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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
14.08.2026journal-article

Journal of Monolingual and Bilingual Speech

The Impact of AI Voice Tutors on Phonetic Acquisition Among Saudi EFL Learners: A Quasi-Experimental Study at Jouf University

Ahmad Mugableh, Mamdouh Alhuwaykim

Abstract This study investigates the impact of AI-powered voice tutors on the phonetic acquisition of Saudi EFL learners. Although digital technologies are increasingly integrated into language education, empirical research has yet to examine the extent to which AI-driven pronunciation feedback yields measurable phonetic gains in Arab EFL contexts. This quasi-experimental study evaluates whether personalized AI feedback enhances both segmental accuracy (e.g., /p/–/b/, /v/–/f/, /ɪ/–/iː/) and suprasegmental control ( …

14.08.2026journal-article

MRS Bulletin

Covalent organic frameworks: Smart nanoarchitectures for targeted cancer therapy and imaging

Pankaj Garg, Sharad S. Singhal

Abstract Cancer remains one of the leading causes of death worldwide and requires new and targeted approaches for early detection and treatment. Covalent organic frameworks (COFs) are emerging as promising nanostructured materials for cancer applications. With remarkable properties such as tunable pore size and high specific surface area, chemical stability, and good biocompatibility, COFs can effectively encapsulate and release drugs, reducing drug toxicity while targeting tumor tissues. In this article, we overvi …

14.08.2026journal-article

Medicine Advances

Decoding Molecular Mechanisms of Pongamia pinnata Phytochemicals in Cancer Therapy

Rajib Dhar, Vetriselvan Subramaniyan

ABSTRACT Pongamia pinnata (L.) Pierre (P. Pinnata) is commonly found in Southeast Asia and is recognized for its multiple bioactive phytochemicals with notable therapeutic potential. The phytochemicals constituents of P. pinnata showing antioxidant, anti‐inflammatory, and anti‐metastasis properties. In cancer therapy, the primary objective is to eliminate malignant cells effectively, with minimal damage on healthy cells. Although conventional treatment chemotherapy, radiotherapy, and immunotherapy effectively targe …

14.08.2026journal-article

Medicine

Effect of dual antiplatelet therapy on prognosis of patients with myocardial infarction with nonobstructive coronary artery disease

Yao Qin, Huan Zhao, Shu-Lei Fu, Wei-Li Cheng, Jun Zhang, Yu-Qing Zhang, Xiao-Qing Lian

Background: The diverse pathogenic mechanisms of myocardial infarction with nonobstructive coronary artery disease (MINOCA) result in therapeutic difficulties. The purpose of this meta-analysis was to assess the impact of dual antiplatelet therapy (DAPT) on prognosis of patients with MINOCA. Methods: Relevant studies published prior to May 2025 were identified through a search of the PubMed, Embase and Web of Science databases. We evaluated the data using hazard ratios (HRs) and 95% confidence interval (CI). Hetero …

14.08.2026journal-article

Journal of Speech, Language, and Hearing Research

False Belief Understanding in Deaf and Hard of Hearing Children: Systematic Review With Meta-Analysis

Vaia Thomaidou, Konstantinos I. Bougioukas, Panagiota Peleka, Panagiota Metallidou

Purpose: This meta-analysis aimed to compare the performance of deaf and hard of hearing (DHH) children who use cochlear implants (CIs) or hearing aids (HAs) with their typically hearing (TH) peers on false belief (FB) understanding tasks. Method: Data were synthesized from 13 studies comprising 292 participants 1.92–14.03 years of age. A multilevel random-effects meta-analysis was conducted, followed by metaregression to examine the effects of age, mean age at onset, type of hearing amplifier, type of FB task, and …

14.08.2026journal-article

Frontiers in Immunology

The LVI Component Hypothesis: the lymphatic-to-vascular invasion ratio as an enrichment biomarker for therapy with PD-L1×VEGF-A bispecific antibodies

Kenneth A. Kern

Lymphovascular invasion (LVI) describes intravasated tumor cells within intratumoral lymphatic or blood vessels. LVI is reported routinely on pathologic examination because it is prognostic for reduced disease-free and overall survival across many solid tumors. In contrast, it is not considered a predictive biomarker because its presence cannot discriminate which patients benefit from a given therapy. To become predictive, a biomarker must reflect the aberrant, specific biology a drug targets. Bispecific antibodies …

14.08.2026journal-article

Microbiome

Adjuvant commensal therapy enhances antibiotic efficacy against Staphylococcus aureus

Chun-Chi Chang, Tomas Demeter, Alejandro Gómez-Mejia, Weronika Barcik, Judith Bergada-Pijuan, Andrew G. Kempchinsky, Umberto Maccio, Eline Cauwenberghs, Nora Ranzoni, Ilke De Boeck, Sarah Lebeer, Srikanth Mairpady Shambat, Silvio D. Brugger

