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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
14.08.2026journal-article

International Journal of Educational Teaching and Research

Discussion on the Sports and Exercise Rehabilitation Majors in New Zealand Universities and their Relationships with Aging Society

Man Li, Xu Dai

With the increase in the number of older people around the world, problems in their health have attracted more attention from society. Sports and exercise rehabilitation play an essential role in improving the physical fitness, boosting the mental health and overall quality of life of older people, and thus have gradually become important ways to address the health problems of an aging society. As the main institutions for knowledge innovation and talent cultivation, universities in New Zealand have achieved good r …

14.08.2026journal-article

JCC Plus

Hepatitis E Infection in Patients With IBD Treated With Advanced Therapy: A Case Series

Jakub Jirsa, Kristyna Kubickova, Dana Duricova

ABSTRACT Background and Aims Hepatitis E virus is an RNA virus with 8 genotypes. Infection is usually acute and asymptomatic, but chronic infection may develop in immunocompromised individuals. Data on the course of hepatitis E virus infection in patients with inflammatory bowel disease receiving advanced therapy are limited. We aimed to describe the clinical course and outcomes of hepatitis E virus infection in this population. Methods We conducted a case series of consecutive patients with inflammatory bowel dise …

14.08.2026journal-article

ACS Applied Materials & Interfaces

Ingestible Hydrogel-Encapsulated Optogenetic Yeast Controlled by Wearable Electronics Enables Programmable IL-10 Delivery for Inflammatory Bowel Disease Therapy

Chao Zhang, Hongxiang Li, Yue Jiang, Lu Wang, Zhijie Feng, Yanyan Shi, Duo Liu, Hanjie Wang

Abstract Engineered yeast-living drugs offer significant potential for oral protein therapy but remain limited by poor intestinal retention and lack of precise spatiotemporal control over therapeutic delivery. Here, we developed an ingestible hydrogel-encapsulated optogenetic yeast system controlled by a wearable electronic device for programmable interleukin-10 (IL-10) delivery in inflammatory bowel disease (IBD). We engineered Pichia pastoris with an EL222-based blue-light-inducible circuit achieving rapid, strin …

14.08.2026journal-article

Frontiers in Pharmacology

Aztreonam–avibactam therapy following surgical source control for blaNDM-positive carbapenem-resistant Klebsiella pneumoniae intra-abdominal infection in an infant: a case report

Jie Liu, Xiaoli He, Wanlin Zhao, Lijia Du, Lina Qiao, Lu Qing

Treating carbapenem-resistant Klebsiella pneumoniae (CRKP) is challenging, particularly when resistance is mediated by New Delhi metallo-β-lactamase (NDM). Clinical experience with fixed-combination aztreonam–avibactam (ATM–AVI) in young infants remains extremely limited. Here, we report a case of a 2-month-old boy who underwent emergency laparotomy for intestinal obstruction owing to small bowel volvulus with segmental necrosis, followed by bowel resection and reanastomosis. His postoperative course was complicate …

14.08.2026journal-article

International Journal of Language & Communication Disorders

Speech and Language Therapists’ Views Regarding Their Scope of Practice in Written Language

Carol Moxam, Claire d'Urban‐Jackson, Lauren Ackerman

ABSTRACT Background Spoken and written language are closely linked, and Speech and Language Therapists (SLTs) have expertise in the language skills that support both. However, unlike countries such as the US and Australia, UK SLTs lack clear guidance on their role in written language. This study explores the views of SLTs working with adults (aged 16+) and children to inform consideration of a UK position statement. Aims To examine UK SLTs’ views on their role and scope of practice in written language assessment an …

14.08.2026journal-article

Journal of Monolingual and Bilingual Speech

The Impact of AI Voice Tutors on Phonetic Acquisition Among Saudi EFL Learners: A Quasi-Experimental Study at Jouf University

Ahmad Mugableh, Mamdouh Alhuwaykim

Abstract This study investigates the impact of AI-powered voice tutors on the phonetic acquisition of Saudi EFL learners. Although digital technologies are increasingly integrated into language education, empirical research has yet to examine the extent to which AI-driven pronunciation feedback yields measurable phonetic gains in Arab EFL contexts. This quasi-experimental study evaluates whether personalized AI feedback enhances both segmental accuracy (e.g., /p/–/b/, /v/–/f/, /ɪ/–/iː/) and suprasegmental control ( …

14.08.2026journal-article

Canadian Journal of Respiratory Therapy

Comparison of the active cycle breathing technique with other self-administered breathing techniques for the management of mucociliary production in cystic fibrosis: A systematic review

