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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
14.08.2026journal-article

Journal of Fungi

Clinical and Economic Trade-Offs in Antifungal Therapy for Invasive Aspergillosis and Mucormycosis: A Markov Model–Based Analysis

Alejandro Rico Mendoza, Alexandra Porras Ramirez, Liliana Encinales, Oscar Madiedo, Marianna Carrillo Encinales, Juan Pablo Duque Bolivar, Juan Fernando Ramon Cuellar, Jorge Andrés Urquijo Mendez, Zuly Moreno Perilla, Roberto Jurado Zambrano

Invasive aspergillosis and mucormycosis are life-threatening fungal infections characterized by high early mortality, substantial toxicity, and intensive healthcare resource utilization. While multiple antifungal therapies are recommended in international guidelines, their comparative clinical and economic value remains uncertain, particularly in resource-limited settings. We developed a hybrid decision tree and Markov model to evaluate antifungal strategies, including liposomal amphotericin B, isavuconazole, voric …

14.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

Identification of exposed body segments and risk levels in specialized construction tasks involving upper limbs above shoulder level

Mario Alberto Villegas Romero, Juan Luis Hernández Arellano, Jorge Hernán Restrepo Correa, Aidé Aracely Maldonado Macías

Background Musculoskeletal disorders are common among specialized construction workers due to repetitive, physically demanding work. However, biomechanical risks and the specific involvement of body segments in vaulted roof construction remain insufficiently characterized. Objective Identify the most exposed body segments and measure biomechanical risk in vaulted roof construction. Methods This observational study took place at six construction sites. Thirteen workers participated: six vault masters and seven helpe …

14.08.2026journal-article

Advances in Translational Research

Pharmacological strategies for relapsed multiple myeloma after T-cell engager therapy: From molecular mechanisms to translational opportunities

Hermina Sánta, Gergely Varga, Gábor Mikala

Abstract The treatment landscape of relapsed/refractory multiple myeloma (RRMM) has evolved significantly with the introduction of T-cell–redirecting therapies, including bispecific antibodies and chimeric antigen receptor (CAR) T-cell therapies. Despite high response rates observed with these approaches, disease progression remains inevitable for most patients, and no standard of care has been established for those relapsing after T-cell engager (TCE) therapies. Mechanisms of resistance include antigen loss, T-cel …

14.08.2026journal-article

Science and Innovation

PSYCHOMOTOR THERAPY COMBINED WITH COGNITIVE-BEHAVIORAL TECHNIQUES FOR NEUROTIC SYMPTOMS IN VASCULAR DEMENTIA: A PROSPECTIVE COMPARATIVE PILOT STUDY

S Karakhonova

Neuropsychiatric symptoms are common in vascular cognitive impairment and can complicate rehabilitation and long-term care. This 30-day prospective comparative pilot study evaluated two multimodal regimens for neurotic symptoms in patients with mild-to-moderate vascular dementia. Forty-six patients were enrolled, and 42 had complete baseline and end-of-treatment records for comparative analysis: 20 received basic neuroprotective therapy, rational psychotherapy, and temgicoluril (Adaptol), whereas 22 received basic …

14.08.2026journal-article

Journal of Marital and Family Therapy

Empirically Supported Couple Therapy Models for Couple Relationship Distress: A Replication and Update

Jeffrey B. Jackson, Luca Codecá, Richard B. Miller, Jessica E. Simpson, Abigail M. O'Leary, Samantha M. Renner

ABSTRACT This systematic review replicated and updated Baucom and colleagues' (1998) evaluation of empirically supported treatments (ESTs) for couple relationship distress using the Chambless criteria, the primary framework used by the American Psychological Association to classify ESTs. Applying these criteria to 40 eligible studies, we found that, in contrast to Baucom and colleagues, no couple therapy models met the standards for strong empirical support; insufficient sample size and lack of independent replicat …

14.08.2026journal-article

Journal of Medical Internet Research

AI-Powered Robotics Are Personalizing Rehabilitation

Benedette Cuffari

Abstract Rehabilitation is crucial for making a full recovery from surgery or managing a chronic physical disability, but it can be resource-intensive and highly individual in treatment response. In this News and Perspectives article, JMIR Correspondent Benedette Cuffari reports on robotics in rehabilitation and how AI is helping to make it more personalized, efficient, and effective.