Abstract Background Staphylococcus aureus is a common human pathobiont whose nasal colonization represents a major risk factor for subsequent infection. The prevalence of antimicrobial resistance, coupled with antibiotic-induced microbiota perturbation, has rendered S. aureus -associated infections increasingly difficult to treat. Commensal bacteria have emerged as potential modulators of both host immune responses and pathogen pathogenesis; however, whether they can act as therapeutic adjuvants to enhance treatmen …

14.08.2026journal-article

Signal Transduction and Targeted Therapy

Oral nonpeptide GLP-1 receptor agonist VCT220 for obesity treatment: a randomized, double-blind, phase II trial

Linong Ji, Leili Gao, Ben Li, Mei Liu, Xianghua Zhang, Chao Meng

Abstract VCT220 is a novel nonpeptide, orally available glucagon-like peptide-1 receptor agonist (GLP-1RA) designed to reduce the complex administration of injectable GLP-1RAs and the limited bioavailability of on-marketing oral agents for obesity care. We conducted a multicenter, randomized, double-blind, placebo-controlled, phase II trial (Registration no. CTR20233978 and NCT06569355) across 13 sites in China. Adults aged 18–75 years with overweight (BMI 24-28 kg/m² plus ≥ 1 comorbidity) or obesity (BMI ≥ 28 kg/m …

14.08.2026journal-article

Journal of Functional Biomaterials

Development of an Electro-Responsive Sorafenib-Loaded Polypyrrole Coating-Modified Nickel–Titanium Alloy for Tumor Ablation Therapy

Lele Liu, Peng Gu, Dan Xia, Yonghao Wen, Baoe Li, Donghui Wang, Yaohong Wu

Nickel–titanium (NiTi) stents have been widely used for the palliative management of portal vein tumor thrombosis (PVTT) due to their excellent mechanical strength and biocompatibility. However, conventional NiTi implants are therapeutically passive and lack intrinsic antitumor activity, rendering them vulnerable to tumor ingrowth and subsequent restenosis. Electrical stimulation-mediated ablation offers a controllable physical strategy for local tumor clearance; however, the native TiO2 passivation layer on the Ni …

14.08.2026journal-article

Frontiers in Nutrition

Five-year patient-reported outcomes of individualized nutrition therapy supporting nutritional ketosis in adults with type 2 diabetes

Rebecca N. Adams, Shaminie J. Athinarayanan, Stephen D. Phinney, Jeff S. Volek, Amy L. McKenzie

Introduction Sleep disturbance, depressive symptoms, and musculoskeletal pain are common in type 2 diabetes (T2D). The long-term patient-reported effects of nutrition-based interventions targeting metabolic dysfunction remain unclear. We examined 5-year changes in sleep, depressive symptoms, and knee pain in adults with T2D participating in a digitally delivered continuous care intervention providing individualized nutrition therapy supporting nutritional ketosis. Methods Adults with T2D enrolled in the interventio …

14.08.2026journal-article

Frontiers in Oncology

Inhibition of ATM, ATR and DNA-PK radiosensitises 3D uveal melanoma models to X-rays and proton beam therapy

Laura Hawkins, Ryan Morris, Helen Kalirai, Karen Aughton, Rumana Hussain, Sarah E. Coupland, Jason L. Parsons

Introduction Proton beam therapy (PBT) is a well-established treatment modality for uveal melanoma (UM), where it exerts its therapeutic effect primarily through the induction of significant DNA damage, particularly DNA double strand breaks (DSBs) that are the most challenging for the cell to repair. Following DSB induction, a coordinated repair response is orchestrated by the key protein kinases, ataxia telangiectasia mutated (ATM), ataxia telangiectasia and Rad3-related (ATR) and DNA-dependent protein kinase cata …

14.08.2026journal-article

Clinics and Practice

Development and Preliminary Assessment of a Mortality Risk Score in Patients with Coronary Artery Disease Receiving Dual Antiplatelet Therapy After Percutaneous Coronary Intervention

Friba Nurmukhammad, Sholpan Zhangelova, Akhmetzhan Sugraliyev, Alexander Arutyunov, Yermagambet Kuatbayev, Zhanetta Mukanova, Dina Kapsultanova

Background: Patients with coronary artery disease (CAD) receiving dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) remain at risk of early adverse outcomes, including in-hospital mortality. Simple risk stratification based on routinely available variables may help identify higher-risk patients, but a limited number of outcome events constrains robust prediction-model development and validation. Aim: This exploratory study aimed to derive a preliminary, interpretable clinical score bas …

14.08.2026journal-article

JMIR Rehabilitation and Assistive Technologies

Ecological Momentary Assessment of Daily Activities in Individuals With Neurological Disorders: Scoping Review