Muhammad Najeeb Ullah Khan, Asma Osama

Background Cystic fibrosis (CF) is characterized by excessive airway mucus, recurrent infections, impaired ventilation, and progressive decline in lung function. Airway clearance techniques are central to management. Among them is the active cycle of breathing technique (ACBT), which incorporates breathing control, thoracic expansion exercises, and the forced expiratory technique (FET). Comparative evaluation with other self-administered exercises is needed to identify the most effective approach for clinical use. …

14.08.2026journal-article

Current Pharmaceutical Research

Peptidomimetics Based Therapy Across Cancer, Diabetes, Infection, Neurological and Cardiovascular Disease

Ankita sharma Sharma, Happy, Kapil kumar verma, Saloni Bhardwaj

Peptidomimetics are synthetic compounds designed to mimic the structural and functional features of natural peptides while overcoming limitations such as poor stability, low bioavailability, and rapid degradation. These compounds maintain the ability to interact with biological targets, offering enhanced receptor selectivity, potency, and pharmacokinetic properties. Traditional classification divides peptidomimetics into structural, functional, and functional-structural types, while modern approaches categorize the …

14.08.2026journal-article

Journal of Humanities and Social Sciences Studies

The effectiveness of a counseling program based on play therapy in reducing shyness among fifth-grade students

Rizan Mohamad Taher Humdan, Saleh Salem Al Khwaldeh

The present study aimed to investigate the effectiveness of a counseling program based on play therapy in reducing shyness among fifth-grade students. To achieve the objectives of the study, the researcher adopted a quasi-experimental design with two groups: an experimental group and a control group. The study sample consisted of (30) fifth-grade female students from Amouriya Basic Second School affiliated with the Directorate of Education of Marka District in Amman. The participants were selected using purposive s …

14.08.2026journal-article

MRS Bulletin

Covalent organic frameworks: Smart nanoarchitectures for targeted cancer therapy and imaging

Pankaj Garg, Sharad S. Singhal

Abstract Cancer remains one of the leading causes of death worldwide and requires new and targeted approaches for early detection and treatment. Covalent organic frameworks (COFs) are emerging as promising nanostructured materials for cancer applications. With remarkable properties such as tunable pore size and high specific surface area, chemical stability, and good biocompatibility, COFs can effectively encapsulate and release drugs, reducing drug toxicity while targeting tumor tissues. In this article, we overvi …

14.08.2026journal-article

Medicine Advances

Decoding Molecular Mechanisms of Pongamia pinnata Phytochemicals in Cancer Therapy

Rajib Dhar, Vetriselvan Subramaniyan

ABSTRACT Pongamia pinnata (L.) Pierre (P. Pinnata) is commonly found in Southeast Asia and is recognized for its multiple bioactive phytochemicals with notable therapeutic potential. The phytochemicals constituents of P. pinnata showing antioxidant, anti‐inflammatory, and anti‐metastasis properties. In cancer therapy, the primary objective is to eliminate malignant cells effectively, with minimal damage on healthy cells. Although conventional treatment chemotherapy, radiotherapy, and immunotherapy effectively targe …

14.08.2026journal-article

Medicine

Effect of dual antiplatelet therapy on prognosis of patients with myocardial infarction with nonobstructive coronary artery disease

Yao Qin, Huan Zhao, Shu-Lei Fu, Wei-Li Cheng, Jun Zhang, Yu-Qing Zhang, Xiao-Qing Lian

Background: The diverse pathogenic mechanisms of myocardial infarction with nonobstructive coronary artery disease (MINOCA) result in therapeutic difficulties. The purpose of this meta-analysis was to assess the impact of dual antiplatelet therapy (DAPT) on prognosis of patients with MINOCA. Methods: Relevant studies published prior to May 2025 were identified through a search of the PubMed, Embase and Web of Science databases. We evaluated the data using hazard ratios (HRs) and 95% confidence interval (CI). Hetero …

14.08.2026journal-article

Journal of Speech, Language, and Hearing Research

False Belief Understanding in Deaf and Hard of Hearing Children: Systematic Review With Meta-Analysis

Vaia Thomaidou, Konstantinos I. Bougioukas, Panagiota Peleka, Panagiota Metallidou