14.08.2026journal-article

Current Oncology

Impact of Lebanon’s Economic Crisis on Cancer Care Delivery: A Multicenter Cross-Sectional Study of Treatment Initiation Delays and Incomplete Therapy

Mohamad Ali Hachem, Nadeen Zayour, Elie Daibess, Jacqueline Najjar, Elie Jean Karam, Solay Farhat, Zeinab Hammoud, Ghadir M. Nasreddine, Mohamad Abbass, Zeinab Sleiman, Maroun Sadek, Ahmad Ibrahim, Issam Chehade, Bassam Matar

Background/Objectives: In Lebanon, the economic crisis since 2019 has severely strained healthcare infrastructure, yet its impact on cancer treatment adherence remains incompletely characterized. This study assessed factors associated with treatment delay and regimen modification to identify barriers to optimal cancer care among Lebanese patients. Methods: This multicenter, cross-sectional study was conducted in five tertiary hospitals in Beirut, Lebanon, between 13 June 2024, and 27 June 2025. Demographic, clinica …

14.08.2026journal-article

Nutrients

Beyond Weight Loss: Skeletal Muscle Health During Incretin-Based Therapy in Patients with Diabesity

Edoardo Luigi Maria Mollero, Ivan Dozzani, Emilia Biamonte, Giulia Bendotti, Paolo Marzullo, Gianluca Aimaretti, Marco Gallo

Background: Incretin-based therapies (IBTs), including glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 receptor agonists (GIP/GLP-1 RAs), have transformed the management of obesity and type 2 diabetes mellitus (T2DM). Although these agents provide substantial metabolic and cardiometabolic benefits, their effects on skeletal muscle, particularly in older adults at increased risk of sarcopenia and functional decline, remain incomplete …

14.08.2026journal-article

Frontiers in Medicine

Therapy-related acute myeloid leukemia with 24-month latency after CD19 CAR-T cell therapy in relapsed/refractory diffuse large B-cell lymphoma: a case report

Manqi Su, Chentong Huang, Zhanna Zhang, Xiaoxia Wang, Panruo Jiang, Yiran Chen, Gongqiang Wu

Background Therapy-related myeloid neoplasms (t-MNs) have emerged as a serious late complication of CD19-directed chimeric antigen receptor (CAR) T-cell therapy. While large-scale studies have characterized the epidemiology of t-MNs, the mechanisms underlying their development remain incompletely understood, and cases with extended latency are rarely documented. We report a case of therapy-related acute myeloid leukemia (t-AML) occurring 24 months after initial CD19 CAR-T cell therapy, with longitudinal genomic mon …

14.08.2026journal-article

Transcultural Psychiatry

Navigating Faith-based Practices in Therapy: Psychotherapists’ Experiences in India

Ananda Krishnan, Amrita Deb

Addressing clients’ faith-based practices (FBPs) is indispensable in psychotherapy, especially in a religiously diverse country like India. This can be particularly challenging in contexts where psychotherapy is highly stigmatized and FBPs are culturally accepted. A review of the literature highlighted a gap in research on how psychotherapists negotiate FBPs in the Indian context. This pilot qualitative study aims to address this gap by exploring the experiences of Indian psychotherapists in navigating FBPs as ment …

14.08.2026journal-article

Journal of Cardiovascular Development and Disease

Acute ST-Segment Elevation Myocardial Infarction Following Multimodality Cancer Therapy in a HER2-Positive Breast Cancer Patient: A Case Report

Jiani Dai, Guohui Chen, Yabin Liu, Yongli Ji, Liangliang Jia

Cardiovascular toxicity associated with anti-tumor therapies is garnering increased attention. Anti-tumor therapies may elevate the risk of acute coronary syndrome, particularly in patients with underlying subclinical atherosclerosis. In this context, a 58-year-old female patient with HER2-positive breast cancer experienced an acute ST-segment elevation myocardial infarction following chemotherapy, dual HER2-targeted therapy, and radiotherapy to the left breast. Prior to the initiation of anti-tumor treatment, ches …

14.08.2026journal-article

Mental Health Weekly

Therapy protocol in pregnancy could have broader application

Gary Enos

A therapeutic intervention with a strong evidence base in preventing postpartum depression in outpatients has now shown promising results in hospitalized women experiencing medical complications during pregnancy. A newly published study has reported that inpatients found the ROSE (Reach Out, Stay Strong, Essentials for mothers of newborns) intervention to be a helpful source of emotional support, and preliminary findings also showed a positive effect on depressive symptoms.

