with those in …

3 Zitationen
13.08.2026journal-article

Oral

Effects of Periodontal Therapy on Psoriasis Severity: A Systematic Review of the Clinical Evidence

Giuseppe Trapanese, Leopoldo Mauriello, Luca Ramaglia, Alessandro E. di Lauro, Vincenzo Iorio-Siciliano, Elio Ramaglia, Andrea Blasi, Vitolante Pezzella

Background: Periodontitis and psoriasis are chronic inflammatory diseases that share common risk factors and immune-mediated pathogenic pathways, suggesting a potential bidirectional relationship. Periodontal inflammation contributes to systemic inflammatory burden, which may influence the severity of immune-mediated diseases, such as psoriasis. Objective: The aim of this systematic review is to evaluate the effects of periodontal therapy on psoriasis severity in patients affected by both conditions. Methods: This …