Purpose: This meta-analysis aimed to compare the performance of deaf and hard of hearing (DHH) children who use cochlear implants (CIs) or hearing aids (HAs) with their typically hearing (TH) peers on false belief (FB) understanding tasks. Method: Data were synthesized from 13 studies comprising 292 participants 1.92–14.03 years of age. A multilevel random-effects meta-analysis was conducted, followed by metaregression to examine the effects of age, mean age at onset, type of hearing amplifier, type of FB task, and …

14.08.2026journal-article

Frontiers in Immunology

The LVI Component Hypothesis: the lymphatic-to-vascular invasion ratio as an enrichment biomarker for therapy with PD-L1×VEGF-A bispecific antibodies

Kenneth A. Kern

Lymphovascular invasion (LVI) describes intravasated tumor cells within intratumoral lymphatic or blood vessels. LVI is reported routinely on pathologic examination because it is prognostic for reduced disease-free and overall survival across many solid tumors. In contrast, it is not considered a predictive biomarker because its presence cannot discriminate which patients benefit from a given therapy. To become predictive, a biomarker must reflect the aberrant, specific biology a drug targets. Bispecific antibodies …

14.08.2026journal-article

Microbiome

Adjuvant commensal therapy enhances antibiotic efficacy against Staphylococcus aureus

Chun-Chi Chang, Tomas Demeter, Alejandro Gómez-Mejia, Weronika Barcik, Judith Bergada-Pijuan, Andrew G. Kempchinsky, Umberto Maccio, Eline Cauwenberghs, Nora Ranzoni, Ilke De Boeck, Sarah Lebeer, Srikanth Mairpady Shambat, Silvio D. Brugger

Abstract Background Staphylococcus aureus is a common human pathobiont whose nasal colonization represents a major risk factor for subsequent infection. The prevalence of antimicrobial resistance, coupled with antibiotic-induced microbiota perturbation, has rendered S. aureus -associated infections increasingly difficult to treat. Commensal bacteria have emerged as potential modulators of both host immune responses and pathogen pathogenesis; however, whether they can act as therapeutic adjuvants to enhance treatmen …

14.08.2026journal-article

Signal Transduction and Targeted Therapy

Oral nonpeptide GLP-1 receptor agonist VCT220 for obesity treatment: a randomized, double-blind, phase II trial

Linong Ji, Leili Gao, Ben Li, Mei Liu, Xianghua Zhang, Chao Meng

Abstract VCT220 is a novel nonpeptide, orally available glucagon-like peptide-1 receptor agonist (GLP-1RA) designed to reduce the complex administration of injectable GLP-1RAs and the limited bioavailability of on-marketing oral agents for obesity care. We conducted a multicenter, randomized, double-blind, placebo-controlled, phase II trial (Registration no. CTR20233978 and NCT06569355) across 13 sites in China. Adults aged 18–75 years with overweight (BMI 24-28 kg/m² plus ≥ 1 comorbidity) or obesity (BMI ≥ 28 kg/m …

14.08.2026journal-article

Journal of Functional Biomaterials

Development of an Electro-Responsive Sorafenib-Loaded Polypyrrole Coating-Modified Nickel–Titanium Alloy for Tumor Ablation Therapy

Lele Liu, Peng Gu, Dan Xia, Yonghao Wen, Baoe Li, Donghui Wang, Yaohong Wu

Nickel–titanium (NiTi) stents have been widely used for the palliative management of portal vein tumor thrombosis (PVTT) due to their excellent mechanical strength and biocompatibility. However, conventional NiTi implants are therapeutically passive and lack intrinsic antitumor activity, rendering them vulnerable to tumor ingrowth and subsequent restenosis. Electrical stimulation-mediated ablation offers a controllable physical strategy for local tumor clearance; however, the native TiO2 passivation layer on the Ni …

14.08.2026journal-article

Frontiers in Nutrition

Five-year patient-reported outcomes of individualized nutrition therapy supporting nutritional ketosis in adults with type 2 diabetes

Rebecca N. Adams, Shaminie J. Athinarayanan, Stephen D. Phinney, Jeff S. Volek, Amy L. McKenzie

Introduction Sleep disturbance, depressive symptoms, and musculoskeletal pain are common in type 2 diabetes (T2D). The long-term patient-reported effects of nutrition-based interventions targeting metabolic dysfunction remain unclear. We examined 5-year changes in sleep, depressive symptoms, and knee pain in adults with T2D participating in a digitally delivered continuous care intervention providing individualized nutrition therapy supporting nutritional ketosis. Methods Adults with T2D enrolled in the interventio …