Eva Delooz, Barbara Piškur, Aki Rintala, Bruno Bonnechère, Annemie Spooren

Background Daily activities shape individuals’ health and well-being, reflecting functioning and lived health. For people with neurological conditions, these activities are often disrupted, affecting autonomy and quality of life. Traditional assessments miss subtle, real-time fluctuations, whereas ecological momentary assessment (EMA) captures moment-to-moment activity within natural contexts, offering insight into person-environment-occupation interactions. Despite its growing use, it remains unclear how EMA proto …

14.08.2026journal-article

İşletme Bilimi Dergisi

Examining the Association between Healthcare Workers’ Pandemic Fear and Occupational Anxiety Levels and Their Life Satisfaction

Zeynep Merve Dinler, İbrahim Halil Cankul, Abdul Yusuf Tuncer

Healthcare workers experience high levels of job stress and occupational anxiety, and the emergence of infectious diseases may further increase their fear and anxiety levels. This study aimed to examine the associations between healthcare workers’ fear of COVID-19, occupational anxiety, and life satisfaction. This descriptive, cross-sectional, and correlational study was conducted with 205 healthcare workers, including doctors, nurses, and healthcare technicians, who volunteered from a population of 235 employees a …

14.08.2026journal-article

Frontiers in Oncology

Targeted therapy plus chemotherapy for advanced or metastatic triple-negative breast cancer: a PRISMA 2020 systematic review and meta-analysis

Yanbing Li, Zijun Li, Xin Shi, Hongbo Zuo

Objective To systematically review the efficacy of chemotherapy combined with targeted therapy in the handling of advanced triple-negative breast cancer (TNBC). Methods A thorough literature search was carried out across several databases, including PubMed, EMBASE, ScienceDirect, and Chinese medical databases, for case-control trials on TNBC patients treated with chemotherapy combined with targeted therapy versus chemotherapy alone. Two separate researchers extracted the data, and the risk of bias was assessed usin …

14.08.2026journal-article

Frontiers in Neurology

Efgartigimod as a salvage therapy for anti-NMDAR encephalitis patients after first-line treatment failure: a case series

Yanbo Zhang, Zhijiao Song, Lulu Zheng, Lantao Liang, Hui Zhao, Hui Bu

Background As an Fc receptor inhibitor, efgartigimod (EFG) could reduce serum IgG level, which might have a positive effect in the treatment of anti-N-methyl-D-aspartate-receptor (NMDAR) encephalitis (NMDARE). This study aimed to evaluate the treatment effects and safety of EFG on NMDARE patients following a first-line treatment failure. Methods We retrospectively reviewed five NMDARE patients who failed in first-line treatment. All patients received intravenous EFG (10 mg/kg/week). We conducted neurological functi …

14.08.2026journal-article

Cancer Immunology Research

TIM3 blockade with hypomethylating therapy restores NK-cell and cytotoxic CD4+ T-cell activity in patients with AML or MDS

Jani Huuhtanen, Sofia Forstén, Brittany Ford, Johannes Smolander, Oscar Brück, Sofie Lundgren, Anna Kreutzman, Olli Dufva, Matti Kankainen, Mette Ilander, Hanna Lähteenmäki, Tiina Kasanen, Jay Klievink, Judith Leitner, Peter Steinberger, Mika Kontro, Marc R. Pelletier, Harri Lähdesmäki, Catherine Sabatos-Peyton, Mikael L. Rinne, Kimmo Porkka, Karita Peltonen, Satu Mustjoki

Abstract Occasional complete responses to immune checkpoint inhibitor therapy demonstrate that acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) can be immune-sensitive when appropriately targeted. Here, we analyzed AML/MDS patients (n=14) treated with the anti-TIM3 sabatolimab and the hypomethylating agent decitabine in a phase Ib clinical trial (NCT03066648) using single-cell RNA and T cell receptor (TCR) sequencing (n=6) and functional co-culture assays. Unlike T cell–restricted CTLA4 and PD1, TIM3 …

14.08.2026journal-article

Pharmaceutics

A Preliminary Evaluation of 177Lu-PSMA-617-Based Targeted Radioligand Therapy with X-Ray Stimulated PSMA Relocation Using the PiggyBac Reporter-Gene-Engineered Orthotopic Prostate Tumor Model

Yen-Ta Chen, Ke-Hsin Huang, Chun-Yi Wu, Yi-Jang Lee

Background/Objectives: Because human prostate cancer (PCa) typically exhibits slow tumor growth, establishing reliable PCa tumor models is often time-consuming and unpredictable, thereby limiting the efficiency of preclinical theranostic research. To overcome this limitation, this study employed a non-viral PiggyBac transposon system to introduce triple-reporter genes into PSMA-expressing C4-2 cells, generating orthotopic and subcutaneous xenograft models that allow noninvasive, real-time monitoring of PCa progress …