14.08.2026journal-article

Journal of Health Economics and Outcomes Research

Cognitive Behavioral Therapy in Early Intervention for Psychosis: A Cost-Effectiveness Analysis

Maximilian Duckworth, Sofia Venturini, Andres Roman-Urrestarazu

Background: Early intervention for psychosis (EIP) is a multidisciplinary service that treats individuals experiencing early psychosis. Treatment often consists of pharmacotherapy and cognitive behavioral therapy for psychosis (CBTp). While EIP demonstrates clinical efficacy and cost-effectiveness as a comprehensive package, the incremental contribution of its individual components remains unclear. With mental health services facing sustained funding pressures, understanding which EIP elements offer value for money …

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14.08.2026journal-article

Pediatria. Journal named after G.N. Speransky

PRE-CONGRESS «CURRENT ISSUES IN THE DIAGNOSIS AND THERAPY OF HUNTER SYNDROME» OF THE VIII ALL-RUSSIAN SCIENTIFIC AND PRACTICAL CONGRESS WITH INTERNATIONAL PARTICIPATION «ORPHAN DISEASES»

A.G. Rumyantsev

Pre-Congress «Current Issues in the Diagnosis and Therapy of Hunter Syndrome» of the VIII All-Russian Scientific and Practical Congress with International Participation «Orphan Diseases». Pediatria n.a. G.N. Speransky. 2026; 105 (4): 151–153. DOI: 10.24110/0031-403X-2026-105-4-151-153.

14.08.2026journal-article

Frontiers in Nutrition

Medical nutrition therapy in incretin-treated obesity-related heart failure with preserved ejection fraction

Qiuli Ming, Ze Li

Glucagon-like peptide-1 receptor agonists and dual agonists of the glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptors, exemplified by semaglutide and tirzepatide, respectively, have reshaped care for obesity-related heart failure with preserved ejection fraction (HFpEF). Their benefits extend beyond weight reduction to symptoms and physical function and, for tirzepatide, a lower risk of worsening heart failure. Yet kilograms lost do not reveal whether treatment preferentially reduces …

14.08.2026journal-article

ACS Applied Materials & Interfaces

Regulating Triplet Energy Level and Intramolecular Motion: An Aggregation-Induced Emission BODIPY for Near-Infrared Type I Photodynamic/Photothermal Synergistic Therapy

Xue Chen, Xudong Xie, Yuanhang Li, Li Yang, Chaolin Liu, Shuhe Huang, Zhixian Liu, Mengqin Li, Yue Zhang, Zhengjian Qi

Abstract The combination of photodynamic therapy (PDT) and photothermal therapy (PTT) holds considerable promise for cancer treatment, but conventional Type II PDT is strongly limited by tumor hypoxia. Here, we designed a D-π-A-π-D BODIPY-based near-infrared aggregation-induced emission (AIE) photosensitizer, TBSN, by integrating tetraphenylethylene units and a rotatable N,N-diethylaniline moiety. Theoretical calculations identified S1 → T2 as the predominant intersystem crossing pathway and showed that the N,N-die …

14.08.2026journal-article

Journal of Midwifery & Women's Health

Nutritional Interventions During Pregnancy Improve Maternal and Neonatal Outcomes: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Güleren Sabuncular, Elif Akbaş, Elif Uca, Rabia Bağlayici, Döndü Kurnaz, Şule Aktaç

Introduction This systematic review and meta‐analysis aimed to evaluate the effects of nutritional interventions during pregnancy on maternal and neonatal outcomes. Methods The review followed Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines and was registered in PROSPERO (CRD42024528918). Randomized controlled trials published between 2014 and 2024 were identified through systematic searches conducted between May and July 2024. Methodological quality was assessed using the Revised Coch …

14.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Pediatric Auditory-Perceptual Evaluation of Voice Part I: Voice Stimuli for Children

Robert Brinton Fujiki, Rebecca Johnson, Sijia Huang, Susan L. Thibeault

Purpose: The purpose of this study was to develop and test standardized stimuli for the Pediatric Auditory-Perceptual Evaluation of Voice protocol. The use of these stimuli for cepstral/spectral voice measures was also considered. Method: Three sets of standardized sentences and four prompts designed to elicit connected speech were developed and tested in order to identify the most effective stimuli for use with children. One hundred forty children with ( n = 50) and without ( n = 90) benign vocal fold lesions reco …

14.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Effect of Speaking Rate and Sentence Context on Comprehension and Recognition Memory of Degraded Speech