14.08.2026journal-article

Frontiers in Oncology

Inhibition of ATM, ATR and DNA-PK radiosensitises 3D uveal melanoma models to X-rays and proton beam therapy

Laura Hawkins, Ryan Morris, Helen Kalirai, Karen Aughton, Rumana Hussain, Sarah E. Coupland, Jason L. Parsons

Introduction Proton beam therapy (PBT) is a well-established treatment modality for uveal melanoma (UM), where it exerts its therapeutic effect primarily through the induction of significant DNA damage, particularly DNA double strand breaks (DSBs) that are the most challenging for the cell to repair. Following DSB induction, a coordinated repair response is orchestrated by the key protein kinases, ataxia telangiectasia mutated (ATM), ataxia telangiectasia and Rad3-related (ATR) and DNA-dependent protein kinase cata …

14.08.2026journal-article

Clinics and Practice

Development and Preliminary Assessment of a Mortality Risk Score in Patients with Coronary Artery Disease Receiving Dual Antiplatelet Therapy After Percutaneous Coronary Intervention

Friba Nurmukhammad, Sholpan Zhangelova, Akhmetzhan Sugraliyev, Alexander Arutyunov, Yermagambet Kuatbayev, Zhanetta Mukanova, Dina Kapsultanova

Background: Patients with coronary artery disease (CAD) receiving dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) remain at risk of early adverse outcomes, including in-hospital mortality. Simple risk stratification based on routinely available variables may help identify higher-risk patients, but a limited number of outcome events constrains robust prediction-model development and validation. Aim: This exploratory study aimed to derive a preliminary, interpretable clinical score bas …

14.08.2026journal-article

JMIR Rehabilitation and Assistive Technologies

Ecological Momentary Assessment of Daily Activities in Individuals With Neurological Disorders: Scoping Review

Eva Delooz, Barbara Piškur, Aki Rintala, Bruno Bonnechère, Annemie Spooren

Background Daily activities shape individuals’ health and well-being, reflecting functioning and lived health. For people with neurological conditions, these activities are often disrupted, affecting autonomy and quality of life. Traditional assessments miss subtle, real-time fluctuations, whereas ecological momentary assessment (EMA) captures moment-to-moment activity within natural contexts, offering insight into person-environment-occupation interactions. Despite its growing use, it remains unclear how EMA proto …

14.08.2026journal-article

İşletme Bilimi Dergisi

Examining the Association between Healthcare Workers’ Pandemic Fear and Occupational Anxiety Levels and Their Life Satisfaction

Zeynep Merve Dinler, İbrahim Halil Cankul, Abdul Yusuf Tuncer

Healthcare workers experience high levels of job stress and occupational anxiety, and the emergence of infectious diseases may further increase their fear and anxiety levels. This study aimed to examine the associations between healthcare workers’ fear of COVID-19, occupational anxiety, and life satisfaction. This descriptive, cross-sectional, and correlational study was conducted with 205 healthcare workers, including doctors, nurses, and healthcare technicians, who volunteered from a population of 235 employees a …

14.08.2026journal-article

Frontiers in Oncology

Targeted therapy plus chemotherapy for advanced or metastatic triple-negative breast cancer: a PRISMA 2020 systematic review and meta-analysis

Yanbing Li, Zijun Li, Xin Shi, Hongbo Zuo

Objective To systematically review the efficacy of chemotherapy combined with targeted therapy in the handling of advanced triple-negative breast cancer (TNBC). Methods A thorough literature search was carried out across several databases, including PubMed, EMBASE, ScienceDirect, and Chinese medical databases, for case-control trials on TNBC patients treated with chemotherapy combined with targeted therapy versus chemotherapy alone. Two separate researchers extracted the data, and the risk of bias was assessed usin …

14.08.2026journal-article

Frontiers in Neurology

Efgartigimod as a salvage therapy for anti-NMDAR encephalitis patients after first-line treatment failure: a case series

Yanbo Zhang, Zhijiao Song, Lulu Zheng, Lantao Liang, Hui Zhao, Hui Bu

Background As an Fc receptor inhibitor, efgartigimod (EFG) could reduce serum IgG level, which might have a positive effect in the treatment of anti-N-methyl-D-aspartate-receptor (NMDAR) encephalitis (NMDARE). This study aimed to evaluate the treatment effects and safety of EFG on NMDARE patients following a first-line treatment failure. Methods We retrospectively reviewed five NMDARE patients who failed in first-line treatment. All patients received intravenous EFG (10 mg/kg/week). We conducted neurological functi …