14.08.2026journal-article

American Journal of Speech-Language Pathology

EmotionaL and Language Recovery in Aphasia (ELLA): Codesigning and Proof-of-Concept Testing a Novel Intervention

Sarah Northcott, Niamh Devane, Nicholas Behn, Shirley Thomas, Anne Morris, Laura Sockett, May Wickham, Katerina Hilari

Purpose: People with aphasia are at risk of becoming depressed, anxious, and isolated. They want therapy to focus on improving communication, confidence, and finding ways to live well; family members want to be involved in the therapy process. We aimed to codesign and test a novel intervention (EmotionaL and Language recovery in Aphasia [ELLA]) that would address these priorities through integrating two evidence-based therapy approaches: elaborated semantic feature analysis (SFA), a naming therapy, and solution-foc …

14.08.2026journal-article

REVISTA DE ESTUDOS INTERDISCIPLINARES

VIVÊNCIAS ACADÊMICAS E QUALIDADE DE VIDA NO ENSINO SUPERIOR

Beatriz Freitas Launé, Cleiziane Lima de Oliveira, Elson Ferreira Costa Costa, Lucivaldo da Silva Araújo, Debóra Ribeiro da Silva Campos Folha

O estudo analisou a relação entre vivências acadêmicas e qualidade de vida de estudantes do curso de Terapia Ocupacional da Universidade do Estado do Pará. A pesquisa permite a compreensão de que o ingresso e permanência no ensino superior exige adaptações significativas e pode impactar tanto o desempenho acadêmico quanto o bem-estar dos discentes. O objetivo central buscou analisar as vivências acadêmicas e as percepções sobre a qualidade de vida de estudantes de Terapia Ocupacional, considerando aspectos sociodem …

14.08.2026journal-article

BDJ Open

Impact of post-resection maxillofacial defects on outcomes of 3D-printed prosthetic rehabilitation in oral cancer patients: a scoping review protocol

Smitha Sammith Shetty, Shibani Shetty, Sameep S. Shetty, Swapna BV

Abstract Introduction Oral cancer patients undergoing surgical resection often develop extensive maxillofacial defects that compromise function, aesthetics, and quality of life. Three-dimensional (3D) printing has enabled the development of customized, patient-specific prostheses, offering improved precision in rehabilitation. However, the extent to which defect type and location influence prosthetic outcomes remains inadequately synthesized in the current literature. Objective To map and synthesize the available e …

14.08.2026journal-article

Gynecology and Minimally Invasive Therapy

Resection of Ovarian Teratoma for the Treatment of Anti-N-Methyl-D-aspartate Receptor Encephalitis – The New Battey’s Operation: A Case Report

Poh Ting Lim, Siak Ming Goh, Satish Kumar Reddy Challa, Simon Robert Ling

Abstract We present the case of a 14-year-old girl diagnosed with Anti-N-Methyl-D-aspartate Receptor (NMDAR) encephalitis following the onset of acute seizures associated with dysautonomia and hallucinations, successfully treated after a laparoscopic ovarian cystectomy and immunotherapy. Histology of the ovarian cyst confirmed the diagnosis of an ovarian teratoma with neural tissues. She then underwent neurorehabilitation and had full recovery of her neurological and functional status. This case highlights the impo …

14.08.2026journal-article

eneuro

Auditory brainstem encoding of speech-in-noise predicts word identification, narrative comprehension, and subjective listening effort in a selective attention task

Kelsey Mankel, Daniel C. Comstock, Brett M. Bormann, Soukhin Das, Doron Sagiv, Hilary Brodie, Lee M. Miller

The auditory brainstem plays a crucial role in speech-in-noise listening, refining numerous acoustic features such as pitch and spatial location under continual descending influence from cortex. However, the difficulty of characterizing brainstem activity during continuous speech listening has obscured its functional role in ecologically valid contexts—not only the effects of selective attention on neural responses, but also their impact on comprehension and listening effort. Here, we evaluated the role of the brai …

14.08.2026journal-article

International Journal of Law and Society

Juridical Analysis of Criminal Punishment and Rehabilitation for Narcotics Offenders in Islamic Criminal Law.

Resi Darwis, A. Husin Ritonga, Hermanto Harun, Abdul Halim

This study aims to analyze the criminalization provisions for narcotic abuse under Indonesian positive law, examine the concept of rehabilitation for narcotic abusers within the Indonesian legal system, and investigate the Islamic criminal law perspective on the criminalization and rehabilitation of narcotic abusers. This research employs a normative-juridical approach using qualitative methods through library research. Data were collected from primary sources including the Qur'an, Hadith, and narcotic-related legi …