Tirth R. Patel, Victoria A. Sevich, Xiaoke Feng, Liping Du, Terrin N. Tamati

Purpose: Variability in speaking rate and sentence context affects the cognitive processing of speech. Individuals relying on a degraded speech signal may be particularly susceptible to these effects. In this study, we examine how artificial alterations to speaking rates and sentence context affect sentence comprehension and recognition memory for cochlear implant (CI) users and normal-hearing (NH) adults presented with spectrally degraded speech. Method: Thirty-seven adult CI users and 71 NH adults participated in …

14.08.2026journal-article

The Brown University Child and Adolescent Behavior Letter

Managing eating disorders in outpatient therapy: Clinical tools and best practices

Pamela A. Scalise

Eating disorders encountered in outpatient practice span a broad spectrum: anorexia nervosa, bulimia nervosa, binge eating disorder, avoidant/restrictive food intake disorder (ARFID), and other specified feeding or eating disorders (OSFED). Eating disorders rank among the most lethal psychiatric conditions with an estimated prevalence of 6 to 8% among adolescents, though are often undetected or overlooked in outpatient settings (Galmiche et al., 2019). In a society that normalizes and celebrates weight loss, “atypi …

14.08.2026journal-article

Medical Psychology in Russia

The "FaBo Mirror" therapy protocol in the neuropsychological correction of phantom limb pain: theoretical rationale and description of the method

E. D. Shagina, V. B. Nikishina, I. V. Zapesotskaya, V. A. Movsisyan, G. G. Melkonyan

Objective : to introduce and provide a theoretical rationale for the FaBo Mirror, a standardized clinical–psychological and neuropsychological mirror therapy protocol developed for the correction of phantom limb pain (PLP), and to describe its construction principles, procedure, and efficacy assessment system. Materials and Methods : a theoretical–methodological analysis of PLP was combined with a structured description of the protocol. The framework integrates Anokhin's theory of functional systems with the neurom …

14.08.2026journal-article

BMC Ophthalmology

Comparison of morphological and functional parameters after switching therapy from brolucizumab to faricimab in neovascular age-related macular degeneration

Agnes Boltz, Jasmin Paster, Sarah Mehany, Veronika Pia Vécsei-Marlovits

Abstract Background Brolucizumab, an anti-vascular endothelial growth factor (VEGF) agent, offers extended dosing intervals in neovascular age-related macular degeneration (nAMD) but carries a rare risk of retinal vasculitis. Faricimab, a bispecific antibody targeting VEGF and angiopoietin-2 (Ang-2), maintained efficacy with dosing intervals of up to 16 weeks in the TENAYA and LUCERNE trials and carries a lower reported inflammatory risk. Patients may therefore be switched from brolucizumab to faricimab. This study …

14.08.2026journal-article

Alzheimer's Research & Therapy

Optimal amyloid and tau CSF biomarkers for the detection of amyloid and tau PET positivity in a memory clinic population

Sophie Mutel, Federica Ribaldi, Augusto J. Mendes, Daniele Altomare, Cecilia Boccalini, Claire Chevalier, Miguel A. Frias, Ilse Kern, Moira Marizzoni, Debora Peretti, Chen Wang, Valentina Garibotto, Aurélien Lathuilière, Giovanni B. Frisoni

Abstract Background Accurate detection of Alzheimer’s disease (AD) pathophysiological changes is crucial for research and clinical practice. While positron emission tomography (PET) imaging is an established reference standard for detecting brain amyloid and tau deposition, cerebrospinal fluid (CSF) biomarkers offer a more accessible alternative. This study aimed to identify optimal CSF biomarkers and thresholds for predicting tau and amyloid PET positivity in a memory clinic population. Methods This cross-sectiona …

14.08.2026journal-article

Healthcare

Implementing Rehabilitation Robotics in Routine Care: A Mapping Review of Service Delivery Models, Implementation Determinants, Strategies, and Real-World Outcomes

Rocco Salvatore Calabrò, Andrea Calderone, Maria Felicita Crupi, Marcello Nucifora, Maurizio Lanza, Angelo Quartarone

Background/Objectives: Rehabilitation robotics is increasingly used in neurorehabilitation, yet evidence on how robotic services are organized, maintained and scaled in routine care remains fragmented. This mapping review examined service-delivery models, implementation determinants, strategies, outcomes, workflows and resource signals for robotic rehabilitation in service-linked clinical care. Methods: Six search sources were queried from inception to 21 February 2026. Eligible reports were studies addressing reha …